The impact of the changing climate on natural resources is among the greatest challenges that currently threaten Earth. This textbook focuses on the basic scientific principles of climate change that may be used to help develop long-term strategies to cope with the resulting broader environmental, societal, and economic impacts. Using a multidisciplinary approach, the book combines the principles of changing climate with specialized fields of the Water-Energy-Food-Health (WEFH) Nexus to examine how the Earth operates as an integrated system. It can be used at introduction-level courses in high school, undergraduate, and graduate programs, or as a scientific reference book. It will prepare students for future challenges regarding the climate and expose them to opportunities to meet these challenges.