This interdisciplinary monograph in philosophy of medicine examines models of explanation in health science and their relation with current medical trends, such as personalized and person-centered medicine. Medicine has provided challenging case studies for the general philosophy of science that have prompted rethinking of a wide range of philosophical notions – such as scientific law, theory and evidence – and contributed to the elaboration of pluralistic approaches to modeling, causality and explanation. The health sciences have increasingly recognized the role of philosophy of medicine as both a field of conceptual and methodological reflection, capable of addressing practical issues, and hence relevant for a proper understanding of the construction of medical knowledge, modeling practices, therapeutic strategies and preventive decisions. 'Explaining Disease' contains various case studies in medicine to describe the assumptions underpinning the construction of explanatory models of diseases. It shows the impact different explanatory strategies can have on practical matters, which in turn affect clinical evaluation and therapy and public health decisions. The book concludes with a few open-ended reflections to foster more thorough consideration of the role of philosophy of medicine can play its dialogue with the health sciences.
This is the first investigation of the history of Russian Freemasonry, based on the premise that the facts of the Russian Enlightenment preclude application of the interpretative framework commonly used for the history of western thought. Coverage includes the development of early Russian masonry, the formation of the Novikov circle in Moscow, the ‘programme’ of Rosicrucianism and its Russian variant and, finally, the clash between the Rosicrucians and the State.
The second edition of the Diary of a Writer (1876-1877) marked a crucial point in Dostoevskii's literary career. In spite of critics' attacks, many ordinary readers were overwhelmed by Dostoevskii's charisma and began writing to him from different parts of Russia, expressing their views of the moral, social and political issues dealt with in the Diary. Such success was guaranteed also by the original rhetorical style of the Diary of a Writer, which aimed to involve readers and persuade them to share Dostoevskii's beliefs. By concentrating on new material, consisting of correspondence between Dostoevskii and his readers, and applying a new methodology, reader-response criticism and genre studies, the author investigates how Dostoevskii's rhetoric in the Diary of a Writer affected the Russian reading public, transformed Dostoevskii's image in Russian society, and reawakened national identity.
It is generally assumed that microorganisms synthesize, release, detect and respond to small signaling hormone-like molecules. These molecules are used for a process termed “quorum sensing” (QS), a phenomenon that enables bacteria to sense when the minimal number of cells, or “quorum,” is achieved for a concerted response to be initiated. Words such as “language” and “behavior” are frequently used to depict QS in the literature. More simply put, language and cross-talk between bacteria, and between bacteria and animal or plant hosts, determines the behavior (e.g., beneficial or pathogenic effects) of bacteria. Currently, the major concern is to understand and decode this language. Overall, bacterial cross-talk was mainly studied on environmental, plant, and human pathogenic bacteria. Few studies considered food-related lactic acid bacteria. The cross-talk between bacteria influences the behavior and, in turn, the environmental adaptation and phenotypes. Therefore, it is understood that bacterial cross-talk has important applicative repercussions. The language spoken between bacteria populating the same food ecosystem may condition the phenotypic traits of starter lactic acid bacteria and, consequently, their performance. This Brief aims to define the basis of cell-to-cell signalling in food fermentation and will highlight: (i) microbiology, nutritional, chemical and functional aspects; (ii) functional properties due to microbial adaptation to the gastrointestinal tract; (iii) principal phenotypes under control of QS circuitries; (iv) quorum quenching. This Brief will be the first reference on this topic and it will highlight the main results for a more productive industrial application. Draft content 1. Signals of food related Gram-negative and Gram-positive bacteria The chapter will describe the different signaling languages used by Gram-negative bacteria (N-acyl-L-homoserine lactones) and Gram-positive bacteria (based on the synthesis of post-translationally modified peptides) and the universal chemical lexicon, shared by both Gram-positive and -negative bacteria (autoinducer-2 through the activity of the LuxS enzyme). 2. Phenotypes related to quorum sensing The chapter will describe the bacterial phenotypes, such as virulence, biofilm maturation, bacteriocin synthesis, and secondary metabolite production under control of QS circuitries. 3. Cell-to-cell signalling in fermented food: sourdough The chapter will describe the language spoken between bacteria populating the same food ecosystem (sourdough) and will provide an overview of the conditioned phenotypic traits of starter lactic acid bacteria and, consequently, their performance. 4. Cell-to-cell signalling in fermented food: yoghurt The chapter will describe the language spoken between bacteria populating the same food ecosystem (yoghurt) and will provide an overview of the conditioned phenotypic traits of starter lactic acid bacteria and, consequently, their performance. 5. Probiotic message at the intra-, inter-species and inter-kingdom level The chapter will describe the mechanisms that regulate the interaction between microorganism and host, and the capacity of the microorganism to adapt to environment. Particular reference will also be made to: (i) pathogen inhibition and restoration of microbial homeostasis through microbe-microbe interactions; (ii) enhancement of epithelial barrier function; and (iii) modulation of immune responses. 6. New Perspectives of quorum sensing This chapter will provide an overview of the future perspective regarding quorum sensing, showing that bacterial cross-talk may have important applicative repercussions. It will highlight the interference on the language of QS, which is defined as quorum quenching (QQ). Increasing translation of the bacterial cross-talk has shown that in some environmental circumstances, quenching of the language may occur.
Thoroughly updated, this sixth edition of Hancock et al.’s Politics in Europe remains an approachable yet rigorous introduction to the region—the UK, France, Germany, Italy, Sweden, Russia, Poland, and the European Union. Its strong analytic framework and organization, coupled with detailed country coverage written by country experts, ensure that students not only get a robust introduction to each country, but also are able to make meaningful cross-national comparisons. Key updates include the latest in European politics, including recent election results, the content and impact of the Eurozone crisis, the emergence of a new “Nordic model” of welfare capitalism, and coverage of key social and political issues including globalization, terrorism, immigration, gender, religion, and transatlantic relations.
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