The global prevalence of neurodevelopmental disorders is accelerating. Numbers of children affected by an autism spectrum disorder (ASD) in the United States have reached 1 in 88 -- 1 in 56 among boys -- and even more children have developed attention deficit/hyperactivity disorders (ADHD). The burden of these disorders to individuals and society overall is enormous; ASD alone costs the United States a staggering $130 billion, with ADHD costs reaching similar heights. Genetic causes of these neurodevelopmental disorders cannot account for such radically increased rates of incidence. The causes must also implicate environmental chemicals, many of which have been shown to disrupt normal thyroid function. In this book, Barbara Demeneix makes the case that thyroid hormone signaling bridges the environment and gene programs needed for brain development--and that environmental chemicals that disrupt normal thyroid function pose significant risks to the inherited intelligence and mental health of future generations. The first chapter provides an historical overview of documented cases in which environmental pollution has caused IQ loss across populations. The following chapters explain the physiology of thyroid hormone action, the importance of iodine and selenium for thyroid hormone signaling and brain development, and why thyroid hormone is such a sensitive target for environmental pollution. The final chapters discuss the role of gene-environment interactions in neurodevelopmental disorders and address what can and must be done by individuals, associations, and decision-makers to staunch these epidemics.
This book explodes the common view that pro- and anti-German factions dominated Byzantine politics at the turn of the century, and in so doing it rewrites the history of a brief but crucial period in early Byzantium."--Robert Kaster, author of Guardians of Language
Allan F. Moore presents a study of recorded popular song, from the recordings of the 1920s through to the present day. Analysis and interpretation are treated as separable but interdependent approaches to song. Analytical theory is revisited, covering conventional domains such as harmony, melody and rhythm, but does not privilege these at the expense of domains such as texture, the soundbox, vocal tone, lyrics. Moore continues by developing a range of hermeneutic strategies largely drawn from outside the field (in the most part, within psychology and philosophy) but still deeply relevant to the experience of song.
The 1850s saw in America the breakdown of the Jacksonian party system in the North and the emergence of a new sectional party--the Republicans--that succeeded the Whigs in the nation's two-party system. This monumental work uses demographic, voting, and other statistical analysis as well as the more traditional methods and sources of political history to trace the realignment of American politics in the 1850s and the birth of the Republican party. Gienapp powerfully demonstrates that the organization of the Republican party was a difficult, complex, and lengthy process and explains why, even after an inauspicious beginning, it ultimately became a potent political force. The study also reveals the crucial role of ethnocultural factors in the collapse of the second party system and thoroughly analyzes the struggle between nativism and antislavery for political dominance in the North. The volume concludes with the decisive triumph of the Republican party over the rival American party in the 1856 presidential election. Far-reaching in scope yet detailed in analysis, this is the definitive work on the formation of the Republican party in antebellum America.
An exploration of all that is known about the origin of birds and of avian flight. It draws on fossil evidence and studies of the structure and biochemistry of living birds to present knowledge and data on avian evolution and to propose a new model of this evolutionary process.
Based on the author s analysis of in-depth interviews and relevant research literature, this booki nvestigates and explores the experiences, problems and pressures faced by black and ethnic minority women managers in the United Kingdom. To date, research addressing the issues of black managers has been almost exclusively American, predominantly black African-Americans, and the overall amount of published research has been limited. Indeed, studies of black and ethnic minority professional women, especially in corporate settings, have been virtually excluded from the growing body of research on women in management. This book has been written to fill this gap.
This book contributes to an understanding of the nature of mid-life transitions and crises by focusing on the unique personal meaning of the transitional experience for the individual. There is an implicit structure to the way in which such a transition is experienced by the individual, and this can be made explicit by the techniques and methods of the approach outlined and illustrated in the book. The value of making this structure explicit is that it enables us to understand and assess the nature and dimensions of the transition, whether or not it will reach crisis proportions, and to assess possible intervention strategies. Meaning in Mid-Life Transitions should be of interest to human service practitioners as well as teachers and students of human development and behavior. It evidences an integrative approach and structural framework, including a series of in-depth clinical and research studies.
Pathology of the Human Placenta has become the gold standard in the field for pathologists and obstetrician-gynecologists. Completely up-to-date, this fifth edition continues to be the essential reference for professionals in the field and includes many revised features such as a more detailed index; 700 total illustrations (350 color illustrations); and updated tables.
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