Mathematical epidemiology of infectious diseases usually involves describing the flow of individuals between mutually exclusive infection states. One of the key parameters describing the transition from the susceptible to the infected class is the hazard of infection, often referred to as the force of infection. The force of infection reflects the degree of contact with potential for transmission between infected and susceptible individuals. The mathematical relation between the force of infection and effective contact patterns is generally assumed to be subjected to the mass action principle, which yields the necessary information to estimate the basic reproduction number, another key parameter in infectious disease epidemiology. It is within this context that the Center for Statistics (CenStat, I-Biostat, Hasselt University) and the Centre for the Evaluation of Vaccination and the Centre for Health Economic Research and Modelling Infectious Diseases (CEV, CHERMID, Vaccine and Infectious Disease Institute, University of Antwerp) have collaborated over the past 15 years. This book demonstrates the past and current research activities of these institutes and can be considered to be a milestone in this collaboration. This book is focused on the application of modern statistical methods and models to estimate infectious disease parameters. We want to provide the readers with software guidance, such as R packages, and with data, as far as they can be made publicly available.
An accessible, up-to-date and legally rigorous introduction to contemporary international environmental law. Detailed references combined with numerous figures and tables provide a conceptually clear understanding of the law in this area.
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.
This book explores the unity of life. It proposes that the concept of information is the inner essence of what we today call life. The importance of information for our species is obvious. Human beings are highly dependent on information, constantly exchanging with conspecifics. In a less apparent way, we are the product of genetic and epigenetic information which determines our development in a given environment from a fertilized egg to the adult stage. Even less apparent is that information plays a determining role in ecosystems. This observation may include the prebiotic systems in which life emerged. Our claim is that Nature processes information continuously. This means that even beyond living entities, we can see messages and decoding procedures. Nature can be said to send messages to its own future and then to decode them. Nature “talks” to itself! The systematic organization of messages suggests that, in some respects, we should even speak of the “languages” of Nature.
A complete review of the fast-developing topic of high performance concrete (HPC) by one of the leading researchers in the field. It covers all aspects of HPC from materials, properties and technology, to construction and testing. The book will be valuable for all concrete technologists and construction engineers wishing to take advantage of the re
“If Huckleberry Finn were set on the Mexican-American border and written by the creators of South Park, it might read something like this.” —San Francisco Chronicle Hailed by critics and lauded by readers for its riotously funny and scathing portrayal of America in an age of trial by media, materialism, and violence, Vernon God Little was an international sensation when it was first published in 2003 and awarded the prestigious Man Booker Prize. The memorable portrait of America is seen through the eyes of a wry, young protagonist. Fifteen-year-old Vernon narrates the story with a cynical twang and a four-letter barb for each of his townsfolk, a medley of characters. With a plot involving a school shooting and death-row reality TV shows, Pierre’s effortless prose and dialogue combine to form a novel of postmodern gamesmanship. “A dangerous, smart, ridiculous, and very funny first novel . . . Pierre renders adolescence brilliantly, capturing with seeming effortlessness the bright, contradictory hormone rush of teenage life.” —Sam Sifton, The New York Times
Linking theory to practice, this book provides a better fundamental understanding of Portland cement and hydraulic binders which is necessary to make better concrete. It has been clearly demonstrated that concrete durability is closely linked to its water/binder ratio and proper curing during the first week after casting. In this rigorously present
An exploration of hypothetical turning points in history from Ancient Greece to September 11 What if history, as we know it, had run another course? Touching on alternate histories of the future and the past, or uchronias, A Past of Possibilities encourages deeper consideration of watershed moments in the course of history. Wide-ranging in scope, it examines the Boxer Rebellion in China, the 1848 revolution in France, and the assassination of Archduke Franz Ferdinand in 1914, and integrates science fiction, history, historiography, sociology, anthropology, and film. In probing the genre of literature and history that is fascinated with hypotheticals surrounding key points in history, Quentin Deluermoz and Pierre Singaravélou reach beyond a mere reimagining of history, exploring the limits and potentials of the futures past. From the most bizarre fiction to serious scientific hypothesis, they provide a survey of the uses of counterfactual histories, methodological issues on the possible in social sciences, and practical proposals for using alternate histories in research and the wider public.
This dissertation endeavours to shed light on the paradox of the persistence of informal finance in urban African markets despite the emergence of a vibrant microfinance sector. To do so, it analyses the rationale of the financial choices of the micro-entrepreneurs operating in the markets of Ouagadougou (Burkina Faso). In particular, a careful examination of the motives driving the combinative use of informal and formal microfinance is carried. In order to lay deep theoretical foundations to this analysis, this thesis develops a model describing the financial behaviour of the micro-entrepreneurs in the presence of hyperbolic preferences and social influences. The solution of this model shows, inter alia, that the financial choices are not solely driven by economic motivations but also by social motivations. This result is confirmed by empirical observations which show, among other things, that social relations play an important role in explaining the persistence of informal finance. Besides, it appeared also that the combinative use of informal finance and microfinance can be explained, on the one side, by the fact that the motives driving the demand for informal and for formal finance are not always the same and, on the other side, by the fact that these two types of financial mechanisms are more likely to be used as complements than as substitutes. Ultimately, this thesis unfolds a new perspective for apprehending the coexistence of informal and formal microfinance. Informal finance is no longer considered as a makeshift, but as an integral part of the financial landscape of the Sub-Saharan urban financial markets. Therefore, microfinance institutions and policy makers ought to adopt a more positive and pro-active attitude vis-à-vis informal finance.
High-technology and environmental applications of the rare-earth elements (REE) have grown dramatically in diversity and importance over the past four decades. This book provides a scientific understanding of rare earth properties and uses, present and future. It also points the way to efficient recycle of the rare earths in end-of-use products and efficient use of rare earths in new products. Scientists and students will appreciate the book's approach to the availability, structure and properties of rare earths and how they have led to myriad critical uses, present and future. Experts should buy this book to get an integrated picture of production and use (present and future) of rare earths and the science behind this picture. This book will prove valuable to.non-scientists as well in order to get an integrated picture of production and use of rare earths in the 21st Century, and the science behind this picture. - Defines the chemical, physical and structural properties of rare earths. - Gives the reader a basic understanding of what rare earths can do for us. - Describes uses of each rare earth with chemical, physics, and structural explanations for the properties that underlie those uses. - Allows the reader to understand how rare earths behave and why they are used in present applications and will be used in future applications. - Explains to the reader where and how rare earths are found and produced and how they are best recycled to minimize environmental impact and energy and water consumption.
The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Business Law and Economics for Civil Law Systems highlights the relevance of economic analysis of business law from a civilian perspective. It integrates a comparative approach (common law and civil law) to economic analysis using tools and illustrations to assist in conducting critical economic analysis of rules in the field of business law. This book is a valuable contribution to the reflection on the place and meaning of value creation and accountability as goals for business law. It will be of great value to academics interested in business law, competition law, comparative law and legal theory, students studying law, business and economics, and to policy makers and regulators.
Presenting a unified approach, this book focusses on the concepts and theoretical methods that are necessary for an understanding of the physics and chemistry of the fluid state. The authors do not attempt to cover the whole field in an encyclopedic manner. Instead, important ideas are presented in a concise and rigorous style, and illustrated with examples from both simple molecular liquids and more complex soft condensed matter systems such as polymers, colloids, and liquid crystals.
In the recent years, the study of cointegrated time series and the use of error correction models have become extremely popular in the econometric literature. This book provides an analysis of the notion of (weak) exogeneity, which is necessary to sustain valid inference in sub-systems, inthe framework of error correction models (ECMs). In many practical situations, the applied econometrician wants to introduce "structure" on his/her model in order to get economically meaningful coefficients. For thispurpose, ECMs in structural form provide an appealing framework, allowing the researcher to introduce (theoretically motivated) identification restrictions on the long run relationships. In this case, the validity of the inference will depend on a number of conditions which are investigated here. In particular,we point out that orthogonality tests, often used to test for weak exogeneity or for general misspecification, behave poorly in finite samples and are often not very useful in cointegrated systems.
Born Unloved is inspired by a true story. Pierre wrote this autobiography book to help people fully understand the importance of unconditional love to humanity. His mother never loved him. His father abandoned him. Darkness of fear paralyzed his heart. His speech impediment frustrated him. His grandmother had no vision for him. Bitter days awaited him. Demons poisoned his soul. He was mistaken for a problem child. Loneliness angered him. He drowned in depression. Born in one country but raised in another, Pierres bilingual childhood explains the conflict between three different cultures. While his life could have been born unloved in any nation of this world, Pierres life still adapted to Gods plans that encourages and edifies his character. On the road of gaining spiritual growth, his life led to a detour where the language of love is uncommon. He learns to rebuild the street culture by spreading the message of love that saved him from death. His vision is to enlighten and edify everyone with the language of love. Supreme wisdom guided Pierre even when he least expected. After falling in love with the gift of encouragement, his heart feels alive again. Without unconditional love, Pierre would not have overcome the emotional pains he endured since his childhood. He forgave his dysfunctional family and those who mistreated and neglected him. Love is a blessing. Let it shine on earth. Everyone needs to be thirsty for love. Let the words of love be written on your heart.
Demonstrates that the study of international migration has really come of age. From acculturation to undocumented immigration, the authors consider more than three dozen concepts at the heart of migration studies. Clearly written in a highly readable style, the book is a valuable resource for students and scholars alike." - Nancy Foner, City University of New York "This very useful and authoritative compendium explicates thirty-eight concepts central to analysis of international migration. It is accessible to undergraduate students and even can enrich graduate courses. It nicely complements books like The Age of Migration or Exceptional People. Concision is a virtue!" - Mark J. Miller, University of Delaware This book provides lucid and intuitive explanations of the most important migration concepts as used in classrooms, among policymakers, and in popular and academic discourse. Arguing that there is a clear need for a better public understanding of migration, it sets out to clarify the field by exploring relevant concepts in a direct and engaging way. Each concept: Includes an easy to understand definition Provides real-world examples Gives suggestions for further reading Is carefully cross-referenced to other related concepts It is an ideal resource for undergraduate and post-graduate students studying migration in sociology, politics, development and throughout the social sciences, as well as scholars in the field and practitioners in governmental and non-governmental organizations.
The Renaissance of Etching is a groundbreaking study of the origins of the etched print. Initially used as a method for decorating armor, etching was reimagined as a printmaking technique at the end of the fifteenth century in Germany and spread rapidly across Europe. Unlike engraving and woodcut, which required great skill and years of training, the comparative ease of etching allowed a wide variety of artists to exploit the expanding market for prints. The early pioneers of the medium include some of the greatest artists of the Renaissance, such as Albrecht Dürer, Parmigianino, and Pieter Bruegel the Elder, who paved the way for future printmakers like Rembrandt, Goya, and many others in their wake. Remarkably, contemporary artists still use etching in much the same way as their predecessors did five hundred years ago. Richly illustrated and including a wealth of new information, The Renaissance of Etching explores how artists in Germany, the Netherlands, Italy, and France developed the new medium of etching, and how it became one of the most versatile and enduring forms of printmaking. p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 14.0px Verdana}
Measuring the Skin presents all techniques devoted to non-invasive normal or diseased skin measurement. As opposed other books, this text embraces old and new validated techniques for all skin suborgans and functions. The book is ideal as a small encyclopedia since it provides the answer to any question concerning skin measurement. Each technique is discussed to help select the most appropriate one for each special case. Another novel feature is that the book bases the skin investigation on the physiology and anatomy. Each chapter is preceded by a compendium of current knowledge on the structure or function dealt with. The book may also be used as a research tool. It contains a novel, and presently unique list of more than 400 physical and biological skin constants, which are all referenced.
Photoinitiators A comprehensive text that covers everything from the processes and mechanisms to the reactions and industrial applications of photoinitiators Photoinitiators offers a wide-ranging overview of existing photoinitiators and photoinitiating systems and their uses in ever-growing green technologies. The authors—noted experts on the topic—provide a concise review of the backgrounds in photopolymerization and photochemistry, explain the available structures, and examine the excited state properties, involved mechanisms, and structure, reactivity, and efficiency relationships. The text also contains information on the latest developments and trends in the design of novel tailor-made systems. The book explores the role of current systems in existing and emerging processes and applications. Comprehensive in scope, it covers polymerization of thick samples and in-shadow areas, polymerization under LEDs, NIR light induced thermal polymerization, photoinitiators for novel specific and improved properties, and much more. Written by an experienced and internationally renowned team of authors, this important book: Provides detailed information about excited state processes, mechanisms and design of efficient photoinitiator systems Discusses the performance of photoinitiators of polymerization by numerous examples of reactions and application Includes information on industrial applications Presents a review of current developments and challenges Offers an introduction to the background information necessary to understand thefield The role played by photoinitiators in a variety of different polymerization reactions Written for polymer chemists, photochemists, and materials scientists, Photoinitiators will also earn a place in the libraries of photochemists seeking an authoritative, one-stop guide to the processes, mechanisms, and industrial applications of photoinitiators.
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.