Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. - Provides a current, expansive, and well-documented resource on chromatin and epigenetics - Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease - Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward
A compelling portrait of a unique moment in American history when the ideas of Charles Darwin reshaped American notions about nature, religion, science and race “A lively and informative history.” – The New York Times Book Review Throughout its history America has been torn in two by debates over ideals and beliefs. Randall Fuller takes us back to one of those turning points, in 1860, with the story of the influence of Charles Darwin’s just-published On the Origin of Species on five American intellectuals, including Bronson Alcott, Henry David Thoreau, the child welfare reformer Charles Loring Brace, and the abolitionist Franklin Sanborn. Each of these figures seized on the book’s assertion of a common ancestry for all creatures as a powerful argument against slavery, one that helped provide scientific credibility to the cause of abolition. Darwin’s depiction of constant struggle and endless competition described America on the brink of civil war. But some had difficulty aligning the new theory to their religious convictions and their faith in a higher power. Thoreau, perhaps the most profoundly affected all, absorbed Darwin’s views into his mysterious final work on species migration and the interconnectedness of all living things. Creating a rich tableau of nineteenth-century American intellectual culture, as well as providing a fascinating biography of perhaps the single most important idea of that time, The Book That Changed America is also an account of issues and concerns still with us today, including racism and the enduring conflict between science and religion.
Examining the interaction of the Dutch and the English in colonial New York and New Jersey, this study charts the decline of European culture in North America. Balmer argues that the combination of political intrigue, English cultural imperialism, and internal socio-economic tensions eventually drove the Dutch away from their hereditary customs, language, and culture. He shows how this process, which played itself out most visibly and poignantly in the Dutch Reformed Church between 1664 and the American Revolution, illustrates the difficulty of maintaining non-English cultures and institutions in an increasingly English world. A Perfect Babel of Confusion redresses some of the historiographical neglect of the Middle Colonies and, in the process, sheds new light on Dutch colonial culture.
Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. - Provides a current, expansive, and well-documented resource on chromatin and epigenetics - Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease - Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward
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