The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides.
This monograph presents new constructive design methods for boundary stabilization and boundary estimation for several classes of benchmark problems in flow control, with potential applications to turbulence control, weather forecasting, and plasma control. One of the main features of the book is a unique "backstepping" approach to parabolic partial differential equations, which yields not only the stabilization of the flow, but also the explicit solvability of the closed-loop system. The work is an excellent reference for a broad, interdisciplinary engineering and mathematics audience: control theorists, fluid mechanicists, mechanical engineers, aerospace engineers, chemical engineers, electrical engineers, applied mathematicians, as well as research and graduate students in these fields.
Practical and clinically oriented, Specialty Imaging: Acute and Chronic Pain Intervention provides unique, authoritative guidance on the use of image-guided techniques for periprocedural analgesia and pain management procedures. Ideal for practicing and trainee interventional radiologists, pain physicians, and anesthesiologists, this one-stop resource is tailored to your decision support needs, with coverage of everything from neuroanatomy and specific pain conditions to interventional procedures for acute and chronic pain. Provides up-to-date content informed by best practices and the perspectives of both interventional radiology and anesthesiology Discusses key topics such as multimodal opioid sparing techniques as adjuncts and alternatives to the use of opioids for acute pain management, as well as shared decision making in interventional radiology pain management Demonstrates the new fascial pain blocks as well as sympathetic nerve blocks for periprocedural analgesia during interventional procedures Covers adult and pediatric acute and chronic pain conditions Integrates neuroanatomy and the "why" of clinical procedures for a better understanding of the pathways and various options for therapeutic intervention Presents information consistently, using a highly templated format with bulleted text for quick, easy reference Begins each section with a discussion of neuroanatomy, followed by succinct chapters that provide "how-to" information on a clinically useful, imaging-guided interventional procedure for treating a specific acute or chronic pain condition Features procedural videos and clear, high-quality drawings for visual reinforcement, e.g., sequential illustrations that show where nerves are located through successive peeling of anatomic layers
This book is about algebraic and differential methods, as well as fractional calculus, applied to diagnose and reject faults in nonlinear systems, which are of integer or fractional order. This represents an extension of a very important and widely studied problem in control theory, namely fault diagnosis and rejection (using differential algebraic approaches), to systems presenting fractional dynamics, i.e. systems whose dynamics are represented by derivatives and integrals of non-integer order. The authors offer a thorough overview devoted to fault diagnosis and fault-tolerant control applied to fractional-order and integer-order dynamical systems, and they introduce new methodologies for control and observation described by fractional and integer models, together with successful simulations and real-time applications. The basic concepts and tools of mathematics required to understand the methodologies proposed are all clearly introduced and explained. Consequently, the book is useful as supplementary reading in courses of applied mathematics and nonlinear control theory. This book is meant for engineers, mathematicians, physicists and, in general, to researchers and postgraduate students in diverse areas who have a minimum knowledge of calculus. It also contains advanced topics for researchers and professionals interested in the area of states and faults estimation.
This book presents a framework for the reuse-based design of AMS circuits. The framework is founded on three key elements: (1) a CAD-supported hierarchical design flow; (2) a complete, clear definition of the AMS reusable block; (3) the design for a reusability set of tools, methods, and guidelines. The book features a detailed tutorial and in-depth coverage of all issues and must-have properties of reusable AMS blocks.
With the vision of including authors from different parts of the world, different educational backgrounds, and offering open-access to their published work, InTech proudly presents the latest edited book in epilepsy research, Epilepsy: Histological, electroencephalographic, and psychological aspects. Here are twelve interesting and inspiring chapters dealing with basic molecular and cellular mechanisms underlying epileptic seizures, electroencephalographic findings, and neuropsychological, psychological, and psychiatric aspects of epileptic seizures, but non-epileptic as well.
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