This IBM® RedpaperTM publication describes best practices for deploying IBM FlashSystemTM V9000 enterprise storage system in a VMware vSphere environment. It includes guidelines and examples of the latest FlashSystem V9000 hardware and software, integrated with VMware version 6, to demonstrate the business benefits these solutions. Topics illustrate planning, configuring, operations, and preferred practices that include integration of FlashSystem V9000 with the VMware vCloud suite of applications: vCenter Web Client (VWC) vStorage APIs for Storage Awareness (VASA) vStorage APIs for Array Integration (VAAI) vCenter Site Recovery Manager (SRM/SRA) The authors also describe how to deploy a cloud-based solution with FlashSystem V9000 in an environment with VMware and IBM SpectrumTM Control Base Edition 2.1.1. This paper is intended for presales consulting engineers, sales engineers, and IBM clients who want to deploy IBM FlashSystem V9000 in virtualized data centers that are based on VMware vSphere.