Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.
This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals in spinal cord damage, subarachnoid hemorrhage, reperfusion damage, and cytotoxicity! With over 2400 references, tables, drawings, photographs, and micrographs, Free Radicals in Brain Pathophysiology focuses on important biological signaling molecules such as superoxide anion and nitric oxide evaluates the action of low levels of oxygen- and nitrogen-centered radicals on cell membranes and receptors to modulate signal transduction pathways and gene expression links high mitochondrial density in neural tissue to brain disease considers how prions and -amyloid proteins influence the level of free radicals within cells assesses the abnormalities of superoxide dismutase in the familial form of amyotrophic lateral sclerosis highlights the occurrence of oxidative stress and the impact of oxidative injury in brain physiology and neurodegeneration and more! With contributions from nearly 70 internationally recognized researchers, physiologists, and clinicians who describe their latest findings and provide new insights into the factors underlying neurological disorders, Free Radicals in Brain Pathophysiology is an unsurpassed reference for nutritionists and dietitians, clinical neurologists, pathologists, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
Mobility and Environment calls for a mobility revolution which does not simply mean taking a bus instead of a car: it implies a dramatic shift in the political debate from a technical to a political culture. The author introduces his book by disputing “non-political” Sustainable Development policies which are among the major culprits for the conservatism in environmental policies. For at least forty years, urban mobility policies, based on compulsive infrastructure building, have failed both in satisfying transportation demand and in coping with high environmental impacts. Nonetheless decision-makers keep employing the same professionals and therefore they act as shepherds who commit their sheep in the wolf’s custody. Corrado Poli treats mobility policy as a political, ethical, social and educational issue rather than as a mere civil engineering one. Mobility and Environment challenges some deeply entrenched professional and economic monopolies which negatively affect urban and transportation planning in North America and Europe, and argues the old idea which bounded transportation and communication. A real environmentalist effort in traffic planning should begin from new technologies and from the analysis of citizens preferences. A series of new projects are presented which include mobility demand reduction and focus on democracy in planning.
On the initiative of Susi Pelotti, MD, Director of the School for Doctoral Degree in Forensic Medicine, Italy, with the support of School Tutors Tiziana Balbi, Patologist, MD, and Giovanni Pierini, BD, the Doctors (MD) of the School at the end of their training present the first organic practical (microscopic) review on electric burns and injuries, with case discussion. The whole research is an advancement for practice in differential diagnosis criteria.
Research Management: Europe and Beyond addresses the myriad responsibilities related to research management and administration. The book incorporates narratives from those working in the field to provide insight into the profession. The book also offers a unique perspective on the topic by incorporating global perspectives to address the growing interdisciplinary nature of research collaboration. The book outlines practical advice for those in the research management and administration profession at all levels of experience. It is also a useful tool that research institutions and research groups can use to assist in planning and streamlining their research support. - Offers a deeper understanding of the research management and administrative landscape through single and collective definitions and experiences - Provides an overview of the research environment and explores the international research arena - Discusses some of the most complex issues in research management and administration by covering topics such as ethics, innovation, research impact, organizational structures, and processes for the project life cycle
This book presents the theory of anticipation, and establishes anticipation of the future as a legitimate topic of research. It examines anticipatory behavior, i.e. a behavior that ‘uses’ the future in its actual decisional process. The book shows that anticipation violates neither the ontological order of time nor causation. It explores the question of how different kinds of systems anticipate, and examines the risks and uses of such anticipatory practices. The book first summarizes the research on anticipation conducted within a range of different disciplines, and describes the connection between the anticipatory point of view and futures studies. Following that, its chapters on Wholes, Time and Emergence, make explicit the ontological framework within which anticipation finds its place. It then goes on to discuss Systems, Complexity, and the Modeling Relation, and provides the scientific background supporting anticipation. It restricts formal technicalities to one chapter, and presents those technicalities twice, in formal and plain words to advance understanding. The final chapter shows that all the threads presented in the previous chapters naturally converge toward what has come to be called “Discipline of Anticipation”
The Italian community in Artificial Life and Evolutionary computation has grown remarkably in recent years, and this book is the first broad collection of its major interests and achievements (including contributions from foreign countries). The contributions in Artificial Life as well as in Evolutionary Computation allow one to see the deep connections between the two fields. The topics addressed are extremely relevant for present day research in Artificial Life and in Evolutionary Computation, which include important contributions from very well-known researchers. The volume provides a very broad picture of the Italian activities in this field.
Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.
This volume provides an authoritative, comprehensive view of the most current issues in brain pathophysiology and offers a critical evaluation of antioxidant-based therapeutic approaches to neurodegeneration, providing an up-to-date account of the role of antioxidants in the prevention and moderation of clinical symptoms. Examines free radicals
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