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Diet, immunity and inflammation

17. Modulation of inflammatory and immune responses by short-chain fatty acids

By: M.A.R. Vinolo,H.G. Rodrigues,R.T. Nachbar,R. Curi

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Diet, immunity and inflammation

17. Modulation of inflammatory and immune responses by short-chain fatty acids

By: M.A.R. Vinolo,H.G. Rodrigues,R.T. Nachbar,R. Curi

Short-chain fatty acids (SCFAs) are the main metabolic products of anaerobic bacterial fermentation in the intestine. In addition to their important role as fuel for intestinal epithelial cells, SCFAs modulate different processes in the gastrointestinal (GI) tract and in other tissues such as adipose and immune tissues. In this chapter, we first present a brief description of basic aspects of SCFA physiology, such as production, absorption and metabolism. The main mechanisms by which SCFAs act on cells and the effects of these fatty acids in isolated leukocytes are then discussed. We also highlight the results obtained by studies performed in vivo using SCFAs in the treatment of inflammatory pathologies. A brief discussion about the perspectives in this research field is presented at the end of the chapter.

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Page Count

32

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128087099

ISBN 13

9780128087091

Diet, immunity and inflammation

17. Modulation of inflammatory and immune responses by short-chain fatty acids

By: M.A.R. Vinolo,H.G. Rodrigues,R.T. Nachbar,R. Curi

Write a review Read reviews Take a Quiz Solve Book Puzzle

Diet, immunity and inflammation

17. Modulation of inflammatory and immune responses by short-chain fatty acids

By: M.A.R. Vinolo,H.G. Rodrigues,R.T. Nachbar,R. Curi

Short-chain fatty acids (SCFAs) are the main metabolic products of anaerobic bacterial fermentation in the intestine. In addition to their important role as fuel for intestinal epithelial cells, SCFAs modulate different processes in the gastrointestinal (GI) tract and in other tissues such as adipose and immune tissues. In this chapter, we first present a brief description of basic aspects of SCFA physiology, such as production, absorption and metabolism. The main mechanisms by which SCFAs act on cells and the effects of these fatty acids in isolated leukocytes are then discussed. We also highlight the results obtained by studies performed in vivo using SCFAs in the treatment of inflammatory pathologies. A brief discussion about the perspectives in this research field is presented at the end of the chapter.

Average ratings

N/A

5

0%

4

0%

3

0%

2

0%

1

0%

Solve jigsaw puzzle

Age

Page Count

32

Publisher

Elsevier Inc. Chapters

Published Date

ISBN 10

0128087099

ISBN 13

9780128087091