In an era defined by rapid urbanization and ever-increasing mobility demands, effective transportation management is paramount. This book takes readers on a journey through the intricate web of contemporary transportation systems, offering unparalleled insights into the strategies, technologies, and methodologies shaping the movement of people and goods in urban landscapes. From the fundamental principles of traffic signal dynamics to the cutting-edge applications of machine learning, each chapter of this comprehensive guide unveils essential aspects of modern transportation management systems. Chapter by chapter, readers are immersed in the complexities of traffic signal coordination, corridor management, data-driven decision-making, and the integration of advanced technologies. Closing with chapters on modeling measures of effectiveness and computational signal timing optimization, the guide equips readers with the knowledge and tools needed to navigate the complexities of modern transportation management systems. With insights into traffic data visualization and operational performance measures, this book empowers traffic engineers and administrators to design 21st-century signal policies that optimize mobility, enhance safety, and shape the future of urban transportation.
Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy explores the design, synthesis, and application of different multifunctional nanocomposites drug delivery system for cancer treatment. It encompasses initial chapters discussing introductory information about cancer, followed by chapters focusing on the detailed information about various novel drug delivery systems for treatment of several organ site cancers such as prostate, skin, breast, lung, liver, pancreas, stomach, colon, blood, mouth and throat. It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical research who need to understand more about novel nanotechnologies applied to cancer treatment. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Presents chapters dedicated to each cancer type and the best nanocomposite therapies used, making the content easily discoverable by readers Written by world-renowned experts and researchers in the areas of nanomedicine, drug delivery and cancer research to explore thoroughly the topic with diverse perspectives
This book examines the representation of Birsa's political life, memory politics and the making of anticolonialism in contemporary Jharkhand. It offers contrasting features of political imaginations deployed in developing memorial landscapes. Framing of Birsa in the heroic narrative through a grand scale of memorialisation, often in the form of the built environment, curates a selective version. This isolates the scope of elaborating his political ideas outside the confines of atypical historical records and their relevance in the contemporary context. The book argues that everyday politics through affective sites such as memorials and statues produce political visions, emotions, and opportunities. It shows how such symbolic sites are often strategically placed and politically motivated to inscribe ideologies. This process outlines how the state and Adivasi use memory as a political tool to lay claims to the past of the Birsa Movement.
This issue of Critical Care Clinics focuses on Hepatology and Critical Care. Articles include: Acute on Chronic and Decompensated Chronic Liver Failure, Hepatic Encephalopathy, Respiratory Complication in Liver Disease, GI Issues in Liver Disease, Bridging the Patient with Liver Disease to Transplant or Recovery, Infections in Liver Disease, Kidney Injury in Liver Disease, The Liver in Critical Illness, Hematological Issues in Liver Disease, Pharmacological Issues in Liver Disease and more!
Cellular, Molecular and Environmental Contribution in Cardiac Remodeling: From Lab Bench to Clinical Perspective consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucidating their mechanisms of action and the clinical outcomes of cardiac remodeling. It extensively covers the factors determining cardiac remodeling, including cardiomyocyte regeneration, cardiac stem cells and their therapeutic potential, cardiac resident pericytes, the role of natural bioactive compounds in cardiac remodeling, chronic cardiac adaptations to exercise and more. This book provides basic science researchers and clinical investigators in cardiology with a current and comprehensive resource on molecular mechanisms and contributing factors to cardiac remodeling, and its effects and impacts on heart health. New research areas for the future, aimed at preventing, limiting, and reversing bad remodeling, are also discussed. - Provides a concise summary of recent developments in cardiac remodeling research, combining novel information and the latest data published in this field - Discusses not only cellular and molecular factors impacting cardiac remodeling, but also environmental contributions such as lifestyle and exercise - Identifies areas for future research and potential novel strategies for translating basic research knowledge to applications in patients
This book is a comprehensive guide to critical care medicine for postgraduate medical students. Presented in a case-based, question and answer format, the text begins with guidance on patient examination in the intensive care unit (ICU). Each of the following chapters covers a different disorder, from acute severe asthma, pulmonary embolism and septic shock, to traumatic brain injury, acute liver failure and much more. The book concludes with cases examining out-of-hospital cardiac arrest, brain death and organ donation, as well as end-of-life care in the ICU. A large selection of Objective Structured Clinical Examination (OSCE) practice questions are included to assist students in their preparation for examinations. Nearly 300 clinical photographs, illustrations and tables further enhance learning. Key points Comprehensive guide to critical care medicine for postgraduates Presented in a case-based, question and answer format Includes numerous OSCE practice questions to help students prepare for examinations Highly illustrated with clinical photographs, diagrams and tables
This book provides, for the first time, a broad and deep treatment of the fields of both ultra low power electronics and bioelectronics. It discusses fundamental principles and circuits for ultra low power electronic design and their applications in biomedical systems. It also discusses how ultra energy efficient cellular and neural systems in biology can inspire revolutionary low power architectures in mixed-signal and RF electronics. The book presents a unique, unifying view of ultra low power analog and digital electronics and emphasizes the use of the ultra energy efficient subthreshold regime of transistor operation in both. Chapters on batteries, energy harvesting, and the future of energy provide an understanding of fundamental relationships between energy use and energy generation at small scales and at large scales. A wealth of insights and examples from brain implants, cochlear implants, bio-molecular sensing, cardiac devices, and bio-inspired systems make the book useful and engaging for students and practicing engineers.
Mankind is in the midst of a golden age. Humankind has spread out and colonized planets near and far. There is a coalition of planets, and peace exists. But when a science experiment goes awry and a research ship discovers a sinister object in space, mankind must band together for one final night and take a stand against the most destructive natural and unnatural elements of the galaxy, which seek to end all life as we know it.
Rapid advancements in the application of soft computing tools and techniques have proven valuable in the development of highly scalable systems and resulted in brilliant applications, including those in biometric identification, interactive voice response systems, and data mining. Although many resources on the subject adequately cover the theoreti
Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. - Includes full synthetic schemes of all approved and in-trial third generation inhibitors - Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds - Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity
Mayo Clinic Infectious Diseases Case Review is a comprehensive collection of case studies covering a wide array of infectious diseases. This volume addresses many common illnesses that primary care clinicians and infectious diseases specialists will see during their practice. With a focus on epidemiology, the investigative study of each case addresses laboratory tools to be used and how to interpret the results. This volume contains: - 54 unique case vignettes - Highlighted key takeaways for each case - Practice questions and answers for review Mayo Clinic Infectious Diseases Case Review collects some of the most experienced voices in the field. Coming from different areas of expertise in the specialty of epidemiology, the authors of this volume robustly investigate and examine specific infection syndromes. This book will be useful to busy clinicians for their treatment of different infectious diseases in their daily practice, as well as for those interested in evaluating their knowledge and familiarity with infectious diseases.
This book elaborately discusses techniques commonly used to improve generalization performance in classification approaches. The contents highlight methods to improve classification performance in numerous case studies: ranging from datasets of UCI repository to predictive maintenance problems and cancer classification problems. The book specifically provides a detailed tutorial on how to approach time-series classification problems and discusses two real time case studies on condition monitoring. In addition to describing the various aspects a data scientist must consider before finalizing their approach to a classification problem and reviewing the state of the art for improving classification generalization performance, it also discusses in detail the authors own contributions to the field, including MVPC - a classifier with very low VC dimension, a graphical indices based framework for reliable predictive maintenance and a novel general-purpose membership functions for Fuzzy Support Vector Machine which provides state of the art performance with noisy datasets, and a novel scheme to introduce deep learning in Fuzzy Rule based classifiers (FRCs). This volume will serve as a useful reference for researchers and students working on machine learning, health monitoring, predictive maintenance, time-series analysis, gene-expression data classification.
With over 100 years of operation, the current automobile industry has settled into an equilibrium with the development of methodologies, regulations, and processes for improving safety. In addition, a nearly $2-trillion market operates in the automotive ecosystem with connections into fields ranging from insurance to advertising. Enabling this ecosystem is a well-honed, tiered supply chain and an established development environment. Autonomous vehicle (AV) technology is a leap forward for the existing automotive industry; now the automobile is expected to manage perception and decision-making tasks. The safety technologies associated with these tasks were presented in an earlier SAE EDGE™ Research Report, “Unsettled Technology Areas in Autonomous Vehicle Test and Validation.” In a later SAE EDGE™ Research Report, “Unsettled Topics Concerning Automated Driving Systems and the Transportation Ecosystem,” senior executives from the automotive ecosystem explored the impact of AV technology as they faced the prospect of this disruptive technology entering their marketplace. Interestingly, stable use-models and market penetration were all gated primarily by the demonstration of AV safety. Building on these previous verification and validation (V&V)-related reports, “Unsettled Topics Concerning Automated Driving Systems and the Development Ecosystem” explores the open issues in the shift of the development and supplier environment toward a new AV-enabled future. NOTE: SAE EDGE™ Research Reports are intended to identify and illuminate key issues in emerging, but still unsettled, technologies of interest to the mobility industry. The goal of SAE EDGE™ Research Reports is to stimulate discussion and work in the hope of promoting and speeding resolution of identified issues. SAE EDGE™ Research Reports are not intended to resolve the challenges they identify or close any topic to further scrutiny. Click here to access the full SAE EDGETM Research Report portfolio. https://doi.org/10.4271/EPR2020004
South Asia’s Path to Sustainable and Inclusive Growth highlights the remarkable development progress in South Asia and how the region can advance in the aftermath of the COVID-19 pandemic. Steps include a renewed push toward greater trade and financial openness, while responding proactively to the distributional impact and dislocation associated with this structural transformation. Promoting a green and digital recovery remains important. The book explores ways to accelerate the income convergence process in the region, leveraging on the still-large potential demographic dividend in most of the countries. These include greater economic diversification and export sophistication, trade and foreign direct investment liberalization and participation in global value chains amid shifting regional and global conditions, financial development, and investment in human capital.
This book studies the experiences of Brazil and India, the major economic powerhouses of the 21st century, during the neoliberal era. Both the nations have become important players in global markets and their economic performance has captured the attention of policymakers and academicians across the world. The book explores the patterns of growth and the changing status of human development in the two regions, since the 1980s. In an attempt to better grasp the subtleties of their developmental experiences, it also highlights the political and institutional dynamics that have under girded the liberalization of the two countries.
This issue of Critical Care Clinics focuses on Gastrointestinal Critical Care. Articles include: Non variceal Upper Gastrointestinal bleeds; Lower Gastrointestinal bleeds; Mesenteric Ischemia; Peritonitis; The open abdomen and intra abdominal infections; Gut motility issues in critical illness; Gut as the motor of multiple organ dysfunction; Intra abdominal hypertension and abdominal compartment syndrome; Abdominal circulatory interactions in critical illness; Severe acute pancreatitis and necrotizing pancreatitis; and Nutrition in the critically ill.
Autonomous Mobile Robots: Planning, Navigation, and Simulation presents detailed coverage of the domain of robotics in motion planning and associated topics in navigation. This book covers numerous base planning methods from diverse schools of learning, including deliberative planning methods, reactive planning methods, task planning methods, fusion of different methods, and cognitive architectures. It is a good resource for doing initial project work in robotics, providing an overview, methods and simulation software in one resource. For more advanced readers, it presents a variety of planning algorithms to choose from, presenting the tradeoffs between the algorithms to ascertain a good choice. Finally, the book presents fusion mechanisms to design hybrid algorithms. - Presents intuitive and practical coverage of all sub-problems of mobile robotics to enable easy comprehension of sophisticated modern-day robots - Covers a wide variety of motion planning algorithms, giving a near-exhaustive treatment of the domain with thought provoking comparisons between algorithms - Dives into detailed discussions on robot operating systems and other simulators to get hands-on knowledge without the need of in-house robots
Machine learning techniques provide cost-effective alternatives to traditional methods for extracting underlying relationships between information and data and for predicting future events by processing existing information to train models. Efficient Learning Machines explores the major topics of machine learning, including knowledge discovery, classifications, genetic algorithms, neural networking, kernel methods, and biologically-inspired techniques. Mariette Awad and Rahul Khanna’s synthetic approach weaves together the theoretical exposition, design principles, and practical applications of efficient machine learning. Their experiential emphasis, expressed in their close analysis of sample algorithms throughout the book, aims to equip engineers, students of engineering, and system designers to design and create new and more efficient machine learning systems. Readers of Efficient Learning Machines will learn how to recognize and analyze the problems that machine learning technology can solve for them, how to implement and deploy standard solutions to sample problems, and how to design new systems and solutions. Advances in computing performance, storage, memory, unstructured information retrieval, and cloud computing have coevolved with a new generation of machine learning paradigms and big data analytics, which the authors present in the conceptual context of their traditional precursors. Awad and Khanna explore current developments in the deep learning techniques of deep neural networks, hierarchical temporal memory, and cortical algorithms. Nature suggests sophisticated learning techniques that deploy simple rules to generate highly intelligent and organized behaviors with adaptive, evolutionary, and distributed properties. The authors examine the most popular biologically-inspired algorithms, together with a sample application to distributed datacenter management. They also discuss machine learning techniques for addressing problems of multi-objective optimization in which solutions in real-world systems are constrained and evaluated based on how well they perform with respect to multiple objectives in aggregate. Two chapters on support vector machines and their extensions focus on recent improvements to the classification and regression techniques at the core of machine learning.
Mankind is in the midst of a golden age. Humankind has spread out and colonized planets near and far. There is a coalition of planets, and peace exists. But when a science experiment goes awry and a research ship discovers a sinister object in space, mankind must band together for one final night and take a stand against the most destructive natural and unnatural elements of the galaxy, which seek to end all life as we know it.
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