Peter Tompa's Books

Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa,Alan Fersht

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Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa,Alan Fersht

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362

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CRC Press

Published Date

ISBN 10

1420078933

ISBN 13

9781420078930

Computer-aided Specification Techniques

By: Janos Demetrovics,Elod Knuth,Peter Rado

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Computer-aided Specification Techniques

By: Janos Demetrovics,Elod Knuth,Peter Rado

This book gives an overview of the works performed by the Computer and Automation Institute of the Hungarian Academy of Sciences. Since the late 1970s, there was a need for the recognition of the fundamental role of adequate abstractions and higher level conceptual models in all fields of computer applications. The approach presented explores various conceptual descriptive methods of specification processing.

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125

Publisher

World Scientific

Published Date

ISBN 10

9814507989

ISBN 13

9789814507981

Do, Die, Or Get Along

A Tale of Two Appalachian Towns

By: Peter Crow

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Do, Die, Or Get Along

A Tale of Two Appalachian Towns

By: Peter Crow

Do, Die, or Get Along weaves together voices of twenty-six people who have intimate connections to two neighboring towns in the southwestern Virginia coal country. Filled with evidence of a new kind of local outlook on the widespread challenge of small community survival, the book tells how a confrontational "do-or-die" past has given way to a "get-along" present built on coalition and guarded hope. St. Paul and Dante are six miles apart; measured in other ways, the distance can be greater. Dante, for decades a company town controlled at all levels by the mine owners, has only a recent history of civic initiative. In St. Paul, which arose at a railroad junction, public debate, entrepreneurship, and education found a more receptive home. The speakers are men and women, wealthy and poor, black and white, old-timers and newcomers. Their concerns and interests range widely, including the battle over strip mining, efforts to control flooding, the 1989-90 Pittston strike, the nationally acclaimed Wetlands Estonoa Project, and the grassroots revitalization of both towns led by the St. Paul Tomorrow and Dante Lives On organizations. Their talk of the past often invokes an ethos, rooted in the hand-to-mouth pioneer era, of short-term gain. Just as frequently, however, talk turns to more recent times, when community leaders, corporations, unions, the federal government, and environmental groups have begun to seek accord based on what will be best, in the long run, for the towns. The story of Dante and St. Paul, Crow writes, "gives twenty-first-century meaning to the idea of the good fight." This is an absorbing account of persistence, resourcefulness, and eclectic redefinition of success and community revival, with ramifications well beyond Appalachia.

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249

Publisher

University of Georgia Press

Published Date

ISBN 10

0820338974

ISBN 13

9780820338972

Weak Links

The Universal Key to the Stability of Networks and Complex Systems

By: Peter Csermely

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Weak Links

The Universal Key to the Stability of Networks and Complex Systems

By: Peter Csermely

How can our societies be stabilized in a crisis? Why can we enjoy and understand Shakespeare? Why are fruitflies uniform? How do omnivorous eating habits aid our survival? What makes the Mona Lisa’s smile beautiful? How do women keep our social structures intact? – Could there possibly be a single answer to all these questions? This book shows that the statement: "weak links stabilize complex systems" provides the key to understanding each of these intriguing puzzles, and many more besides. The author, a recipient of several distinguished science communication prizes, explains weak or low probability interactions, and uses them as connecting threads in a vast variety of networks from proteins to ecosystems. This unique book and the ideas it develops will have a significant impact on diverse, seemingly unrelated fields of study.

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422

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3540311572

ISBN 13

9783540311577

Computational Methods for Understanding Bacterial and Archaeal Genomes

By: Ying Xu,J. Peter Gogarten

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Computational Methods for Understanding Bacterial and Archaeal Genomes

By: Ying Xu,J. Peter Gogarten

Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.

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Page Count

494

Publisher

World Scientific

Published Date

ISBN 10

1860949827

ISBN 13

9781860949821

Computational Systems Bioinformatics

CSB2007 Conference Proceedings, San Diego, 13-17 August 2007

By: Peter Markstein,Ying Xu,Life Sciences Society

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Computational Systems Bioinformatics

CSB2007 Conference Proceedings, San Diego, 13-17 August 2007

By: Peter Markstein,Ying Xu,Life Sciences Society

This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. Abstracts from the keynote addresses and invited talks are also included. The papers not only cover theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Whole-Genome Analysis of Dorsal Gradient Thresholds in the Drosophila Embryo (102 KB). Contents: Learning Predictive Models of Gene Regulation (C Leslie); Algorithms for Selecting Breakpoint Locations to Optimize Diversity in Protein Engineering by Site-Directed Protein Recombination (W Zheng et al.); Cancer Molecular Pattern Discovery by Subspace Consensus Kernel Classification (X Han); Transcriptional Profiling of Definitive Endoderm Derived from Human Embryonic Stem Cells (H Liu et al.); A Markov Model Based Analysis of Stochastic Biochemical Systems (P Ghosh et al.); Clustering of Main Orthologs for Multiple Genomes (Z Fu & T Jiang); Extraction, Quantification and Visualization of Protein Pockets (X Zhang & C Bajaj); Consensus Contact Prediction by Linear Programming (X Gao et al.); An Active Visual Search Interface for Medline (W Xuan et al.); Exact and Heuristic Algorithms for Weighted Cluster Editing (S Rahmann et al.); Reconcilation with Non-binary Species Trees (B Vernot et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. Graduate researchers in bioinformatics and computational biology.

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472

Publisher

World Scientific

Published Date

ISBN 10

1860948731

ISBN 13

9781860948732

Advanced Database Systems

10th British National Conference on Databases, BNCOD 10, Aberdeen, Scotland, July 6 - 8, 1992. Proceedings

By: Peter M.D. Gray

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Advanced Database Systems

10th British National Conference on Databases, BNCOD 10, Aberdeen, Scotland, July 6 - 8, 1992. Proceedings

By: Peter M.D. Gray

The theme of this book is the potential of new advanced database systems. The volume presents the proceedings of the 10th British National Conference on Databases, held in Aberdeen, Scotland, in July 1992. The volume contains two invited papers, one on the promise of distributed computing andthe challenges of legacy systems by M.L. Brodie, and the other on object-oriented requirements capture and analysis and the Orca project by D.J.L. Gradwell. The following four parts each contain three submitted papers selected from a total of 36 submissions. The parts are entitled: - Object-oriented databases - Parallel implementationsand industrial systems - Non-relational data models - Logic programming and databases

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280

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Springer Science & Business Media

Published Date

ISBN 10

3540556931

ISBN 13

9783540556930

Enchanted by Daphne

The Life of an Evolutionary Naturalist

By: Peter R. Grant

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Enchanted by Daphne

The Life of an Evolutionary Naturalist

By: Peter R. Grant

The extraordinary life story of the celebrated naturalist who transformed our understanding of evolution Enchanted by Daphne is legendary ecologist Peter Grant’s personal account of his remarkable life and career. In this revelatory book, Grant takes readers from his childhood in World War II–era Britain to his ongoing research today in the Galápagos archipelago, vividly describing what it's like to do fieldwork in one of the most magnificent yet inhospitable places on Earth. This is also the story of two brilliant and courageous biologists raising a family together while balancing the demands of professional lives that would take them to the far corners of the globe. In 1973, Grant and his wife, Rosemary, embarked on a journey that would fundamentally change how we think about evolution. Over the next four decades, they visited the Galápagos every year to observe Darwin’s famous finches on the remote, uninhabited island of Daphne Major. Documenting how eighteen species have diversified from a single ancestral species, they demonstrated that we could actually see and measure evolution in a natural setting. Grant recounts the blind alleys and breathtaking triumphs of this historic research as he and Rosemary followed in Darwin’s footsteps—and ushered in a new era in ecology. A wonderfully absorbing portrait of a life in science, Enchanted by Daphne is an unforgettable chronicle of the travels and discoveries of one of the world’s most influential naturalists.

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360

Publisher

Princeton University Press

Published Date

ISBN 10

0691246246

ISBN 13

9780691246246

The Long Road to Stockholm

The Story of Magnetic Resonance Imaging - An Autobiography

By: Peter Mansfield

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The Long Road to Stockholm

The Story of Magnetic Resonance Imaging - An Autobiography

By: Peter Mansfield

In this autobiography, Sir Peter Mansfield describes his life from war time childhood that initially sparked his interest in physics to his work in magnetic resonance imaging (MRI) that eventually led to the award of the Nobel Prize in 2003. Peter Mansfield grew up in London, but was evacuated to Devon during the blitz and following the V1 and V2 attacks on London. At the end of hostilities, he worked briefly in the printing industry before deciding to pursue his real interests in science by joining the Rocket Propulsion Department at Westcott near Aylesbury. Following a period of National Service and his studies at Queen Mary College, University of London, he married and moved to the USA for two years, returning in 1964 as a Lecturer in Physics at the University of Nottingham. In 1972 he spent a sabbatical period in Heidelberg, and during this period corresponded with his student, Peter Grannell, in Nottingham on the novel idea of magnetic resonance imaging. This led to his first paper on MRI which was presented at the first Specialised Colloque Ampère in 1973. During this period, he demonstrated how the MRI radio signals can be analysed and turned into images of the body. In 2003 the Nobel Prize in Physiology or Medicine was awarded jointly to Sir Peter and Paul Lauterbur for their crucial achievements in the development of MRI.

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Page Count

253

Publisher

OUP Oxford

Published Date

ISBN 10

0191641774

ISBN 13

9780191641770

The Making of the Oxford English Dictionary

By: Peter Gilliver

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The Making of the Oxford English Dictionary

By: Peter Gilliver

This book tells the history of the Oxford English Dictionary from its beginnings in the middle of the nineteenth century to the present. The author, uniquely among historians of the OED, is also a practising lexicographer with nearly thirty years' experience of working on the Dictionary. He has drawn on a wide range of sources--including previously unexamined archival material and eyewitness testimony--to create a detailed history of the project. The book explores the cultural background from which the idea of a comprehensive historical dictionary of English emerged, the lengthy struggles to bring this concept to fruition, and the development of the book from the appearance of the first printed fascicle in 1884 to the launching of the Dictionary as an online database in 2000 and beyond. It also examines the evolution of the lexicographers' working methods, and provides much information about the people--many of them remarkable individuals--who have contributed to the project over the last century and a half.

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646

Publisher

Oxford University Press

Published Date

ISBN 10

0199283621

ISBN 13

9780199283620

Evolutionary Dynamics of a Natural Population

The Large Cactus Finch of the Galapagos

By: B. Rosemary Grant,Peter R. Grant

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Evolutionary Dynamics of a Natural Population

The Large Cactus Finch of the Galapagos

By: B. Rosemary Grant,Peter R. Grant

The result of one of the most detailed and careful examinations of the behavior and ecology of a vertebrate ever conducted in the wild, this study addresses one of the major questions in evolutionary biology: why do some populations vary so much in morphological, ecological, behavioral, and physiological traits? By documenting the full range of variation within one population of a species and investigating the causal factors, Rosemary and Peter Grant provide impressive evidence that species are capable of evolutionary change within observable periods of time. Among the most dramatic examples of recent speciation and adaptive diversification are Darwin's Finches, which live in the Galápagos Islands. Darwin theorized that these closely related birds had evolved from a common ancestor to fill the available ecological niches on this remote archipelago. Not only have they evolved into thirteen species, but more recent study has shown that many of them exhibit striking variation in beak structure and other traits. For more than a decade, the Grants have studied one of these species, the large cactus finch, on the isolated Isla Genovesa. They present information on the environment and demographic features of the population, then discuss the range of genetic, ecological, and behavioral factors responsible for the unusually large morphological variation. They place the large cactus finch in its community setting to better understand its evolution and conclude by discussing the implications of the study for the genetic structure of small populations and the problems of conserving them. They illustrate their findings with an array of drawings, tables, and photographs.

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Page Count

394

Publisher

University of Chicago Press

Published Date

ISBN 10

0226305902

ISBN 13

9780226305905

Data on the Web

From Relations to Semistructured Data and XML

By: Serge Abiteboul,Peter Buneman,Dan Suciu

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Data on the Web

From Relations to Semistructured Data and XML

By: Serge Abiteboul,Peter Buneman,Dan Suciu

Data model. Queries. Types. Sysems. A syntax for data. XML.. Query languages. Query languages for XML. Interpretation and advanced features. Typing semistructured data. Query processing. The lore system. Strudel. Database products supporting XML. Bibliography. Index. About the authors.

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280

Publisher

Morgan Kaufmann

Published Date

ISBN 10

155860622X

ISBN 13

9781558606227

Autism and Joint Attention

Development, Neuroscience, and Clinical Fundamentals

By: Peter C. Mundy

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Autism and Joint Attention

Development, Neuroscience, and Clinical Fundamentals

By: Peter C. Mundy

From a preeminent researcher, this book looks at the key role of joint attention in both typical and atypical development. Peter C. Mundy shows that no other symptom dimension is more strongly linked to early identification and treatment of autism spectrum disorder (ASD). He synthesizes a wealth of knowledge on how joint attention develops, its neurocognitive underpinnings, and how it helps to explain the learning, language, and social-cognitive features of ASD across the lifespan. Clinical implications are explored, including reviews of cutting-edge diagnostic methods and targeted treatment approaches.

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369

Publisher

Guilford Publications

Published Date

ISBN 10

1462525091

ISBN 13

9781462525096

Algebraic Complexity Theory

By: Peter Bürgisser,Michael Clausen,Mohammad A. Shokrollahi

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Algebraic Complexity Theory

By: Peter Bürgisser,Michael Clausen,Mohammad A. Shokrollahi

The algorithmic solution of problems has always been one of the major concerns of mathematics. For a long time such solutions were based on an intuitive notion of algorithm. It is only in this century that metamathematical problems have led to the intensive search for a precise and sufficiently general formalization of the notions of computability and algorithm. In the 1930s, a number of quite different concepts for this purpose were pro posed, such as Turing machines, WHILE-programs, recursive functions, Markov algorithms, and Thue systems. All these concepts turned out to be equivalent, a fact summarized in Church's thesis, which says that the resulting definitions form an adequate formalization of the intuitive notion of computability. This had and continues to have an enormous effect. First of all, with these notions it has been possible to prove that various problems are algorithmically unsolvable. Among of group these undecidable problems are the halting problem, the word problem theory, the Post correspondence problem, and Hilbert's tenth problem. Secondly, concepts like Turing machines and WHILE-programs had a strong influence on the development of the first computers and programming languages. In the era of digital computers, the question of finding efficient solutions to algorithmically solvable problems has become increasingly important. In addition, the fact that some problems can be solved very efficiently, while others seem to defy all attempts to find an efficient solution, has called for a deeper under standing of the intrinsic computational difficulty of problems.

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Page Count

630

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3662033380

ISBN 13

9783662033388

Bretherick's Handbook of Reactive Chemical Hazards

An indexed guide to published data

By: Peter Urben

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Bretherick's Handbook of Reactive Chemical Hazards

An indexed guide to published data

By: Peter Urben

Bretherick' is widely accepted as the reference work on reactive chemical hazards and is essential for all those working with chemicals. It attempts to include every chemical for which documented information on reactive hazards has been found. The text covers over 5000 elements and compounds and as many again of secondary entries involving two or more compounds. One of its most valuable features is the extensive cross referencing throughout both sections which links similar compounds or incidents not obviously related. The fifth edition has been completely updated and revised by the new Editor and contains documented information on hazards and appropriate references up to 1994, although the text still follows the format of previous editions. Volume 1 is devoted to specific information on the stability of the listed compounds, or the reactivity of mixtures of two or more of them under various circumstances. Each compound is identified by an UPAC-based name, the CAS registry number, its empirical formula and structure. Each description of an incident or violent reaction gives reference to the original literature. Each chemical is classified on the basis of similarities in structure or reactivity, and these groups are listed alphabetically in Volume 2. The group entries contain a complete listing of all the compounds in Volume 1 assigned to that group to assist cross referral to similar compounds. Volume 2 also contains hazard topic entries arranged alphabetically, some with lists. Appendices include a fire related data table for higher risk chemicals, indexes of registry numbers and chemical names as well as reference abbreviations and a glossary.

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2509

Publisher

Elsevier

Published Date

ISBN 10

1483294080

ISBN 13

9781483294087

Genomes, Browsers and Databases

Data-Mining Tools for Integrated Genomic Databases

By: Peter Schattner

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Genomes, Browsers and Databases

Data-Mining Tools for Integrated Genomic Databases

By: Peter Schattner

The recent explosive growth of biological data has lead to a rapid increase in the number of molecular biology databases. Held in many different locations and often using varying interfaces and non-standard data formats, integrating and comparing data from these multiple databases can be difficult and time-consuming. This book provides an overview of the key tools currently available for large-scale comparisons of gene sequences and annotations, focusing on the databases and tools from the University of California, Santa Cruz (UCSC), Ensembl, and the National Centre for Biotechnology Information (NCBI). Written specifically for biology and bioinformatics students and researchers, it aims to give an appreciation of the methods by which the browsers and their databases are constructed, enabling readers to determine which tool is the most appropriate for their requirements. Each chapter contains a summary and exercises to aid understanding and promote effective use of these important tools.

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Page Count

329

Publisher

Cambridge University Press

Published Date

ISBN 10

1139472712

ISBN 13

9781139472715

Engineering Web Applications

By: Sven Casteleyn,Florian Daniel,Peter Dolog,Maristella Matera

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Engineering Web Applications

By: Sven Casteleyn,Florian Daniel,Peter Dolog,Maristella Matera

Nowadays, Web applications are almost omnipresent. The Web has become a platform not only for information delivery, but also for eCommerce systems, social networks, mobile services, and distributed learning environments. Engineering Web applications involves many intrinsic challenges due to their distributed nature, content orientation, and the requirement to make them available to a wide spectrum of users who are unknown in advance. The authors discuss these challenges in the context of well-established engineering processes, covering the whole product lifecycle from requirements engineering through design and implementation to deployment and maintenance. They stress the importance of models in Web application development, and they compare well-known Web-specific development processes like WebML, WSDM and OOHDM to traditional software development approaches like the waterfall model and the spiral model. .

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Page Count

357

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3540922016

ISBN 13

9783540922018

Creating an art community

By: Peter Wakelin

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Creating an art community

By: Peter Wakelin

Explores the main themes that have exercised visual art in Wales throughout most of the twentieth century, by outlining the conception and history of the largest community of artists in Wales - The Welsh Group. This title brings together names as diverse in practice as Sir Cedric Morris, Ceri Richards and Brenda Chamberlin.

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Page Count

104

Publisher

National Museum Wales

Published Date

ISBN 10

0720004721

ISBN 13

9780720004724

The Emergence of an Iron Age Economy

The Mecklenburg Grave Groups from Hallstatt and Stična

By: Peter S. Wells

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The Emergence of an Iron Age Economy

The Mecklenburg Grave Groups from Hallstatt and Stična

By: Peter S. Wells

These three volumes deal with the Iron Age grave materials from Magdalenska gora, excavated by the Duchess Paul Friedrich von Mecklenburg-Schwerin. Volume III presents data and analysis of the horse remains and human skeletal materials.

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Page Count

258

Publisher

Peabody Museum of Archaeology and Ethnology, Harvard University Publications Department

Published Date

ISBN 10

0873655362

ISBN 13

9780873655361

Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa,Alan Fersht

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Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa,Alan Fersht

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362

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CRC Press

Published Date

ISBN 10

1420078933

ISBN 13

9781420078930

Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa,Alan Fersht

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Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa,Alan Fersht

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs. Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.

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359

Publisher

Chapman and Hall/CRC

Published Date

ISBN 10

1420078925

ISBN 13

9781420078923

Function and Flexibility: Friend or Foe?

By: Kris Pauwels,Peter Tompa

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Function and Flexibility: Friend or Foe?

By: Kris Pauwels,Peter Tompa

Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan’s quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.

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Page Count

104

Publisher

Frontiers Media SA

Published Date

ISBN 10

288919972X

ISBN 13

9782889199723

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