Tuning your database for optimal performance means more than following a few short steps in a vendor-specific guide. For maximum improvement, you need a broad and deep knowledge of basic tuning principles, the ability to gather data in a systematic way, and the skill to make your system run faster. This is an art as well as a science, and Database Tuning: Principles, Experiments, and Troubleshooting Techniques will help you develop portable skills that will allow you to tune a wide variety of database systems on a multitude of hardware and operating systems. Further, these skills, combined with the scripts provided for validating results, are exactly what you need to evaluate competing database products and to choose the right one. Forward by Jim Gray, with invited chapters by Joe Celko and Alberto Lerner Includes industrial contributions by Bill McKenna (RedBrick/Informix), Hany Saleeb (Oracle), Tim Shetler (TimesTen), Judy Smith (Deutsche Bank), and Ron Yorita (IBM) Covers the entire system environment: hardware, operating system, transactions, indexes, queries, table design, and application analysis Contains experiments (scripts available on the author's site) to help you verify a system's effectiveness in your own environment Presents special topics, including data warehousing, Web support, main memory databases, specialized databases, and financial time series Describes performance-monitoring techniques that will help you recognize and troubleshoot problems
In this ambitious book, Girard employs the latest tools of the historian's craft, multi-archival research in particular, and applies them to the climactic yet poorly understood last years of the Haitian Revolution. Haiti lost most of its archives to neglect and theft, but a substantial number of documents survive in French, U.S., British, and Spanish collections, both public and private. In all, this book relies on contemporary military, commercial, and administrative sources drawn from nineteen archives and research libraries on both sides of the Atlantic.
This timely reference analyzes the rationale, impact, and feasibility of taxation of sugar-sweetened beverages (SSBs) as a public health measure to contribute curbing obesity and diabetes rates, specifically in Canada. It presents the pros and cons of taxing soda, with the latest data on adverse health effects of its consumption, plus the various business and political issues surrounding the contentious proposition. Reviewed research is multidisciplinary, spanning health and medicine to ethics, economics, and law. Conclusions and caveats are clear and presented at a comfort level for the general reader. The result is a blueprint for analyzing the relevancy of taxes on sweetened soft drinks or other low-nutrition food products, plus a trove of valuable insights into aspects of government decision-making and consumer food behavior. Included in the coverage: · Reasons for specifically targeting SSBs · SSB taxation as a public health policy instrument · Effects of SSB taxation on energy intakes and population health · Potential undesirable effects relating to SSB taxation · Social and political acceptability of SSB taxation · Evaluability of SSB taxation Taxing Soda for Public Health will interest policymakers, public health professionals, advocacy groups, and researchers at the Canadian and international levels (e.g., in areas such as public health, nutrition, food and health policies, health economics, and evaluation), as well as students and all other parties interested in nutrition policies.
One family of viruses is responsible for the infection of many species of vertebrates. These are the retroviruses whose genomic RNA is used to support genetic information and ensures many essential functions that are required for the formation of an infectious viral particle. These functions depend on structures formed by the folding of the genomic RNA. Structures and Functions of Retroviral RNAs describes the formation of these structures and their specific interactions with nucleic acids and proteins. In light of recent advances in molecular virology, it provides an understanding of the various facets of the retroviral genome. It emphasizes in particular that the study of the structure–function relationship of retroviral RNAs is a driving force behind increased research into HIV-1, the main causal agent of AIDS. Indeed, one of the challenges of pharmacology lies in the exploitation of several targets which allow us to anticipate and stem the emergence of resistance to anti-HIV drugs. The book also presents structures and interactions that may be potential future targets in this regard.
Montaigne's Essays resemble a patchwork of personal reflections, but they engage with questions that animate the human mind, and tend to a single goal: to live better in the present and to prepare for death. For this reason, Montaigne's thought and writings have been a subject of enduring interest across disciplines. This Handbook brings together essays by prominent scholars that examine Montaigne's literary, philosophical, and political contributions, and assess his legacy and relevance today in a global perspective. It presents Montaigne's Essays not only in their historical context but also as a starting point for discussing issues that concern us today.
Shells and plates have been widely studied by engineers during the last fifty years. As a matter of fact an important number of papers have been based on analytical calculations. More recently numerical simulations have been extensively used. for instance for large displacement analysis. for shape optimization or even -in linear analysis -for composite material understanding. But all these works lie on a choice of a finite element scheme which contains usually three kinds of approximations: 1. a plate or shell mndel including smnll parameters associated to the thickness, 2. an approximntion of the geometry (the medium sUrface of a shell and its boundary), 3. afinite element scheme in order to solve the mndel chosen. VI Obviously the conclusions that we can draw are very much depending on the quality of the three previous choices. For instance composite laminated plates with damage like a delamination is still an open problem even if interesting papers have already been published and based on numerical simulation using existing fmite element and even plate models. • In our opinion the understanding of plate modelling is still an area of interest. Furthermore the links between the various models have to be handled with care. The certainly best understood model is the Kirchhoff-Love model which was completely justified by P. O. Ciarlet and Ph. Destuynder in linear analysis using asymptotic method. But the conclusion is not so clear as far as large displacements are to be taken into account.
This dictionary refers to current and obsolete Welsh. First of all, this dictionary refers to a former language, older than Sanskrit or old Persian: this is the former language, originating from a very former religion, born in northwest India around ten thousand years ago. I have called this language: the Vedic language, because its vocabulary and its mechanisms can be observed in the Rg-Veda. Briefly: this language is based on the division of the Universe in two parts: day and night. Personally, I have studied this language mainly in Sanskrit, this is a sort of primitive sanskrit, nevertheless I have found help in the Gaulish and Welsh languages. Through this book, I show many origins and etymologies in French, old French, English, old English, German, Basque, and many other languages that I know fairly well. Sometimes, unfortunately rarely, I refer to Arabic, Chinese, Japanese or African languages. The analysis of these languages, much closer than one says until now, will be another great phase for a better knowledge of the past.
Information Systems Management is intended to sensitize the heads of organizations to the issues raised by information systems (IS). Through its pedagogical presentation, the book ensures that issues related to IS are not left solely to the experts in the field. The book combines and analyzes three key concepts of IS: governance, urbanization and alignment. While governance requires the implementation of a number of means, bodies and procedures to manage IS more effectively, urbanization involves visualization methods to enable the manager to take into account the different levels of the organization of an IS and their coherence. Finally, alignment assesses the ability of the IS to make a significant contribution to the organization's strategy.
Write applications in C#/.NET that will stand the test of time, evolving with the information systems they belong to and the services they interoperate with by using standards and solid business-related architecture rules Key Features Learn the principles of business-aligned software architecture Relate theory to several well-known architecture frameworks Apply the knowledge you gain to create a .NET application with a standard-based API Purchase of the print or Kindle book includes a free PDF eBook Book DescriptionThe software development domain continues to grow exponentially, and information systems have become the backbone of most industries, including non-digital-native ones. However, technical debt, coupling, and a high level of maintenance - sometimes bringing IT systems to a complete halt – continue to present a problem. The software industry has to still apply standards-based, modular, and repeatable approaches that exist in other industries. This book demonstrates such methods in action, particularly business/IT alignment principles. As you progress, you’ll cover advanced concepts and theories currently researched in academia. Then, you’ll be guided toward a practical framework to transfer these approaches to actual software architecture. Finally, a dedicated section will help you apply the knowledge you gain to a sample application in .NET where API design, dependency management, and code writing will be explained in detail to relate to the business-alignment principles explained at the beginning. Throughout the book, you’ll get equipped with the skills to create modular, long-living applications that serve your users better. By the end of this .NET book, you’ll not only have learned new concepts but also gained the ability to apply them immediately to your upcoming software endeavors. What you will learn Comprehend the main problems in real-world software development Understand what business alignment means Create a four-layer map of an information system Become proficient in SOLID, C4, and domain-driven design (DDD) architecture Get up to speed with semantics, APIs, and standards for better interoperability Include BPM, MDM, and BRMS in information systems Design an application with strict responsibility separation Who this book is for This book is for software architects who want to have an in-depth understanding of how their applications will be used and how they can fight technical debt as well as design software to keep it working even when business requirements evolve. If your previous software designs experienced progressive loss of performance and the capacity to evolve, this book is for you.
The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.
This book describes the capabilities of nuclear techniques for elemental microanalysis in the biological field. A description of basic principles is given at the beginning, with special emphasis on X-ray Fluorescence, Rutherford Backscattering Spectrometry, Nuclear Reaction Analysis and Scanning Transmission Ion Microscopy. The major part of the volume is devoted to the applications in the life sciences and presents a general review of the subjects investigated during the last fifteen years. In addition, technical aspects of nuclear microanalysis in living tissues, including data processing and specimen preparation, are detailed. Examples of recent applications in cellular pharmacology, cell physiology and biomedicine are presented. The last part concerns the studies of unicellular micro-organisms involved in pollution problems. Postgraduate students and confirmed scientists will be able to find here basic information, references and practical aspects of this new tool, with in each case a comparison with other analytical techniques.
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