When Pierre Jovanovic was a reporter for Quotidien de Paris, he had just finished an interview and was driving home on a Silicon Valley freeway when he was suddenly hurled to the side of the car by a mysterious force. Seconds later, a bullet crashed through the windshield and buried itself in the back of the passenger's seat. Highway patrolmen told him that if he hadn't moved, he would have been killed instantly." "Shaken and curious, he began to compare notes with other journalists, many of whom were war-zone survivors. Most had had some kind of comparable experience of being snatched from death by an unseen hand." "Pierre began to interview authorities on near-death experience: Melvin Morse, Kenneth Ring, and Elisabeth Kubler-Ross. He collected first-hand accounts of the appearance of spiritual beings from adults and children all over the world. Voraciously, he began to read about the lives and Angelic accounts of the saints." "The book is the sum of his investigations and includes eyewitness accounts of the experiences of pilots, doctors, and journalists; interviews with leading near-death researchers and scientists; interviews with modern saints and visionaries on their mystical experiences from the Middle Ages to the present."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Creative work has been celebrated as the highest form of achievement since at least Aristotle. But our understanding of the dynamics and market for creative work--artistic work in particular--often relies on unexamined clichés about individual genius, industrial engineering of talent, and the fickleness of fashion. Pierre-Michel Menger approaches the subject with new rigor, drawing on sociology, economics, and philosophy to build on the central insight that, unlike the work most of us do most of the time, creative work is governed by uncertainty. Without uncertainty, neither self-realization nor creative innovation is possible. And without techniques for managing uncertainty, neither careers nor profitable ventures would surface. In the absence of clear paths to success, an oversupply of artists and artworks generates boundless differentiation and competition. How can artists, customers, entrepreneurs, and critics judge merit? Menger disputes the notion that artistic success depends solely on good connections or influential managers and patrons. Talent matters. But the disparity between superstardom and obscurity may hinge initially on minor gaps in intrinsic ability. The benefits of early promise in competition and the tendency of elite professionals to team up with one another amplify and disproportionately reward even small differences. Menger applies his temporal and causal analysis of behavior under uncertainty to the careers and oeuvres of Beethoven and Rodin. The result is a thought-provoking book that brings clarity to our understanding of a world widely seen as either irrational or so free of standards that only power and manipulation count.
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
Originally published in 2004. This comprehensive collection provides an innovative analysis and a comparison between economic and financial integration in Europe and Latin America, addressed from a global, regional and country-specific perspective. It constitutes a valuable overview focusing on three topics: regional integration and monetary cooperation in Europe and Latin America, exchange rate strategies and financial sector structure. The collection is the outcome of a Workshop and high-level Seminar organized by the Banco de España and the European Central Bank that brought together senior European and Latin American central bankers, as well as senior representatives from international institutions. The 31 contributors presented high quality papers, allowing the reader to take advantage of a rigorous economic analysis that uses first-hand information and draws useful lessons for the future.
Written by four recognized experts with senior experience in research and government, this text is the first comprehensive survival kit for students and practitioners of economic policy. It is set to become an indispensable resource for everyone involved or interested in modern economic policy. Academic scholars willing to engage in policy discussions and students at graduate or advanced undergraduate levels will find it an essential bridge to the policy world. What makes the book unique is that it combines like no other, facts-based analysis, state-of-the art theories and models, and insights from first-hand policy experience at national and international levels. The book has grown out of ten years of experience teaching economic policy at the graduate level. It provides an intellectually coherent framework to understand the potentialities and limits of economic policy. It addresses positive dimensions (how do policies impact on modern economies?), normative dimensions (what should policymakers aim to achieve and against what should their action be judged?) and political-economy constraints (which are the limits and obstacles to public intervention?). It fills an important gap by reconciling in each major policy area stylized facts of recent economic history, key questions faced by contemporary policymakers, and essential lessons from theory which are captured and explained in a clear, concise, and self-contained way. All major areas of domestic and international policymaking are covered: fiscal policy, monetary policy, international finance and exchange-rate policy, tax policy, and long-term growth policies. The book concludes with a special chapter on the lessons of the financial crisis. The authors are intellectually non-partisan and they draw examples from various countries and experiences; from emerging markets to developing economies, shedding light when necessary on local specificities such as European Union rules and instruments. Economic Policy: Theory and Practice is the essential guide to economic policy in the new post-crisis context.
Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.
This book is intended to foster a better understanding of Roma in Europe by describing their culture and lifestyle and the strength of their identity as well as the mistreatment they have suffered over the centuries. The final pages of the book set out the foundations for a program of action.--Publisher's description.
The new edition of a widely used, comprehensive graduate-level text and professional reference covering all aspects of labor economics, with substantial new material. This landmark graduate-level text combines depth and breadth of coverage with recent, cutting-edge work in all the major areas of modern labor economics. Its command of the literature and its coverage of the latest theoretical, methodological, and empirical developments make it also a valuable resource for practicing labor economists. This second edition has been substantially updated and augmented. It incorporates examples drawn from many countries, and it presents empirical methods using contributions that have proved to be milestones in labor economics. The data and codes of these research publications, as well as numerous tables and figures describing the functioning of labor markets, are all available on a dedicated website (www.labor-economics.org), along with slides that can be used as course aids and a discussion forum. This edition devotes more space to the analysis of public policy and the levers available to policy makers, with new chapters on such topics as discrimination, globalization, income redistribution, employment protection, and the minimum wage or labor market programs for the unemployed. Theories are explained on the basis of the simplest possible models, which are in turn related to empirical results. Mathematical appendixes provide a toolkit for understanding the models.
Economic Policy provides a unique combination of facts-based analysis, state-of-the art economic theory, and insights from first-hand policy experience at the national and international levels to shed light on current domestic and international policy challenges. It is ideally suited for students, practitioners, and scholars seeking understanding both of the pragmatic constraints of real-world policy making and the analytical tools that enhance inquiry and inform debates. The authors draw on their experiences as academics and as policy makers in European and international institutions to offer a deep dive into the rationale, design, and implementation of economic policy across a range of policy domains: fiscal policy, monetary policy, international finance, financial stability, taxes, long-term growth and inequality. Highlighting the ways experience, theories, and institutions interact, each chapter starts with historical examples of dilemmas and shows how theoretical approaches can help policy makers understand what is at stake and identify solutions. The authors highlight the differences between the positive approach to economic policy (how do policies impact the economy), the normative approach (what should be policymakers' objectives and against which criteria should their action be judged), and the political-economy constraints (what are the limits and obstacles to public intervention). They rely on the most recent academic research, providing technical boxes while explaining the mechanisms in plain English in the text, with appropriate illustrations. This new edition is informed by such important recent developments as the Great Recession, the strains on the European Union and the Euro, the challenges of public and private debt, the successes and setbacks to emerging markets, changes to labor markets along with the increased attention to inequality, the debates on secular stagnation and its implications for conventional and unconventional monetary policy, the re-regulation of the financial sector, the debt overhang in both the public and the private sector.
This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors
Lagoons and estuaries are transition spaces between earth and sea. Beyond their expanse, geographic repartition, geomorphological, hydroclimatic and ecobiological diversity and biodiversity, they play an important role in regional economies and are some of the ecosystems most vulnerable to global change. Reinforced by numerous references, this book studies Mediterranean lagoonal and estuarine fishes whose diversity largely depends on the composition of neighboring marine and continental ichtyofauna. The authors describe their morphological, biological, ecological and behavioral characteristics by evoking their distinctive features and differences with their marine or freshwater homologues. Their adaptation strategies, elucidated thanks to recent advances in morphology, genetics and molecular biology, are recognized as a major advantage in the context of climate change. This book is for natural environment managers, engineers, teachers, students and researchers.
This report first analyzes what lies behind the historic segmentation of EU financial markets because a clear view about these issues is needed to predict the changes that EMU will bring about. The authors then examine the policy implications of these changes and propose measures to address the problems that may be encountered.
The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
The key social issues of health, medicine, the environment, food and safety cannot be addressed without the support of chemical sensors and biosensors, whose performance is constantly improving in terms of reliability and cost, particularly in the production of autonomous devices connected to the Internet. Obtaining high-intensity transduction signals arising from the interaction of an analyte and a sensor, enabling the identification and dosage of a given compound, requires the selection of suitable physical measurement methods and the creation of structures that react specifically to different types of analyte. Nanotechnologies and Nanomaterials Applied to Chemical Sensors and Biosensors details recent advances in the field of sensor design using carbon-based nanomaterials (graphene, carbon nanotubes, carbon quantum dots, etc.) and inorganic nanomaterials (metallic nanoparticles, nanocrystals, transition metal dichalcogenides, etc.), as well as a variety of physical sensing methods (electrochemical, piezoelectric, electromagnetic, optic, optoelectronic, etc.).
Biologie des poissons d’eau douce européens, par son champ d’étude vaste et ambitieux, est un ouvrage de référence en ichtyologie dulçaquicole. Couvrant l’ensemble des aspects écologiques, écobiologiques, écophysiologiques et éthologiques, il dresse une présentation détaillée de 88 espèces auto- ou allochtones : morphologie, anatomie, distribution géographique, habitats, modes de vie et activités physiologiques. 453 autres espèces sont également répertoriées. Cette 2e édition a été largement revue et augmentée, compte tenu de l’importance des données scientifiques récentes. Outre des compléments utiles portant sur les habitats et les modes de vie, cet ouvrage s’enrichit des nombreux apports génétiques qui ont parfois « révolutionné » les concepts anciens relatifs aux origines paléo-historiques et paléo-géographiques des espèces. Des extensions ou des réductions de répartitions géographiques ont été consécutives à des transferts d’origine anthropique, à des dégradations physiques et chimiques et à la récente influence du Global Warming, sans oublier les changements de statut dans le domaine de la systématique. Au fil d’un livre d’une grande rigueur scientifique, abondamment illustré (dont 64 aquarelles originales et plus de 70 cartes géographiques pertinentes) et complété par un glossaire et une importante bibliographie, le lecteur abordera la connaissance des poissons européens d’une façon à la fois originale et attrayante. Cet ouvrage s’adresse à un large public : étudiants de 2e et 3e cycles en biologie, zoologie, écologie, hydrobiologie, environnement, ingénieurs et techniciens chargés de l’aménagement, de la gestion, de la qualité et de la protection des milieux aquatiques (services vétérinaires, de l’Environnement, de l’Agriculture, de l’Équipement…) auxquels il apportera les bases fondamentales nécessaires à leur action, et plus largement tous les passionnés d’ichtyofaune.
This book aims to provide an original perspective on the changes that Greece has undergone in recent decades, by examining questions related to border disputes and migration, minority issues and national inclusion, and their effect in reinforcing discourses of glorification of the past and tradition on the fringes of Greek territory.
The aim of this reference work is to provide the researcher with a comprehensive compilation of all up to now crystallographically identified inorganic substances in only one volume. All data have been processed and critically evaluated by the "Pauling File" editorial team using a unique software package. Each substance is represented in a single row containing information adapted to the number of chemical elements.
4 zettabytes (4 billion terabytes) of data generated in 2013, 44 zettabytes predicted for 2020 and 185 zettabytes for 2025. These figures are staggering and perfectly illustrate this new era of data deluge. Data has become a major economic and social challenge. The speed of processing of these data is the weakest link in a computer system: the storage system. It is therefore crucial to optimize this operation. During the last decade, storage systems have experienced a major revolution: the advent of flash memory. Flash Memory Integration: Performance and Energy Issues contributes to a better understanding of these revolutions. The authors offer us an insight into the integration of flash memory in computer systems, their behavior in performance and in power consumption compared to traditional storage systems. The book also presents, in their entirety, various methods for measuring the performance and energy consumption of storage systems for embedded as well as desktop/server computer systems. We are invited on a journey to the memories of the future. - Ideal for computer scientists, featuring low level details to concentrate on system issues - Tackles flash memory aspects while spanning domains such as embedded systems and HPC - Contains an exhaustive set of experimental results conducted in the Lab-STICC laboratory - Provides details on methodologies to perform performance and energy measurements on flash storage systems
Destinado a comprender mejor a los gitanos e itinerantes, este libro subraya la riqueza de su cultura y de su estilo de vida, la fuerza de su identidad y el trato recibido a lo largo de su historia. Dividido en dos partes -datos socioculturales y datos sociopolíticos- proporciona información útil para las organizaciones gitanas, los enseñantes, los animadores y trabajadores sociales y para los responsables locales, regionales o nacionales.
The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity. - Presents a clear differentiation of Charcot neuroarthropathy with other conditions such as osteoarthritis, gout, psoriasis, rheumatoid arthritis, the Madura foot, and others - Provides a state-of-art catalogue of all radiological features of Charcot neuroarthropathy with MRI - Describes the pre-and post-surgical procedures used for the management of Charcot neuroarthropathy and their socioeconomic impacts - Includes MRI color images of soft tissue damages for ease of understanding
The ultimate reference book : the 5th updated edition of the famous “blue guide”. Incluided : A DVD with new sequences completes each chapter! Epileptology changes. The syndromic approach is completed by an etiological approach, based on the major advances in genetics and functional genetics. New entities have found their place, and a purely descriptive, “electroclinical” approach is no longer adapted in many circumstances. The 5th edition of the Blue Guide includes the most recent advances. It was necessary to justify the physiological, epidemiologic, genetic and therapeutic approaches and to consider them in the light of the new classification efforts, which are still in the making. Nevertheless, the description of epileptic syndromes, both classical and recent, remains at the core of this book.
Since the discovery of X-ray diffraction in 1913 over 100 000 different inorganic substances (also called compounds or phases) have been structurally characterized. The aim of this reference work is to provide the researcher with a comprehensive compilation of all up to now crystallographically identified inorganic substances in only one volume. All data have been processed and critically evaluated by the "Pauling File" editorial team using a unique software package. Each substance is represented in a single row containing information adapted to the number of chemical elements.
Un DVD inclus avec des séquences vidéos inédites pour chaque chapitre ! L’épileptologie change, et les approches syndromiques sont maintenant complétées par une approche étiologique fondée sur les progrès considérables en génétique. Une approche purement « électro-clinique » n’est plus adaptée aujourd’hui dans bien des cas. Cette 5e édition du « Guide bleu » fait le point sur les plus récents progrès. Ainsi, la structure du livre a un peu évolué, laissant plus de place aux approches : - physiologiques - épidémiologiques - génétiques - thérapeutique Néanmoins, la description des syndromes épileptiques reste au cœur de cet ouvrage. La diversité des contributeurs – coordinateurs et auteurs – confère à ce livre des qualités d’objectivité et de sérieux qui en font la réputation depuis maintenant près de 30 ans.
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