Previously unreleased, the late Philip Nutman's expanded his short story of the same name into this spectacular full length novel. It is A Rebel without a Cause colliding with A Clockwork Orange. A tale of manslaughter, death, rebirth, redemption and the road.Praise for Philip Nutman"Philip Nutman brought a fresh eye and deep enthusiasm to the business of horror. The genre is much enriched by his insight and creativity. A vital and original talent." Clive Barker, author of The Great and Secret Show and Mister B. Gone"The short stories of Philip Nutman are rare and delicious treats, full of punk attitude, brooding darkness, and genuine emotion. I've been waiting for this book for years!" Christopher Golden, author of Wildwood Road and The Chamber of Ten (with Tim Lebbon)"Nutman writes with ferocity, verve and intelligence. Not to mention a nasty sense of humour." Jack Ketchum, author of Cover and The Girl Next Door
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
The Australide orogen, the southern hemisphere Neoproterozoic to Mesozoic terrane accretionary orogen that forms the palaeo-Pacific margin of Gondwana, is one of the largest and longest-lived orogens on Earth. This book brings together a series of reviews and multidisciplinary research papers that comprehensively cover the Australides from the Tasman orogen of eastern Australia to the Neoproterozoic and Palaeozoic orogens of South America, taking in New Zealand and Antarctica along the way. It deals with the evolution of the southern Gondwana margin, as it grew during a series of terrane accretion episodes from the late Proterozoic through to final fragmentation in mid-Cretaceous times. Global perspectives are given by comparison with the Palaeozoic northern Gondwana margin and documentation of world-wide terrane accretion episodes in the Late Triassic-Early Jurassic and mid-Cretaceous. The Tasmanides of eastern Australia, and the terrane histories of New Zealand and southern South America are given comprehensive up-to-date reviews.
Public discussion of global healthcare issues is dominated by those who believe that top-down, government-driven interventions are the solution to the myriad health problems suffered by people in less developed countries. This thinking is responsible for a plethora of harmful policies, ranging from a drive towards socialized healthcare systems, to calls for the centralization and semi-nationalization of pharmaceutical research and development, to impractical but grandiose UN-sponsored schemes for tackling HIV/AIDS and malaria.In spite of the abysmal track record of top-down approaches, non-governmental organizations and UN agencies continue to promote them, to the detriment of the private sector, economic development, and human health. The resulting politicization of diseases such as HIV/AIDS has led to a diversion of resources away from more easily treatable diseases that affect more people. Meanwhile, cost-effective and simple interventions such as vaccination are being subordinated to other more politically correct diseases.This centralizing mindset has also resulted in many governments in less developed countries attempting to plan and control universal healthcare systems, which has encouraged rationing, inequitable access, and entrenched corruption. It has also seriously undermined the effectiveness of overseas development aid. Moreover, the politicization of diseases such as HIV/AIDS has led to a diversion of resources away from more easily treatable diseases that affect more people. As a result, cost-effective and simple interventions are neglected by donors.There has to date been little public discussion of the role of markets and their underlying institutions--property rights and the rule of law--in improving human health. Economic growth and globalization has led to unprecedented improvements in human health. The challenge is to enable the poorest countries to take part more fully in this process. This work demonstrates how current
Natural infections with Ascaris lumbricoides and A. suum of pigs and humans, respectively, have a worldwide distribution. Ascaris infections induce strong Th2 responses in the host that appear to be central to the development of protective immunity. Th2 responses may be modulated actively through a complex host–parasite interaction that allows the parasite to survive but also limits severe Th2-mediated pathology in the host. The increased production of IL-10 by regulatory cell populations may have a key role in the modulation of the immune response during chronic ascariasis although most evidence in support is derived from experimental infections with A. suum and A. suum antigen extracts. Antigen fractions of A. suum have potent anti-inflammatory effects in experimental models of arthritis and asthma, but other antigen fractions are strong inducers of inflammation. The clinical effects of such immune modulation in humans is uncertain although there is some evidence that chronic infections may be associated with impaired immune responses to vaccines indicating potentially important effects on both mucosal and systemic immunity. Human ascariasis has been associated with an increased risk of asthma and other allergic reactions, observations that preclude the use of experimental infections for the treatment of inflammation in favor of the study of the anti-inflammatory properties of specific molecules derived from Ascaris.
A dinosaur book like no other, this irreverent chronicle of science and pseudoscience takes the reader on a journey through numerous bizarre ideas about ancient reptiles. Were dragon legends inspired by human encounters with fire-breathing dinosaurs? Do the Bible and other ancient works of literature and art depict dinosaurs? Astoundingly, those and other strange notions have infiltrated grade-school science textbooks. This exposé unmasks the errors that underlie such notions and reveals the science that flattens them, while treating readers to explanations of rocket fuel, nuclear power plants, the electric eel’s shocking capabilities, and how the young-Earth creationist position contradicts the very scripture that it strives to uphold. Finding humor in absurdity, the book shows fans of science, religious studies, folklore, and fire that young-Earth creationist dinosaur pseudoscience is deeply comic once one gets to know it properly.
Youth unemployment is one of the most critical problems generated by any recession. Widespread changes in the structure of the youth labour market, together with the increasing affluence amongst the employed, meant that the experience of unemployment for young people in the 1970s and 1980s was quite different from that of previous decades. Originally published in 1988, this book examines the psychological consequence of prolonged periods of joblessness among a national cohort of 16-19 year olds. It places the problem in a historical context and then examines evidence for the effect of unemployment on the work ethic, motivation to work, the search for jobs, psychological health, political views, lifestyles and early careers. Particular attention is paid to gender and ethnic group differences. Original research was integrated with existing literature with the aim of bringing together a wide variety of studies and theoretical positions previously dispersed throughout the literature.
This second volume describes a further wide variety of parasitic infections and other diseases,including benign and malignant tumors. Some are widespread, others re- stricted to specific geographical or climatic regions; almost all affect countless patients, some with generalized illnesses, others with limited involvement which may nonetheless be serious for the individual. The book contains numerous images at the important stages of the diseases, with photographs and histopathological sections to help understand the clinical progress, and often the response to treatment. These two volumes will be of great value to all who care for patients with tropical diseases, clinicians as well as radiologists.
The first textbook to fully cover the revolution in pulmonary pathology Lung and Pleural Pathology goes beyond the scope of traditional pulmonary pathology textbooks by analyzing all of the changing paradigms that are reshaping pulmonary pathology practice. Authored by renowned pulmonary pathologists, it is the one comprehensive, up-to-date pulmonary pathology textbook that covers important new clinical approaches, including new WHO classification of lung cancer; the current status of lung cancer biomarkers; and emerging concepts in lung fibrosis and interstitial lung diseases, which have implications for newer treatments. The book also discusses the identification and characterization of recently publicized pulmonary infections. Encompassing text, abundant color figures, and multiple tables, Lung and Pleural Pathology is a practical yet complete guide to the current pathologic diagnosis of pulmonary disease, including: · Emerging pulmonary diseases · Latest classifications of lung cancer and non-neoplastic diseases · Biomarkers in lung cancer · Pediatric pulmonary pathology · Smoking-related lung diseases · Small airways disease · Acute lung injury · Pulmonary lymphomas · Lung transplant pathology Philip T. Cagle, MD is Medical Director, Pulmonary Pathology, Department of Pathology and Genomic Medicine, The Methodist Hospital Research Institute, Houston, Texas; and Professor of Pathology and Laboratory Medicine, Weill Cornell Medical College of Cornell University, New York, New York. Timothy C. Allen, MD is Professor, Department of Pathology; and Director of Anatomic Pathology, The University of Texas Medical Branch, Galveston.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
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