Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a volume in the Advances in Surgical Pathology series, features chapters on current and impending changes in the field with an emphasis on practical issues, recent developments, and emerging concepts. Created as a quick review to be used during pathologic evaluation of cancer specimens from the lower gastrointestinal tract, this book contains the latest information regarding emerging endoscopic techniques that aid in tumor classification and staging, mechanisms of pathogenesis, and clinical management. It combines gross and microscopic images and user-friendly tables for quick reference with a succinct, comprehensive review of issues important to management of patients with colorectal carcinoma. Not only does it discuss the applied concern of cancer epidemiology and prevention, the book also covers pathological features of cancer precursors. Plus, an introduction to future diagnostic and treatment modalities, such as biomarker analysis, chemotherapeutic strategies, targeted molecular therapies, and aggressive multidisciplinary approaches to patients with advanced stage disease.
Approximately 20 million gastrointestinal tract biopsies are performed each year in the United States. While many of these are straightforward, some are histologically subtle or involve a complex differential diagnosis. This concise visual guide to the full range of neoplastic gastrointestinal specimens provides the practicing pathologist or trainee with a clear analysis and diagnosis of both common and potentially misleading variants of disease. The authors cover the full tubular GI tract with over 600 high-quality images and a concise description of the key features of each entity: definitions and terminology, gross and morphologic features, differential diagnoses, useful ancillary tests, staging and grading parameters, and special clinical considerations. Images depict differential diagnosis features, frequently seen variants that can potentially lead to misclassification or misdiagnosis, and correlated molecular and immunologic techniques.
As a handbook for practicing pathologists, this book will be an indispensable aid to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts will be readily accessible to the users of this handbook. Currently, there is no other up-to-date single-source reference specifically focused on frozen sections of the lower gastrointestinal tract.
This issue of Surgical Pathology Clinics, edited by Rhonda K. Yantiss, will focus on Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas. Topics in this issue include, but are not limited to: Other forms of esophagitis; Diagnosis and management of Barrett-related neoplasia in the modern era; Patterns of gastric injury; Practical approach to the flat duodenal biopsy specimen; Chronic colitis in biopsy samples; Mucosal biopsy following bone marrow transplantation; The many faces of medication-related injury in the GI tract; The differential diagnosis of acute colitis: Clues to a specific diagnosis; Problematic colorectal polyps; Persistent problems in colorectal cancer reporting; Emerging concepts in gastric neoplasia; Immunohistochemistry pitfalls; Molecular testing in the modern era, and Lymphoproliferative diseases of the gut.
As a handbook for practicing pathologists, this book will be an indispensable aid to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts will be readily accessible to the users of this handbook. Currently, there is no other up-to-date single-source reference specifically focused on frozen sections of the lower gastrointestinal tract.
Approximately 20 million gastrointestinal tract biopsies are performed each year in the United States. While many of these are straightforward, some are histologically subtle or involve a complex differential diagnosis. This concise visual guide to the full range of neoplastic gastrointestinal specimens provides the practicing pathologist or trainee with a clear analysis and diagnosis of both common and potentially misleading variants of disease. The authors cover the full tubular GI tract with over 600 high-quality images and a concise description of the key features of each entity: definitions and terminology, gross and morphologic features, differential diagnoses, useful ancillary tests, staging and grading parameters, and special clinical considerations. Images depict differential diagnosis features, frequently seen variants that can potentially lead to misclassification or misdiagnosis, and correlated molecular and immunologic techniques.
This issue of Surgical Pathology Clinics, edited by Rhonda K. Yantiss, will focus on Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas. Topics in this issue include, but are not limited to: Other forms of esophagitis; Diagnosis and management of Barrett-related neoplasia in the modern era; Patterns of gastric injury; Practical approach to the flat duodenal biopsy specimen; Chronic colitis in biopsy samples; Mucosal biopsy following bone marrow transplantation; The many faces of medication-related injury in the GI tract; The differential diagnosis of acute colitis: Clues to a specific diagnosis; Problematic colorectal polyps; Persistent problems in colorectal cancer reporting; Emerging concepts in gastric neoplasia; Immunohistochemistry pitfalls; Molecular testing in the modern era, and Lymphoproliferative diseases of the gut.
Pathologists play a particularly important role in the care of patients with persistent gastrointestinal symptoms. They must be able to focus on key features present in biopsy material in order to narrow the differential diagnosis and facilitate patient management. This atlas addresses these needs in a succinct and pragmatic fashion.
Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a volume in the Advances in Surgical Pathology series, features chapters on current and impending changes in the field with an emphasis on practical issues, recent developments, and emerging concepts. Created as a quick review to be used during pathologic evaluation of cancer specimens from the lower gastrointestinal tract, this book contains the latest information regarding emerging endoscopic techniques that aid in tumor classification and staging, mechanisms of pathogenesis, and clinical management. It combines gross and microscopic images and user-friendly tables for quick reference with a succinct, comprehensive review of issues important to management of patients with colorectal carcinoma. Not only does it discuss the applied concern of cancer epidemiology and prevention, the book also covers pathological features of cancer precursors. Plus, an introduction to future diagnostic and treatment modalities, such as biomarker analysis, chemotherapeutic strategies, targeted molecular therapies, and aggressive multidisciplinary approaches to patients with advanced stage disease.
There have been many advances in the pathology of intestinal tumours since the publication of the Third Series Intestines Fascicle in 2003, but many of the foundations of intestinal tumour diagnosis remain tried and true. Tubular adenomas are still tubular adenomas, but better understanding of serrated polyps has been a key advance in the years since the publication of the Third Series volume. Additionally, developments in molecular biology of colorectal carcinoma have allowed for targeted therapy and refinements to our evaluation of Lynch syndrome, which was termed hereditary nonpolyposis colorectal carcinoma (HNPCC) in the past. Our understanding of other polyposis syndromes has similarly blossomed in the past 15 years. Neuroendocrine tumours have been reclassified in the 2010 World Health Organization classification of gastrointestinal tumours. The molecular basis of gastrointestinal stromal tumours of the intestines has been a subject of great interest as well. In producing this update, this group of authors has enjoyed working together in gathering images and information to update this edition of the Intestines atlas. In doing so, we stand on the shoulders of giants before us, namely Drs. Robert H. Riddell, Robert E. Petras, Geraint T. Williams, and Leslie H. Sobin. While many areas of intestinal tumour pathology are without controversy, the classification and nomenclature for appendiceal tumours remain a subject of debate, including among ourselves. We have attempted to offer information on the various divergent viewpoints where they exist for this topic and others. Our efforts have been synergistic, and we hope that readers will enjoy the many interesting illustrations that we were able to amass.
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