Peter W. Hochachka's Books

Surviving Hypoxia

Mechanisms of Control and Adaptation

By: Peter W. Hochachka,Peter L. Lutz,Thomas J. Sick,Myron Rosenthal

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Surviving Hypoxia

Mechanisms of Control and Adaptation

By: Peter W. Hochachka,Peter L. Lutz,Thomas J. Sick,Myron Rosenthal

Surviving Hypoxia: Mechanisms of Control and Adaptation is a synthesis of findings and thoughts concerning hypoxia. The thermodynamics of hypoxia are discussed in detail, including acid-base balance and self-pollution resulting from the accumulation of anaerobic end-products. The book focuses on descriptions and discussions of common facets, contrasting solutions in a variety of physiological hypoxia defense strategies, including those shown by plants, invertebrates, and vertebrates. Special treatment is given to the distinctive problems that hypoxia presents to vulnerable organs such as the kidney, liver, and brain. It also addresses pathological events in addition to protective mechanisms. Clinical implications of basic research are examined in the book, which provides new insights into underlying pathological processes occuring in hypoxic-induced organ failure and indicates new paths for successful clinical intervention. Surviving Hypoxia: Mechanisms of Control and Adaptation is an excellent reference for all researchers interested in the physiological effects of hypoxia, underlying pathological events, and protective mechanisms.

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Page Count

587

Publisher

CRC Press

Published Date

ISBN 10

1000714217

ISBN 13

9781000714210

Muscles as Molecular and Metabolic Machines

By: Peter W. Hochachka

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Muscles as Molecular and Metabolic Machines

By: Peter W. Hochachka

First published in 1994, this book explores the paradigm of muscles as molecular and metabolic machines in which all structures and functions are exquisitely integrated and matched to each other. The analysis begins with a standard reductionist approach-reviewing the integrated machine parts. The key working components of the complete muscle machine are proteins (soluble, organelle, or membrane localized), and a conservative count indicates that today more than 100 such machine parts are known, essentially all occurring as cell specific isoforms. Random assortment of these machine parts or protein isoforms could generate an astronomical number of "muscle machines" and an equally enormous number of muscle fiber types. The question is, why aren't such large numbers ever seen? To attack this problem, the reductionist approach is complemented with an integrationist/adaptational one. Evidence is presented that the more highly specialized the muscle type, the further one moves from the above extreme; in the most highly specialized muscles, typically only one fiber type is found. It is argued that instead of random assortment of isoforms or machine parts, only specific and often unique combinations can work in appropriate fashion. A few established examples of this fundamental principle are reviewed, but emphasis is placed on the fact that we know dreadfully little about why this is so and what kinds of further studies are needed. The issue of why the very large numbers of fiber types theoretically possible are never even approximately realized has never before been addressed. Indeed, it is rarely recognized. Muscles as Molecular and Metabolic Machines is the first work of its kind on the subject.

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Page Count

171

Publisher

CRC Press

Published Date

ISBN 10

1000006298

ISBN 13

9781000006292

Biochemical Adaptation

By: Pater W. Hochachka,George N. Somero

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Biochemical Adaptation

By: Pater W. Hochachka,George N. Somero

This book discusses biochemical adaptation to environments from freezing polar oceans to boiling hot springs, and under hydrostatic pressures up to 1,000 times that at sea level. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

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Page Count

559

Publisher

Princeton University Press

Published Date

ISBN 10

1400855411

ISBN 13

9781400855414

Metabolic Arrest and the Control of Biological Time

By: Peter W. Hochachka,Michael Guppy

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Metabolic Arrest and the Control of Biological Time

By: Peter W. Hochachka,Michael Guppy

Freshwater turtles and goldfish can survive for several days without oxygen, some diving turtles for several months; hibernating animals can exist without food for long periods; others can survive extreme conditions such as desiccation, freezing, and thawing. These creatures are, in effect, self-sustaining life-support systems, with a mysterious ability to regulate their own metabolisms. These capabilities raise important questions, which Hochachka and Guppy explore in this seminal new book. What mechanisms turn down (or off) cell metabolism and other cell functions? How does an animal such as an opossum know when to activate mechanisms for slowing or stopping tissue and organ functions? How does it know when to turn them on again? How extensive is metabolic arrest as a defense against harsh environmental conditions? Can we decipher universal principles of metabolic arrest from available data? The lessons to be learned are of potentially great interest to clinicians, because the authors provide a theoretical framework in which to organize an attack on the all-too-practical problem of protecting tissues against hypoxia. Areas that may be influenced include research on cardiac arrest, strokes, acute renal failure, liver ischemia, lung injury, respiratory defense syndrome, claudication, shock, and organ transplant. Investigation of other metabolic arrest mechanisms may be similarly useful in both clinical and agricultural fields. This is a pioneering book of great use to biomedical/clinical researchers and to biologists, biochemists, and physiologists generally.

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Page Count

260

Publisher

Harvard University Press

Published Date

ISBN 10

0674569768

ISBN 13

9780674569768

Book's by Peter W. Hochachka

Surviving Hypoxia

Surviving Hypoxia

Muscles as Molecular and Metabolic Machines

Muscles as Molecular and Metabolic Machines

Biochemical Adaptation

Biochemical Adaptation

Metabolic Arrest and the Control of Biological Time

Metabolic Arrest and the Control of Biological Time

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