Ralf Middendorff's Books

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

By: Michail S. Davidoff,Ralf Middendorff,D. Müller,Adolf F. Holstein

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The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

By: Michail S. Davidoff,Ralf Middendorff,D. Müller,Adolf F. Holstein

cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells, by our group was the first step to define mural cells (pericytes and vascular smooth muscle cells) of the testis microvascu- ture as the stem/progenitor cells of the adult Leydig cells. In summary, we were able to demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells, which – in addition – rapidly acquire neuronal and glial properties. Since both newly developed fetal and adult Leydig cell populations show the same features, a common origin of both popu- tions seems likely. Pericytes are distributed throughout the body, and there is convincing evidence for their stem/progenitor cell properties in diverse organs. Under appropriate (locally defined) conditions these pericytes, which reside in the vascular stem cell niche as dormant stem cells, become activated, proliferate, migrate and differentiate towards different somatic cell types of the body. Since most mesenchymal stem/ progenitor cell types exhibit essential similarity to pericytes and certain mesenchymal stem cells represent pericyte descendants, we propose that mesenchymal stem cells in the perivascular niche are daughter cells of pericytes. Thus, pericytes are promising candidates for ancestor cells of all adult stem cells in the organism. There is strong evidence that early stem cells (cells arising during embryogenesis), such as the pericytes, exhibit both mesodermal and neural progeny, which might explain the neuroendocrine properties of the Leydig cells.

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Page Count

157

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642005136

ISBN 13

9783642005138

Using Substances to Enhance Performance: A Psychology of Neuroenhancement

By: Ralf Brand

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Using Substances to Enhance Performance: A Psychology of Neuroenhancement

By: Ralf Brand

Neuroenhancement (NE) is a behavior conceptualized as the use of a potentially psychoactive substance to enhance ones’ already proficient cognitive capacities. Depending on the specific definitions used, prevalence estimates vary greatly between very low 0.3% (for illicit substances) to astonishingly high 89% (for freely available lifestyle substances). These variations indicate that further research and more conceptual and theoretical clarification of the NE construct is dearly needed. The contributions of this research topic aim to do just that. Specific questions addressed are: How prevalent is NE behavior? How can NE research profit from the already more evolved field of social science research on doping in sports? How is NE perceived by the public? What psychological processes and variables play a role in the decision to neuroenhance? A wide array of methodological approaches is used to investigate these questions. The topics contributions range from theoretical to experimental accounts on NE, and they utilize a diverse set of methods ranging from qualitative to neuroscientific approaches. The research presented here represents a first step towards what we have labeled a psychological approach to NE. By addressing the questions above this research topic hopefully advances our understanding of NE behavior. As with every new field of research, new answers always prompt new questions. In light of what we know now about NE, we hope that the findings presented here will be pursued by other researchers in the future. Clearly, the endeavor to understand NE behavior has only just begun.

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116

Publisher

Frontiers Media SA

Published Date

ISBN 10

2889450759

ISBN 13

9782889450756

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

By: Michail S. Davidoff,Ralf Middendorff,D. Müller,Adolf F. Holstein

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The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

By: Michail S. Davidoff,Ralf Middendorff,D. Müller,Adolf F. Holstein

Average ratings

N/A

Write a review

Solve jigsaw puzzle

Age

Page Count

157

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642005136

ISBN 13

9783642005138

Book's by Ralf Middendorff

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

Using Substances to Enhance Performance: A Psychology of Neuroenhancement

Using Substances to Enhance Performance: A Psychology of Neuroenhancement

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

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