This concise handbook provides oncologists and other healthcare providers with crucial updates in the field, including an updated review of the current understanding of the biology of the HER2 pathway, an overview of HER2-testing, and evidence-based discussions of available and emerging HER2-targeted treatment options. An essential clinical text for physicians that screen and treat patients with breast cancer and require an accessible, up-to-date survey of the dynamic treatment landscape.
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15–25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.
This concise handbook provides oncologists and other healthcare providers with crucial updates in the field, including an updated review of the current understanding of the biology of the HER2 pathway, an overview of HER2-testing, and evidence-based discussions of available and emerging HER2-targeted treatment options. An essential clinical text for physicians that screen and treat patients with breast cancer and require an accessible, up-to-date survey of the dynamic treatment landscape.
The book "The Transmission Electron Microscope" contains a collection of research articles submitted by engineers and scientists to present an overview of different aspects of TEM from the basic mechanisms and diagnosis to the latest advancements in the field. The book presents descriptions of electron microscopy, models for improved sample sizing and handling, new methods of image projection, and experimental methodologies for nanomaterials studies. The selection of chapters focuses on transmission electron microscopy used in material characterization, with special emphasis on both the theoretical and experimental aspect of modern electron microscopy techniques. I believe that a broad range of readers, such as students, scientists and engineers will benefit from this book.
This pages include the results derived during last ten years about both suppression and synchronization of chaotic -continuous time- systems. Along this time, our concept was to study how the intrinsic properties of dynamical systems can be exploited to suppress and to synchronize the chaotic behavior and what synchronization phen- ena can be found under feedback interconnection. Our findings have caused surprise to us and have stimulated our astonishing capability. Perhaps, reader can imagine our faces with opens eyes like children seeing around objects; which are possibly obvious for others and novel for us. A compilation of our surprises about these findings is being described along this book. Book contains both objectives to share our ama- ment and to show our perspective on synchronization of chaotic systems. Thus, while we were writing the preface, we discussed its scope. Thinking as a book readers, we found that a preface should answer, in few words, the following question: What can the reader find in this book?, reader can find our steps toward understanding of c- otic behavior and the possibility of suppressing and synchronizing it. We firstly show the chaos suppression form experimental domain to potential implementation in high tech system as a levitation system based on High Temperature Superconductors (HTS). This chapter is used as departing point towards a more complicated problem the chaotic synchronization. Then, reader travels by the synchronization of the chaotic behavior world throughout distinct feedback approaches.
Few scientific developments have given rise to as much controversy as biotechnology. Numerous groups are united in their opposition, expressing concern over environmental and health risks, impacts on rural livelihoods, the economic dominance of multinational companies and the ethical implications of crossing species boundaries. Among the supporters of the technology are those that believe in its potential to enhance food security, further economic development, increase productivity and reduce environmental pressures. As a result, countries - and sectors within countries - find themselves at odds with each other while potential opportunities for development offered by the use of biotechnology are seized or missed, and related risks go unmanaged. This book, a unique interdisciplinary collection of perspectives from the developing world, examines the ongoing debate. Writing for the International Centre for Trade and Sustainable Development, leading experts address issues such as diffusion of technology, intellectual property rights, the Cartagena Protocol, impacts of international trade, capacity building and biotechnology research and regulation. With the most recent and relevant examples from around the world, Trading in Genes offers the reader a single-volume overview of the connections between biotechnology, trade and sustainability that is both wide-ranging and thorough
Engineer and implement sustainable transportation solutions Featuring in-depth coverage of passenger and freight transportation, this comprehensive resource discusses contemporary transportation systems and options for improving their sustainability. The book addresses vehicle and infrastructure design, economics, environmental concerns, energy security, and alternative energy sources and platforms. Worked-out examples, case studies, illustrations, equations, and end-of-chapter problems are also included in this practical guide. Sustainable Transportation Systems Engineering covers: Background on energy security and climate change Systems analysis tools and techniques Individual choices and transportation demand Transportation systems and vehicle design Physical design of transportation infrastructure Congestion mitigation in urban passenger transportation Role of intelligent transportation systems Public transportation and multimodal solutions Personal mobility and accessibility Intercity passenger transportation Freight transportation function and current trends Freight modal and supply chain management approaches Spatial and geographic aspects of freight transportation Alternative fuels and platforms Electricity and hydrogen as alternative fuels Bioenergy resources and systems Transportation security and planning for extreme weather events PRAISE FOR SUSTAINABLE TRANSPORTATION SYSTEMS ENGINEERING: "This book addresses one of the great challenges of the 21st century--how to transform our resource-intensive passenger and freight transportation system into a set of low-carbon, economically efficient, and socially equitable set of services." -- Dan Sperling, Professor and Director, Institute of Transportation Studies, University of California, Davis, author of Two Billion Cars: Driving toward Sustainability "...provides a rich tool kit for students of sustainable transportation, embracing a systems approach. The authors aptly blend engineering, economics, and environmental impact analysis approaches." -- Susan Shaheen, Professor, Department of Civil and Environmental Engineering, and Co-Director, Transportation Sustainability Research Center, University of California, Berkeley
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