Phillip L. Pearl's Books

Swaiman's Pediatric Neurology E-Book

Principles and Practice

By: Kenneth F. Swaiman,Stephen Ashwal,Donna M Ferriero,Nina F Schor,Richard S. Finkel,Andrea L. Gropman,Phillip L Pearl

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Swaiman's Pediatric Neurology E-Book

Principles and Practice

By: Kenneth F. Swaiman,Stephen Ashwal,Donna M Ferriero,Nina F Schor,Richard S. Finkel,Andrea L. Gropman,Phillip L Pearl

Since 1975, Dr. Kenneth Swaiman's classic text has been the reference of choice for authoritative guidance in pediatric neurology, and the 6th Edition continues this tradition of excellence with thorough revisions that bring you fully up to date with all that's new in the field. Five new sections, 62 new chapters, 4 new editors, and a reconfigured format make this a comprehensive and clearly-written resource for the experienced clinician as well as the physician-in-training. - Nearly 3,000 line drawings, photographs, tables, and boxes highlight the text, clarify key concepts, and make it easy to find information quickly.

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Page Count

2955

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323374816

ISBN 13

9780323374811

Inherited Metabolic Epilepsies

By: Phillip L. Pearl, MD

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Inherited Metabolic Epilepsies

By: Phillip L. Pearl, MD

This book fills an important and unique niche in pediatric neurology, and will be a frequently referenced textbook for all clinicians caring for children with epilepsy. It is well-organized and readable, and provides essential and up-to-date clinical data on these individually rare, but collectively more common, disorders." -Elaine Wirrell, MD, Neurology "Specialists in pediatric neurology, epilepsy, and biochemical genetics will find this volume to be indispensable for their daily practice. The organized approach to an incredibly complex set of disorders will also benefit trainees trying to make sense of the complex field and developing their own clinical approach, as knowledge about metabolic epilepsies continues to grow." -Carl E. Stafstrom, MD, PhD, Journal of Pediatric Epilepsy The continued explosion of information in neurogenetics and metabolism mandates increasing awareness of current diagnostic and therapeutic strategies in disease settings where prompt identification and intervention is crucial for a positive outcome. This thoroughly revised and greatly expanded new edition of the first book to bridge clinical epilepsy with inherited metabolic diseases brings together leading authorities to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies, Second Edition contains 15 new chapters, and all existing chapters have been updated to reflect the latest science and clinical advances in this fast-moving field. New sections on basic and clinical science —covering energetics, metabolomics, pathways, the use of novel investigations like transcranial magnetic stimulation, neuropathology, and genomic technologies—supplement the disease-focused sections. Dedicated chapters focus on recently recognized disorders having novel therapeutic implications, pyridoxal-5-phosphate dependency, Menkes disease, and thiamine transporter deficiency. The book also includes new clinical applications of genomics and advanced generation gene sequencing in the diagnosis of inherited metabolic epilepsies. This readable, well-illustrated reference concludes with an updated clinical algorithm to aid physicians in screening and identifying suspected metabolic disorders and a collection of resources for families. Features Synthesizes cutting-edge diagnostic, clinical, and scientific information on epilepsy and inborn errors of metabolism Completely updated and expanded second edition contains the latest knowledge and 15 entirely new chapters Authored and edited by international experts in neurology, metabolic disorders, and genetics A readable and well-illustrated reference for clinicians Essential coverage of the new generation of genetic tests, which were not widely available or utilized when the first edition was published New chapter on inherited metabolic epilepsies in adult

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Page Count

565

Publisher

Springer Publishing Company

Published Date

ISBN 10

0826168647

ISBN 13

9780826168641

Inherited Metabolic Epilepsies

By: Phillip L. Pearl

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Inherited Metabolic Epilepsies

By: Phillip L. Pearl

The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together the leading authorities working in this area to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. The book begins with general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, seizure patterns and EEG findings, imaging, new technologies, and the ketogenic diet. The next two sections are devoted to the cohort of specific small molecule and large molecule disorders that are treatable yet can be so vexing to clinicians and investigators. The book concludes with a clinical algorithm designed to be a resource for the physician in search of direction while considering an inherited metabolic disorder as the explanation for a patient with epilepsy.

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Page Count

377

Publisher

Demos Medical Publishing

Published Date

ISBN 10

1936287250

ISBN 13

9781936287253

Neuro-Logic

A Primer on Localization

By: Phillip L. Pearl, MD,Helene A. Emsellem,Helene Emsellem, MD

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Neuro-Logic

A Primer on Localization

By: Phillip L. Pearl, MD,Helene A. Emsellem,Helene Emsellem, MD

NEURO-LOGIC is a foundational text about localization in the nervous system-the fundamental skill of clinical neurology. Written in an easily understandable and entertaining expanded outline format, the book integrates basic neuroscience information, the art of neurological examination, and disease-based knowledge. Over 95 crystal-clear illustrations illuminate topography, anatomic relationships, and clinical concepts. The material in this book is field-tested, and evolved from a syllabus the authors developed over many years of teaching introductory neurology to medical students. With a logical approach to the nervous system, the book takes readers step-by-step from the basics of the cerebral hemispheres and Brodmann areas to complex details about brainstem stroke syndromes, basal ganglia pathways, and brachial/lumbosacral plexi. It also contains a neuropsychiatry section exploring the relationship of frontal lobes and psychiatric disorders, and includes a section on special applications covering coma, epilepsy, movement, vertigo, cord compression, and autonomics. Written by renowned neurological educators, this concise primer will serve students throughout medical school rotations, post-graduate residency training, and medical practice during the lifelong learning task of evaluating patients with neurological problems. It is also a useful aid for neurology residents for reviewing the basics or preparing for their Residency In Service Training Exam (RITE), and for clinicians in related specialties who want to sharpen their neurological acumen. Key Features of NEURO-LOGIC: Teaches the fundamentals of localization and how to apply examination findings to sound clinical reasoning Written in a clear, accessible outline format that reflects how neurologists think Presents a logical approach to localization of lesions in the nervous system based on knowledge of neuroanatomy and clinical concepts Includes over 95 original drawings that make localization understandable

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Page Count

170

Publisher

Demos Medical Publishing

Published Date

ISBN 10

1620700417

ISBN 13

9781620700419

Pediatric Neurology Part III

Chapter 186. Monoamine neurotransmitter deficiencies

By: Phillip L. Pearl

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Pediatric Neurology Part III

Chapter 186. Monoamine neurotransmitter deficiencies

By: Phillip L. Pearl

Pediatric neurotransmitter disorders refer to a constellation of inherited neurometabolic syndromes attributable to disturbances of neurotransmitter synthesis, degradation, or transport. Monoamine deficiencies represent defects in synthesis of dopamine, serotonin, norepinephrine, and epinephrine or in availability of tetrahydrobiopterin, an important cofactor for monoamine synthesis. Some disorders do not manifest peripheral hyperphenyalaninemia and require CSF neurotransmitter metabolite assay for diagnosis. These include Segawa dopa-responsive dystonia and enzymatic deficiencies of aromatic amino acid decarboxylase, tyrosine hydroxylase, and sepiapterin reductase. The first, autosomal dominantly inherited GTP cyclohydrolase deficiency, has a satisfying response to therapy at any age with benefits maintained over time. The others have more severe and treatment-refractory phenotypes, typically with manifestations well beyond movement disorders. Disorders detectable by elevated serum phenylalanine are deficiencies of GTP cyclohydrolase (homozygous), pterin-carbinolamine dehydratase, dihydropteridine reductase, and pyruvoyl-tetrahydropterin synthase. The latter is the most prevalent and heterogeneous but typically has infantile onset with extrapyramidal as well as bulbar, hypothalamic, limbic, and epileptic manifestations. There are therapeutic roles for neurotransmitter supplementation, and dopaminergic agonists. Basal ganglia calcifications in dihydropteridine reductase deficiency are reversible with folinic acid. Deficiencies of monoamine degradation lead to cognitive, behavioral, and autonomic disorders.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128084529

ISBN 13

9780128084526

Inherited Metabolic Epilepsies

By: Phillip L. Pearl, MD

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Inherited Metabolic Epilepsies

By: Phillip L. Pearl, MD

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565

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Springer Publishing Company

Published Date

ISBN 10

0826168647

ISBN 13

9780826168641

Book's by Phillip L. Pearl

Swaiman's Pediatric Neurology E-Book

Swaiman's Pediatric Neurology E-Book

Inherited Metabolic Epilepsies

Inherited Metabolic Epilepsies

Inherited Metabolic Epilepsies

Inherited Metabolic Epilepsies

Neuro-Logic

Neuro-Logic

Pediatric Neurology Part III

Pediatric Neurology Part III

Inherited Metabolic Epilepsies

Inherited Metabolic Epilepsies

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