This is the third volume in the Paris-Princeton Lectures in Financial Mathematics, which publishes, on an annual basis, cutting-edge research in self-contained, expository articles from outstanding specialists, both established and upcoming. Coverage includes articles by René Carmona, Ivar Ekeland/Erik Taflin, Arturo Kohatsu-Higa, Pierre-Louis Lions/Jean-Michel Lasry, and Huyên Pham.
Provides the background, tools, and models required to understand organic synthesis and plan chemical reactions more efficiently Knowledge of physical chemistry is essential for achieving successful chemical reactions in organic chemistry. Chemists must be competent in a range of areas to understand organic synthesis. Organic Chemistry provides the methods, models, and tools necessary to fully comprehend organic reactions. Written by two internationally recognized experts in the field, this much-needed textbook fills a gap in current literature on physical organic chemistry. Rigorous yet straightforward chapters first examine chemical equilibria, thermodynamics, reaction rates and mechanisms, and molecular orbital theory, providing readers with a strong foundation in physical organic chemistry. Subsequent chapters demonstrate various reactions involving organic, organometallic, and biochemical reactants and catalysts. Throughout the text, numerous questions and exercises, over 800 in total, help readers strengthen their comprehension of the subject and highlight key points of learning. The companion Organic Chemistry Workbook contains complete references and answers to every question in this text. A much-needed resource for students and working chemists alike, this text: -Presents models that establish if a reaction is possible, estimate how long it will take, and determine its properties -Describes reactions with broad practical value in synthesis and biology, such as C-C-coupling reactions, pericyclic reactions, and catalytic reactions -Enables readers to plan chemical reactions more efficiently -Features clear illustrations, figures, and tables -With a Foreword by Nobel Prize Laureate Robert H. Grubbs Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis is an ideal textbook for students and instructors of chemistry, and a valuable work of reference for organic chemists, physical chemists, and chemical engineers.
What does political science tell us about important real-world problems and issues? And to what extent does and can political analysis contribute to solutions? Debates about the funding, impact and relevance of political science in contemporary democracies have made this a vital and hotly contested topic of discussion, and in this original text authors from around the world respond to the challenge. A robust defence is offered of the achievements of political science research, but the book is not overly sanguine given its sustained recognition of the need for improvement in the way that political science is done. New insights are provided into the general issues raised by relevance, into blockages to relevance, and into the contributions that the different subfields of political science can and do make. The book concludes with a new manifesto for relevance that seeks to combine a commitment to rigour with a commitment to engagement.
Which Springbok match saw the least number of spectators ever attending a test match? Who was the unofficial arm-wrestling champion in the Springbok side on the 1981 tour to New Zealand? Which Springbok lock played with a glass eye? Welcome to the ultimate rugby quiz book for real rugby fans! Springbok Rugby Quiz examines the lore of rugby in an unusually entertaining way: it comprises 1001 questions and answers. Rugby lovers can now enjoy some of the most outlandish anecdotes, as well as cold, hard facts and statistics, about this game we all love. This well-researched book covers the entire spectrum of our rugby history, from the first test match in 1891, up to modern times. The book has two sections: test yourself by reading the question in the first part and then cross-check your answer in the second part. Rugby fans will certainly find more than enough challenges among the 1001 questions included here. And, as a bonus, the author also includes his Dream Team – the best players of all time united in one super team. Fun, informative and factual, this is a must-read for all rugby fans.
This book describes the 60-year history of the AO Foundation and its impact on the treatment of bone trauma. Originally founded by a group of Swiss surgeons, the AO has since established its osteosynthesis treatment approach to trauma, using surgery and implants, as the global standard. The AO successfully convinced the medical community that surgery of bone trauma was superior to the standard conservative treatment using plaster casts. This new technique meant that patients no longer had to spend long weeks at the hospital in traction, and prevented many disabilities. This book describes the struggle with the medical community, explains how the AO surgeons enlisted the support of an entire industry for their advanced tools and their research and teaching efforts, and details the AO’s evolution into a non-profit foundation that now trains more than 50,000 surgeons, on all continents, every year. The efforts of the AO’s affiliated surgeons, undertaken largely on a volunteer basis and with their own financial resources, serve as a stellar example of social entrepreneurship. Today the AO Foundation numbers over 20,000 surgeon members worldwide, and the industry that emerged to produce related implants and tools employs thousands of skilled staff. Professionals in consulting as well as in healthcare can use this book as a source of successful strategies, and as a blueprint for active social entrepreneurship.
Written by today's leading experts, this book keeps practitioners completely current with the latest in disease management of horses, taking a clear and practical approach ideal for daily equine practice. Arranged by subject for efficient searching, each topic covers clinical signs, diagnosis, treatment, and follow-up. Practitioners gain quick access to information about conditions and disorders encompassing behavior, cardiology, dermatology, endocrinology, gastroenterology, hematology, infectious diseases, laboratory tests, musculoskeletal, neonatology, neurology, ophthalmology, respiratory, theriogenology, toxicology, and urinary diseases. Blackwell's Five-Minute Veterinary Consult: Equine, Third Edition enhances the practitioner's skills in evidence-based treatment planning, and is unmatched for its comprehensive coverage of more than 500 diseases and conditions. This handy, practical guide will help cut down on time spent navigating through other resources, so that equine veterinarians and veterinary students can study, diagnose, and treat with greater efficacy. Key Features The premier all-in-one equine resource designed specifically for quick information retrieval Divided into identically formatted topics for easy searching by alphabetical listing or by body system Coverage of more than 500 diseases and conditions Fast access to the accumulated wisdom of hundreds of veterinary experts Includes a companion website with 43 editable client handouts, 3 video clips, 8 color images, and select further reading
A thermodynamic system is defined according to its environment and its compliance. This book promotes the classification of materials from generalized thermodynamics outside the equilibrium state and not solely according to their chemical origin. The author goes beyond standard classification of materials and extends it to take into account the living, ecological, economic and financial systems in which they exist: all these systems can be classified according to their deviation from an ideal situation of thermodynamic equilibrium. The concepts of dynamic complexity and hierarchy, emphasizing the crucial role played by cycles and rhythms, then become fundamental. Finally, the limitations of the uniqueness of this description that depend on thermodynamic foundations based on the concepts of energy and entropy are discussed in relation to the cognitive sciences.
Using numerous practical examples,this book examines the evolution of EC telecommunications law following the achievement of liberalisation, the main policy goal of the 1990s. After reviewing the development of regulation in the run-up to liberalisation, the author identifies the methods used to direct the liberalisation process and tests their validity in the post-liberalisation context. A critical analysis is made of the claim that competition law will offer sufficient means to regulate the sector in the future. Particular emphasis is given to the way in which EC Competition Law changed in the 1990s using the essential facilities doctrine, an expansive non-discrimination principle and the policing of cross-subsidisation to tackle what were then thought of as regulatory matters. Also examined within the work is the procedural and institutional interplay between competition law and telecommunications regulation. In conclusion, Larouche explores the limits of competition law and puts forward a long-term case for sector-specific regulation, with a precise mandate to ensure that the telecommunications sector as a whole fulfils its role as a foundation for economic and social activity.
This book contains the most recent information on optical nanoscopy. Far-Field and Near-Field properties on e.m. waves are presented which illustrate how optical images can be obtained from sub-micron objects. Scanning Probe techniques and computer processing are covered here. An explanation is given on how propagating photons or evanescent waves can behave over distances shorter than the wavelength, taking into account the presence of small objects. Quantum tunneling of photons is explained comparatively with the electron mechanism. Technical details are given on photon tunneling microscopes. Typical results already obtained with these techniques are also described.
Esperanto, spoken by thousands of people across the world, is the most successful international language project. In this book, the French linguist and literary critic Pierre Janton describes the history of Esperanto since its invention in nineteenth-century Eastern Europe and offers a comprehensive linguistic description of the language. This book is the best general introduction to Esperanto and its role in the modern world. Rooted in the populism and internationalism of the late nineteenth century, Esperanto owes its origins in part to western European educational currents and in part to the cultural history of eastern European Jewry. It is a fascinating historical and sociological phenomenon as well as a remarkable linguistic system. The book contains a survey of today's movement for the promotion of Esperanto as an international language, and a description of the extensive literature in Esperanto, both original and translated. Janton also provides a survey of the other global language projects, explaining why Esperanto has prevailed.
The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Business Law and Economics for Civil Law Systems highlights the relevance of economic analysis of business law from a civilian perspective. It integrates a comparative approach (common law and civil law) to economic analysis using tools and illustrations to assist in conducting critical economic analysis of rules in the field of business law. This book is a valuable contribution to the reflection on the place and meaning of value creation and accountability as goals for business law. It will be of great value to academics interested in business law, competition law, comparative law and legal theory, students studying law, business and economics, and to policy makers and regulators.
Environmental DNA (eDNA) refers to DNA that can be extracted from environmental samples (such as soil, water, feces, or air) without the prior isolation of any target organism. The analysis of environmental DNA has the potential of providing high-throughput information on taxa and functional genes in a given environment, and is easily amenable to the study of both aquatic and terrestrial ecosystems. It can provide an understanding of past or present biological communities as well as their trophic relationships, and can thus offer useful insights into ecosystem functioning. There is now a rapidly-growing interest amongst biologists in applying analysis of environmental DNA to their own research. However, good practices and protocols dealing with environmental DNA are currently widely dispersed across numerous papers, with many of them presenting only preliminary results and using a diversity of methods. In this context, the principal objective of this practical handbook is to provide biologists (both students and researchers) with the scientific background necessary to assist with the understanding and implementation of best practices and analyses based on environmental DNA.
This addition to the ISOR series addresses the analytics of the operations of electric energy systems with increasing penetration of stochastic renewable production facilities, such as wind- and solar-based generation units. As stochastic renewable production units become ubiquitous throughout electric energy systems, an increasing level of flexible backup provided by non-stochastic units and other system agents is needed if supply security and quality are to be maintained. Within the context above, this book provides up-to-date analytical tools to address challenging operational problems such as: • The modeling and forecasting of stochastic renewable power production. • The characterization of the impact of renewable production on market outcomes. • The clearing of electricity markets with high penetration of stochastic renewable units. • The development of mechanisms to counteract the variability and unpredictability of stochastic renewable units so that supply security is not at risk. • The trading of the electric energy produced by stochastic renewable producers. • The association of a number of electricity production facilities, stochastic and others, to increase their competitive edge in the electricity market. • The development of procedures to enable demand response and to facilitate the integration of stochastic renewable units. This book is written in a modular and tutorial manner and includes many illustrative examples to facilitate its comprehension. It is intended for advanced undergraduate and graduate students in the fields of electric energy systems, applied mathematics and economics. Practitioners in the electric energy sector will benefit as well from the concepts and techniques explained in this book.
Myopathies and Tendinopathies of the Diabetic Foot: Anatomy, Pathomechanics, and Imaging is a unique reference of valuable instructive data that reinforces the understanding of myopathies and tendinopathies related to diabetes-induced Charcot foot. Diabetic myopathies usually precede other complications (i.e., deformity, ulceration, infection) seen in the diabetic foot. Oftentimes, these myopathies may be isolated especially during their initial stage. In the absence of clinical information relevant to diabetes, the solitaire occurrence of myopathies may lead to confusion, misinterpretation, and misdiagnosis. The misdiagnosis can cause delay of management and consequent high morbidity. This book emphasizes the complications of diabetic myopathies and tendinopathies and all their aspects, including pathophysiology, pathomechanics, imaging protocols, radiological manifestations, histological characteristics, and surgical management.Diabetes type II and its complications (diabetic myopathies and tendinopathies) have reached a dreadful high incidence worldwide. Likewise, the need for better understanding of these complications becomes indispensable. In this book, the readers of all genres will find all they need to know about these conditions. This book serves as a classic academic reference for educators, healthcare specialists, healthcare givers, and healthcare students. - Presents dedicated chapters on tendons and myotendinous junction which are anatomical components frequently ignored in the study of muscles - Includes descriptions of diabetic foot myopathies featured by magnetic resonance imaging (MRI) - Provides illustrations of myopathies and tendinopathies with state-of-the-art MRI images and MR imaging protocols for myopathies - Covers anatomical and biomechanic descriptions of all intrinsic and extrinsic muscles
To develop innovations in quantum engineering and nanosystems, designers need to adopt the expertise that has been developed in research laboratories. This requires a thorough understanding of the experimental measurement techniques and theoretical models, based on the principles of quantum mechanics. This book presents experimental methods enabling the development and characterization of materials at the nanometer scale, based on practical engineering cases, such as 5G and the interference of polarized light when applied for electromagnetic waves. Using the example of electromechanical, multi-physical coupling in piezoelectric systems, smart materials technology is discussed, with an emphasis on scale reduction and mechanical engineering applications. Statistical analysis methods are presented in terms of their usefulness in systems engineering for experimentation, characterization or design, since safety factors and the most advanced reliability calculation techniques are included from the outset. This book provides valuable support for teachers and researchers but is also intended for engineering students, working engineers and MasterÂs students.
Spectroscopy and Modeling of Biomolecular Building Blocks presents an overview of recent advances in the intertwining of the following research fields: photon and electron spectroscopy, quantum chemistry, modelling and mass-spectrometry. The coupling of these disciplines offers a new point of view to the understanding of isolated elementary building blocks of biomolecules and their assemblies. It allows the unambiguous separation between intrinsic properties of biomolecular systems and those induced by the presence of their environment. The first chapters provide background in modelling (I), frequency-resolved spectroscopy using microwave, infrared and UV photons, time-resolved spectroscopy in the femtosecond domain and energy-resolved electron spectroscopy (II) and production of gas-phase neutral and ionic biomolecular species, mass-spectrometry, ion mobility and BIRD techniques (III). Chapter IV is devoted to case studies of gas-phase experimental investigations coupled to quantum or classical calculations. The topics are structural studies of nucleobases and oligonucleotides, peptides and proteins, sugars; neuromolecules; non-covalent complexes; chiral systems, interactions of low-energy electrons with biomolecules in the radiation chemistry context and very large gas-phase biomolecular systems. The fifth chapter concerns the link between gas-phase and liquid-phase. Different treatments of solvation are illustrated through examples pointing out the influence of progressive addition of water molecules upon properties of nucleobases, peptides, sugars and neuromolecules. - Offer a new perspective to the understanding of isolated elementary building blocks of bio molecules - Includes case studies of experimental investigations coupled to quantum or classical calculations
Nanoscience, nanotechnologies and the laws of quantum physics are sources of disruptive innovation that open up new fields of application. Quantum engineering enables the development of very sensitive materials, sensor measurement systems and computers. Quantum computing, which is based on two-level systems, makes it possible to manufacture computers with high computational power. This book provides essential knowledge and culminates with an industrial application of quantum engineering and nanotechnologies. It presents optical systems for measuring at the nanoscale, as well as quantum physics models that describe how a two-state system interacts with its environment. The concept of spin and its derivation from the Dirac equation is also explored, while theoretical foundations and example applications aid in understanding how a quantum gate works. Application of the reliability-based design optimization (RBDO) method of mechanical structures is implemented, in order to ensure reliability of estimates from the measurement of mechanical properties of carbon nanotube structures. This book provides valuable support for teachers and researchers but is also intended for engineering students, working engineers and Masters students.
Written for scientists, researchers, and engineers, Non-volatile Memories describes the recent research and implementations in relation to the design of a new generation of non-volatile electronic memories. The objective is to replace existing memories (DRAM, SRAM, EEPROM, Flash, etc.) with a universal memory model likely to reach better performances than the current types of memory: extremely high commutation speeds, high implantation densities and retention time of information of about ten years.
It's a commonplace that citizens in Western democracies are disaffected with their political leaders and traditional democratic institutions. But in Democratic Legitimacy, Pierre Rosanvallon, one of today's leading political thinkers, argues that this crisis of confidence is partly a crisis of understanding. He makes the case that the sources of democratic legitimacy have shifted and multiplied over the past thirty years and that we need to comprehend and make better use of these new sources of legitimacy in order to strengthen our political self-belief and commitment to democracy. Drawing on examples from France and the United States, Rosanvallon notes that there has been a major expansion of independent commissions, NGOs, regulatory authorities, and watchdogs in recent decades. At the same time, constitutional courts have become more willing and able to challenge legislatures. These institutional developments, which serve the democratic values of impartiality and reflexivity, have been accompanied by a new attentiveness to what Rosanvallon calls the value of proximity, as governing structures have sought to find new spaces for minorities, the particular, and the local. To improve our democracies, we need to use these new sources of legitimacy more effectively and we need to incorporate them into our accounts of democratic government. An original contribution to the vigorous international debate about democratic authority and legitimacy, this promises to be one of Rosanvallon's most important books.
Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.
As a result of new statistical and mathematical approaches, improved visualization tools, and recognition by international regulatory groups, quantitative structure-activity relationships (QSARs) now play important roles in pharmacology for the design of new drugs as well as in toxicology and ecotoxicology for hazard identification and risk assessm
The actuarial analysis of social protection schemes is a challenge that requires a balancing act between the demographic, economic, financial, and actuarial fields. This text provides a practical tool to enhance and modernize social protection systems while maintaining this balance.
Solar PV is now the third most important renewable energy source, after hydro and wind power, in terms of global installed capacity. Bringing together the expertise of international PV specialists Photovoltaic Solar Energy: From Fundamentals to Applications provides a comprehensive and up-to-date account of existing PV technologies in conjunction with an assessment of technological developments. Key features: Written by leading specialists active in concurrent developments in material sciences, solar cell research and application-driven R&D. Provides a basic knowledge base in light, photons and solar irradiance and basic functional principles of PV. Covers characterization techniques, economics and applications of PV such as silicon, thin-film and hybrid solar cells. Presents a compendium of PV technologies including: crystalline silicon technologies; chalcogenide thin film solar cells; thin-film silicon based PV technologies; organic PV and III-Vs; PV concentrator technologies; space technologies and economics, life-cycle and user aspects of PV technologies. Each chapter presents basic principles and formulas as well as major technological developments in a contemporary context with a look at future developments in this rapidly changing field of science and engineering. Ideal for industrial engineers and scientists beginning careers in PV as well as graduate students undertaking PV research and high-level undergraduate students.
The purpose of this book is to offer an overview of the most popular domain decomposition methods for partial differential equations (PDEs). These methods are widely used for numerical simulations in solid mechanics, electromagnetism, flow in porous media, etc., on parallel machines from tens to hundreds of thousands of cores. The appealing feature of domain decomposition methods is that, contrary to direct methods, they are naturally parallel. The authors focus on parallel linear solvers. The authors present all popular algorithms, both at the PDE level and at the discrete level in terms of matrices, along with systematic scripts for sequential implementation in a free open-source finite element package as well as some parallel scripts. Also included is a new coarse space construction (two-level method) that adapts to highly heterogeneous problems.?
Written in the irreverent style that made How to Talk About Books You Haven't Read a critical and commercial success, Pierre Bayard takes readers on a trip around the world, giving us essential guidance on how to talk about all those fantastic places we've never been. Practical, funny, and thought-provoking, How to Talk About Places You've Never Been will delight and inform armchair globetrotters and jet-setters, all while never having to leave the comfort of the living room. Bayard examines the art of the "non-journey," a tradition that a succession of writers and thinkers, unconcerned with moving away from their home turf, have employed in order to encounter the foreign cultures they wish to know and talk about. He describes concrete situations in which the reader might find himself having to speak about places he's never been, and he chronicles some of his own experiences and offers practical advice. How to Talk About Places You've Never Been is a compelling and delightful book that will expand any travel enthusiast's horizon well beyond the places it's even possible to visit in a single lifetime.
Nanotechnologies: Concepts, Processing and Applications describes and explains how nanotechnologies have entered our everyday lives through scientific and industrial applications with the emphasis placed on the new perspectives in various fields related to societal problems. This book details how successive discoveries of new nanocarbon structures along with progress in different microscopy techniques have caused nanomaterials to take on an increasingly important role in electronics, electrochemical energy storage – batteries and fuel cells – and the electrical conversion of solar energy. Views once seen as futuristic on nanomachines and nanorobotics, therapeutic hopes and medical advances – such as those resulting from the application of new in-situ drug-delivery nanotechniques – are all presented. The most innovative developments are analyzed in terms of applications and should enable the reader to form his or her own opinion about the reality of the progress that can be expected from nanotechnologies in the near future. The book offers background reading for teachers in colleges who wish to have an overview on this subject.
It is well known that solid carbons can be found in various guises with different forms of bulk phases (graphites, diamonds and carbynes) as well as more molecular forms (fullerenes,nanotubes and graphenes) resulting from recent discoveries. The cause of this rich polymorphism is analyzed in the first part of this book (chapters 1-5) with the propensity of carbon atoms for forming different types of homopolar chemical bonds associated with variable coordination numbers. Precursor organic molecules and parent compounds are also described to establish specific links with this rich polymorphism. Then in a second part (chapters 6-10) a comparative review of the main classes of bulk physical properties is presented. This approach emphasizes in particular the electronic behavior of (pi) polyaromatic systems organized in plane and curved atomic sheets. Finally in a third part (chapters 11-15) the surface and interface characteristics are introduced together with the texture and morphology of these multiscale carbon materials. An overview of the main field of applications is related showing the large use and interest for these solids.
Angiogenesis is the growth of blood vessels from the existing vasculature. The field of angiogenesis has grown enormously in the past 30 years, with only 40 papers published in 1980 and nearly 6000 in 2010. Why has there been this explosive growth in angiogenesis research? Angiogenic therapies provide a potential to conquer cancer, heart diseases, and more than 70 of life's most threatening medical conditions. The lives of at least 1 billion people worldwide could be improved with angiogenic therapy, according to the Angiogenesis Foundation. In this little book, we provide a simple approach to understand the essential elements of the angiogenic process, we critique the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and we provide an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body. All tissues of the body require a continuous supply of oxygen to burn metabolic substrates that are needed for energy. Oxygen is conducted to these tissues by blood capillaries: more capillaries can improve tissue oxygenation and thus enhance energy production; fewer capillaries can lead to hypoxia and even anoxia in the tissues. This means that angiogenic therapies designed to control the growth and regression of blood capillaries can be used to improve the survival of poorly perfused tissues that are essential to the body (heart, brain, skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors). Table of Contents: Overview of Angiogenesis / Angiogenesis Assays / Regulation: Metabolic Factors / Regulation: Mechanical Factors / Glossary / References / Author Biographies
The Neoliberal Republic traces the corrosive effects of the revolving door between public service and private enrichment on the French state and its ability to govern and regulate the private sector. Casting a piercing light on this circulation of influence among corporate lawyers and others in the French power elite, Antoine Vauchez and Pierre France analyze how this dynamic, a feature of all Western democracies, has developed in concert with the rise of neoliberalism over the past three decades. Based on interviews with dozens of public officials in France and a unique biographical database of more than 200 civil-servants-turned-corporate-lawyers, The Neoliberal Republic explores how the always-blurred boundary between public service and private interests has been critically compromised, enabling the transformation of the regulatory state into either an ineffectual bystander or an active collaborator in the privatization of public welfare. The cumulative effect of these developments, the authors reveal, undermines democratic citizenship and the capacity to imagine the public good.
This book describes the methods used to detect material defects at the nanoscale. The authors present different theories, polarization states and interactions of light with matter, in particular optical techniques using polarized light. Combining experimental techniques of polarized light analysis with techniques based on theoretical or statistical models to study faults or buried interfaces of mechatronic systems, the authors define the range of validity of measurements of carbon nanotube properties. The combination of theory and pratical methods presented throughout this book provide the reader with an insight into the current understanding of physicochemical processes affecting the properties of materials at the nanoscale.
The computer-aided design of novel molecular systems has undoubtedly reached the stage of a mature discipline offering a broad range of tools available to virtually any chemist. However, there are few books coveringmost of these techniques in a single volume and using a language which may generally be understood by students or chemists with a limited knowledge of theoretical chemistry. The purpose of this book is precisely to review, in such a language, both methodological aspects and important applications of computer-aided molecular design (CAMD), with a special emphasis on drug design and protein modeling.Using numerous examples ranging from molecular models to shapes, surfaces, and volumes, Computer-Aided Molecular Design provides coverage of the role molecular graphics play in CAMD. The text also treats the very notion of the structure of molecular systems by presenting both the various experimental techniques giving access to it and the most common model builders based on force fields. Separate chapters are devoted to other important topics in CAMD, such as Monte Carlo and molecular dynamics simulations; most common quantum chemical methods; derivation and visualization of molecular properties; and molecular similarity. Finally, strategies used in protein modeling and drug design, such as receptor mapping and the pharmacophore approach, are presented and illustrated by several examples.The book is addressed to students and researchers who wish to enter this new exciting field of molecular sciences, but also practitioners in CAMD as a comprehensive source of refreshing information in their field.Key Features* Presents a comprehensive introduction to computer-aided molecular design* Describes applications of CAMD through the use of numerous examples* Emphasizes strategies used in protein modeling and drug design* Includes separate chapters devoted to other important topics in CAMD, such as:* Monte Carlo and molecular dynamics simulations* Common quantum chemical methods* Derivation and visualization of molecular properties* Molecular similarity
Alexis de Tocqueville, John Stuart Mill, and the U.S. Supreme Court have all alleged that jury service promotes civic and political engagement, yet none could prove it. Finally, The Jury and Democracy provides compelling systematic evidence to support this view. Drawing from in-depth interviews, thousands of juror surveys, and court and voting records from across the United States, the authors show that serving on a jury can trigger changes in how citizens view themselves, their peers, and their government--and can even significantly increase electoral turnout among infrequent voters. Jury service also sparks long-term shifts in media use, political action, and community involvement. In an era when involved Americans are searching for ways to inspire their fellow citizens, The Jury and Democracy offers a plausible and realistic path for turning passive spectators into active political participants.
This topical insight in the role of cytokines in joint inflammation and joint destruction is important for a better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of well-known and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. New information on the novel cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay is provided, in addition to an outline of the role of established cytokines, such as TNF, IL-1 and IL-6. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
Echinoderms are now considered as a biological and geological model that underlies researches of primary importance. The extent of the contributions made by the International Echinoderm Conferences to various fields of research is attested by the scope covered by presentation at the international conferences. These proceedings contain the complete papers or abstracts of all the presentations and posters presented at the eighth International Echinoderm Conference, held in Dijon, France in September, 1994. Coverage includes: general; extinct classes; crinoids; asteroids; ophiuroids; holothuroids; and echinoids.
Acute Coronary Syndromes—a Companion to Braunwald’s Heart Disease—covers the state-of-the-art scientific and clinical information you need to rapidly evaluate and manage acute coronary syndromes. Dr. Pierre Theroux and his team of expert contributors present advances in diagnostic and imaging techniques such as biomarkers, nuclear cardiology, echocardiography, and multislice CT; secondary prevention; and new antiplatelet, anti-ischemic, and gene therapies. Tap into the most definitive knowledge available from one of the leading experts in the field and a stellar cast of contributors. Understand the special considerations for the care of acute coronary syndromes in the emergency department and the coronary care unit. Effectively handle the treatment of special populations and chronic patients thanks to coverage of these challenges See techniques and procedures in greater detail and clarity through the all-new full-color design. Approach treatment with a global perspective from the new section on Population-Based Perspective that discusses the INTERHEART study, insights from the REACH registry, lessons learned from European registries, and ACS in North America. Gain a comprehensive understanding of ACS through coverage of pathophysiology, molecular mechanisms, the role of the immune system, and brand-new chapters on cell necrosis and cell regeneration and pharmacogenetics in the section on Disease-Based Perspectives. Integrate the latest testing and treatment techniques into your practice thanks to new chapters on biomarkers in acute ischemic heart disease; the role of noninvasive testing in prognostic risk stratification; the culprit lesions and patient at risk; non-responsiveness to antiplatelet therapy; bleeding in the acute coronary syndromes; and the refractory patient.
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