The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. - Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them - Focused chapters on toxin applications and common properties or general features of toxins
A total CBT training solution, with practical strategies for improving educational outcomes. Teaching and Supervising Cognitive Behavioral Therapy is the first comprehensive package to provide empirically-validated CBT training and supervisory techniques. Applicable to a variety of behavioral health care disciplines, this multi-modal guide provides educators with the information and tools that can help improve educational outcomes. An examination of CBT developments over the past twenty years leads into a discussion of practical applications for improving CBT education, while addressing the technological advances that facilitate dissemination and the specific challenges posed to confidentiality and patient care. The digital component contains additional audio and video content, plus downloadable worksheets that reinforce and expand upon the strategies presented. Coverage includes advice geared specifically toward the most commonly-encountered problems, with video of training sessions that address issues like frustration with patients, disbelief in psychotherapy, dislike of the method, and lack of skills. Readers will gain insight into effective goal setting, and implement a structured approach to supervision. Examine existing literature and research on training, supervision, and evaluation Integrate theory with practical strategies to improve learning outcomes Customize training approaches to specifically suit different professional groups Fit the methods to the environment, including workshops, webinars, and podcasts Mental health professionals who favor an empirically-based approach to therapy will appreciate the effectiveness of an empirically-based approach to pedagogy. Backed by over two decades of CBT research and the insight of leading CBT experts, Teaching and Supervising Cognitive Behavioral Therapy provides trainers with the tools and information they need to improve therapist educational outcomes.
The mistreatment of older people is categorized in many societies as “elder abuse and neglect,” yet the concept has not been subjected to rigorous critical inquiry. Instead, it has most often represented the interests of professionals, academics, and governments, while policy makers and researchers frequently overlook or disregard the complexity of issues that fall under this designation. Contesting Elder Abuse and Neglect questions existing understandings about the mistreatment of older people. It explores how and why the designation “elder abuse and neglect” came to be and shows how this term masks problems concerning the mistreatment of older people, their place in society, and how they see themselves. Joan R. Harbison and her colleagues expose how supposed solutions to the problem of abuse can take their toll on those people they were originally intended to protect. The book is an important contribution to the literature that encourages new thinking about issues concerning the mistreatment of older people.
This pioneering study describes the quest of Baptists in the different colonies (later states) to develop their identity as Australians and Baptists. The first comprehensive history of Baptists in Australia with a national focus, the Baptist story is traced from their beginnings in 1831 with the first baptisms in Woolloomooloo Bay (Sydney) in 1832 down to modern times. Changes and continuities, achievements and failures are carefully analyzed and related to the wider social, political and cultural context.The first volume covers the period from 1831 until the outbreak of the First World War in 1914 and shows how a strong sense of becoming an Australian Church shaped much of their development from the various types of British Baptists who began the movement in the new nation. What it meant to be an Australian Baptist is described using denominational newspapers, church records and personal memoirs.
This book is a brief and focused introduction to the reverse mathematics and computability theory of combinatorial principles, an area of research which has seen a particular surge of activity in the last few years. It provides an overview of some fundamental ideas and techniques, and enough context to make it possible for students with at least a basic knowledge of computability theory and proof theory to appreciate the exciting advances currently happening in the area, and perhaps make contributions of their own. It adopts a case-study approach, using the study of versions of Ramsey's Theorem (for colorings of tuples of natural numbers) and related principles as illustrations of various aspects of computability theoretic and reverse mathematical analysis. This book contains many exercises and open questions.
Leadership for Health Professionals: Theory, Skills, and Applications concentrates on leadership as a subject of study and enables students to apply and practice the theories, models, and responsibilities of leadership within a health organization context. This thorough, well-organized text includes practical cases from leaders in various health professions, presenting leadership principles with an emphasis on enabling and empowering students and professionals to become better leaders in practice, develop an efficacious personal leadership model, and improve health outcomes through better leadership. Leadership for Health Professionals: Theory, Skills, and Applications provides students with the fundamentals of leadership theory and bridges the gap between theory and practice with an emphasis on practical application. With exercises and discussion questions to reinforce key concepts and create critical thinking opportunities, Leadership for Health Professionals combines theoretical foundations with practical applications and is the ideal text to prepare students and professionals for leadership opportunities. Instructor Resources Include: Instructor's Manual, TestBank, Exercises, PowerPoint Slides and Exercises
This book is the product of the good will and hardwork of many people. The contributors, all recognized experts in their fields, are thanked for providing thoughtful, informative chapters and for accommodating editorial suggestions and revisions. Westview Press is thanked for providing the opportunity to address a serious omission in the energy literature. The Geography Department at the University of Maryland made a similarly generous commitment of secretarial staff and faciltiies. Allen Eney aided in the construction of computerized maps. Many skilled, conscientious individuals at state energy offices, public utility commissions, the U.S. Department of Energy, and other organizations supplied essential data and produced many of the analytic studies that underlie the contents of the book. Patti Leedham provided patient and expert typing through numerous revisions of the chapters and many tables. Patricia Sawyer provided essential guidance, support, and proofreading throughout the entire effort.
Learn the fundamentals and foundations of modern organic chemistry with this comprehensive guide Foundations of Organic Chemistry: Unity and Diversity of Structures, Pathways, and Reactions, 2nd Edition, is a substantive guide for students beginning their study of organic chemistry and instructors, as well as senior undergraduates and graduate students seeking to further their understanding of the subject. Foundations of Organic Chemistry is a serious attempt to show students who want to learn organic chemistry how we know what we know about the subject and to guide them to learn. In this work, the emphasis of the discussion of structures, pathways, and reactions is placed on the original literature and the fundamentals and use of spectroscopic and kinetic tools. Application of the resulting working knowledge of the substance of organic chemistry will lead the serious student to ask additional questions and, ultimately, to solve problems we face. The book also includes solutions guides for instructors and lecturers, as well as access to a companion website for furthering the reader’s knowledge of organic chemistry.
The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a conceptual structure that would allow the synapse to be identified at the beginning of the 20th century. Numerous illustrations explain either the technical approach or the experimental finding.
A compact but comprehensive review of the most important preparative methods for the synthesis and chemical modification of polymers. The contents of the two-volume handbook (Part A was cited in the May 1992 SciTech Book News) are subdivided according to the chemical structure of the polymer backbone on the one hand (Chapters 1-14 of Part A and 15-18 of Part B) and special properties and applications of polymers regardless of their chemical structure on the other hand (Chapters 19-27 of Part B). The latter chapters deal with, for instance, electroconductive polymers, polymeric reagents, and models of bio-polymers. Includes some 11,000 references to the original literature. Annotation c. by Book News, Inc., Portland, Or.
This book covers the application of psychological principles and techniques to situations and problems of aviation. It offers an overview of the role psychology plays in aviation, system design, selection and training of pilots, characteristics of pilots, safety, and passenger behavior. It covers concepts of psychological research and data analysis and shows how these tools are used in the development of new psychological knowledge. The new edition offers material on physiological effects on pilot performance, a new chapter on aviation physiology, more material on fatigue, safety culture, mental health and safety, as well as practical examples and exercises after each chapter.
Internationally lauded as the preeminent text in the field, Campbell-Walsh Urology continues to offer the most comprehensive coverage of every aspect of urology. Perfect for urologists, residents, and practicing physicians alike, this updated text highlights all of the essential concepts necessary for every stage of your career, from anatomy and physiology through the latest diagnostic approaches and medical and surgical treatments. The predominant reference used by The American Board of Urology for its examination questions. Algorithms, photographs, radiographs, and line drawings illustrate essential concepts, nuances of clinical presentations and techniques, and decision making. Key Points boxes and algorithms further expedite review. Features hundreds of well-respected global contributors at the top of their respective fields. A total of 22 new chapters, including Evaluation and Management of Men with Urinary Incontinence; Minimally-Invasive Urinary Diversion; Complications Related to the Use of Mesh and Their Repair; Focal Therapy for Prostate Cancer; Adolescent and Transitional Urology; Principles of Laparoscopic and Robotic Surgery in Children; Pediatric Urogenital Imaging; and Functional Disorders of the Lower Urinary Tract in Children. Previous edition chapters have been substantially revised and feature such highlights as new information on prostate cancer screening, management of non–muscle invasive bladder cancer, and urinary tract infections in children. Includes new guidelines on interstitial cystitis/bladder pain syndrome, uro-trauma, and medical management of kidney stone disease. Anatomy chapters have been expanded and reorganized for ease of access. Boasts an increased focus on robotic surgery, image-guided diagnostics and treatment, and guidelines-based medicine. Features 130 video clips that are easily accessible via Expert Consult. Periodic updates to the eBook version by key opinion leaders will reflect essential changes and controversies in the field. Expert Consult eBook version included with purchase. This enhanced eBook experience offers access to all of the text, figures, tables, diagrams, videos, and references from the book on a variety of devices.
Isocrates is one of the most remarkable and influential figures in the history of human thought. The influence of his ideas in the history of historical writing, rhetoric, the visual arts, music, religion and theology, political science, philosophy and, above all, educational philosophy and practice in Europe, Australia, North America, North Africa, and the Middle East are well established and widely known. This book argues careful study of the educational philosophy of Isocrates and its legacy can contribute to an improved understanding of the historiography of educational thought, his distinctive normative methodology in both political and educational philosophy, and his arguments about the primary importance of the virtues of self-knowledge and realistic self-appraisal for educational philosophers and practitioners. At a time when educational philosophy has an increasingly precarious academic existence and educationists are actively seeking new historiographical and methodological approaches to the philosophical study of education, there is much to be gained by recovering and reevaluating the historiography and normative methodology of Isocrates and the role they play in educational discourse and practice today.
Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.
Published by the American Geophysical Union as part of the Geophysical Monograph Series, Volume 152. Sea salt aerosol (SSA) exerts a major influence over a broad reach of geophysics. It is important to the physics and chemistry of the marine atmosphere and to marine geochemistry and biogeochemistry generally. It affects visibility, remote sensing, atmospheric chemistry, and air quality. Sea salt aerosol particles interact with other atmospheric gaseous and aerosol constituents by acting as sinks for condensable gases and suppressing new particle formation, thus influencing the size distribution of these other aerosols and more broadly influencing the geochemical cycles of substances with which they interact. As the key aerosol constituent over much of Earth's surface at present, and all the more so in pre-industrial times, SSA is central to description of Earth's aerosol burden.
The fourth edition of this internationally acclaimed, seminal textbook on the subject of clinical pediatric urology is completely updated. World-renowned experts in the field present state-of-the-art developments in all areas of clinical pediatric urology, from diagnosis to treatment and from theory to practice. Clinical Pediatric Urology is clinical in orientation and practical in presentation, covering every illness, diagnostic method and appropriate treatment in pediatric urology from the embryo onwards. Each chapter is lavishly illustrated with full color photographs and medical artwork. Tables, graphs and charts lend further support to the detailed and comprehensive text, all in a single, easily accessed volume. This is a useful and informative reference for students and specialists alike.
Bringing together the history of educational philosophy, political philosophy, and rhetoric, this book examines the influence of the philosopher Isocrates on educational thought and the history of education. Unifying philosophical and historical arguments, Muir discusses the role of Isocrates in raising two central questions: What is the value of education? By what methods ought the value of education to be determined? Tracing the historical influence of Isocrates’ ideas of the nature and value of education from Antiquity to the modern era, Muir questions normative assumptions about the foundations of education and considers the future status of education as an academic discipline.
The standard-setting reference in medical toxicology—trusted as the leading evidencebased resource for poison emergencies A Doody's Core Title for 2017! For decades, one name has been synonymous with the most respected, rigorous perspectives on medical toxicology and the treatment of poisoned and overdosed patients: Goldfrank's Toxicologic Emergencies. Presented in full color, Goldfrank’s delivers essential, patientcenteredcoverage of every aspect of poison management. The editors and authors are recognized as preeminent scholars in their specialties and provide unmatched coverage of all aspects of toxicologic emergencies, from pharmacology and clinical presentation to cutting-edge treatment strategies. Goldfrank's Toxicologic Emergencies, Tenth Edition begins with an examination of medical toxicology principles and techniques. It then reviews the biochemical, molecular, and pathophysiologic basis of toxicology, followed by an intense focus on toxicologic principles related to special patient populations. Features Case studies enhance your understanding of the clinical application of the text material Practical focus on the pathophysiologic basis of medical toxicology The Antidotes in Depth sections delivers the expertise of toxicologists across the world as they present treatments for critically ill poisoned and overdosed patients and allow you to easily identify key issues relating to the use of complex and often unfamiliar therapies The principles of risk management, medicolegal decision making, patient safety, post mortem toxicology and the assessment of ethanol induced impairment described in chapters and Special Considerations emphasize the interface between medical toxicology, the law, and quality care
The Human Thymus presents the immunological aspect of the thymus. It discusses the lymphopoietic and immunological functions of the human thymus. It addresses the physiological function of thymus that regulates neuromuscular transmission by the secretion of thymin. Some of the topics covered in the book are the origin of thymic lymphocytes; development of Hassall's corpuscles; humoral immune responses; neonatal thymectomy and wasting disease; mode of action of thymin at the neuromyal synapse; experimental autoimmune thymitis; and neuromuscular block associated with experimental autoimmune thymitis. The diseases induced with Freund's complete adjuvant are covered. The spontaneously occurring autoimmune diseases are discussed. The text describes the size of the human thymus. A study of the experimental effect of hormones on thymic size is presented. A chapter is devoted to the thymic hypoplasia and immunological deficiencies. Another section focuses on the histopathology of thymus in myasthenia gravis. The book can provide useful information to scientists, doctors, students, and researchers.
The studies presented in this monograph concentrate on the glycoconjugate characterisation of the mouse and human GALT and on the overlying follicle-associated epithelium (FAE), in order to identify their cell-specific carbohydrate residues.
This book portrays how the commercial development of safflower oil was done, how the different players involved approached the problem, and what can be learned from this that might help in the evolution of other "new" crops.
The fields of molecular evolution, genome evolution, and evolutionary genetics are now well-established. Remarkably, however, although all evolutionary modifications begin at the cellular level, and despite the advances made in cell biology and microbiology over the past few decades, there is as yet no recognised discipline of evolutionary cell biology. The goal of this book is to help establish the foundations for this emerging field. Its principal aims are twofold: firstly, to promote an understanding among evolutionary biologists as to why the cellular details matter if we are to understand the mechanisms of evolution; secondly, to make clear to non-evolutionary biologists - cell biologists in particular - that evolution is not just a matter of natural selection and optimization, but a process whose reach depends on other population genetic features such as mutation, recombination, and random genetic drift. Although there are many excellent books on cell biology, microbiology, and biophysics, almost no attention is given to evolution. Likewise, although there are numerous evolutionary biology books on the market, none of them gives more than passing attention to details at the cellular level. Thus Evolutionary Cell Biology is genuinely novel, offering a broader understanding of evolutionary processes and an appreciation for the many interesting problems that remain to be solved at the cellular and subcellular levels. This advanced textbook is aimed at both cell biologists and evolutionary biologists. It will be accessible to upper-level undergraduates in biology, and certainly to graduate students in all areas of the life sciences. Professionals from a wide range of fields - cell biology, microbiology, evolution, biophysics, biochemistry, and mathematics - will be exposed to entirely new ideas not traditionally covered in their primary fields of expertise.
In the second volume of his planned trilogy that will recast the history of the university in a fresh and surprising light, Adam R. Nelson aims to show how knowledge, which had been commodified starting in the late eighteenth century, became industrialized in the nineteenth century. Nelson explains how the idea of the modern university arose from a set of institutional and ideological reforms designed to foster the mass production and mass consumption of knowledge--that is, the industrialization of ideas. Fusing the history of higher education with the history of capitalism, Nelson suggests that this "marketization" of knowledge propelled the institutionalization of the university, far earlier than previously understood"--
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo (“neurosteroids”). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
This volume is dedicated to the memory of the late Professor WERNER BRAUN, one of the most devoted and active members of the Editorial Board of the Current Topics in Microbiology and Immunology, who passed away, after suffering a heart attack, in November 1972. Dr. WERNER BRAUN was born in Berlin, Germany, on November 16,1914. During his highschool days in Berlin he did research work on problems of genetics as a young guest in the Kaiser-Wilhelm-Institut fur Biologie, in the department of Prof. R. GOLDSCHMIDT. I remember his colourful description of his discussions during this period, while still a teen-ager, with OTTO WAR BURG. He studied biology and medicine at the University of G6ttingen and received a Ph.D. degree in biology in 1936. In the same year he left Nazi Germany and came to the United States first as a Guest Investigator in Genetics at the University of Michigan at Ann Arbor, and then in Berkeley, where he carried out his work in the Depart ments of Zoology and of Veterinary Science until 1948. He was engaged during this period in the study of problems concerned with physiological genetics, bacterial variation, immunology and biochemistry.
This book challenges the popular view that established ideologies no longer make sense in today's globalizing world. Considered from a broad historical perspective, major ideological traditions have not become destabilized and incoherent by globalization, but remain meaningful political beliefs that shape the globalization debate.
In order to use rare earths successfully in various applications, a good understanding of the chemistry of these elements is of paramount importance. Nearly three to four decades have passed since titles such as The Rare Earths edited by F.H. Spedding and A.H. Daane, The chemistry of the Rare Earth Elements by N.E. Topp and Complexes of the Rare Earths by S.P. Sinha were published. There have been many international conferences and symposia on rare earths, as well as the series of volumes entitled Handbook of Physics and Chemistry of Rare Earths edited by K.A. Gschneidner and L. Eyring. Thus, there is a need for a new title covering modern aspects of rare earth complexes along with the applications. The present title consists of twelve chapters. 1. Introduction2. General aspects3. Stability of complexes4. Lanthanide complexes5. Structural chemistry of lanthanide compounds6. Organometallic complexes7. Kinetics and mechanisms of rare earths complexation8. Spectroscopy of lanthanide complexes9. Photoelectron spectroscopy of rare earths10. Lanthanide NMR shift reagents11. Environmental ecological biological aspects12. Applications The authors studied in schools headed by pioneers in rare earth chemistry, have a combined experience of one hundred and fifty years in inorganic chemistry, rare earth complex chemistry, nuclear and radiochemistry of rare earths and supramolecular chemistry. The present monograph is a product of this rich experience.
The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. - Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats - Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace - Each chapter will include a map of the world showing where that particular disease is naturally found
This comparative study of industrial capitalism is an examination of state-economy relations in mixed economies ranging from the interventionist German and Japanese to the less interventionist Anglo-American. Following the postwar consensus that resulted in the 'golden age' (1950-1973) and ended with the energy crisis, the Anglo-American economies adopted neoliberalism while Germany and Japan remained interventionist. This resulted in the emergence of national types of capitalism. While analyzing the increased competition between them, R.C.Mascarenhas also notes the influence of globalization as well as 'alternative capitalism' with the survival and re-emergence of industrial districts.
Shows how poststructuralist ideas can be usefully applied in the areas of welfare, health, education and science and technology policy, making particular reference to the theme of citizenship.
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