This book gathers together chemical ideas which are important for understanding how drugs act and how new drugs may be developed. Students meet some of these ideas in courses in chemistry, biochemistry and pharmacology but in my experience they find it difficult to put together information often acquired in different years and from different departments; they need it set out in a book. I believe also that it helps if they can see how these ideas may be applied to numerical problems so I have included examples (with answers), many of which are taken from research work. These should therefore provide a chance for the student both to test his or her own understanding and to see the sort of results which form the bricks of which any experimental science is made. In all the problems the arithmetic takes less than ten minutes with a small calculator which has exponential functions and logarithms.
Forgotten Figure was fiery lawyer and politician A new biography reveals influential Henry Wynn Williams riled Canterbury establishment figures with his working class advocacy. Humbug is not a pretty word. It has connotations of hoaxing, fraud and falseness. It was commonly used in the 1800s, mostly in reference to politicians. So, when The Press in an 1883 editorial described early Christchurch political figure Henry Wynn Williams as ‘‘free from humbug and deception’’, it was high praise. Wynn Williams’ great-grandson Robert says The Press editorial was ‘‘extraordinarily effusive about Henry’’, especially considering how critical the newspaper had been of Wynn Williams’ policies. Robert, a Lincoln scientist, has used the phrase in the title of his biography of the influential lawyer-politician. Free From Humbug is not an effusive biography, though. It presents a ‘‘warts and all’’ portrayal of one of the most interesting characters in early Canterbury. Historians have largely ignored Wynn Williams and he remains unknown to most people. Perhaps the Welshman was too liberal and supportive of the working class to be accepted socially by The Establishment of wealthy squatters, merchants and professionals. However, Robert takes obvious delight in the fact that two of New Zealand’s leading law firms, Wynn Williams & Co and Russell McVeagh, were founded at about the same time by brothers; by Henry Wynn Williams in Christchurch and by his younger brother in Auckland. The Petrus van der Velden portrait of Wynn Williams on the book’s cover could almost be of David Lloyd George. The two politicians shared more than their appearance and their Welsh birth. Wynn Williams came to New Zealand by happy accident. The parson’s son qualified in law in 1853 and practised for four years. Restless and hard-up he opted for a move to the colonies. His choice was South Africa but he met an acquaintance in the street who recommended New Zealand. Wynn Williams could not afford the fare so his acquaintance pulled strings with a shipping company to let him work his passage. Robert still finds it hard to believe that his great-grandfather, who had never been to sea, was taken on as third mate in a ship that had no first or second mate. The landlubber who knew nothing about ships became second-in-command of the emigrant vessel Hastings for the long voyage. Another happy accident came after leaving (possibly deserting) the ship at Wellington in 1858. Wynn Williams accompanied an on-board friend to Nelson. There he met a farmer who warmed to the penniless new arrival and took him under his wing. For the next two years he did a variety of work, including droving, cooking and general farm duties. In 1860 he settled in Christchurch and established his legal practice in the Shands Emporium building on Hereford Street. He married Emily Coward (the name being a contraction of cow herd) and they raised seven children, a further two having died in infancy. He might have been regarded askance by the establishment, but Wynn Williams’ skills brought him custom, which led to some friendships. Future Premier Sir John Hall advanced him sufficient money to buy a grand home on the south-east corner of Latimer Square, in 1863. He developed the rambling garden and lawns which were used for bowls, croquet, tennis, fetes and garden parties. His prominence brought election to the provincial council and, eventually, to the House of Representatives (Parliament). In these forums his advocacy for the poor and downtrodden raised his profile further. Robert’s book contains highlights of his legal and political careers. It shows reactions to his outspoken and forthright manner, ranging from homage to horror. ‘‘He was a genuine egalitarian,’’ Robert says. He campaigned for land reform to break up large estates and settle small farmers. He fought for workers’ rights. He espoused tax reform that would ensure everyone paid a fair share. He was a keen reader and, influenced by Mark Twain, whom he met, had ambitions to be a writer. The diaries he kept of his travels in New Zealand and around the world, including a railway trip across the USA, could have been prototypes for travel books. Wynn Williams died in 1913. Marking the centenary of his death, Robert felt drawn to research his life. ‘‘I am not spiritual but I got a feeling he was waiting for me to come along and do it. It was all sitting there for me to pick up,’’ Robert says. He knew enough of his great-grandfather’s story to believe it should be turned into a book. He found reference to a journal in some historical notes at Wynn Williams and Co. This led him to a relative who had the journal. It was a treasure trove of information that drew him ever closer to his great-grandfather. Finding he had an affinity for ‘‘the small people’’ was ‘‘an agreeable surprise’’, Robert says. It launched him on further research in New Zealand and Britain. Mike Crean Fairfax. NZ
The developments and achievements of the Irish administration, overshadowed by the more spectacular aspects of Irish history have received comparatively little attention. But Irish conditions in the 19th Century encouraged and compelled the state to exert itself on a more extensive front than in contemporary England and a number of government departments played a very active and often creative part in Irish social and economic life. In this work, originally published in 1964, and based on a wide range of printed and manuscript sources, the author shows how the administrative structure was drastically rationalised and modernised. The author is also interested both in the work the administration performed and the men who staffed it. The Irish administration during the century came into contact with many different aspects of Irish society.
Scandal in the Church reconstructs the extraordinary story of Dr Edward Drax Free DD, the Rector of Sutton in Bedfordshire, and the sequence of events that led, following a series of court battles, to his deprivation in 1830. Free is the only Church of England clergyman since 1800 to have rivalled the notorious Harold Davidson, the Rector of Stiffkey, defrocked in 1932 following the disclosure of his links with prostitutes. Dr Free was a Fellow of StJohn's College and Vicar of St Giles, Oxford, whose behaviour had been so outrageous that the college had considered expelling him. In the event, they were only too glad to appoint him the living of Sutton when it fell vacant in 1808. He soon offended his new parishioners, failing to perform his duties, selling the lead off the church roof and allowing pigs to desecrate the graveyard. Free quarrelled with all and sundry, both when sober and drunk. He kept pornographic literature and seduced a series of housekeepers, producing five illegitimate children, besides causing at least one of the women to miscarry. Extraordinarily, he would have probably kept his benefice had he not been inept enough also to offend the local gentry family, the Burgoynes, over a burial in their family vault. Montague Burgoyne laid a complaint on behalf of the village that eventually led to Free's deprivation in the Court of Arches.
In the course of this work, Dr Dobson is able to throw new light on the universal aspirations and pre occupations of medieval monasticism. He reconstructs life in Durham in the century before its final dissolution and concludes that it was an example of 'comparatively successful conservatism' during a period in English history characterized by institutional resistance to social and intellectual change.
They reveal how genomic medicine will provide predictive, preventive, and personalized care in the future; discuss "designer babies"; consider the legal status of genetic discrimination as it relates to employment, health insurance, and life insurance; and delve into many other fascinating and timely issues."--BOOK JACKET.
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