When asked, "Where is Murray Bay?" US President Taft always replied, "Murray Bay is a state of mind." For over two hundred years the Charlevoix region has played host to some of the world's most famous and adventurous travellers. Considered the "Newport" of Canada, Charlevoix has been a meeting place for rural French Canadians and urban English-speaking visitors.
The second edition of Implant Dentistry at a Glance, in the highly popular at a Glance series, provides an accessible, thoroughly revised and updated comprehensive introduction that covers all the essential sub-topics that comprise implant dentistry. Features an easy-to-use double-page spread, with text and corresponding images Expanded and updated throughout, with 13 new chapters and coverage of many advances Includes access to a companion website with self-assessment questions and illustrative case studies
This book presents a thorough description of morphosyntactic knowledge developed by learners of French in four different learning situations first language (L1) acquisition, second (L2) language acquisition, bilingualism, and acquisition by children with Specific Language Impairment within the theoretical framework of generative grammar. This approach allows for multiple comparisons across acquisition contexts, which provides the reader with invaluable insights into the nature of the acquisition process. The book is divided into four parts each dealing with a major morphosyntactic domain of acquisition: the verbal domain, the pronominal domain, the nominal domain, and the CP domain. Each part contains four chapters, the first one presenting an overview of the basic facts and analyses of the relevant properties of French, and the next three focusing on the different acquisition contexts. This book will be useful to anyone interested in the acquisition of French and in language development in general. It is also meant to stimulate cross-linguistic research from a theoretical perspective.
This text challenges the traditional view of the history of econometrics and provides a more complete story. In doing so, the book sheds light on the hitherto under-researched contribution of French thinkers to econometrics. Fascinating and authoritative, it is a comprehensive overview of what went on to be one of the defining subsets within t
After publishing the Quebec Major Junior hockey League: from Lafleur to Lemieux and Crosby, in 2012, authors, Jean-Pierre D’Auteuil (right) and Jean-Philippe Otis (left), present The Game Is Not Over: The epic story of the most prestigious Pee wee hockey tournament in the world. The Quebec City International Pee Wee Hockey Tournament took off in 1960, when five die-hard hockey fans, led by Gérard Bolduc, decided to bring together young Pee-Wee calibre players in Quebec City. After starting out at the Aréna du Parc Victoria, the adventure continued for many years at the Colisée de Québec and currently takes place at the Centre Vidéotron. This book tells the beautiful and great story of this prestigious event, which has enabled millions of hockey fans to see the great players of yesterday and the stars of today at work: Guy Lafleur, Auston Matthews, Wayne Gretzky, Manon Rhéaume, Connor McDavid, Patrick Roy, Jonathan Quick, Nikolaj Ehlers, Brett Hull, Brendan Gallagher, Nico Hischier, Mario Lemieux, Sylvain Côté, Steven Stamkos, Thomas Chabot, Anze Kopitar, Jonathan Audy-Marches-sault, Pierre Larouche, Yanni Gourde, Réal Cloutier, Mathew Barzal et Guy Chouinard, just to name a few. While reading this book, you will also discover Gaétan Boucher, Arthur Quoquochi, Raynald Fortier, Gilles Levasseur, Benoît Parke, Jeannot Ferland, Tim Connolly, Gilles Duclos, Freddie Meyer and many others, as well as players, who are less well known today, but who have made their own mark on the history of the Quebec City International Pee-Wee Hockey Tournament. Statistics, anecdotes, highlights, quotes and more than 400 photos. A real piece of anthology!
What does it mean to be resilient in a societal or in an international context? Where does resilience come from? From which discipline was it 'imported' into international relations (IR)? If a particular government employs the meaning of resilience to its own benefit, should scholars reject the analytical purchase of the concept of resilience as a whole? Does a government have the monopoly of understanding how resilience is defined and applied? This book addresses these questions. Even though resilience in global politics is not new, a major shift is currently happening in how we understand and apply resilience in world politics. Resilience is indeed increasingly theorised, rather than simply employed as a noun; it has left the realm of vocabulary and entered the terrain of concept. This book demonstrates the multiple origins of resilience, traces the diverse expressions of resilience in IR to various historical markers, and propose a theory of resilience in world politics.
As issues of history, memory, and identity collide with increasing frequency and intensity in the classroom and society, the timing is ideal to investigate the impact of these forces on twenty-first-century students. Relying on the theory of historical consciousness, this book presents the results of a comprehensive study conducted with over 600 French Canadian students that examines their narrative views of the collective past. The authors offer new evidence on how young citizens from various regions and ethnocultural groups in Quebec and Ontario think about their national history and what impact education, historical culture, and the “real-life” curriculum of meaningful experiences have on the formation of narration, identity, and historical consciousness.
Cinema has been long associated with France, dating back to 1895, when Louis and Auguste Lumi_re screened their works, the first public viewing of films anywhere. Early silent pioneers Georges MZli_s, Alice Guy BlachZ and others followed in the footsteps of the Lumi_re brothers and the tradition of important filmmaking continued throughout the 20th century and beyond. In Encyclopedia of French Film Directors, Philippe Rège identifies every French director who has made at least one feature film since 1895. From undisputed masters to obscure one-timers, nearly 3,000 directors are cited here, including at least 200 filmmakers not mentioned in similar books published in France. Each director's entry contains a brief biographical summary, including dates and places of birth and death; information on the individual's education and professional training; and other pertinent details, such as real names (when the filmmaker uses a pseudonym). The entries also provide complete filmographies, including credits for feature films, shorts, documentaries, and television work. Some of the most important names in the history of film can be found in this encyclopedia, from masters of the Golden Age_Jean Renoir and RenZ Clair_to French New Wave artists such as Fran_ois Truffaut and Jean-Luc Godard.
This book addresses the application of Raman spectroscopic techniques to a range of diverse problems which arise in the study, conservation and restoration of artefacts and sites closely related to our cultural heritage as well as in authentication. These themes are naturally wider than what at first might be considered as artworks and archaeological artefacts and the topics include pigments, paintings, ceramics, glass, sculpture and patination / corrosion, textiles, industrial archaeology, the degradation and preservation of biomaterials, mummies and human skeletal remains. An interesting feature is the inclusion of modern case studies which describe specific problems and approaches to the Raman spectral analysis of items important to our cultural heritage. The text is prefaced with an introduction to the important parameters used in nondestructive Raman measurements and also highlights some future applications based upon novel miniaturised instrumentation for in-field studies and potential screening work which will identify specimens which would repay further studies in the laboratory. An attempt is made to give a snapshot of the state-of-the-art evolution since the beginning of the technique (1970s) and to point out potential further development. The book is co-edited by three international experts with many years' experience in the application of Raman spectroscopy to artworks, archaeological artefacts and in the investigation of materials and sites for cultural heritage preservation and each editor has undertaken to write individual chapters and different topics personally. The adopted approach is designed to convey the sort of information which has become available from the adoption of analytical Raman spectroscopy to different problems in the field of cultural heritage preservation through the spectral interrogation of artefacts and how the interpretation of the spectral data can assist museum curators, archaeologists and cultural heritage historians in the preservation and conservation of ancient materials and sites : a particular advantage in this respect is the ability of Raman spectroscopy to determine –generally in a strictly noninvasive procedure - at the laboratory or on-site with mobile instruments, the presence of both organic and inorganic components in a particular specimen together nondestructively without any chemical and mechanical pretreatment being undertaken, which is an essential requirement for rare and valuable samples . An important aside from this work is the means of spectral identification of ongoing biodeterioration and biological colonisation in specimens in storage and the effects of environmental deterioration such as humidity and temperature upon their integrity.
The first book to offer a rigorous, sophisticated analysis of ISIS’s rhetoric and why it is so persuasive ISIS wages war not only on the battlefield but also online and in the media. Through a close examination of the words and images ISIS uses, with particular attention to the “digital caliphate” on the web, Philippe-Joseph Salazar theorizes an aesthetic of ISIS and its self-presentation. As a philosopher and historian of ideas, well versed in both the Western and the Islamic traditions, Salazar posits an interpretation of Islam that places speech—the profession of faith—at the center of devotion and argues that evocation of the simple yet profound utterance of faith is what gives power to the rhetoric that ISIS and others employ. At the same time, Salazar contends that Western discourse has undergone a “rhetorical disarmament.” To win the fight against ISIS and Islamic extremism, Western democracies, their media, politicians, and counterterrorism agencies must consider radically changing their approach to Islamic extremism.
The authors of the essays in Depression and the Social Environment explore the etiological role of the social environment, suggesting that for "neglected populations" -- immigrants and refugees, native Indians, the unemployed, the physically disabled, the elderly, caregivers of the impaired elderly, children and adolescents, and women -- depression has significant environmental roots. These populations and the manifestations of depression that they exhibit have been largely overlooked because the importance of the social environment itself has been insufficiently investigated. The contributors of most of the essays discuss empirical findings and, taken together, provide a unique in-depth review and analysis of the international literature on etiology, intervention, and policy implications. The approach developed in this volume has obvious significance for other mental health problems with social-environmental roots. In bridging the academic/practice divide, the authors address the interrelated concerns of researchers, practitioners, and policy makers.
Stephen Harper's Conservative government has reversed the trend of its predecessors by giving the Crown a higher profile through royal tours, publications, and symbolic initiatives. Based on papers given at a Diamond Jubilee conference on the Crown held in Regina in 2012, Canada and the Crown assesses the historical and contemporary importance of constitutional monarchy in Canada. Established and emerging scholars consider the Canadian Crown from a variety of viewpoints, including the ways in which the monarch relates to Quebec, First Nations, the media, education, Parliament, the constitution, and the military. They also consider a republican option for Canada. Editors D. Michael Jackson and Philippe Lagassé provide context for the essays, summarize and expand on the issues discussed by the contributors, and offer a perspective on further study of the Crown in Canada. Contributors include Richard Berthelsen, Lieutenant-Colonel Alexander Bolt (Office of the Judge Advocate General), James W.J. Bowden, Stephanie Danyluk (Whitecap-Dakota First Nation), Linda Cardinal (University of Ottawa), Phillip Crawley (CEO, The Globe and Mail), John Fraser (Massey College), Carolyn Harris (University of Toronto), Robert E. Hawkins (University of Regina), Ian Holloway (University of Calgary), Senator Serge Joyal, Nicholas A. MacDonald, Christopher McCreery (Office of Lieutenant Governor of Nova Scotia), J.R. (Jim) Miller (University of Saskatchewan), Peter H. Russell (University of Toronto), David E. Smith (Toronto Metropolitan University), and John D. Whyte (University of Regina).
Solidarity is an ‘unthought’ in the fields of organizational theory and management sciences. However, it is an increasingly important feature in the management of organizations. The contemporary world suffers from a double unsustainability: the abusive exploitation of natural resources endangers the balance of the climate and biodiversity, while growing inequalities condemn our ability to maintain a balanced society. These unsustainabilities are mutually reinforcing and call for the affirmation of a double solidarity, which unites humans among themselves, and links humans and nonhumans. Such an effort cannot be decreed. It must be organized. Based on numerous grassroots initiatives and citizens’ experimentations that are being invented every day around the world and on a historical and anthropological approach, this book explores different ways of combining solidarity and organization. Solidarity-based management, governance of the commons, and Buen Vivir approaches are some of the perspectives analyzed in the context of a North-South dialogue in order to formulate the conceptual framework and practical steps of a social and environmental transition. It offers both theoretical background and living examples to students, professors and researchers to better understand and better teach new avenues for management.
Scientific and Technical Report No. 24 Performance-Based Contracts (PBC) for Improving Utilities Efficiency: Experiences and Perspectives is a compendium of articles written by members of the PBC taskforce. It focuses on new approaches without delegated management to private operator i.e. service contracts, consulting contracts, Alliance approach, public-public partnership. It also mentions new design and generation of more traditional PPPs, (MC, lease, concession), where a larger proportion of performance-based design is being applied. List of Contents: Performance Based Contracts – Setting the scene; PBC and Results Based Financing: the inverse approach; PBC and Energy Efficiency; Internal Performance Contracts: A Case of the National Water and Sewerage Corporation in Uganda; Performance-Based Service Contracts in Navi Mumbai; Financial Comparison of PBCs and Conventional Approach; Tegucigalpa PBC Case Study; Performance Based Contracts – Key Design Issues; NRW Reduction Optimization Framework; How to improve water services performance? Performance Based Contracts (PBC) and Regulatory issues; Peer-to-Peer Partnerships Operational for sustainable water services; Performance Based Contracts in Malawi: Teamwork Works; Performance based affermage contracts; Performance based Contracts, The Aroona Integrated Alliance Experience; Experience from Eastern Europe; NRW Performance Contract – Kingdom of Bahrain; The way forward and perspectives/trends
“Gives to anthropological reflection a new starting point and will become the compulsory reference for all our debates in the years to come.” —Claude Lévi-Strauss, on the French edition Beyond Nature and Culture has been a major influence in European intellectual life since its French publication in 2005. Here, finally, it is brought to English-language readers. At its heart is a question central to both anthropology and philosophy: what is the relationship between nature and culture? Culture—as a collective human making, of art, language, and so forth—is often seen as essentially different from nature, which is portrayed as a collective of the nonhuman world, of plants, animals, geology, and natural forces. Philippe Descola shows this essential difference to be not only a Western notion, but also a very recent one. Drawing on ethnographic examples from around the world and theoretical understandings from cognitive science, structural analysis, and phenomenology, he formulates a sophisticated new framework, the “four ontologies” —animism, totemism, naturalism, and analogism—to account for all the ways we relate ourselves to nature. By thinking beyond nature and culture as a simple dichotomy, Descola offers a fundamental reformulation by which anthropologists and philosophers can see the world afresh. “A compelling and original account of where the nature-culture binary has come from, where it might go—and what we might imagine in its place.” —Somatosphere “The most important book coming from French anthropology since Claude Lévi-Strauss’s Anthropologie Structurale.” —Bruno Latour, author of An Inquiry into Modes of Existence “Descola’s challenging new worldview should be of special interest to a wide range of scientific and academic disciplines from anthropology to zoology . . . Highly recommended.” —Choice
This book offers a comprehensive exploration of the major key concepts common to economics and evolutionary biology. Written by a group of philosophers of science, biologists and economists, it proposes analyses of the meaning of twenty-five concepts from the viewpoint respectively of economics and of evolutionary biology –each followed by a short synthesis emphasizing major discrepancies and commonalities. This analysis is surrounded by chapters exploring the nature of the analogy that connects evolution and economics, and chapters that summarize the major teachings of the analyses of the keywords. Most scholars in biology and in economics know that their science has something in common with the other one, for instance the notions of competition and resources. Textbooks regularly acknowledge that the two fields share some history – Darwin borrowing from Malthus the insistence on scarcity of resources, and then behavioral ecologists adapting and transforming game theory into evolutionary game theory in the 1980s, while Friedman famously alluded to a Darwinian process yielding the extant firms. However, the real extent of the similarities, the reasons why they are so close, and the limits and even the nature of the analogy connecting economics and biological evolution, remain inexplicit. This book proposes basis analyses that can sustain such explication. It is intended for researchers, grad students and master students in evolutionary and in economics, as well as in philosophy of science.
This book addresses several key issues in the biological study of death with the intent of capturing their genealogy, the assumptions and presuppositions they make, and the way that they open specific new research avenues. The book is divided into two sections: the first considers physiology and the second evolutionary biology. In the first part, Huneman reconstructs a conceptual genealogy of experimental physiology based on an in-depth analysis of Bichat's investigations of death processes. In the second part he explains that biologists in the late 1950s put forth a research framework that evolutionarily accounts for death in terms of either an effect of the weakness of natural selection or a by-product of natural selection for early reproduction. He illustrates how the biology of death is a central field and that studying it provides insight into the way that the epistemic structure of this knowledge has been constituted, persists until now, and may conflict with some traditional philosophical ideas.
The Mysteries of Mary shows how the life of the Blessed Virgin Mary is perfectly and intimately identified with that of her Son. It is both a reflection on the most profound moments in Mary's earthly life, from the Immaculate Conception to Cana to Pentecost, and a systematic approach to the doctrine of Mary's spiritual maternity. Mary is the mother of all the faithful because she educates us as a mother, showing us through her example, her life, how we must live the mysteries of faith, hope, and the growth of charity. The early mysteries of Mary's life show us unswerving faith as Mary's soul and flesh are prepared to receive Jesus in the Nativity of the Lord. Through trial, charity is rooted and grows in Mary's heart, until finally that heart is pierced in the mysteries of sorrow. At last, the hope for the resurrected Lord blossoms in glory. Having endured with her Son the agonies of Calvary, Mary most immediately and fully experiences His return to life indeed, from the first beat of His glorious heart. The mysteries of Mary's life are signs that truly point us to the saving grace of Jesus. Highly recommended to anyone who wishes to imitate Mary through growth in the theological virtues of faith, hope, and charity.
The purpose of virtual reality is to make possible a sensorimotor and cognitive activity for a user in a digitally created artificial world. Recent advances in computer technology have led to a new generation of VR devices such as VR headsets. Accordingly, virtual reality poses many new scientific challenges for researchers and professionals. The aim of this book, a manual meant for both designers and users of virtual reality, is to present the current state of knowledge on the use of VR headsets in the most complete way possible. The book is divided into 13 chapters. The objective of the first chapter is to give an introduction to VR and clarify its scope. The next chapter presents a theoretical approach to virtual reality through our Immersion and Interaction methodology also known as "3I2 model’’. Then, a chapter about human senses is necessary to understand the sensorimotor immersion, especially vision. These chapters are followed by several chapters which present the different visual interfaces and the VR headsets currently available on the market. These devices can impart comfort and health problems due to sensorimotor discrepancies. A chapter is devoted to these problems, followed by a chapter that gives a detailed discussion of methods and 32 solutions to dispel, or at least to decrease, VR sickness. The following three chapters present different VR applications that use VR headsets (behavioural sciences, industrial uses and Digital Art) and the final chapter provides conclusions and discusses future VR challenges.
An “absolutely magnificent” book (The New Republic)—the fruit of almost two decades of study—that traces the changes in Western attitudes toward death and dying from the earliest Christian times to the present day. A truly landmark study, The Hour of Our Death reveals a pattern of gradually developing evolutionary stages in our perceptions of life in relation to death, each stage representing a virtual redefinition of human nature. Starting at the very foundations of Western culture, the eminent historian Phillipe Ariès shows how, from Graeco-Roman times through the first ten centuries of the Common Era, death was too common to be frightening; each life was quietly subordinated to the community, which paid its respects and then moved on. Ariès identifies the first major shift in attitude with the turn of the eleventh century when a sense of individuality began to rise and with it, profound consequences: death no longer meant merely the weakening of community, but rather the destruction of self. Hence the growing fear of the afterlife, new conceptions of the Last Judgment, and the first attempts (by Masses and other rituals) to guarantee a better life in the next world. In the 1500s attention shifted from the demise of the self to that of the loved one (as family supplants community), and by the nineteenth century death comes to be viewed as simply a staging post toward reunion in the hereafter. Finally, Ariès shows why death has become such an unendurable truth in our own century—how it has been nearly banished from our daily lives—and points out what may be done to “re-tame” this secret terror. The richness of Ariès's source material and investigative work is breathtaking. While exploring everything from churches, religious rituals, and graveyards (with their often macabre headstones and monuments), to wills and testaments, love letters, literature, paintings, diaries, town plans, crime and sanitation reports, and grave robbing complaints, Aries ranges across Europe to Russia on the one hand and to England and America on the other. As he sorts out the tangled mysteries of our accumulated terrors and beliefs, we come to understand the history—indeed the pathology—of our intellectual and psychological tensions in the face of death.
Telepatients using connected objects to collect time-sensitive data about their health are not neutral carriers of diagnosable symptoms. Patients are persons, or personal beings as well as co-carers, whose personal experience, history and know-how must be acknowledged in time-sensitive telecare practices. Such practices require a relational ethics, inspired by medical ethics and an ethics of virtues, focusing on vulnerability and emotional health, to oversee telecare good practices, define a new therapeutic alliance compliant with patients' values, and reconcile the technical and human sides of telemedicine. - The ethical challenges of telemedicine in chronic patients today - The key features of a person-centered and relational ethics in telemedical settings - The concepts of "emotional health care and "chrono-sensitivity of the "connected sick body
Thorough overview of virtual reality technology fundamentals and latest advances, with coverage of hardware, software, human factors and applications, plus companion Laboratory Manual in Unity 3D. The Third Edition of the first comprehensive technical book on the subject of virtual reality, Virtual Reality Technology, provides updated and expanded coverage of VR technology, including where it originated, how it has evolved, and where it is going. Its primary objective is to be a complete, up-to-date textbook, as well as a source of information on a rapidly developing field of science and technology with broad societal impact. The two highly qualified authors cover all of the latest innovations and applications that are making virtual reality more important than ever before. Unlike other books on the subject, the book also includes a chapter on Human Factors, which are very important in designing technology around the human user. Virtual Reality Technology provides Instructors with a website-accessible Laboratory Manual using the Unity 3D game engine and programming language. Unity 3D is the preferred VR language these days and will prepare the student for the VR gaming and mobile applications industry. For universities Unity 3D is cost-effective as its student license is freely available. With comprehensive coverage of the subject, Virtual Reality Technology discusses sample topics such as: Input and output interfaces, including holographic displays, foveated head-mounted displays, neural interfaces, haptic and olfactory feedback Computing architecture, with emphasis on the rendering pipeline, the graphics processing unit and distributed/edge rendering Object modeling, including physical and behavioral aspects, Artificial Intelligence controlled characters, and model management techniques Programming toolkits for virtual reality and the game production pipeline Human factors issues such as user performance and sensorial conflict, cybersickness and societal impact aspects of VR Application examples in medical education, virtual rehabilitation, virtual heritage, gaming, and military use of virtual reality. Virtual Reality Technology provides thorough and complete coverage of an in-demand sector of technology, making it a highly valuable resource for undergraduate and graduate students in computer science, engineering, and science, along with a variety of professionals across many different industries, including but not limited to engineering, gaming, healthcare, and defense.
The international movement of people is provoking worldwide anxiety and apprehension. Nation-states around the globe, especially Western ones, are cracking down on migration for security reasons. International migration has become a key security issue and is perceived, by some, as an existential security threat. The Securitization of Migration is about the movement of people and the system of order underpinning the movement. In undertaking a comparative study of Canada and France, the study analyzes the process of securitizing migration. It explores the process of discursively and institutionally integrating international migration into security frameworks that emphasize policing and defence. Drawing upon social theory, migration studies, and Securitization Theory, Philippe Bourbeau seeks to understand the concepts of power underlying security frameworks and how these affect the treatment of migrants and immigrants. This book is one of the first to systematically and comparatively examine the role of political agents, media agents, and contextual factors in the process of securitizing migration. The book will be of interest to students and scholars concerned with comparative and theoretical approaches to security and migration studies.
Depuis les premières descriptions cliniques datant de la fin du XIXe siècle, montrant l’intérêt médical relativement récent pour l’anxiété, les symptômes anxieux et les troubles anxieux, les concepts ont considérablement évolué au cours du XXe siècle pour aboutir aux classifications syndromiques en vigueur dans la nosographie actuelle. Pourtant, un certain nombre de questions demeurent, par exemple sur l’existence d’un continuum entre une anxiété normale et adaptative et une anxiété pathologique, la nature de la réactivité émotionnelle dans les troubles anxieux par rapport à celle décrite dans les troubles bipolaires, etc... La première partie d’ouvrage présente les diverses approches actuelles pour comprendre les troubles anxieux : modèles émotionnels, approche évolutionniste, psychodynamique, théorie de l’attachement, génétique, neurobiologie, neuropsychologie, électrophysiologie et neuro-imagerie. Sont ensuite exposés les différents troubles anxieux (attaque de panique, phobie sociale, trouble anxieux généralisé, hypocondrie, état de stress post-traumatique, TOC, etc.) et les associations co-morbides (dépression, conduites suicidaires, troubles bipolaires, addictions, etc...). Réunissant plus d’une quarantaine de spécialistes reconnus, riche d’une trentaine tableaux et schémas explicatifs et d’un index détaillé, cet ouvrage offre un état des connaissances et des recherches sur les troubles anxieux. Jean-Pierre Lépine, Professeur des Universités, Praticien hospitalier, service de Psychiatrie Adultes, hôpital Lariboisière, Paris. Jean-Philippe Boulenger, Professeur des Universités, Praticien hospitalier, service de Psychiatrie Adultes, CHU, Montpellier.
Insights Into Low Molecular Weight and Cytotoxic Aggregates from in Vitro and Computer Experiments - Molecular Basis of Amyloid-Beta Protein Aggregation and Fibril Formation
Insights Into Low Molecular Weight and Cytotoxic Aggregates from in Vitro and Computer Experiments - Molecular Basis of Amyloid-Beta Protein Aggregation and Fibril Formation
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39OCo43 amino acids called amyloid-? (A?). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early A?-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of A? oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease.
An artist, in my eyes, is someone who can lighten up a dark room. I have never and will never find difference between the pass from Pele to Carlos Alberto in the final of the World Cup in 1970, and the poetry of the young Rimbaud' - Eric Cantona Football, and art. Eric Cantona – legend, maverick, troubled artist or just plain trouble – never saw a need to make a distinction between the two. For all the heat and noise surrounding his infamous Crystal Palace 'kung-fu kick', it is for the sheer exuberant beauty of his play that Eric Cantona is chiefly remembered by English football fans. At Leeds United he transformed the team into title contenders, but became a true talisman at Manchester United, where to this day fans sing of 'King Eric'. And yet the effortless style of Cantona's play could not hide a darker side to his temperament. In his own words, 'I play with passion and fire. I have to accept that sometimes, this fire does harm.' In Cantona: The Rebel Who Would Be King leading French football journlist Philippe Auclair has interviewed over 200 key protagonists in Cantona's career, searching for the man behind the myth. Marrying a deep knowledge of Cantona's impact on the pitch with soulful, pin-sharp insight into the heart and inner thoughts of this most complex of characters, this is nothing less than the definitive biography of a one-time rebel of the French game, who rose to be the King of Old Trafford. 'I'd give all the champagne I've ever drunk to be playing alongside Cantona in a big European match at Old Trafford' - George Best
Today, one out of every six children suffers from some form of neurodevelopmental abnormality. The causes are mostly unknown. Some environmental chemicals are known to cause brain damage and many more are suspected of it, but few have been tested for such effects. Philippe Grandjean provides an authoritative and engaging analysis of how environmental hazards can damage brain development and what we can do about it. The brain's development is uniquely sensitive to toxic chemicals, and even small deficits may negatively impact our academic achievements, economic success, risk of delinquency, and quality of life. Chemicals such as mercury, polychlorinated biphenyls (PCBs), arsenic, and certain pesticides pose an insidious threat to the development of the next generation's brains. When chemicals in the environment affect the development of a child's brain, he or she is at risk for mental retardation, cerebral palsy, autism, ADHD, and a range of learning disabilities and other deficits that will remain for a lifetime. We can halt chemical brain drain and protect the next generation, however, and Grandjean tells us how. First, we need to control all of the 200 industrial chemicals that have already been proven to affect brain functions in adults, as their effects on the developing brain are likely even worse. We must also push for routine testing for brain toxicity, stricter regulation of chemical emissions, and more required disclosure on the part of industries who unleash hazardous chemicals into products and the environment. Decisions can still be made to protect the brains of future generations. -In his crisply written, deeply documented book, Dr. Philippe Grandjean, renowned physician and public health specialist, describes the exquisite vulnerability of the developing human brain to toxic chemicals in the environment, a vulnerability that he ascribes to the brain's almost unimaginable complexity. Today, nearly one in 6 children is born with a neurodevelopmental disorder - a birth defect of the brain. One in 8 has attention deficit disorder. One in 68 is diagnosed with autism spectrum disorder. These rates are far higher than those of a generation ago, and, although they are less publicized, the problems are more prevalent than those caused by thalidomide in the 1960's. The increases are far too rapid to be genetic. They cannot be explained by better diagnosis. How then could they have come to be? Dr. Grandjean has a diagnosis -- the thousands of toxic chemicals that have been released to the environment in the past 40 years with no testing for toxicity. David P. Rall, former Director of the US National Institute of Environmental Health Sciences, once stated that 'If thalidomide had caused a ten-point loss of IQ rather than obvious birth defects of the limbs, it would probably still be on the market'. This is the core message of Dr. Grandjean's 'must read' book.- - Philip J. Landrigan, Dean for Global Health, Ethel H. Wise Professor and Chairman and Director, Children's Environmental Health Center, Mount Sinai School of Medicine
Although medicine is practised in a secular setting, religious and spiritual issues have an impact on patient perspectives regarding their health and the management of any disorders that may afflict them. This is especially true in psychiatry, as feelings of spirituality and religiousness are very prevalent among the mentally ill. Clinicians are rarely aware of the importance of religion and understand little of its value as a mediating force for coping with mental illness. This book addresses various issues concerning mental illness in psychiatry: the relation of religious issues to mental health; the tension between a theoretical approach to problems and psychiatric approaches; the importance of addressing these varying approaches in patient care and how to do so; and differing ways to approach Christian, Muslim and Buddhist patients.
Chemical peels have returned to the forefront of the practitioner's armamentarium and are popular because they offer nearly immediate results. The Textbook of Chemical Peels is the definitive guide to all types of chemical peel treatments. It covers the practical application and scientific background for a wide variety of chemical peels. The book reflects the new classification of peels as a medical, rather than cosmetic, treatment and helps providers by making chemical peel formulas easier, safer, and quicker to use. The book covers the appropriate selection of peels to treat the face, scalp, neck, hands, body, and forearms. It also discusses the use of peels to treat aging skin, stretch marks, scars, melasma, chloasma, acne, postinflammatory hyperpigmentation, and scalp keratoses. The mechanism of action, indication, application, and results are discussed for a variety of chemical peels including alpha hydroxy acids, trichloroacetic acid, salicylic acid, resorcine, and phenols. Also covered are any contraindications, precautions, and safety issues. This edition includes new material on adjunctive procedures such as microneedling and mesotherapy as well as new information on mosaic peels. Treatment prior to and following the peel are also discussed in detail, and a full chapter is devoted to discussing complications associated with chemical peels. The book incorporates color clinical photographs throughout as well as descriptive tables summarizing key information. Based on the author’s extensive experience in both research and practice, this updated reference is an invaluable guide to all providers involved with chemical peel treatments.
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