A scathing indictment of the growing role of junk science in our courtrooms. Peter W. Huber shows how time and again lawyers have used—and the courts have accepted—spurious claims by so-called expert witnesses to win astronomical judgments that have bankrupted companies, driven doctors out of practice, and deprived us all of superior technologies and effective, life-saving therapies.
Never before have two revolutions with so much potential to save and prolong human life occurred simultaneously. The converging, synergistic power of the biochemical and digital revolutions now allows us to read every letter of life's code, create precisely targeted drugs to control it, and tailor their use to individual patients. Cancer, diabetes, Alzheimer's and countless other killers can be vanquished -- if we make full use of the tools of modern drug design and allow doctors the use of modern data gathering and analytical tools when prescribing drugs to their patients. But Washington stands in the way, clinging to outdated drug-approval protocols developed decades ago during medicine's long battle with the infectious epidemics of the past. Peter Huber, an expert in science, technology, and public policy, demonstrates why Washington's one-size-fits-all drug policies can't deal with diseases rooted in the complex molecular diversity of human bodies. Washington is ill-equipped to handle the torrents of data that now propel the advance of molecular medicine and is reluctant to embrace the statistical methods of the digital age that can. Obsolete economic policies, often rationalized as cost-saving measures, stifle innovation and suppress investment in the medicine that can provide the best cures at the lowest cost. In the 1980s, an AIDS diagnosis was a death sentence, until the FDA loosened its throttling grip and began streamlining and accelerating approval of life-saving drugs. The Cure in the Code shows patients, doctors, investors, and policy makers what we must now do to capture the full life-saving and cost-saving potential of the revolution in molecular medicine. America has to choose. At stake for America is the power to lead the world in mastering the most free, fecund, competitive, dynamic, and intelligent natural resource on the planet -- the molecular code that spawns human life and controls our health.
This definitive legal guide to the new world of telecommunications provides you with thorough, authoritative analysis you need to understand and comply with the complex regulatory landscape in the industry. You'll find timely review of key legislation, FCC rules, regulations and orders, and court decisions with extensive citations and cross-references for such essential topics as the economics of interconnection and detailed discussions of pricing methodologies of offering services for resale; interconnection rules for wire line networks, including the specific rules imposed on incumbent LECs; antitrust litigation in the wake of the 1996 Act, with comprehensive analysis of the cases brought against incumbent local telephone companies; significant changes to universal services requirements; regulations and policies involving horizontal and vertical mergers and acquisitions; the FCC's rule-making and other powers; rights and duties arising from the laws of privacy, intellectual property and free speech; and much more. Federal Telecommunications Law, Second Edition provides all the laws and rules -- including those for price regulation, common carriage, universal service, regulations and court decisions -- are analyzed in detail to provide you with a thorough understanding of the environment within which you must work. Trends in competition, industry structures and technology are explored -- offering you a total picture of the telecommunications industry, in areas such as telecommunications equipment; long distance services; wireless services; the Internet and data services; information services; video services; and more.
A unique approach to a core topic in organic chemistry presented by an experienced teacher to students and professionals Heterocyclic rings are present in the majority of known natural products, contributing to enormous structural diversity. In addition, they often possess significant biological activity. Medicinal chemists have embraced this last property in designing most of the small molecule drugs in use today. This book offers readers a fundamental understanding of the basics of heterocyclic chemistry and their occurrence in natural products such as amino acids, DNA, vitamins, and antibiotics. Based on class lectures that the author has developed over more than 40 years of teaching, it focuses on the chemistry of such heterocyclic substances and how they differ from carbocyclic systems. Introductory Heterocyclic Chemistry offers in-depth chapters covering naturally occurring heterocycles; properties of aromatic heterocycles; π-deficient heterocycles; π-excessive heterocycles; and ring transformations of heterocycles. It then offers an overview of 1,3-dipolar cycloadditions before finishing up with a back-to-basics section on nitriles and amidines. Presents a conversational approach to a fundamental topic in organic chemistry teaching Offers a unique look at this core organic chemistry topic via important naturally occurring and/or biologically active heterocycles Based on the author's many years of class lectures for teaching at the undergraduate and graduate level as well as pharmaceutical-industry courses Clear, concise, and accessible for advanced students of chemistry to gain a fundamental understanding of the basics of heterocyclic chemistry Introductory Heterocyclic Chemistry is an excellent text for undergraduate and graduate students as well as chemists in industrial environments in chemistry, pharmacy, medicinal chemistry, and biology.
The sheer volume of talk about energy, energy prices, and energy policy on both sides of the political aisle suggests that we must know something about energy. But according to Peter Huber and Mark Mills, the things we "know" are mostly myths. In The Bottomless Well , Huber and Mills debunk the myths and show how a better understanding of energy will radically change our views and policies on a number of very controversial issues. They explain why demand will never go down, why most of what we think of as "energy waste" actually benefits us; why greater efficiency will never lead to energy conservation; and why the energy supply is infinite-it's quality of energy that's scarce and expensive. The Bottomless Well will also revolutionize our thinking about the automotive industry (gas prices don't matter and the hybrid engine is irrelevant), coal and uranium, the much-maligned power grid (it's the worst system we could have except for all the others), what energy supplies mean for jobs and GDP, and many other hotly debated subjects.
Law is an increasingly pervasive force in our society. At the same time, however, the obstacles to law’s effectiveness are also growing. In The limits of Law, Yale law professor Peter H, Schuck draws on law, social science, and history to explore this momentous clash between law’s compelling promise of ordered liberty and the realistic limits of its capacity to deliver on this promise. Schuck first discusses the constraints within which law must work–law’s own complexity, the cultural chasms it must bridge, and the social diversity it must accommodate–and proceeds to consider the ways law uses regulatory, legislative, and adjudicatory processes to influence social behavior. He shows how politics shapes regulation, how regulation might incorporate individualized equity, and how it can best be reformed. Turning to legislation, he justifies a strong role for special interest groups, dissects purely symbolic statutes, and defends broad delegations of legislative power to regulatory agencies. Concerning adjudication, Schuck analyzes the courts’ efforts to advance social justice by controlling federal agencies, constitutionalizing politics, managing mass toxic tort disputes, and reforming public services and institutions. His concluding chapter draws together some general lessons about law’s limits and possibilities for improving democratic governance.
The historic European Union Directive on Data Protection will take effect in October 1998. A key provision will prohibit transfer of personal information from Europe to other countries if they lack “adequate” protection of privacy. If enforced as written, the Directive could create enormous obstacles to commerce between Europe and other countries, such as the United States, that do not have comprehensive privacy statutes. In this book, Peter Swire and Robert Litan provide the first detailed analysis of the sector-by-sector effects of the Directive. They examine such topics as the text of the Directive, the tension between privacy laws and modern information technologies, issues affecting a wide range of businesses and other organizations, effects on the financial services sector, and effects on other prominent sectors with large transborder data flows. In light of the many and significant effects of the Directive as written, the book concludes with detailed policy recommendations on how to avoid a coming trade war with Europe. The book will be of interest to the wide range of individuals and organizations affected by the important new European privacy laws. More generally, the privacy clash discussed in the book will prove a major precedent for how electronic commerce and world data flows will be governed in the Internet Age.
Written by some of the best known POF experts from Germany, one of the leading countries in POF technology, this is the most comprehensive introduction and survey of POF data communication systems currently available. Half a decade after it was first published, this second edition has been completely revised and updated; it has doubled in size. It features recent experimental results, and more than 1000 figures, 600 references and numerous tables complete the text.
Subjectivity and Identity is a philosophical and interdisciplinary study that critically evaluates critically the most important philosophical, sociological, psychological and literary debates on subjectivity and the subject. Starting from a history of the concept of the subject from modernity to postmodernity - from Descartes and Kant to Adorno and Lyotard - Peter V. Zima distinguishes between individual, collective, mythical and other subjects. Most texts on subjectivity and the subject present the topic from the point of view of a single discipline: philosophy, sociology, psychology or theory of literature. In Subjectivity and Identity Zima links philosophical approaches to those of sociology, psychology and literary criticism. The link between philosophy and sociology is social philosophy (e.g. Althusser, Marcuse, Habermas), the link between philosophy and literary criticism is aesthetics (e.g. Adorno, Lyotard, Vattimo). Philosophy and psychology can be related thanks to the psychological implications of several philosophical concepts of subjectivity (Hobbes, Stirner, Sartre).
How government can implement more successful policies, more often From healthcare to workplace and campus conduct, the federal government is taking on ever more responsibility for managing our lives. At the same time, Americans have never been more disaffected with Washington, seeing it as an intrusive, incompetent, wasteful giant. Ineffective policies are caused by deep structural factors regardless of which party is in charge, bringing our government into ever-worsening disrepute. Understanding why government fails so often—and how it might become more effective—is a vital responsibility of citizenship. In this book, lawyer and political scientist Peter Schuck provides a wide range of examples and an enormous body of evidence to explain why so many domestic policies go awry—and how to right the foundering ship of state. An urgent call for reform, Why Government Fails So Often is essential reading for anyone curious about why government is in such a disgraceful state and how it can do better.
Why, when we have been largely socialized into good behavior, are there more laws that govern our behavior than ever before? Voted one of the best law books of 2021 by the UK Times. Levels of violent crime have been in a steady decline for centuries--for millennia, even. Over the past five hundred years, homicide rates have decreased a hundred-fold. We live in a time that is more orderly and peaceful than ever before in human history. Why, then, does fear of crime dominate modern politics? Why, when we have been largely socialized into good behavior, are there more laws that govern our behavior than ever before? In Command and Persuade, Peter Baldwin examines the evolution of the state's role in crime and punishment over three thousand years. Baldwin explains that the involvement of the state in law enforcement and crime prevention is relatively recent. In ancient Greece, those struck by lightning were assumed to have been punished by Zeus. In the Hebrew Bible, God was judge, jury, and prosecutor when Cain killed Abel. As the state’s power as lawgiver grew, more laws governed behavior than ever before; the sum total of prohibited behavior has grown continuously. At the same time, as family, community, and church exerted their influences, we have become better behaved and more law-abiding. Even as the state stands as the socializer of last resort, it also defines through law the terrain on which we are schooled into acceptable behavior.
Attempting to reconcile the law's need for workable rules of evidence with the views of scientific validity and reliability. What is scientific knowledge and when is it reliable? These deceptively simple questions have been the source of endless controversy. In 1993, the Supreme Court handed down a landmark ruling on the use of scientific evidence in federal courts. Federal judges may admit expert scientific evidence only if it merits the label scientific knowledge. The testimony must be scientifically reliable and valid. This book is organized around the criteria set out in the 1993 ruling. Following a general overview, the authors look at issues of fit--whether a plausible theory relates specific facts to the larger factual issues in contention; philosophical concepts such as the falsifiability of scientific claims; scientific error; reliability in science, particularly in fields such as epidemiology and toxicology; the meaning of scientific validity; peer review and the problem of boundary setting; and the risks of confusion and prejudice when presenting science to a jury. The book's conclusion attempts to reconcile the law's need for workable rules of evidence with the views of scientific validity and reliability that emerge from science and other disciplines.
Never before have two revolutions with so much potential to save and prolong human life occurred simultaneously. The converging, synergistic power of the biochemical and digital revolutions now allows us to read every letter of life's code, create precisely targeted drugs to control it, and tailor their use to individual patients. Cancer, diabetes, Alzheimer's and countless other killers can be vanquished -- if we make full use of the tools of modern drug design and allow doctors the use of modern data gathering and analytical tools when prescribing drugs to their patients. But Washington stands in the way, clinging to outdated drug-approval protocols developed decades ago during medicine's long battle with the infectious epidemics of the past. Peter Huber, an expert in science, technology, and public policy, demonstrates why Washington's one-size-fits-all drug policies can't deal with diseases rooted in the complex molecular diversity of human bodies. Washington is ill-equipped to handle the torrents of data that now propel the advance of molecular medicine and is reluctant to embrace the statistical methods of the digital age that can. Obsolete economic policies, often rationalized as cost-saving measures, stifle innovation and suppress investment in the medicine that can provide the best cures at the lowest cost. In the 1980s, an AIDS diagnosis was a death sentence, until the FDA loosened its throttling grip and began streamlining and accelerating approval of life-saving drugs. The Cure in the Code shows patients, doctors, investors, and policy makers what we must now do to capture the full life-saving and cost-saving potential of the revolution in molecular medicine. America has to choose. At stake for America is the power to lead the world in mastering the most free, fecund, competitive, dynamic, and intelligent natural resource on the planet -- the molecular code that spawns human life and controls our health.
“[An] extensively researched complete history of the famous SBD Dauntless dive bomber, hero of the Battle of Midway. Very Highly Recommended.” —Firetrench The Douglas SBD Dauntless, a monoplane dive-bomber designed by Ed Heinemann for the United States Navy and United States Marine Corps, arrived in service in the months just preceding America’s entry into World War II. The first such aircraft were being shipped out to the USMC units just as the Japanese Task Force arrived in position to launch their attack on Pearl Harbor, while those Dauntless embarked aboard the American aircraft carriers of the Pacific Fleet became among the very first casualties of that surprise attack. Very quickly the Dauntless established herself as a highly accurate naval bomber at sea. In the early raids on Japanese-held islands—and in 1942 at the naval battles of the Coral Sea and Midway, Eastern Solomons and elsewhere—she proved herself a key and decisive instrument to first halt and then turn the die against Japanese expansion. The SBD (nicknamed “Slow But Deadly”) fought ashore the bitter fighting at Guadalcanal and the subsequent Solomon Island campaigns working from both shore and carrier bases. The Dauntless continued to fight at sea until right up to 1944 and then carried on with the Marine Corps to provide the American Army with close air support in their conquest of the Philippines. In The Dauntless in Battle, Peter Smith “traces its illustrious history throughout the second world war and beyond in vivid detail” (Books Monthly). “Lots of fine detail on both the aircraft and the crews who flew them in action.” —Military Model Scene
Disease and Democracy is the first comparative analysis of how Western democratic nations have coped with AIDS. Peter Baldwin's exploration of divergent approaches to the epidemic in the United States and several European nations is a springboard for a wide-ranging and sophisticated historical analysis of public health practices and policies. In addition to his comprehensive presentation of information on approaches to AIDS, Baldwin's authoritative book provides a new perspective on our most enduring political dilemma: how to reconcile individual liberty with the safety of the community. Baldwin finds that Western democratic nations have adopted much more varied approaches to AIDS than is commonly recognized. He situates the range of responses to AIDS within the span of past attempts to control contagious disease and discovers the crucial role that history has played in developing these various approaches. Baldwin finds that the various tactics adopted to fight AIDS have sprung largely from those adopted against the classic epidemic diseases of the nineteenth century—especially cholera—and that they reflect the long institutional memories embodied in public health institutions.
Patients are not alike! This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the “average” patient. As a result, potential variability between patients is ignored when presenting, e.g., the results of a multiple linear regression model. In medicine there are more and more attempts to individualize therapy; thus, from the author’s point of view biostatis- cians should support these efforts. Therefore, one of the tasks of the statistician is to identify heterogeneity of patients and, if possible, to explain part of it with known explanatory covariates. Finite mixture models may be used to aid this purpose. This book tries to show that there are a large range of applications. They include the analysis of gene - pression data, pharmacokinetics, toxicology, and the determinants of beta-carotene plasma levels. Other examples include disease clustering, data from psychophysi- ogy, and meta-analysis of published studies. The book is intended as a resource for those interested in applying these methods.
Problems for environmental management are taking on a new urgency. This book addresses aspects of environmental management that raise fundamental questions about governmental roles and the relationship of humans to the environment. It examines the interaction of local and national governments and the strengths and weaknesses of co-operative vs. coercive environmental management, through a focus on the management of natural hazards. Leading experts in the field examine new and innovative environmental management and planning programmes with particular focus on North America and Australia. This book offers a new understanding of environmental problems and explores the appropriate policy mix that must be developed for environmental management to strive towards environmental sustainability.
Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms
This book sets out the case for Hard Green, a conservative environmental agenda. Modern environmentalism, Peter Huber argues, destroys the environment. Captured as it has been by the Soft Green oligarchy of scientists, regulators, and lawyers, modern environmentalism does not conserve forests, oceans, lakes, and streams - it hastens their destruction. For all its scientific pretension, Soft Green is not green at all. Its effects are the opposites of green. This book lays out the alternative: a return to Yellowstone and the National Forests, the original environmentalism of Theodore Roosevelt and the conservation movement. Chapter by chapter, Hard Green takes on the big issues of environmental discourse from scarcity and pollution to efficiency and waste disposal. This is the Hard Green manifesto: Rediscover TAR. Reaffirm the conservationist ethic. Expose the Soft Green fallacy. Reverse the Soft Green agenda. Save the environment from the environmentalists.
Social postmodernism and systematic theology can be considered the new pair in some of the most creative discussions on the future of theological method on a global scale. Both in the academy and in the public square, as well as in the manifold local and pastoral moments of ministry and community social activism, the social, the postmodern, and the theological intermingle in engaging and border-crossing ways. The Community of the Weak presents a new kind of jazzy fundamental theology with a postmodern touch, using jazz as a metaphor, writing ethnographically messy texts out of the personal windows of lived experiences, combining fragments of autobiography with theological reconstruction. A comparative perspective on North American and European developments in contemporary systematic theology serves as a hermeneutical horizon to juxtapose two continents in their very different contexts. The author proposes a systematic and fundamental theology that is more jazzy, global, and narrative, deeply embedded in pastoral ministry to tell its postmodern story.
Muskoxen, shaggy denizens of the Far North, are creatures long enveloped in myth. In this first major work on the muskox, Peter C. Lent presents a comprehensive account of how its fortunes have been intertwined with our own since the glaciations of the Pleistocene era.
This book represents volume 2 of a 3-volume monograph on Particle Penetration and Radiation Effects. While volume 1 addressed the basic theory of scattering and stopping of swift point charges, i.e., protons, antiprotons and alpha particles, the present volume focuses on ions heavier than helium as well as molecules and clusters over an energy range from a few keV/u to a few hundred MeV/u. The book addresses the foundations in atomic-collision physics of a wide variety of application areas within materials and surface science and engineering, micro and nano science and technology, radiation medicine and biology as well as nuclear and particle physics. Problems have been added to all chapters. This should make the book useful for both self-study and advanced university courses. An effort has been made to establish a unified notation throughout the monograph.
This book provides a novel view of spectroscopic methods: it describes spectroscopy holistically in terms of integral physical aspects instead of the classical methodic order according to wavelengths. The book introduces the reader to UV/Vis, NIR, IR, ESR, and NMR spectroscopy. These methods and their common physical basis, namely the reversible absorption of energy from the respective region of the electromagnetic spectrum, are illustrated in a comprehensive manner with the help of a multitude of explicative colored graphics.
The last decade has seen the emergence and explosive growth of a new field of condensed matter science: materials chemistry. Transcending the traditional boundaries of organic, inorganic and physical chemistry, this new approach aims to create new molecular and lattice ensembles with unusual physical properties. One of its pioneers, the author has worked on structure-property relations in the inorganic and metal-organic solid state for over 40 years. His seminal work on mixed-valency compounds and inorganic charge transfer spectra in the 1960s set the scene for this new type of chemistry, and his discovery of transparent metal-organic ferromagnets in the 1970s laid the ground rules for much current work on molecular magnets. He has also published extensively on molecular metals and superconductors, especially on charge transfer salts combining conductivity with magnetism. This indispensable volume brings together for the first time a selection of his articles on all these topics, grouped according to theme. Each group is prefaced by a brief introduction for the general reader, putting the articles into their context in the evolution of the subject and describing the intellectual circumstances in which each project was conceived and executed.
Why do so many people voluntarily consent to searches by have the police search their person or vehicle when they know that they are carrying contraband or evidence of illegal activity? Does everyone understand the Miranda warning? How well can people recognize a voice on tape? Can linguistic experts identify who wrote an anonymous threatening letter? Speaking of Crime answers these questions and examines the complex role of language within our criminal justice system. Lawrence M. Solan and Peter M. Tiersma compile numerous cases, ranging from the Lindbergh kidnapping to the impeachment trial of Bill Clinton to the JonBenét Ramsey case, that provide real-life examples of how language functions in arrests, investigations, interrogations, confessions, and trials. In a clear and accessible style, Solan and Tiersma show how recent advances in the study of language can aid in understanding how legal problems arise and how they might be solved. With compelling discussions current issues and controversies, this book is a provocative state-of-the-art survey that will be of enormous value to legal scholars and professionals throughout the criminal justice system.
The sheer volume of talk about energy, energy prices, and energy policy on both sides of the political aisle suggests that we must know something about energy. But according to Peter Huber and Mark Mills, the things we "know" are mostly myths. In The Bottomless Well , Huber and Mills debunk the myths and show how a better understanding of energy will radically change our views and policies on a number of very controversial issues. They explain why demand will never go down, why most of what we think of as "energy waste" actually benefits us; why greater efficiency will never lead to energy conservation; and why the energy supply is infinite-it's quality of energy that's scarce and expensive. The Bottomless Well will also revolutionize our thinking about the automotive industry (gas prices don't matter and the hybrid engine is irrelevant), coal and uranium, the much-maligned power grid (it's the worst system we could have except for all the others), what energy supplies mean for jobs and GDP, and many other hotly debated subjects.
It is widely recognized that analytical technologies and techniques are playing a pioneering role in a range of today's foremost challenging scientific endeavours, including especially biological and biomedical research. Worthy of mention, for example, are the role that high performance separation techniques played in mapping the human genome and the pioneering work done within mass spectrometry. It is also apparent that state-of-the-art pharmaceutical and biomedical research is the major driving force of the development of new analytical techniques. Advancements in genomics research has provided the opportunity for a call for new drug targets for new technologies, which has speeded up drug discovery and helped to counteract the trend towards inflation of R&D costs.This book has been designed to be a reference covering a wide range of protein and genomic material analysis techniques. Emerging developments are presented with applications where relevant, and biological examples are included. It was developed to meet the ever growing need for a comprehensive and balanced text on an analytical technique which has generated a tremendous amount of interest in recent years.In addition, this book also serves as a modern textbook for advanced undergraduate and graduate courses in various disciplines including chemistry, biology and pharmacy.Authors of the individual chapters are recognized champions of their individual research disciplines and also represent contemporary major research centres in this field.·Contains state-of-the-art knowledge of the field and detailed descriptions of new technologies·Provides examples of relevant applications and case studies·Contributing authors are leading scientists in their own respective research fields
Freshwater field tests are an integral part of the process of hazard assessment of pesticides and other chemicals in the environment. This book brings together international experts on microcosms and mesocosms for a critical appraisal of theory and practice on the subject of freshwater field tests for hazard assessment. It is an authoritative and comprehensive summary of knowledge about freshwater field tests, with particular emphasis on their optimization for scientific and regulatory purposes. This valuable reference covers both lotic and lentic outdoor systems and addresses the choice of endpoints and test methodology. Instructive case histories show how to extrapolate test results to the real world.
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