Sustainment' (as commonly defined by industry and government), is comprised of maintenance, support, and upgrade practices that sustain or improve the performance of a system and maximize the availability of goods and services while minimizing their cost and footprint or, more simply, the capacity of a system to endure. Sustainment is a multi-trillion-dollar enterprise for critical systems, in both government (infrastructure and defense) and industry (transportation, industrial controls, data centers, and energy generation).This book is a mix of engineering, operations research, and policy sciences intended to provide students with a thorough understanding of the concept of sustainability and sustainable product life-cycles, and an appreciation of the importance of sustaining critical systems. It starts from the key attributes for system sustainment that includes data analytics, engineering analysis and the public policy needed to support the development of technologies, processes, and frameworks required for the management of sustainable processes and practices. The specific topics covered include: acquisition of critical systems, reliability, maintenance, availability, readiness, inventory management, supply-chain management and risks, contracting for sustainment, and various analysis methodologies (discounted cash flow analysis, discrete-event simulation and Monte Carlo methods). Practice problems are included at the end of each chapter.
Supply chains for electronic products are primarily driven by consumer electronics. Every year new mobile phones, computers and gaming consoles are introduced, driving the continued applicability of Moore's law. The semiconductor manufacturing industry is highly dynamic and releases new, better and cheaper products day by day. But what happens to long-field life products like airplanes or ships, which need the same components for decades? How do electronic and also non-electronic systems that need to be manufactured and supported of decades manage to continue operation using parts that were available for a few years at most? This book attempts to answer these questions. This is the only book on the market that covers obsolescence forecasting methodologies, including forecasting tactics for hardware and software that enable cost-effective proactive product life-cycle management. This book describes how to implement a comprehensive obsolescence management system within diverse companies. Strategies to the Prediction, Mitigation and Management of Product Obsolescence is a must-have work for all professionals in product/project management, sustainment engineering and purchasing.
Maintenance combines various methods, tools, and techniques in a bid to reduce maintenance costs while increasing the reliability, availability, and security of equipment. Condition-based maintenance (CBM) is one such method, and prognostics forms a key element of a CBM program based on mathematical models for predicting remaining useful life (RUL). Prognostics and Remaining Useful Life (RUL) Estimation: Predicting with Confidence compares the techniques and models used to estimate the RUL of different assets, including a review of the relevant literature on prognostic techniques and their use in the industrial field. This book describes different approaches and prognosis methods for different assets backed up by appropriate case studies. FEATURES Presents a compendium of RUL estimation methods and technologies used in predictive maintenance Describes different approaches and prognosis methods for different assets Includes a comprehensive compilation of methods from model-based and data-driven to hybrid Discusses the benchmarking of RUL estimation methods according to accuracy and uncertainty, depending on the target application, the type of asset, and the forecast performance expected Contains a toolset of methods and a way of deployment aimed at a versatile audience This book is aimed at professionals, senior undergraduates, and graduate students in all interdisciplinary engineering streams that focus on prognosis and maintenance.
The second edition of a bestseller, this book discusses an integrated product and process design that has been successfully used to conceptualize, design, and rapidly product competitively-priced quality products. It examines the overlapping, interacting, and iterative nature of the engineering aspects that impact the product realization process. A detailed introduction to the creation of high quality products, the new edition explores the role of innovation, requirements engineering, smart materials, different rapid prototyping methods, and life-cycle cost determination, to name just a few. The book delineates proven methods that have been used successfully to create products.
Understanding the cost ramifications of design, manufacturing and life-cycle management decisions is of central importance to businesses associated with all types of electronic systems. Cost Analysis of Electronic Systems contains carefully developed models and theory that practicing engineers can directly apply to the modeling of costs for real products and systems. In addition, this book brings to light and models many contributions to life-cycle costs that practitioners are aware of but never had the tools or techniques to address quantitatively in the past.Cost Analysis of Electronic Systems melds elements of traditional engineering economics with manufacturing process and life-cycle cost management concepts to form a practical foundation for predicting the cost of electronic products and systems. Various manufacturing cost analysis methods are addressed including: process-flow, parametric, cost of ownership, and activity-based costing. The effects of learning curves, data uncertainty, test and rework processes, and defects are considered. Aspects of system sustainment and life-cycle cost modeling including reliability (warranty, burn-in), maintenance (sparing and availability), and obsolescence are treated. Finally, total cost of ownership of systems and return on investment are addressed.Real life design scenarios from integrated circuit fabrication, electronic systems assembly, substrate fabrication, and electronic systems managementare used as examples of the application of the cost estimation methods developed within the book.
This book provides an introduction to the cost modeling for electronic systems that is suitable for advanced undergraduate and graduate students in electrical, mechanical and industrial engineering, and professionals involved with electronics technology development and management. This book melds elements of traditional engineering economics with manufacturing process and life-cycle cost management concepts to form a practical foundation for predicting the cost of electronic products and systems. Various manufacturing cost analysis methods are addressed including: process-flow, parametric, cost of ownership, and activity based costing. The effects of learning curves, data uncertainty, test and rework processes, and defects are considered. Aspects of system sustainment and life-cycle cost modeling including reliability (warranty, burn-in), maintenance (sparing and availability), and obsolescence are treated. Finally, total cost of ownership of systems, return on investment, cost-benefit analysis, and real options analysis are addressed.
Authors have attempted to create coherent chapters and sections on how the fundamentals of maintenance cost should be organized, to present them in a logical and sequential order. Necessarily, the text starts with importance of maintenance function in the organization and moves to life cycle cost (LCC) considerations followed by the budgeting constraints. In the process, they have intentionally postponed the discussion about intangible costs and downtime costs later on in the book mainly due to the controversial part of it when arguing with managers. The book will be concluding with a short description of a number of sectors where maintenance cost is of critical importance. The goal is to train the readers for a deeper study and understanding of these elements for decision making in maintenance, more specifically in the context of asset management. This book is intended for managers, engineers, researchers, and practitioners, directly or indirectly involved in the area of maintenance. The book is focused to contribute towards better understanding of maintenance cost and use of this knowledge to improve the maintenance process. Key Features: • Emphasis on maintenance cost and life cycle cost especially under uncertainty. • Systematic approach of how cost models can be applied and used in the maintenance field. • Compiles and reviews existing maintenance cost models. • Consequential and direct costs considered. • Comparison of maintenance costs in different sectors, infrastructure, manufacturing, transport.
Conceptual Design of Multichip Modules and Systems treats activities which take place at the conceptual and specification level of the design of complex multichip systems. These activities include the formalization of design knowledge (information modeling), tradeoff analysis, partitioning, and decision process capture. All of these functions occur prior to the traditional CAD activities of synthesis and physical design. Inherent in the design of electronic modules are tradeoffs which must be understood before feasible technology, material, process, and partitioning choices can be selected. The lack of a complete set of technology information is an especially serious problem in the packaging and interconnect field since the number of technologies, process, and materials is substantial and selecting optimums is arduous and non-trivial if one truly wants a balance in cost and performance. Numerous tradeoff and design decisions have to be made intelligently and quickly at the beginning of the design cycle before physical design work begins. These critical decisions, made within the first 10% of the total design cycle, ultimately define up to 80% of the final product cost. Conceptual Design of Multichip Modules and Systems lays the groundwork for concurrent estimation level analysis including size, routing, electrical performance, thermal performance, cost, reliability, manufacturability, and testing. It will be useful both as a reference for system designers and as a text for those wishing to gain a perspective on the nature of packaging and interconnect design, concurrent engineering, computer-aided design, and system synthesis.
Sustainment' (as commonly defined by industry and government), is comprised of maintenance, support, and upgrade practices that sustain or improve the performance of a system and maximize the availability of goods and services while minimizing their cost and footprint or, more simply, the capacity of a system to endure. Sustainment is a multi-trillion-dollar enterprise for critical systems, in both government (infrastructure and defense) and industry (transportation, industrial controls, data centers, and energy generation).This book is a mix of engineering, operations research, and policy sciences intended to provide students with a thorough understanding of the concept of sustainability and sustainable product life-cycles, and an appreciation of the importance of sustaining critical systems. It starts from the key attributes for system sustainment that includes data analytics, engineering analysis and the public policy needed to support the development of technologies, processes, and frameworks required for the management of sustainable processes and practices. The specific topics covered include: acquisition of critical systems, reliability, maintenance, availability, readiness, inventory management, supply-chain management and risks, contracting for sustainment, and various analysis methodologies (discounted cash flow analysis, discrete-event simulation and Monte Carlo methods). Practice problems are included at the end of each chapter.
Supply chains for electronic products are primarily driven by consumer electronics. Every year new mobile phones, computers and gaming consoles are introduced, driving the continued applicability of Moore's law. The semiconductor manufacturing industry is highly dynamic and releases new, better and cheaper products day by day. But what happens to long-field life products like airplanes or ships, which need the same components for decades? How do electronic and also non-electronic systems that need to be manufactured and supported of decades manage to continue operation using parts that were available for a few years at most? This book attempts to answer these questions. This is the only book on the market that covers obsolescence forecasting methodologies, including forecasting tactics for hardware and software that enable cost-effective proactive product life-cycle management. This book describes how to implement a comprehensive obsolescence management system within diverse companies. Strategies to the Prediction, Mitigation and Management of Product Obsolescence is a must-have work for all professionals in product/project management, sustainment engineering and purchasing.
Authors have attempted to create coherent chapters and sections on how the fundamentals of maintenance cost should be organized, to present them in a logical and sequential order. Necessarily, the text starts with importance of maintenance function in the organization and moves to life cycle cost (LCC) considerations followed by the budgeting constraints. In the process, they have intentionally postponed the discussion about intangible costs and downtime costs later on in the book mainly due to the controversial part of it when arguing with managers. The book will be concluding with a short description of a number of sectors where maintenance cost is of critical importance. The goal is to train the readers for a deeper study and understanding of these elements for decision making in maintenance, more specifically in the context of asset management. This book is intended for managers, engineers, researchers, and practitioners, directly or indirectly involved in the area of maintenance. The book is focused to contribute towards better understanding of maintenance cost and use of this knowledge to improve the maintenance process. Key Features: • Emphasis on maintenance cost and life cycle cost especially under uncertainty. • Systematic approach of how cost models can be applied and used in the maintenance field. • Compiles and reviews existing maintenance cost models. • Consequential and direct costs considered. • Comparison of maintenance costs in different sectors, infrastructure, manufacturing, transport.
Conceptual Design of Multichip Modules and Systems treats activities which take place at the conceptual and specification level of the design of complex multichip systems. These activities include the formalization of design knowledge (information modeling), tradeoff analysis, partitioning, and decision process capture. All of these functions occur prior to the traditional CAD activities of synthesis and physical design. Inherent in the design of electronic modules are tradeoffs which must be understood before feasible technology, material, process, and partitioning choices can be selected. The lack of a complete set of technology information is an especially serious problem in the packaging and interconnect field since the number of technologies, process, and materials is substantial and selecting optimums is arduous and non-trivial if one truly wants a balance in cost and performance. Numerous tradeoff and design decisions have to be made intelligently and quickly at the beginning of the design cycle before physical design work begins. These critical decisions, made within the first 10% of the total design cycle, ultimately define up to 80% of the final product cost. Conceptual Design of Multichip Modules and Systems lays the groundwork for concurrent estimation level analysis including size, routing, electrical performance, thermal performance, cost, reliability, manufacturability, and testing. It will be useful both as a reference for system designers and as a text for those wishing to gain a perspective on the nature of packaging and interconnect design, concurrent engineering, computer-aided design, and system synthesis.
A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.
Stay up to date on today's most common GI and liver disorders and their management with GI/Liver Secrets Plus. This enhanced medical reference book is an excellent resource for understanding the physiology and therapy in hepatic and digestive disease. Whether preparing for an exam or quickly checking a clinical question, the user-friendly Secrets Series® style makes this book a valuable addition to your library! Easily locate important information with bulleted lists, tables, boxes, short answers, and a highly detailed index to expedite reference. Access a broad range of topics that focus on all of today's most common GI and liver disorders and their management.
Written specifically for gastroenterologists at all levels, Imaging in Gastroenterolog, by Drs. Michael P. Federle, Peter D. Poullos, and Sidhartha Sinha, is an authoritative, single-volume resource that provides clear, relevant imaging information for the diagnosis and management of adult GI and hepatobiliary disorders. Easy-to-understand terminology, anatomy chapters tailored for gastroenterologists, and superb images throughout make this an ideal point-of-care reference for practicing physicians, fellows, and residents in gastroenterology. Provides introductory background information, normal imaging anatomy, and radiology terminology relevant to gastroenterologists Features high-quality images with detailed, easy-to-understand captions, and presents information in a bulleted, templated format for quick reference Details how to choose between different imaging tests in evaluating specific clinical situations, including the strengths and weaknesses of those tests Covers imaging evaluation of the "incidental" pancreatic or hepatic cystic mass; GI motility disorders; the evolving role of fluoroscopy, CT and MR enterography, and the advantages and limitations of each study; imaging evaluation and interventional techniques for GI bleeding and hepatic and biliary malignancies; and much more
GI/Liver Secrets Plus, 4th Edition, by Peter R. McNally, DO, FACP, FACG - a volume in the popular Secrets Series® - uses a convenient Q&A approach to provide rapid reference and review of today's most common GI and liver disorders and their management. An expanded size and layout, user-friendly two-color page layout, question-and-answer approach, and list of the "Top 100 GI/Liver Secrets" make it a perfect concise board review tool and a handy clinical reference. Updated coverage throughout equips you with all of the most current and essential knowledge in the field. Uses bulleted lists, tables, boxes, short answers, and a highly detailed index to expedite reference. Includes Key Points and memory aids in each chapter that make it perfect for board review or clinical reference. Covers all of today's most common GI and liver disorders and their management. Features the new "Secrets PLUS" format - with an expanded size and layout, more information, and more visual elements - for easier review and an overall enhanced reference experience. Contains new images and illustrations to provide more detail and offer a clearer picture of what is seen in practice. Incorporates revisions throughout to provide you with an up-to-date overview of gastroenterology and hepatology, including new chapters on Esophageal and Stomach Pathology, Pathology of the Lower GI Tract, Gastroesophageal Reflux and Esophageal Hernias, and Surgery of Achalasia and Esophageal Cancer. Offers reorganized and expanded sections covering the bowels and colon for more specific and easier reference: Small and Large Bowel Disorders; Colon Disorders; and General Symptoms and Conditions.
This thorough examination of the roots and motivations for U.S. national security space policy provides an essential foundation for considering current space security issues. During the Cold War era, space was an important arena for the clashing superpowers, yet the United States government chose not to station weapons there. Today, new space security dynamics are evolving that reflect the growing global focus upon the broad potential contributions of space capabilities to global prosperity and security. Space and Security: A Reference Handbook examines how the United States has developed and implemented policies designed to use space capabilities to enhance national security, providing a clear and complete evaluation of the origins and motivations for U.S. national security space policies and activities. The author explains the Eisenhower Administration's quest to develop high-technology intelligence collection platforms to open up the closed Soviet state, and why it focused on developing a legal regime to legitimize satellite overflight for the purposes of gathering intelligence.
For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Gastrointestinal and Liver Secrets, 6th Edition (formerly known as GI/Liver Secrets), offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets’ popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style – making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series® format gives you the most return for your time – succinct, easy to read, engaging, and highly effective. Fully revised and updated throughout, making it an excellent resource for understanding the physiology and therapy of hepatic and digestive disease. New chapters on Microbiome and Surgery for Inflammatory Bowel Disease. Top 100 Secrets provide a fast overview of the secrets you must know for success in practice and on exams. More than 250 full-color illustrations, endoscopic images, micrographs, and algorithms, plus videos and clinical vignettes online. Bulleted lists, mnemonics, practical tips from global leaders in the field – all providing a concise overview of important board-relevant content. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime.
Modern American verse was born in an explosion of creative energy, breaking from traditional poetic forms to create fascinating and wholly original work. The launching pad for legends such as E.E. Cummings, Carl Sandburg and Wallace Stevens, the free verse scene fostered the talents of dozens of writers who are largely forgotten by the general reading public. The New Pagans aims to right history's wrongs by collecting the best work from these neglected heroes of modernist poetry in a bold anthology, spotlighting the efforts of writers whose voices were as brave as they were unique. Featuring poetry by Amy Lowell, Babette Deutsch, Malcolm Cowley, Yvor Winters, Glenway Wescott and many others.
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Hailed as a groundbreaking and important textbook upon its initial publication, the latest iteration of Product Design for Manufacture and Assembly does not rest on those laurels. In addition to the expected updating of data in all chapters, this third edition has been revised to provide a top-notch textbook for university-level courses in product
This best-selling emergency department reference is now in its thoroughly updated Fifth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
Stay up to date on today's most common GI and liver disorders and their management with GI/Liver Secrets Plus. This enhanced medical reference book is an excellent resource for understanding the physiology and therapy in hepatic and digestive disease. Whether preparing for an exam or quickly checking a clinical question, the user-friendly Secrets Series® style makes this book a valuable addition to your library! Easily locate important information with bulleted lists, tables, boxes, short answers, and a highly detailed index to expedite reference. Access a broad range of topics that focus on all of today's most common GI and liver disorders and their management. Apply the latest knowledge and techniques with content thoroughly updated by leaders in the field. Quickly review key concepts with improved "Plus" formatting, which employs a Socratic Q&A approach designed to simulate the types of questions that may be used on patient rounds. Enhance your reference power through bulleted lists, mnemonics, "Key Points" summaries, lists of useful web sites, and practical tips from the authors. Improve content knowledge with a special chapter containing "Top 100 Secrets," providing an overview of essential material for last-minute study or self-assessment. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
Genetics of Complex Disease examines how the identification of genetic variations that increase or reduce the risk of common, genetically complex, diseases can be used to improve our understanding of the pathology of many common diseases; enable better patient management and care; and help with differential diagnosis. It starts with the quest
This book is for students, doctors and indeed for all concerned with evidence-based drug therapy. A knowledge of pharmacological and therapeutic principles is essential if drugs/medicines are to be used safely and effectively for increasingly informed and critical patients. Doctors who understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more successfully than those who do not. The principles involved are neither so numerous nor so difficult to understand as to deter any prescriber, including those whose primary interests lie elsewhere than in pharmacology. All who use drugs cannot escape either the moral or the legal 'duty of care' to prescribe in an informed and responsible way. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. New colour design Increased use of graphics Slightly shorter by removal of out of date material
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. Access the entire text and illustrations online, fully searchable, at Expert Consult.
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