Sex and Cohabitation Among Early Humans: Anthropological and Genetic Evidence for Interbreeding Among Early Humans explores the available information regarding interbreeding among different ancestral human species. In addition, it reviews evidence in support of cohabitation as well as cultural and technological interactions and exchanges among early humans, particularly Neanderthal-sapiens interactions. The fields of archaeology, anthropology, genetics, linguistics and molecular evolution have provided a wealth of information on the complex processes involved in human evolution. The book will help readers will develop knowledge on the complexity and multiplicity of hominins, including Homo heidelbergensis, Homo sapiens, and Homo floresiensis. Moreover, the book will help them reach a greater understanding of major topics, such as introgression, migration from Africa, the origin, development and extinction of Neanderthals, interbreeding between Neanderthals and humans, and trait continuity. - Integrates genetic, evolutionary, anthropological, archaeological, anatomical, artistic and linguistic research, among other areas - Written in a simple and direct style that is accessible to readers from different backgrounds and levels of understanding - Provides an integrative and holistic overview of recent developments in research on how different interactions between ancient hominins contributed to the evolution of our species
Endowed with natural resources, majestic bodies of fresh water, and a relatively mild climate, the Great Lakes region of Central Africa has also been the site of some of the world's bloodiest atrocities. In Rwanda, Burundi, and the Congo-Kinshasa, decades of colonial subjugation—most infamously under Belgium's Leopold II—were followed by decades of civil warfare that spilled into neighboring countries. When these conflicts lead to horrors such as the 1994 Rwandan genocide, ethnic difference and postcolonial legacies are commonly blamed, but, with so much at stake, such simple explanations cannot take the place of detailed, dispassionate analysis. The Dynamics of Violence in Central Africa provides a thorough exploration of the contemporary crises in the region. By focusing on the historical and social forces behind the cycles of bloodshed in Rwanda, Burundi, and the Congo-Kinshasa, René Lemarchand challenges much of the conventional wisdom about the roots of civil strife in former Belgian Africa. He offers telling insights into the appalling cycle of genocidal violence, ethnic strife, and civil war that has made the Great Lakes region of Central Africa the most violent on the continent, and he sheds new light on the dynamics of conflict in the region. Building on a full career of scholarship and fieldwork, Lemarchand's analysis breaks new ground in our understanding of the complex historical forces that continue to shape the destinies of one of Africa's most important regions.
Cultural Competence in Sports Medicine provides comprehensive information regarding the cultural attitudes, beliefs, and expectations that health care professionals may encounter in working with athletes and how to modify their professional behavior accordingly.
What do you really want to do? Finding the perfect career isn’t easy, but it’s certainly attainable. This guide offers readers the chance to trade in their unsatisfying jobs for fulfilling careers. This book helps them by providing a process of self-assessment that includes questions on personality, talents, values, interests, and goals; advice on how to make a smooth transition from one career to another; and an action plan to take the steps toward landing the perfect career. • According to The Conference Group, only 48.9% of working Americans are satisfied with their jobs, the lowest level of job satisfaction since pollsters first began surveying the topic in 1995 • Career self-discovery books are among the best-performing in the career category
A comprehensive overview of fluid dynamic models and experimental results that can help solve problems in centrifugal compressors and modern techniques for a more efficient aerodynamic design. Design and Analysis of Centrifugal Compressors isacomprehensive overview of the theoretical fluid dynamic models describing the flow in centrifugal compressors and the modern techniques for the design of more efficient centrifugal compressors. The author — a noted expert in the field, with over 40 years of experience — evaluates relevant numerical and analytical prediction models for centrifugal compressors with special attention to their accuracy and limitations. Relevant knowledge from the last century is linked with new insights obtained from modern CFD. Emphasis is to link the flow structure, performance and stability to the geometry of the different compressor components. Design and Analysis of Centrifugal Compressors is an accessible resource that combines theory with experimental data and previous research with recent developments in computational design and optimization. This important resource Covers the basic information concerning fluid dynamics that are specific for centrifugal compressors and clarifies the differences with axial compressors Provides an overview of performance prediction models previously developed in combination with extra results from research conducted by the author Describes helpful numerical and analytical models for the flow in the different components in relation to flow stability, operating range and performance Includes the fundamental information for the aerodynamic design of more efficient centrifugal compressors Explains the use of computational fluid dynamics (CFD) for the design and analysis of centrifugal compressors Written for engineers, researchers and designers in industry as well as for academics specializing in the field, Design and Analysis of Centrifugal Compressors offers an up to date overview of the information needed for the design of more effective centrifugal compressors.
An indispensable resource for all defense industry professionals—governmental and commercial! Introducing the only book on the market offering valuable best practices and lessons learned for U.S. military program management The U.S. Department of Defense and the related defense industry together form the largest and most powerful government and business entity in the world, developing some of the most expensive and complex major systems ever created. U. S. Military Program Management presents a detailed discussion, from a multi-functional view, of the ins and outs of U.S. military program management and offers recommendations for improving practices in the future. More than 15 leading experts present case studies, best practices, and lessons learned from the Army, Navy, and Air Force, from both the government and industry/contractor perspectives. This book addresses the key competencies of effective U.S. military program management in six comprehensive sections: • Requirements management • Program leadership and teamwork • Risk and financial management • Supply chain management and logistics • Contract management and procurement • Special topics
The Western Indian Ocean in the Eighteenth Century is the first of four volumes offering a sweeping panorama of the Arabian Seas during the early modern period. Focusing on the period 1700-1763, the first volume concentrates on daily life in littoral societies, examining long term issues including climatic change, famine, and the structures of fishing communities. The volume examines littoral societies in each of the major coastal areas of the Western Indian Ocean: East Africa, the Red Seas, the Persian Gulf, and its traditional ties to surrounding hinterlands as well as to the west coast of India. While having particular interest to readers concerned with Indian Ocean history, as an absorbing and innovative account of a much neglected albeit critical area and period, Arabian Seas, 1700-1763 will be of great interest to anyone interested in early modern maritime, social, or economic history. Kings, Gangsters, and Companies, volume two of Arabian Seas, 1700-1763 focuses on European relations with the major states and societies of the Western Indian Ocean during the eighteenth century. As such, it traces the major structural changes in African, South Asian, and Middle Eastern societies during this period. Chapters examine European communities and their relations with the societies of the Indian Ocean basin, the daily life of European soldiers and merchants, relations with Indian women, European views on the Indian caste system as well as the governmental systems they encountered. The volume also details the importance of Indian and Persian merchant communities in the Indian Ocean trading system and the impact of war on the economic development of this system during the eighteenth century. Men and Merchandise, the third volume of Arabian Seas, 1700-1763, provides a detailed examination of the economic and social structures in the Western Indian Ocean focusing on key commodities like bullion, textiles, and the slave trade. Readers will also encounter interesting vignettes of daily life: an Indian nautch girl worried about her inheritance, a Portuguese gangster-friar and pariah workers, the infamous buccaneers of Madagascar, coffee-traders from Yemen, Cairo, and the Crimea, and Iraqi and Iranian bankers who all had relevance to this vast economic system. Men and Merchandise provides insights into other traditionally ignored aspects in the traditional historiography including uprisings aboard slave ships, and details of maroon societies involving refugee slaves in India and Mauritius as well as Dutch slave soldiers in the Persian Gulf. As such, it will prove of great interest to any reader concerned with the social and economic history of the Indian Ocean basin. Europe in Asia, the fourth volume and final volume in Arabian Seas, 1700-1763, details the early phase of European territorial empire building in the western Indian Ocean basin. Particular attention is given to the much neglected history of the Portuguese Estado da India and the attempts of the Portuguese Crown to reform its administration and dwindling possessions in the eighteenth century. The volume examines the direct legacies of the longstanding Portuguese imperial presence in the Arabian Seas, including the experiences of Indian Catholic communities as well as the establishment of Indian settlements and communities in East Africa. Finally, the volume provides an exhaustive treatment of the structures and history of the Dutch East India Company (VOC) and English East India Company (EIC), the establishment of the vast private country trade of the EIC, and the reasons for the relative decline of the VOC and the rise of English power in the region during the eighteenth century.
Complete with valuable FORTRAN programs that help solve nondifferentiable nonlinear LtandLo.-norm estimation problems, this important reference/text extensively delineates ahistory of Lp-norm estimation. It examines the nonlinear Lp-norm estimation problem that isa viable alternative to least squares estimation problems where the underlying errordistribution is nonnormal, i.e., non-Gaussian.Nonlinear LrNorm Estimation addresses both computational and statistical aspects ofLp-norm estimation problems to bridge the gap between these two fields . . . contains 70useful illustrations ... discusses linear Lp-norm as well as nonlinear Lt, Lo., and Lp-normestimation problems . . . provides all appropriate computational algorithms and FORTRANlistings for nonlinear Lt- and Lo.-norm estimation problems . . . guides readers with clear endof-chapter notes on related topics and outstanding research publications . . . contains numericalexamples plus several practical problems .. . and shows how the data can prescribe variousapplications of Lp-norm alternatives.Nonlinear Lp-Norm Estimation is an indispensable reference for statisticians,operations researchers, numerical analysts, applied mathematicians, biometricians, andcomputer scientists, as well as a text for graduate students in statistics or computer science.
The only comprehensive book on geriatric occupational therapy designed specifically for the COTA, Occupational Therapy with Elders: Strategies for the COTA, 3rd Edition provides in-depth coverage of each aspect of geriatric practice, from wellness and prevention to death and dying. A discussion of foundational concepts includes aging trends and strategies for elder care, and coverage of emerging areas includes low-vision rehabilitation, mobility issues including driving, and Alzheimer's disease and other forms of dementia. Expert authors René Padilla, Sue Byers-Connon, and Helene Lohman offer an unmatched discussion of diverse populations and the latest on geriatric policies and procedures in this fast-growing area of practice. Unique! A focus on the occupational therapy assistant highlights the importance of COTAs to the care of elder clients. Case studies illustrate principles and help you apply what you've learned to actual situations. Key terms, chapter objectives, and review questions highlight important content in each chapter. Use of the term "elder" reduces the stereotypical role of dependent patients and helps to dispel myths about aging. A multidisciplinary approach demonstrates how the OT and the COTA can collaborate effectively. Unique! Attention to diverse populations and cultures prepares you to respect and care for clients of different backgrounds. Unique! The companion Evolve website makes review easier with more learning activities, references linked to MEDLINE abstracts, and links to related OT sites. Unique! A discussion of elder abuse, battered women, and literacy includes information on how the COTA can address these often-overlooked issues. New information on alternative treatment settings for elders reflects new trends in OT care. Updated information on Medicare, Medicaid, and HIPAA regulations discusses the latest policies and how to incorporate the newest procedures into practice. Significant additions are made to the chapters on public policy, dementia, and oncology.
Statistical distributions are fundamental to Statistical Science and are a prime indispensable tool for its applications. This monograph is the first to examine an important but somewhat neglected field — univariate continuous distribution on a bounded domain, excluding the beta distribution. It provides an elementary but thorough discussion of “novel” contributions developed in recent years, such as the two-sided power, generalized trapezoidal and generalized Topp and Leone distributions, among others. It discusses a general framework for constructing two-sided distributions and some of its properties. It contains a comprehensive chapter on the triangular distribution as well as a chapter on earlier extensions not emphasized in existing literature. Special attention is given to estimation, in particular, non-standard maximum likelihood procedures. The applications are drawn mainly from the econometric and engineering domains.
Originally published in 1828, Fran√ßois Ren√(c) de Chateaubriand's 2-volume Travels in America and Italy is an important literary travel narrative written by a leading (some would say founding) figure of French Romanticism. Chateaubriand traveled to America in 1791 to escape the volatile atmosphere of Revolutionary France. While some doubt has been raised as to whether he actually traveled to all the areas he claimed, (discrepancies in his descriptions of flora and fauna, lead scholars to believe that Chateaubriand did not travel to the Mississippi River, Florida, Alabama, or to Louisiana, as implied by his writing) Chateaubriand's lush descriptions of nature, particularly that of the sparsely populated landscape of the American South, place this work at the forefront of the French Romantic tradition, strongly impacting leading writers and thinkers of the time. Moral and intellectual concerns are explored throughout the work, for example in the Preface that contains his theories of geographical science and the history of travel. The work is also known for its exploration of the customs, manners, and languages of the Native American tribes Chateaubriand encountered. vol. 2 of 2
So simple and imperfect as it may appear this book has made use of knowledge on invention and discovery accumu lated during a lifetime. Those persons who would be tempted to emphasize only its imperfections should read the correspondence exchanged between Cantor and Dedekind at the end of the nineteenth century; they would then realize how difficult it was, even for an outstanding man, the creator of the set theory, to propose impeccable results in a completely new field. The field I have chosen here is plausibility. I have proposed an intuitive, some would say a naive, presentation as I want to reach as large an audience as possible and because I personally believe that it is easier to axiomatize a mathematical theory precisely than to dis cover it and enunciate its key theorems. Professor Polya said: "The truly creative mathematician is a good guesser first and a good prover afterward. " For centuries a formalized generalized logic was found necessary and many attempts have been made to build it. vi Preface Mine is based on plausibility which covers with precision a wider field than probability and makes the formalization of analogy and generalization possible. As Laplace said: "Even in the mathematical sciences, our principal instru ments to discover the truth are induction and analogy. "* The examples of application I have chosen are not des cribed in detail.
Essay on scientific interpretation of human phenomena, called "marvelous" phenomena. Their integration into biology and the philosophy of evolution. Parapsychology. Body, mind and spirit. An essay that thrills and nourishes.
From Simon & Schuster, The Story of the Law is René A. Wormser's about the men who created the law, from the earliest times to the present. Including chapters on the Jews, the Greeks, the Romans, and the German Barbarians, The Story of Law: And the Men Who Made It explains the creation of law from the earliest civilizations all the way to present day.
First published in 1998. This is part II of the sociology of colonies, and Volume XVIII of the twenty-one in the Race, Class and Social Structure series. Written ten years after part one, in the language in the 1941, this part provides an introduction to the study of the conflict of manners and customs, the progress of law in the colonies: this is the social phenomenon of the relationship between one people and another in a distant country.
This unique book provides a comprehensive description of fluorescence probes and the methodology for the study and diagnostics of oncology. The material is drawn directly from the work of pioneer researchers in cell biology and pathology, and offers a perspective of their most crucial investigations and lifetime experiences; it also opens new horizons on future developments in fundamental methods and diagnostics relevant to cellular physiopathology. Researchers in cell pathology have contributed a broad range of spectral and fluorescence images which most appropriately supplement the information derived from Virchow style microscope slides (these still remain valid after more than 150 years, and a considerable body of knowledge and interpretation can be built around them). The text contains about 100 colour pictures, adding great value to the book./a
Inflation targeting (IT) has gained much traction over the past two decades, becoming a framework of reference for the conduct of monetary policy. However, the debate about its very merits and macroeconomic consequences remains inconclusive. This paper digs deeper into the issue through a meta-regression analysis (MRA) of the existing literature, making it the first application of a MRA to the macroeconomic effects of IT adoption. Building on 8,059 estimated coefficients from a very broad sample of 113 studies, the paper finds that the empirical literature suffers from two types of publication bias. First, authors, editors and reviewers prefer results featuring beneficial effects of IT adoption on inflation volatility, real GDP growth and fiscal performances; second, they promote results with estimated coefficients that are significantly different from zero. However, after filtering out the publication biases, we still find meaningful (genuine) effects of IT in reducing inflation and real GDP growth volatility, but no significant genuine effects on inflation volatility and the level of real GDP growth. Interestingly, the results indicate that the impact of IT varies systematically across studies, depending on the sample structure and composition, the time coverage, the estimation techniques, country-specific factors, IT implementation parameters, and publication characteristics.
In recent years, the global creative economy has experienced unprecedented growth. Considerable research has been conducted to determine what exactly the creative economy is, what occupations are grouped together as such, and how it is to be measured. Organizations on various scales, from the United Nations to local governments, have released ‘creative’ or ‘cultural’ economy reports, developed policies for creative urban renewal, and directed attention to creative placemaking – the purposeful infusion of creative activity into specific urban environments. Parallel to these research and policy interests, academic institutions and professional organizations have begun a serious discussion about training programs for future professionals in the creative and cultural industries. We now have entire colleges offering undergraduate and graduate programs, leading to degrees in arts management, arts entrepreneurship, cultural management, cultural entrepreneurship or cultural economics. And many professional organizations offer specialized training and certificates in cultural heritage, museums studies, entertainment and film. In this book, we bring together over fifty scholars from across the globe to shed light on what we collectively call ‘cultural entrepreneurship’ – the training of professionals for the creative industries who will be change agents and resourceful visionaries that organize cultural, financial, social and human capital, to generate revenue from a cultural and creative activity. Part I of this volume begins with the observation that the creative industries - and the cultural entrepreneurship generated within them - are a global phenomenon. An increasingly mobile, international workforce is moving cultural goods and services across national boundaries at unprecedented rates. As a result, the education of cultural professionals engaged in global commerce has become equally internationalized. Part II looks into the emergence of cultural entrepreneurship as a new academic discipline, and interrogates the theoretical foundations that inform the pedagogy and training for the creative industries. Design thinking, humanities, poetics, risk, strategy and the artist/entrepreneur dichotomy are at the heart of this discussion. Part III showcases the design of cultural entrepreneurship curricula, and the pedagogies employed in teaching artists and culture industry specialists. Our authors examine pedagogy and curriculum at various scales and in national and international contexts, from the creation of entire new schools to undergraduate/graduate programs. Part IV provides case studies that focus on industry- or sector-specific training, skills-based courses (information technology, social media, entrepreneurial competitions), and more. Part V concludes the book with selected examples of practitioner training for the cultural industries, as it is offered outside of academia. In addition, this section provides examples of how professionals outside of academia have informed academic training and course work. Readers will find conceptual frameworks for building new programs for the creative industries, examples of pedagogical approaches and skillsbased training that are based on research and student assessments, and concrete examples of program and course implementation.
These volumes of Copper Proteins and Copper Enzymes are intended to describe the contemporary spectroscopy and other biophysical chemistry now being applied to copper proteins in order to determine the structures of their active sites. Several chapters of the treatise describe the functional understanding which is emerging from the new work. The authors are all major contributors to research progress on copper proteins and the volumes will be found to be definitive and authoritative.
Evolve your knowledge of the fast-moving world of genetic research Genetics For Dummies shines a light on the fascinating field of genetics, helping you gain a greater understanding of how genetics factors into everyday life. Perfect as a supplement to a genetics course or as an intro for the curious, this book is packed with easy-to-understand explanations of the key concepts, including an overview of cell biology. You’ll also find tons of coverage of recent discoveries in the field, plus info on how genetics can affect your health and wellbeing. Whole-genome sequencing, genetic disease treatments, exploring your ancestry, non-invasive prenatal testing—it’s all here, in the friendly and relatable Dummies style you love. Grasp the basics of cell biology and get a primer on the field of genetic research Discover what you can learn about yourself, thanks to advances in genetic testing Learn how your genes influence your health and wellbeing, today and as you age Follow along with your college-level genetics course—or refresh your knowledge—with clear explanations of complex ideas Genetics For Dummies is great for students of the biological sciences, and for the genetically curious everywhere.
For thousands of years, men have struggled to establish their supremacy. At first, they used spirits to secure for themselves a function in a natural world that seemed to have taken sides with the feminine. Eventually, they created an all-mighty divinity, and established their status as second to none other than that highest of all authority. Sailing through history, we show that the way procreation was perceived has determined how men and women positioned themselves in the universe. It has wielded consequences that have deeply affected our evolution, from the primal vision of an all-encompassing natural world in which Mother Nature represented the source of all life, to the subjection of nature and woman, with God the Father sitting at the summit of the creation. This emphasis on gender and nature brings into perspective the current social and economic resurgence of women and the new attitude towards environment that needs to be protected from our own deeds. These intricate leitmotifs make us witness a turning point in our history.
About the Book The life story of Marshall Major Taylor, the world's first acclaimed African American athlete. Major Taylor endured countless examples of social injustice during his reign at the top of cycling's pyramid of success. It was an era when bike racing was bigger than baseball and the fledgling sports of football and basketball combined. Cyclists were the highest-paid athletes in any sport and our country had more than a hundred high-banked velodromes historically reminiscent of what NASCAR represents today. Major Taylor was the world's best-known African American in any endeavor. He was also the first openly Christian athlete whose strength of body, mind, and spirit inspired others, black and white, with his extraordinary athletic achievement. His moral impact and the lessons Major imparted 120 years ago are equally relevant today. About the Author John Kennedy Howard has held world records at both ends of the spectrum of madness; speed and endurance. He is a 3-time Olympian and coached many national and international champions from Olympic gold medal fame to the grueling Race Across America. A cycling journalist, Howard has five book titles and hundreds of articles spanning every facet of cycling. A native San Diegan, Rene has lived in San Diego County for most of her life. She graduated from California State University San Marcos with a BS degree in Chemistry and worked as a research scientist for a manufacturing company. She developed a love for writing and the research needed to tell a factual and compelling story. Writing about Marshall Walter Taylor, the challenges he faced as an African American during a racially-challenged era, and the people he encountered during his life’s journey was an enjoyable and challenging experience.
Get the focused foundation you need to successfully work with older adults. Occupational Therapy with Elders: Strategies for the COTA, 4th Edition is the only comprehensive book on geriatric occupational therapy designed specifically for the certified occupational therapy assistant. It provides in-depth coverage of each aspect of geriatric practice — from wellness and prevention to death and dying. Expert authors Helene Lohman, Sue Byers-Connon, and René Padilla offer an unmatched discussion of diverse populations and the latest on geriatric policies and procedures in this fast-growing area of practice. You will come away with a strong foundation in aging trends and strategies for elder care in addition to having a deep understanding of emerging areas such as low-vision rehabilitation, driving and mobility issues, Alzheimer's disease and other forms of dementia, new technological advancements, health literacy, public policy, dignity therapy, and more. Plus, you will benefit from 20 additional evidence briefs and numerous case studies to help apply all the information you learn to real-life practice. It's the focused, evidence-based, and client-centered approach that every occupational therapy assistant needs to effectively care for today's elder patients. - UNIQUE! Focus on the occupational therapy assistant highlights the importance of COTAs to the care of elder clients. - Unique! Attention to diverse populations and cultures demonstrates how to respect and care for clients of different backgrounds. - UNIQUE! Discussion of elder abuse, battered women, and literacy includes information on how the OTA can address these issues that are often overlooked. - User resources on Evolve feature learning activities to help you review what you have learned and assess your comprehension. - Case studies at the end of certain chapters illustrate principles and help you understand content as it relates to real-life situations. - Multidisciplinary approach demonstrates the importance of collaboration between the OT and OTA by highlighting the OTA's role in caring for the elderly and how they work in conjunction with occupational therapists. - Key terms, chapter objectives, and review questions are found in each chapter to help identify what information is most important. - NEW! 20 Additional evidence briefs have been added to reinforce this book's evidence-based client-centered approach. - NEW! Incorporation of EMR prevalence and telehealth as a diagnostic and monitoring tool have been added throughout this new edition. - NEW! Expanded content on mild cognitive impairment, health literacy, and chronic conditions have been incorporated throughout the book to reflect topical issues commonly faced by OTs and OTAs today. - NEW! Coverage of technological advancements has been incorporated in the chapter on sensory impairments. - NEW! Other updated content spans public policy, HIPAA, power of attorney, advanced directives, alternative treatment settings, dignity therapy, and validation of the end of life. - NEW! Merged chapters on vision and hearing impairments create one sensory chapter that offers a thorough background in both areas.
Ancestral DNA, Human Origins, and Migrations describes the genesis of humans in Africa and the subsequent story of how our species migrated to every corner of the globe. Different phases of this journey are presented in an integrative format with information from a number of disciplines, including population genetics, evolution, anthropology, archaeology, climatology, linguistics, art, music, folklore and history. This unique approach weaves a story that has synergistic impact in the clarity and level of understanding that will appeal to those researching, studying, and interested in population genetics, evolutionary biology, human migrations, and the beginnings of our species. - Integrates research and information from the fields of genetics, evolution, anthropology, archaeology, climatology, linguistics, art, music, folklore and history, among others - Presents the content in an entertaining and synergistic style to facilitate a deep understanding of human population genetics - Informs on the origins and recent evolution of our species in an approachable manner
An increasing number of historical and archaeological finds made around the world have been classified as out-of-place artifacts (ooparts). They have been called this because they appear unexpectedly among the ruins of the past with no evidence of a preceding period of development; their technological sophistication seems far beyond the capabilities of ancient peoples.Drawing on the literature and art of the Chaldeans, Sumerians, Babylonians and others, Rene Noorbergen's contention is that a superior race of man was responsible for these scientific marvels that bear testimony to a civilization with technology comparable to our own.
Phagocytosis is an evolutionarily conserved mechanism that serves as the first line of host defense in multicellular organisms. The traditional definition of phagocytosis involves the engulfment and degradation of large solid particles (>0.5 μm), initiated by receptor activation on phagocytes. It forms an essential aspect of innate immunity through the uptake and destruction of infectious pathogens, while also participating in the removal of apoptotic cells during tissue remodeling and development. Professional phagocytes, such as macrophages, neutrophils, and dendritic cells, are well equipped with a wide range of phagocytic receptors. In addition, these specialized leukocytes can signal to lymphocytes within the adaptive arm of host immunity. This review emphasizes the role of two well-characterized opsonic receptors, the Fcγ receptor and the complement receptor, CR3 in macrophages. In particular, it focuses on the different mechanisms employed by these receptors during particle recognition and phagocytic uptake. Bacterial species often manipulate phagocyte signaling in order to evade their engulfment and degradation and consequently provide further insight into key regulators of the phagocytic process. Finally, we draw attention to the physiological relevance of studying the simultaneous engagement of multiple phagocytic receptors, in order to better understand receptor crosstalk and the underlying coordination of downstream signaling for efficient phagocytosis.
For Business Ethics is a daring adventure into the world of business ethics. It offers a clear and accessible introduction to business ethics and also expands business ethics beyond its current narrow confines. It is ground-breaking in the sense that it invites a distinctively critical approach to business ethics, an approach that the authors argue is part and parcel of ethics. With a thought-provoking glossary and recommendations for further readings, For Business Ethics is an essential purchase for students and practitioners alike. It is at once an introduction to business ethics and a challenge to anyone who wishes to take part in or change contemporary organized society.
Examines in a pedagogical way all pertinent molecular and macroscopic processes that govern the distribution and fate of organic chemicals in the environment and provides simple modeling tools to quantitatively describe these processes and their interplay in a given environmental system Treats fundamental aspects of chemistry, physics, and mathematical modeling as applied to environmentally relevant problems, and gives a state of the art account of the field Teaches the reader how to relate the structure of a given chemical to its physical chemical properties and intrinsic reactivities Provides a holistic and teachable treatment of phase partitioning and transformation processes, as well as a more focused and tailor-made presentation of physical, mathematical, and modeling aspects that apply to environmental situations of concern Includes a large number of questions and problems allowing teachers to explore the depth of understanding of their students or allowing individuals who use the book for self-study to check their progress Provides a companion website, which includes solutions for all problems as well as a large compilation of physical constants and compound properties
The easy way to score your highest in botany Employment of biological scientists is projected to grow 21% over the next decade, much faster than the average for all occupations, as biotechnological research and development continues to drive job growth. Botany For Dummies gives you a thorough, easy-to-follow overview of the fundamentals of botany, helping you to improve your grades, supplement your learning, or review before a test. Covers evolution by natural selection Offers plain-English explanations of the structure and function of plants Includes plant identification and botanical phenomenon Tracking a typical course in botany, this hands-on, friendly guide is your ticket to acing this required course for your major in biology, microbiology, zoology, or elementary education.
This book combines recent information and discoveries in the field of human molecular biology and human molecular evolution. It provides an interdisciplinary approach drawing together data from various diverse disciplines to address both the more classical anthropological content and the current more contemporary molecular focus of courses. Chapters include a history of human evolutionary genetics; the human genome structure and function; population structure and variability; gene and genomic dynamics; culture; health and disease; bioethics; future.
Comprehensive coverage of the entire induced pluripotent stem cell basic work flow Pluripotent stem cells (PSC) can divide indefinitely, self-renew, and can differentiate to functionally reconstitute almost any cell in the normal developmental pathway, given the right conditions. This comprehensive book, which was developed from a training course, covers all of the PSCs (embryonic, embryonic germ, and embryonic carcinoma) and their functions. It demonstrates the feeder-dependent and feeder-free culture of hESC and hiPSC, which will be referred to in all protocols as PSCs. It also addresses the methods commonly used to determine pluripotency, as defined by self-renewal marker expression and differentiation potential. Human Pluripotent Stem Cells: A Practical Guide offers in-depth chapter coverage of introduction to stem cell, PSC culture, reprogramming, differentiation, PSC characterization, and more. It also includes four appendixes containing information on reagents, medias, and solutions; common antibodies; consumable and equipment; and logs and forms. Includes helpful tips and tricks that are normally omitted from regular research papers Features useful images to support the technical aspects and results visually as well as diagrammatic illustrations Presents specific sections (ie: reprogramming, differentiation) in a concise and easily digestible manner Written by experts with extensive experience in stem cell technologies Human Pluripotent Stem Cells: A Practical Guide is an ideal text for stem cell researchers, including principal investigators, and others in university and industry settings, and for new graduate students in PSC labs.
Nationwide there has been an increase in demand for rehabilitation services brought on by an increasingly aging population and improved survival rates after stroke due to advancing medical care and technology. This is a clinical reference that maps out the rehabilitative care of stroke patients. This title covers everything from clinical presentation, to rehabilitation psychological treatments. · Covers clinical presentations. · Treatment during acute rehabilitation. · Complete coverage of deficits of function, medical complications, and pain syndromes. · Very practical orientation. · Complete coverage of the rehabilitation process, from acute care to inpatient care to outpatient care
Photobiology integrates a wide variety of scientific disciplines. As more people become aware of the many ways light interacts with chemical and biological systems, the need for a concise treatment of photobiology has become more critical. Kohen et al. Have written just such a book, intended both as a textbook and as a reference.The authors begin by providing a brief description of the nature of light, how it affects matter, and the means and methods of measuring it. A major section of the book is devoted to how light influences living systems, including discussions of photosynthesis, bioluminescence, regulatory mechanisms, and visual transduction of light. The last half of the book is devoted to the biomedical aspects of light, including photoimmunology, photoallergic reactions and other forms of light sensitivity, the optical properties of skin, and various ways that light can be used in therapy treatments.Useful to photobiologists as a comprehensive overview, this book should also appeal to biomedical researchers and advanced students of photobiology.
The Four Domains of Mental Illness presents an authentic and valid alternative to the DSM-5, which author René J. Muller argues has resulted in many patients being incorrectly diagnosed and wrongly medicated. Dr. Muller points out where the DSM-5 is mistaken and offers a guide to diagnosis based on the psychobiology of psychiatrist Adolf Meyer and the insights of existential philosophy and psychiatry. His model identifies the phenomena of the mental illnesses that clinicians most often see, which are characterized by identifying their structure, or partial structure. Using the FDMI approach, clinicians can grasp how each mental illness is an aberration of Martin Heidegger’s being-in-the-world.
What separates good architecture from great architecture? The difference lies in the details. The way an architect chooses to treat architectural detailingscreens and walls, doors and windows, roofs, bridges, and stairscan transform the merely ordinary into the extraordinary. Detail in Process, the second volume in the new AsBuilt series, features twenty-five awe-inspiring projects characterized by an unusual synthesis of aesthetics and materials: the sunshade at Morphosis's Student Recreation Center in Cincinnati; the embossed and perforated copper skin of Herzog & de Meuron's de Young Museum in San Francisco; the handrails at Mir Rivera Architects', Lake Austin Footbridge in Austin; the stairs at Heatherwick Studio's, Longchamp Store in New York City; plus twenty more. Editors Christine Killory and Ren Davids have collected the best work of the past two years including new buildings by some of today's most daring and detail-obsessed architects: Norman Foster, James Carpenter, John Ronan, Renzo Piano, Marmol Radziner, Tadao Ando, Steven Holl, Jean Nouvel, David Chipperfield, and SANAA. Comprehensively documented, Detail in Process includes the plans, details, and large-scale sections needed to appreciate the innovative ways these architects have responded to complicated design problems.
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