This new multi-authored book reviews the current understanding of the role of thrombin in venous and arterial thrombosis and its inhibition in the clinical setting. Heparin, the most widely used antithrombotic, does not effectively regulate thrombin or its formation. Accumulating evidence suggests that other antithrombins are effective in some of the situations where heparin is not. Discussions include the current knowledge on antithrombotic prophylaxis and therapy, from the perspective of the role in thrombin in venous and arterial vascular disease, the limitations of the current anticoagulant therapies, and potential and limitations of newer antithrombins currently being tested in several experimental and clinical settings. Thrombin helps the clinician to better rationalize the use of specific antithrombins in the prevention and management of thrombotic disease and provides the basic scientist with a better understanding of the goals the clinician attempts to achieve with antithrombotic therapy.
Evidence-Based Practice of Palliative Medicine is the only book that uses a practical, question-and-answer approach to address evidence-based decision making in palliative medicine. Dr. Nathan E. Goldstein and Dr. R. Sean Morrison equip you to evaluate the available evidence alongside of current practice guidelines, so you can provide optimal care for patients and families who are dealing with serious illness. - Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. - Confidently navigate clinical challenges with chapters that explore interventions, assessment techniques, treatment modalities, recommendations / guidelines, and available resources - all with a focus on patient and family-centered care. - Build a context for best practices from high-quality evidence gathered by multiple leading authorities. - Make informed decisions efficiently with treatment algorithms included throughout the book.
Evidence-Based Practice of Palliative Medicine is the only book that uses a practical, question-and-answer approach to address evidence-based decision making in palliative medicine. Dr. Nathan E. Goldstein and Dr. R. Sean Morrison equip you to evaluate the available evidence alongside of current practice guidelines, so you can provide optimal care for patients and families who are dealing with serious illness. Confidently navigate clinical challenges with chapters that explore interventions, assessment techniques, treatment modalities, recommendations / guidelines, and available resources - all with a focus on patient and family-centered care. Build a context for best practices from high-quality evidence gathered by multiple leading authorities. Make informed decisions efficiently with treatment algorithms included throughout the book. Access the complete, fully searchable contents online at www.expertconsult.com.
A fully-updated eighth edition to the guidebook that launched the Great Destinations series. A rich cultural landscape has grown from the natural splendor of the Berkshire Hills of Western Massachusetts, making it a favorite place for travelers of all types. This all-new edition of the original guide to the Berkshires includes information on history, transportation, accommodations, dining, arts, spa retreats, outdoor recreation, and shopping. It covers every corner of the Berkshires, from Great Barrington and Sheffield in the South to the northern towns of Williamstown and North Adamshome of the Massachusetts Museum of Contemporary Art. Stay at the legendary Red Lion Inn and enjoy an evening of classical music at Tanglewood. Spend a night at a reasonably-priced B&B after a day of hiking the trails of Mt. Greylock. Experience a weekend retreat at the world-famous Kripalu Center for Yoga and Health. With helpful maps and lodging and dining indexes to aid you, you won't find a more complete guide to the Berkshires.
This new textbook is the definitive evidence-based resource for pediatric critical care. It is the first ostensibly evidence-based pediatric critical care textbook and will prove an invaluable resource for critical care professionals across the globe.
Compilers Shoemaker and Rudity have assembled a definitive list of 9,000 marriages performed in this southern Ohio county between 1803 and 1860. Each record contains the names of the bride and groom, the date of the marriage, a source citation, and often ages, places of residence, and the names of parents. For convenience, the records are listed in alphabetical order by grooms' names; brides and all others mentioned in the records are listed separately in the index.
This comprehensive book, rich with applications, offers a quantitative framework for the analysis of the various capture-recapture models for open animal populations, while also addressing associated computational methods. The state of our wildlife populations provides a litmus test for the state of our environment, especially in light of global warming and the increasing pollution of our land, seas, and air. In addition to monitoring our food resources such as fisheries, we need to protect endangered species from the effects of human activities (e.g. rhinos, whales, or encroachments on the habitat of orangutans). Pests must be be controlled, whether insects or viruses, and we need to cope with growing feral populations such as opossums, rabbits, and pigs. Accordingly, we need to obtain information about a given population’s dynamics, concerning e.g. mortality, birth, growth, breeding, sex, and migration, and determine whether the respective population is increasing , static, or declining. There are many methods for obtaining population information, but the most useful (and most work-intensive) is generically known as “capture-recapture,” where we mark or tag a representative sample of individuals from the population and follow that sample over time using recaptures, resightings, or dead recoveries. Marks can be natural, such as stripes, fin profiles, and even DNA; or artificial, such as spots on insects. Attached tags can, for example, be simple bands or streamers, or more sophisticated variants such as radio and sonic transmitters. To estimate population parameters, sophisticated and complex mathematical models have been devised on the basis of recapture information and computer packages. This book addresses the analysis of such models. It is primarily intended for ecologists and wildlife managers who wish to apply the methods to the types of problems discussed above, though it will also benefit researchers and graduate students in ecology. Familiarity with basic statistical concepts is essential.
This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. It is fully updated with much molecular, screening and management information. It covers risk analysis and genetic counselling for individuals with a family history of cancer. It also discusses predictive testing and the organisation of the cancer genetics service. There is information about the genes causing Mendelian cancer predisposing conditions and their mechanism of action. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines.
This book is intended to be a cookbook for students and researchers to understand the finite element method and optimization methods and couple them to effect shape optimization. The optimization part of the book will survey optimization methods and focus on the genetic algorithm and Powell’s method for implementation in the codes. It will contain pseudo-code for the relevant algorithms and homework problems to reinforce the theory to compile finite element programs capable of shape optimization. Features Enables readers to understand the finite element method and optimization methods and couple them to effect shape optimization Presents simple approach with algorithms for synthesis Focuses on automated computer aided design (CAD) of electromagnetic devices Provides a unitary framework involving optimization and numerical modelling Discusses how to integrate open-source mesh generators into your code Indicates how parallelization of algorithms, especially matrix solution and optimization, may be approached cheaply using the graphics processing unit (GPU) that is available on most PCs today Includes coupled problem optimization using hyperthermia as an example
The Green Revolution' of the 60's and 70's produced immense gains in food cereal production in the Third World. But there are huge problems in the 'post-revolutionary' era: farmers with small or marginal holdings have benefited less than wealthier farmers; intensive mono-cropping has made production more susceptible to environmental stresses and shocks. Now there is evidence of diminishing returns from intensive and intensively chemical agricultural production. What is needed is a new approach, equally revolutionary, but different in its ideas and style. The authors set out what they mean by 'sustainable' agriculture in the new era and look at the effects of international economic restraints and of national policies on the kind of development they see as necessary. They chart a path for sustainable livelihoods for Third World farmers enmeshed by forces outside their control. They describe methods of evaluating and resolving the tough trade-offs all levels of intervention, from international trade down to the individual farm. This book cannot provide all the answers, but it does indicate what international conditions we need to be aware of, what national policies we need to advocate and what approaches at the local level we need to adopt to ensure the goal of agricultural sustainability. Originally published in 1990
In a typical Wills, Trusts, and Estates (WTE) class there are both students who want to practice in WTE (either exclusively, or as part of a general practice), and those who need only to master the general concepts in order to pass the bar exam. Wills, Trusts, and Estates in Focus by Naomi R. Cahn, Alyssa DiRusso, and Susan Gary attends to the needs of both sets of students. For those who will practice in WTE, the concepts are presented in an engaging way and exemplified by realistic hypothetical scenarios that mirror practice and support the development of lawyering skills. For those who need only to pass the bar, the organization of the text is keyed to multi-state essay examination topics as presented on the multi-state bar exam. The well-crafted pedagogy of the Focus Series makes WTE concepts and procedure clear and accessible for all students. Case Previews shed light on each succinctly-edited case, provide legal context, and direct students to the issue at hand. Post-Case Follow-Ups review the decision and prepare students to apply the relevant legal principles to the set of exercises that follow, called Real Life Applications. Professors will appreciate the accessible approach of Wills, Trusts, and Estates in Focus, which combines straightforward narrative explanations with real-world examples, and problems designed to engage students in active learning. Features of Wills, Trusts, and Estates in Focus: Insightful authorship: The author team consists of three well-known academics with expertise in WTE and complementary areas such as family law, charities, elder law, and tax. All are elected Fellows of the American College of Trust and Estate Counsel (ACTEC), the leading professional organization of trust and estates attorneys. Conscious modernization of the WTE casebook that balances major landmark cases and 21st century authorities, including recent case decisions and developments in the law (such as the 2017 Tax Cuts and Jobs Act) Thorough coverage of core topics, combined with the Focus Series pedagogy Manageable problem sets that allow students to apply doctrine to realistic fact scenarios Research and drafting exercises that support the development of practice-based skills Professors and students will benefit from: Clear writing that promotes the learning outcomes of student competencies in knowledge and understanding of both the substantive and procedural law of WTE legal analysis and reasoning problem-solving how to exercise proper professional and ethical responsibilities with regard to clients and the legal system A balanced emphasis on practice readiness and bar-exam readiness An author team with experience writing for students, practitioners, and lay people A clear and logical book structure and chapter organization, with cross-references to related coverage in other chapters Appendices that provide examples of how doctrine maps on to practice, as in will contest pleadings and probate filings Teaching materials include: Teacher’s Manual with straightforward case summaries and answers to all problems Sample 3-credit syllabus
Public awareness regarding the life-threatening nature and intense traumatic impact of domestic violence has substantially increased in the past decade. At the same time, dramatic changes have taken place regarding criminal justice and social work policies and practices applied to domestic violence intervention. And while the prevalence of domestic violence has declined slightly, national estimates still indicate that every year, approximately eight million women are abused, battered, stalked, or killed by their husbands, boyfriends, and other intimate partners. Featuring cutting-edge research and expert intervention strategies, the Handbook of Domestic Violence Intervention Strategies: Policies, Programs, and Legal Remedies is designed to prepare professionals to swiftly and compassionately meet the multiple needs of women and children who have suffered from domestic violence. This original and indispensable volume focuses on the numerous advances in legal remedies, program developments, treatment protocols, and multidisciplinary perspectives. It is a comprehensive guide to the latest research, public policies, and legal and criminal justice responses, covering federal and state legislation as well as trends in police and court responses to domestic violence. This is the first book to include court-based technology developments and new research related to the duration and intensity of woman battering. Highlighting actual cases and promising programs, the handbook also addresses important social work issues, including risk assessment protocols, a new five level continuum of woman battering, intervention methods, and treatment models. The book also examines the myriad legal issues and health problems facing the most neglected and vulnerable battered women. Written by expert practitioners and leading scholars in the field, the book's 23 chapters provide rich insights into the complexities and challenges of addressing domestic violence. This timely and definitive handbook is recommended for students, clinicians, policy makers, and researchers in the fields of social work, victim services, criminal justice, hospital administration, mental health counseling, public health, pastoral counseling, law enforcement. In fact, this volume is a critical resource for all helping professionals who are assisting abused women in escaping and remaining free from violent relationships.
This is the first textbook to offer a comprehensive account of ocular prosthetics and the evidence used to underpin and support this field of healthcare. It does so by bringing together information from ophthalmology, prosthetic eye and contact lens literature, and from experts actively engaged in these fields. The book describes the psychological, anatomical and physiological aspects of eye loss as well as surgical procedures for removing the eye, patient evaluation, constructing prosthetic eyes (including prosthetic and surgical techniques for dealing with socket complications), the socket’s response to prosthetic eyes, prosthetic eye maintenance and the history of prosthetic eyes. Though primarily intended for prosthetists, ophthalmologists, ophthalmic nurses, optometrists and students in the fields of ocular medicine, maxillofacial medicine and anaplastology, the book also offers a useful resource for other health workers and family members who care for prosthetic eye patients, and for those patients seeking a deeper understanding of the issues affecting them than they can find elsewhere.
Development of Anti-Asthma Drugs reviews existing asthma treatments and novel approaches currently under investigation, in the context of their mode of action and clinical effectiveness, in the hope that this might lead to a greater understanding of the factors involved in the expression of the disease and, therefore, in the design of better drugs. It is planned based on the concept of the causes and treatment of asthma, This book is organized in three main parts. Part I deals with the nature of asthma, its pathological mechanisms, natural history and epidemiology. Part II discusses mediators associated with asthma including platelet-activating factor, leukotrienes and histamine. Part II covers pharmaceutical approaches in the development of anti-asthma drugs and includes sections on inhibitors of mediator release and competitive and functional antagonists. This book will be of interest to persons dealing with studies on anti-asthma drugs and those interested in pharmacological development.
TCP/IP Illustrated, Volume 1, Second Edition, is a detailed and visual guide to today?s TCP/IP protocol suite. Fully updated for the newest innovations, it demonstrates each protocol in action through realistic examples from modern Linux, Windows, and Mac OS environments. There?s no better way to discover why TCP/IP works as it does, how it reacts to common conditions, and how to apply it in your own applications and networks. Building on the late W. Richard Stevens? classic first edition, author Kevin R. Fall adds his cutting-edge experience as a leader in TCP/IP protocol research, updating the book to fully reflect the latest protocols and best practices. He first introduces TCP/IP?s core goals and architectural concepts, showing how they can robustly connect diverse networks and support multiple services running concurrently.
Introduction to the Primates is a comprehensive but compact guide to the long evolutionary history of the world’s prosimians, monkeys, and apes, and to the much shorter history of humankind’s interactions with them, from our earliest recorded observations to the severe threats we now pose to their survival. Daris Swindler provides a detailed description of the major primate groups and their environments, from the smallest lemurs of Madagascar to the gorillas of central Africa. He compares and contrasts the primate species, looking at each with a specific anatomical focus. The range of diversity emerges as the particular characteristics of the species becomes increasingly distinct. Swindler also considers primate behavior and its close connections with environment and evolutionary differences. His account of 65 million years of successful adaptation and evolution demonstrates the drama of paleontology as evidence accrues and gaps in the history of primate evolution gradually close.
Gardening at the Margins tells the remarkable story of a diverse group of neighbors working together to grow food and community in the Santa Clara Valley in California. Based on four years of deeply engaged ethnographic field research via a Participatory Action Research project with the people and ecosystems of La Mesa Verde home garden program, Gabriel R. Valle develops a theory of convivial labor to describe how the acts of care among the diverse gardeners—through growing, preparing, and eating food in one of the most income unequal places in the country—are powerful, complex acts of resistance. Participants in La Mesa Verde home garden program engage in the practices of growing and sharing food to envision and continuously work to enact alternative food systems that connect people to their food and communities. They are building on ancestral knowledge, as well as learning new forms of farming, gardening, and healing through convivial acts of sharing. The individuals featured in the book are imagining and building alternative worlds and futures amid the very real challenges they embody and endure. Climate change, for example, is forcing thousands of migrants to urban areas, which means recent immigrants’ traditional environmental, nutritional, and healing knowledge will continue to be threatened by the pervasiveness of modernity and the homogenization of global capitalism. Moreover, once rural people migrate to urban areas, their ability to retain traditional foodways will remain difficult without spaces of autonomy. The stories in this book reveal how people create the physical space to grow food and the political space to enact autonomy to revive and restore agroecological knowledge needed for an uncertain future.
Advances in cytogenetics continue to crop up in wonderful ways, and we know exponentially more about chromosomes now than mere decades ago. Likewise, the necessary skills in offering genetic counseling continue to evolve. This new edition of Chromosome Abnormalities in Genetic Counseling offers a practical, up-to-date guide for the genetic counselor to marshal cytogenetic data and analysis clearly and effectively to families.
Evolutionary theory is one of the most wide-ranging and inspiring scientific ideas, and it offers a battery of methods that can be used to interpret human behaviour. However, researchers disagree about the best ways to use evolution to explore humanity, and a number of schools of thought have emerged. Sense and Nonsense, third edition, provides an introduction to the ideas, methods and findings of five such schools, namely sociobiology, human behavioural ecology, evolutionary psychology, cultural evolution and gene-culture coevolution. In this revised and updated edition of their successful monograph, Brown and Lala provide a balanced and rigorous analysis that scrutinises both the evolutionary arguments and the allegations of the critics, carefully guiding the reader through the mire of confusing terminology, claim, and counter-claim, and polemical statements. This readable and informative introductory book will be of use to undergraduate and postgraduate students (for example in psychology, anthropology and zoology), as well as experts on one approach who would like to know more about the other perspectives and lay-persons interested in evolutionary explanations of human behaviour. Having completed the book, the reader will feel better placed to assess the legitimacy of claims made about human behaviour under the name of evolution and to make judgements as to what is sense and what is nonsense.
Two decades have passed since the original discovery of recoilless nuclear gamma resonance by Rudolf Mossbauer; the spectroscopic method based on this resonance effect - referred to as Mossbauer spectroscopy - has developed into a powerful tool in solid-state research. The users are chemists, physicists, biologists, geologists, and scientists from other disciplines, and the spectrum of problems amenable to this method has become extraordinarily broad. In the present volume we have confined ourselves to applications of Mossbauer spectroscopy to the area of transition elements. We hope that the book will be useful not only to non-Mossbauer special ists with problem-Oriented activities in the chemistry and physics of transition elements, but also to those actively working in the field of Mossbauer spectroscopy on systems (compounds as well as alloys) of transition elements. The first five chapters are directed to introducing the reader who is not familiar with the technique to the principles of the recoilless nuclear resonance effect, the hyperfme interactions between nuclei and electronic properties such as electric and magnetic fields, some essential aspects about measurements, and the evaluation of Moss bauer spectra. Chapter 6 deals with the interpretation of Mossbauer parameters of iron compounds. Here we have placed emphasis on the information about the electronic structure, in correlation with quantum chemical methods, because of its importance for chemical bonding and magnetic properties.
A new edition of Peter and Rosemary Grant’s classic account of their groundbreaking forty-year study of Darwin’s finches 40 Years of Evolution is a landmark study of the finches first made famous by Charles Darwin, one that documents as never before the evolution of species through natural selection. In this now-legendary study, renowned evolutionary biologists Peter and Rosemary Grant draw on a vast and unparalleled range of ecological, behavioral, and genetic data to continuously measure changes in finch populations over a period of four decades on the small island of Daphne Major in the Galápagos archipelago. In the years since the book’s publication, the field of genomics has developed greatly. In this newly revised edition of 40 Years of Evolution, the Grants combine the results of their historic field study with genomic analyses of their primary findings, resolve unanswered questions from the field, and provide invaluable insights into the genetic basis of beak and body size variation and the history of this iconic adaptive radiation.
This valuable reference provides a wide range of practical, clinical information for physicians who care for patients with neurological and cardiac problems. Clinical Neurocardiology considers neurological complications arising from cardiac surgery and other cardiac interventions describes neurological findings in heart dise
**Selected for Doody's Core Titles® 2024 in Veterinary Medicine** Learn to treat allergic diseases in animals using the latest protocols, procedures, and studies! Allergies and Hypersensitivity Disease in Animals provides an all-in-one review of allergic diseases in dogs, cats, horses, and livestock species. Addressing this growing problem, the book covers key topics such as signs of allergies and hypersensitivity disease, the route by which antigens enter the body, the major mediators of allergies, allergic reactions including anaphylaxis and atopic and contact dermatitis, and diagnosis and treatment. Written by noted veterinary author Ian R. Tizard, this evidence-based reference includes an enhanced eBook with print purchase, with access to a fully searchable version of the text available on a variety of devices. It's a must-have for every veterinary practice! - Advanced immunology reference highlights the essential topics relating to veterinary allergies and hypersensitivity. - Comprehensive coverage provides a single-source review of allergic diseases in dogs, cats, horses and livestock species. - Clear guidelines are provided for treatment protocols and diagnostic procedures, all based on the latest pathogenesis studies. - Expert author Ian R. Tizard is a well-established veterinary writer who is world-renowned on the topic of vaccinations, immunology, and allergies in veterinary medicine. - Consistent organization for each chapter – Introduction, Pathogenesis, Allergens, Clinical Disease, Diagnosis, and Treatment – supports evidence-based veterinary care. - Basic science chapters are useful for exam review and as clinical companion resources. - Enhanced eBook provides access to a fully searchable version of the entire text, making it available on a variety of devices, and is included with each new print purchase.
Newly streamlined and focused on quick-access, easy-to-digest content, Mulholland and Greenfield’s Surgery: Scientific Principles & Practice, 7th Edition, remains an invaluable resource for today’s residents and practicing surgeons. This gold standard text balances scientific advances with clinical practice, reflecting rapid changes, new technologies, and innovative techniques in today’s surgical care. New lead editor Dr. Justin Dimick and a team of expert editors and contributing authors bring a fresh perspective and vision to this classic reference.
A groundbreaking look at how technology with a human touch is revolutionizing government and industry Human Systems Integration (HSI) is very attractive as a new integrating discipline designed to help move business and engineering cultures toward a more people-technology orientation. Over the past decade, the United States and foreign governments have developed a wide range of tools, techniques, and technologies aimed at integrating human factors into engineering systems in order to achieve important cost and performance benefits that otherwise would not have been accomplished. In order for this new discipline to be effective, however, a cultural change is needed that must start with organizational leadership. Handbook of Human Systems Integration outlines the principles and methods that can be used to help integrate people, technology, and organizations with a common objective toward designing, developing, and operating systems effectively and efficiently. Handbook of Human Systems Integration is broad in scope, covering both public and commercial processes as they interface with systems engineering processes. Emphasizing the importance of management and organization concepts as well as the technical uniqueness of HSI, Handbook of Human Systems Integration features: * More than ninety contributors, technical advisors, and reviewers from government, industry, and academia * Comprehensive coverage of the most recent HSI developments, particularly in presenting the cutting-edge tools, techniques, and methodologies utilized by each of the HSI domains * Chapters representing the governments and industries of the United Kingdom and Canada * Contributions from three services of the Department of Defense along with the Federal Aviation Administration and the National Academy of Sciences * Many chapters covering both military and nonmilitary applications * Concepts widely used by government contractors both in the United States and abroad This book will be of special interest to HSI practitioners, systems engineers, and managers, as well as government and industry decision-makers who must weigh the recommendations of all multidisciplines contributing to systems performance, safety, and costs in order to make sound systems acquisition decisions.
Biogeography is a diverse subject, traditionally focusing on the distribution of plants and animals at different taxonomic levels, past and present. Modern biogeography also puts emphasis on the ecological character of the world vegetation types, and on the evolving relationship between humans and their environment. Panbiogeography describes a new synthesis of sciences of plant and animal distribution. The book emphasizes that the geographical patterns of animal and plant distribution contribute directly to the understanding and interpretation of evolutionary history. Geographic location is reintroduced as a critical element of both biogeography and evolutionary biology. The authors present chapters exploring the roles of geology, ecology, evolution in panbiogeographic theory, and introduce new methods, modes of classification, and ways of measuring biodiversity.
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