At the centre of the metaethical debate that took off from G.E. Moore's Principia Ethica (1903) was his critique of ethical naturalism. While Moore's own arguments against ethical naturalism find little acceptance these days, an alternative ground for thinking that ethical properties and facts could not be natural has gained prominence: No natural account can be given of normativity. This collection contains original essays from both sides of the debate. Representing a wide range of metaethical views, the authors develop diverse accounts of normativity and discuss what it means for a concept to be natural. Contributions are by Norbert Anwander, David Copp, Ulvi Doguoglu, Neil Roughley, Peter Schaber, Thomas Schmidt, and Theo van Willigenburg.
The Volcanoes of Mars offers a clear, cohesive summary of Mars volcanology. It begins with an introduction to the geology and geography of the red planet and an overview of its volcanic history, and continues to discuss each distinct volcanic province, identifying the common and unique aspects of each region. Incorporating basic volcanological information and constraints on the regional geologic history derived from geologic mapping, the book also examines current constraints on the composition of the volcanic rocks as investigated by both orbiting spacecraft and rovers. In addition, it compares the features of Martian volcanoes to those seen on other volcanic bodies. Concluding with prospects for new knowledge to be gained from future Mars missions, this book brings researchers in volcanology and the study of Mars up to date on the latest findings in the study of volcanoes on Mars, allowing the reader to compare and contrast Martian volcanoes to volcanoes studied on Earth and throughout the Solar System. - Presents clearly organized text and figures that will quickly allow the reader to find specific aspects of Martian volcanism - Includes definitions of geological and volcanological terms throughout to aid interdisciplinary understanding - Summarizes key results for each volcanic region of Mars and provides copious citations to the research literature to facilitate further discovery - Synthesizes the most current data from multiple spacecraft missions, including the Mars Reconnaissance Orbiter, as well as geochemical data from Martian meteorites - Utilizes published geologic mapping results to highlight the detailed knowledge that exists for each region
Rapid thermal processing has contributed to the development of single wafer cluster processing tools and other innovations in integrated circuit manufacturing environments. Borisenko and Hesketh review theoretical and experimental progress in the field, discussing a wide range of materials, processes, and conditions. They thoroughly cover the work of international investigators in the field.
First published in 1993. The scientific and political debate about poverty has been changing fast -with dramatic implications for intellectual interpretation and action by governments- and the intention in publishing this volume is to contribute to that debate. Scientists concerned to analyse poverty have been thrust by events into greater international service. But there are sinister forces at work which are seeking to divert them into petty issues, to blame the victims of poverty, or to cut them off from the resources or opportunities to investigate and report freely. This book is born of that frustration - and represents the changing debate during the late 1980s and early 1990s.
Venus, closest planet to the Earth, is a torrid world of extremes shrouded from direct view by dense clouds. This Atlas of Venus shows all the fascinating detail discovered on the recent Magellan mission to map the planet surface. Giving the historical background to our perception of the planet, this book clearly explains why Venus has been the goal of so many missions by both Russian and American space programmes. With the latest images from the Magellan mission, this colourful Atlas shows the beautiful landscape of Venus and its dynamic volcanism. Over 100 maps and illustrations show the dramatic beauty of this photogenic planet. Complete with detailed maps of the planet and a gazetteer of all landmarks, this is the essential reference source for all professional and amateur astronomers, and planetary scientists interested in our closest neighbour.
The CRC Handbook of Chromatography is a series of work-bench references for scientists and researchers using chromatographic systems for the analysis of organic and inorganic compounds. This handbook is an assemblage of tables where, besides data obtained by modern separation methods, older sources often difficult to access have been included to give maximum information. For use in scientific research and routine analysis where the exact determination of plant pigments, because of their light absorbing properties and defined tasks, is necessary.
International regimes have been a major focus of research in international relations for over a decade. Three schools of thought have shaped the discussion: realism, which treats power relations as its key variable; neoliberalism, which bases its analysis on constellations of interests; and cognitivism, which emphasizes knowledge dynamics, communication, and identities. Each school articulates distinct views on the origins, robustness, and consequences of international regimes. This book examines each of these contributions to the debate, taking stock of, and seeking to advance, one of the most dynamic research agendas in contemporary international relations. While the differences between realist, neoliberal and cognitivist arguments about regimes are acknowledged and explored, the authors argue that there is substantial scope for progress toward an inter-paradigmatic synthesis.
This book represents the first rigorous treatment of thermoelectrochemistry, providing an overview that will stimulate electrochemists to develop and apply modern thermoelectrochemical methods. While classical static approaches are also covered, the emphasis lies on methods that make it possible to independently vary temperature such as in-situ heating of electrodes by means of electric current, microwaves or lasers. For the first time, “hot-wire electrochemistry” is examined in detail. The theoretical background presented addresses all aspects of temperature impacts in the context of electrochemistry.
A book that rewrites the history of American prosperity and inequality Unequal Gains offers a radically new understanding of the economic evolution of the United States, providing a complete picture of the uneven progress of America from colonial times to today. While other economic historians base their accounts on American wealth, Peter Lindert and Jeffrey Williamson focus instead on income—and the result is a bold reassessment of the American economic experience. America has been exceptional in its rising inequality after an egalitarian start, but not in its long-run growth. America had already achieved world income leadership by 1700, not just in the twentieth century as is commonly thought. Long before independence, American colonists enjoyed higher living standards than Britain—and America's income advantage today is no greater than it was three hundred years ago. But that advantage was lost during the Revolution, lost again during the Civil War, and lost a third time during the Great Depression, though it was regained after each crisis. In addition, Lindert and Williamson show how income inequality among Americans rose steeply in two great waves—from 1774 to 1860 and from the 1970s to today—rising more than in any other wealthy nation in the world. Unequal Gains also demonstrates how the widening income gaps have always touched every social group, from the richest to the poorest. The book sheds critical light on the forces that shaped American income history, and situates that history in a broad global context. Economic writing at its most stimulating, Unequal Gains provides a vitally needed perspective on who has benefited most from American growth, and why.
4th edition of this classic Ecology text Computational methods have largely been replaced by descriptions of the available software Includes procedure information for R software and other freely available software systems Now includes web references for equipment, software and detailed methodologies
This book covers the geomorphology and landscape evolution of South Africa, focusing on arid landscapes, fluvial systems, karst, Quaternary landscapes, macro-scale geomorphic evolution, coastal geomorphology and applied geomorphology. It would appeal to postgraduate students in Physical Geography (Geomorphology) and Physical Geology and all academics in the earth sciences.
The CRC Handbook of Chromatography is a series of work-bench references for scientists and researchers using chromatographic systems for the analysis of organic and inorganic compounds. This handbook is an assemblage of tables where, besides data obtained by modern separation methods, older sources often difficult to access have been included to give maximum information. For use in scientific research and routine analysis where the exact determination of plant pigments, because of their light absorbing properties and defined tasks, is necessary.
Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
Bold is a radical how-to guide for using exponential technologies, moonshot thinking, and crowd-powered tools to create extraordinary wealth while also positively impacting the lives of billions. A follow-up to the authors' Abundance (2012).
This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.
Peter Sutton is a fearless and authoritative voice in Aboriginal politics. In this groundbreaking book, he asks why, after three decades of liberal thinking, has the suffering and grief in so many Aboriginal communities become worse? The picture Sutton presents is tragic. He marshals shocking evidence against the failures of the past, and argues provocatively that three decades of liberal consensus on Aboriginal issues has collapsed. Sutton is a leading Australian anthropologist who has lived and worked closely with Aboriginal communities. He combines clear-eyed, original observation with deep emotional engagement. The Politics of Suffering cuts through the cant and offers fresh insight and hope for a new era in Indigenous politics.
This book contains the first comprehensive review of intrinsic point defects, impurities and their complexes in silicon. Besides compiling the structures, energetic properties, identified electrical levels and spectroscopic signatures, and the diffusion behaviour from investigations, it gives a comprehensive introduction into the relevant fundamental concepts.
Aufbau—a German-language weekly, published in New York and circulated nationwide—was an essential platform for the generation of refugees from Hitler and the displaced people and concentration camp survivors who arrived in the United States after the war. The publication served to link thousands of readers looking for friends and loved ones in every part of the world. In its pages Aufbau focused on concerns that strongly impacted this community in the aftermath of World War II: anti-Semitism in the United States and in Europe, the ever-changing immigration and naturalization procedures, debates about the designation of Hitler refugees as enemy aliens, questions about punishment for the Holocaust and other Nazi crimes, the struggle for compensation and restitution, and the fight for a Jewish homeland. The book examines the columns and advertisements that chronicled the social and cultural life of that generation and maintained a detailed account of German-speaking cultures in exile. Peter Schrag is the first to present a definitive account of the influential publication that brought postwar refugees together and into the American mainstream.
The development of international wildlife law has been one of the most significant exercises in international law-making during the last fifty years. This second edition of Lyster's International Wildlife Law coincides with both the UN Year of Biological Diversity and the twenty-fifth anniversary of Simon Lyster's first edition. The risk of wildlife depletion and species extinction has become even greater since the 1980s. This new edition provides a clear and authoritative analysis of the key treaties which regulate the conservation of wildlife and habitat protection, and of the mechanisms available to make them work. The original text has also been significantly expanded to include analysis of the philosophical and welfare considerations underpinning wildlife protection, the cross-cutting themes of wildlife and trade, and the impact of climate change and other anthropogenic interferences with species and habitat. Lyster's International Wildlife Law is an indispensable reference work for scholars, practitioners and policy-makers alike.
Providing a catalogue of suggested solutions for different categories of issues, this book offers a balanced overview and methodological examples for the practical implementation of the CRA. It considers CRA in the USA, Europe and Germany, using case studies to analyze and exemplify the decision-making processes and challenges involved. The authors then go on to look at the practical lessons learned from these case studies, together with an in-depth discussion of the underlying scientific hypotheses. Sound scientific knowledge for everyone who makes decisions, whether government ministers, regulators, or company directors.
This open access book deals with community-based attempts on the part of Aboriginal communities and groups in Australia to address harms arising from alcohol misuse. Alcohol-related harms are viewed as both a product of colonisation and dispossession and a contributor to ongoing social, economic and health-related disadvantage, both in Australia and in other countries with colonised Indigenous populations, such as Canada, the US and New Zealand. This book contributes to an evidence-base by bringing together a selection of existing Australian documents considered by the editors to have continuing relevance to all those concerned with dealing with alcohol-related harms among Aboriginal peoples, These are contextualised in original chapters that recount key events, ideas, and programs. The book is a practical resource for all people and groups concerned with addressing Aboriginal and Torres Strait Islander alcohol-related harms, both at the community level and at the level of policy-making and administration.
This book explores the theoretical basis of our ethical obligations to others as self-knowing beings - this task being envisaged as an essential supplement to a traditional ethic of respect for persons. Authoritative knowledge of others brings with it certain obligations, which are reflected in (inter alia) the moral and legal safeguards designed to ensure that certain information is ‘put out of play’ for job selection purposes etc. However, the theoretical basis for such obligations has never been fully clarified. This book begins by identifying a distinctive class of ‘interpretive’ moral wrongs (including stereotyping, discrimination and objectification). It then shows how our obligations in respect of these wrongs can be understood, drawing on insights from the tradition of philosophical reflection on recognition. The book will be of interest to anyone concerned with the adequacy of a modern ethic of respect for persons – particularly in applied and professional ethics.
This volume contains very carefully compiled material presenting bibliographic descriptions of approximately 3500 papers, with a computer-generated index on authors, subject headings, corporate addresses and journals. There are many on-line services available on fullerenes, but they serve mainly current-awareness functions; none of them is selectively complete and carefully indexed and none can replace a complete retrospective bibliography, which most researchers in the field would want to have on hand in their laboratories and offices.
Negative Emissions Technologies for Climate Change Mitigation provides a comprehensive introduction to the full range of technologies that are being researched, developed and deployed in order to transition from our current energy system, dominated by fossil fuels, to a negative-carbon emissions system. After an introduction to the challenge of climate change, the technical fundamentals of natural and engineered carbon dioxide removal and storage processes and technologies are described. Each NET is then discussed in detail, including the key elements of the technology, enablers and constraints, governance issues, and global potential and cost estimates.This book offers a complete overview of the field, thus enabling the community to gain a full appreciation of NETs without the need to seek out and refer to a multitude of sources. - Covers the full spectrum of technologies to underpin the transition to a negative emissions energy system, from technical fundamentals to the current state of deployment and R&D - Critically evaluates each technology, highlighting advantages, limitations, and the potential for large scale environmental applications - Combines natural science and environmental science perspectives with the practical use of state-of-the-art technologies for sustainability
The book is a follow-up to the computerized fullerene bibliography related to the 1985-1993 period. It is a well-indexed overview of the journal literature on a topic for which the 1996 Nobel Prize in Chemistry was awarded. It is an indispensable tool for any specialist interested in the literature of one of the most researched interdisciplinary topics in the sciences.
This report by the Nat. Science and Tech. Council¿s U.S. Climate Change Science Program (CCSP) is part of a series of 21 reports aimed at providing current assessments of climate change science to inform public debate, policy, and operational decisions. These reports are also intended to help the CCSP develop future program research priorities. The CCSP¿s guiding vision is to provide the Nation and the global community with the science-based knowledge needed to manage the risks and capture the opportunities associated with climate and related environmental changes. This report assesses the effects of climate change on U.S. land resources, water resources, agriculture, and biodiversity. It was developed with broad scientific input. Illus.
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
The purpose of this book is to discuss the phenomena associated with the segregation of one element in a multicomponent material. It describes the kinetics of segregation and contains a tabular summary of the pros and cons of the various models. The easy-to-read chapters outline in detail the macroscopic approach and provide an in-depth review of broken-bond models. This comprehensive informative resource also addresses important multicomponent systems. These systems include metals with non-metallic constituents, semiconductor-metal interfaces, steels and steel-related alloys, and real catalysts. Readers of this text will gain a good fundamental understanding and overview of surface, interfacial, and selvedge segregation. Those who have an interest in physics, vacuum science, material science, and chemical, mechanical, and electrical engineering will benefit from this imperative work.
Revised and updated, this edition covers general principles of overdose management; the automonic nervous system, neurotransmitters and drugs; drugs used in psychiatry; cardiac drugs; agents that burn; gases and abnormal haemoglobin formation; the
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