In the search for successful antitubercular treatments, investigators have often turned their efforts to ethnobotany, ethnopharmacology, and phytochemistry. Since many of the world’s peoples have well-developed systems of traditional medicine with plants and their extracts as a major component and many of these plants have been used to treat tuberculosis, indigenous herbal medicine is a logical starting point for a research program. The major aims in this chapter are to summarize current antitubercular treatments; look for structural patterns in molecules that have been used successfully in the therapeutics of tuberculosis; examine published evidence of natural products derived principally from macrophytic species with an anecdotal reputation as antitubercular treatments or that have been deliberately tested for antitubercular activity; and identify promising structural classes of plant metabolites that can serve as lead compounds. Finally, I would like to indicate some of the directions being followed by leading researchers in the field and suggest ways forward in drug discovery to treat multidrug-resistant tuberculosis.
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity syndromes, providing hard-core information for researchers and practical guidelines for clinicians caring for obese patients. The book is divided into three sections: the first covers approaches for assessing and investigating the obese individual; the second describes nondysmorphic, monogenic forms of obesity; and the third documents key, multisystem obesity syndromes with various genetic etiologies. It is as much a reference book as it is a manual and will appeal to clinical geneticists, obesity researchers, endocrinologists, nutritionists, and medical biologists.
On 23 April 1918 a force drawn from the Royal Navy and Royal Marines launched one of the most daring raids in history. The aim was to block the Zeebrugge Canal, thereby denying U-boat access, although this meant assaulting a powerfully fortified German naval base. The raid has long been recognised for its audacity and ingenuity but, owing to the fact that the official history took overmuch notice of the German version of events, has been considered only a partial success. The error of that view is now exposed, for in this stirring account there is evidence from many sources that the raid achieved much more than is usually credited to it. The raid is presented from a variety of viewpoints, from the airmen who took part in the preliminary bombing to the motor launches which picked up survivors. The crews of the launches and coastal motor boats were frequently 'amateur' sailors but their courage and skill were second to none. Philip Warner has talked with many of the survivors and corresponded with others, some of whom now live in distant parts of the world.
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