The weak property rights regime governing the world's marine resources as well as the wide-spread large scale subsidization of the fisheries industry has led to serious depletion of global fish stocks. Against this backdrop, taking cognizance of developing country goals and concerns, the Fourth Ministerial Conference of the WTO held in Doha in 2001 mandated that negotiations over fisheries subsidies, formerly subject to the disciplines of the Agreement on Subsidies and Countervailing Measures, be completed by 2005. In view of this development, a country like India with its vast and versatile fisheries resources has to take stock of the state of its fisheries sector, and develop a strategic response to the global debate on fisheries subsidies. This book aims to initiate that process. It begins by providing an overview of the current state of subsidization of the fisheries sector, both domestic and international, under various alternate definitions of fisheries subsidies. It then focuses on the domestic scenario, highlighting the Indian experience with fisheries subsidies and property rights regimes across both inland and marine sectors via the case method, and investigates the necessity and sufficiency of subsidies vis-à-vis an appropriate property rights framework in developing the domestic fisheries sector and resource base in a sustainable manner. Attention is then turned to the international scenario, with a review of selected international case studies which can inform domestic subsidy and property rights issues. This is followed by an analysis of the country submissions of the various major fishing nations in order to identify India's natural allies and competitors in international negotiations. The concluding chapter brings the pieces together. It first outlines a program of reforms to rectify the deficiencies in the existing domestic property rights and fisheries subsidy regimes, on the basis of intensive interactions with all sectoral stakeholders. Subsequently, it suggests negotiating strategies for India in forthcoming WTO meetings. An epilogue sums up recent developments and issues.
Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. - Includes full synthetic schemes of all approved and in-trial third generation inhibitors - Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds - Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity
The weak property rights regime governing the world's marine resources as well as the wide-spread large scale subsidization of the fisheries industry has led to serious depletion of global fish stocks. Against this backdrop, taking cognizance of developing country goals and concerns, the Fourth Ministerial Conference of the WTO held in Doha in 2001 mandated that negotiations over fisheries subsidies, formerly subject to the disciplines of the Agreement on Subsidies and Countervailing Measures, be completed by 2005. In view of this development, a country like India with its vast and versatile fisheries resources has to take stock of the state of its fisheries sector, and develop a strategic response to the global debate on fisheries subsidies. This book aims to initiate that process. It begins by providing an overview of the current state of subsidization of the fisheries sector, both domestic and international, under various alternate definitions of fisheries subsidies. It then focuses on the domestic scenario, highlighting the Indian experience with fisheries subsidies and property rights regimes across both inland and marine sectors via the case method, and investigates the necessity and sufficiency of subsidies vis-à-vis an appropriate property rights framework in developing the domestic fisheries sector and resource base in a sustainable manner. Attention is then turned to the international scenario, with a review of selected international case studies which can inform domestic subsidy and property rights issues. This is followed by an analysis of the country submissions of the various major fishing nations in order to identify India's natural allies and competitors in international negotiations. The concluding chapter brings the pieces together. It first outlines a program of reforms to rectify the deficiencies in the existing domestic property rights and fisheries subsidy regimes, on the basis of intensive interactions with all sectoral stakeholders. Subsequently, it suggests negotiating strategies for India in forthcoming WTO meetings. An epilogue sums up recent developments and issues.
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