This up-to-the-minute reference explores current trends, disease etiology and associations, novel assessment tools, and modern laboratory tests to promote coordinated treatment of comorbid substance abuse, psychiatric disease, and general medical conditions-recognizing the causal relationship between substance abuse and medical and psychiatric diso
Food Microbiology by Adams and Moss has been a popular textbook since it was first published in 1995. Now in its fourth edition, Peter McClure joins the highly successful authorship in order to bring the book right up to date. Maintaining its general structure and philosophy to encompass modern food microbiology, this new edition provides updated and revised individual chapters and uses new examples to illustrate incidents with particular attention being paid to images. Thorough and accessible, it is designed for students in the biological sciences, biotechnology and food science as well as a valuable resource for researchers, teachers and practising food microbiologists.
Peter David's study on the Epistle of James is a contribution to The New International Greek Testament Commentary, a series based on the UBS Greek New Testament, which attempts to provide thorough exegesis of the text that is sensitive to theological themes as well as to the details of the historical, linguistic, and textual context.
This best-selling emergency department reference is now in its thoroughly updated Fourth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department. Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments.
DIGITAL SPEECH TRANSMISSION AND ENHANCEMENT Enables readers to understand the latest developments in speech enhancement/transmission due to advances in computational power and device miniaturization The Second Edition of Digital Speech Transmission and Enhancement has been updated throughout to provide all the necessary details on the latest advances in the theory and practice in speech signal processing and its applications, including many new research results, standards, algorithms, and developments which have recently appeared and are on their way into state-of-the-art applications. Besides mobile communications, which constituted the main application domain of the first edition, speech enhancement for hearing instruments and man-machine interfaces has gained significantly more prominence in the past decade, and as such receives greater focus in this updated and expanded second edition. Readers can expect to find information and novel methods on: Low-latency spectral analysis-synthesis, single-channel and dual-channel algorithms for noise reduction and dereverberation Multi-microphone processing methods, which are now widely used in applications such as mobile phones, hearing aids, and man-computer interfaces Algorithms for near-end listening enhancement, which provide a significantly increased speech intelligibility for users at the noisy receiving side of their mobile phone Fundamentals of speech signal processing, estimation and machine learning, speech coding, error concealment by soft decoding, and artificial bandwidth extension of speech signals Digital Speech Transmission and Enhancement is a single-source, comprehensive guide to the fundamental issues, algorithms, standards, and trends in speech signal processing and speech communication technology, and as such is an invaluable resource for engineers, researchers, academics, and graduate students in the areas of communications, electrical engineering, and information technology.
This book addresses all those interested in the origins, development and fate of intelligent species in the observable part of our universe. In particular, the author scrutinizes what kind of information about extraterrestrial intelligent life can be inferred from our own biological, cultural and scientific evolution and the likely future of mankind. The first part of the book provides the necessary background information from space and life sciences, thus making the book also accessible to students and the scientifically educated layman. -The first book of its kind that goes beyond the popular science level.
EXECUTIVE SUMMARY AND KEY RECOMMENDATIONS The nature of the problem: • Geographical inequalities in the UK are a longstanding and persistent problem rooted in deepseated and cumulative processes of local and regional divergence with antecedents in the inter-war years and accelerating since the early 1980s. • This spatial divergence has been generated by the inability of some places to adapt to the emergence of the post-industrial service and knowledge-based economy whose geographies are very different from those of past heavy industries. As a consequence, the "left behind" problem has become spatially and systemically entrenched. • Challenging ideas of market-led adjustment, there is little evidence that real cost advantages in Northern areas are correcting and offsetting the geographically differentiated development of skilled labour and human capital and the quality of residential and business environments. • A variety of different types of "left behind place" exist at different scales, and these types combine common problems with distinctive economic trajectories and varied causes. These different types will need policies that are sensitive and adaptive to their specific problems and potentialities. • Contemporary economic development is marked by agglomeration in high-skilled and knowledge-intensive activities. Research-based concentrations of high-skilled activity in the UK have been limited and concentrated heavily in parts of London and cities in the Golden Triangle, especially Oxford and Cambridge. Even in London, the benefits have been unevenly spread between boroughs. • Existing analyses of the predicaments of left behind places present a stark division between rapid growth in "winning" high-skilled cities and relative decline in "losing" areas. This view is problematic because it oversimplifies the experience in the UK and other countries. A false binary distinction is presented to policymakers which offers only the possibility of growth in larger cities and derived spillovers and other compensations elsewhere. • Yet, the post-industrial economy involves strong dispersal of activity and growth to smaller cities, towns and rural areas. However, this process has been highly selective between local areas and needs to be better understood. The institutional and policy response: • Past policies in the UK have lacked recognition of the scale and importance of the left behind problem and committed insufficient resources to its resolution. The objective of achieving a less geographically unequal economy has not been incorporated into mainstream policymaking. When compared with other countries, the UK has taken an overcentralized, "top-down" approach to policy formulation and implementation, often applying "one size fits all" policy measures to different geographical situations. • Political cycles have underpinned a disruptive churn of institutions and policies. In contrast with other Organisation for Economic Co-operation and Development (OECD) countries, particularly in Europe, there has been limited long-term strategy and continuity, and inadequate development of local policymaking capacity and capabilities, especially for research, analysis, monitoring and evaluation. • Past policies have been underfunded, inconsistent, and inadequately tailored and adapted to the needs of different local economies. We estimate that, on average over the period 1961–2020, the UK government invested on average £2.9 billion per annum in direct spatial policy (2020 prices), equivalent to around 0.15% of gross national income (GNI) per annum over the period. European Union Structural and Cohesion Policy support has added around 0.12% GNI (2020 prices) per annum to this over the period from the late 1970s. • These broad estimates suggest that discretionary expenditure in the UK on urban and regional policy when both domestic and European Union spatial policy was in operation was equivalent to 0.27% per annum of UK GNI (2020 prices). This is dwarfed by mainstream spending programmes (by comparison, the UK committed £14.5 billion (0.7% of GNI) to international aid in 2019). The level of resources devoted to spatial policy has been modest given the entrenched and cumulative nature of the problem. • Policies for "levelling up" need clearly to distinguish different types of left behind places and devise a set of place-sensitive and targeted policies for these types of "clubs" of left behind areas. This shift will need a radical expansion of "place-based" policymaking in the UK which allows national and local actors to collaborate on the design of appropriate targeted programmes. • A key priority for "levelling up" is revitalizing Northern cities and boosting their contribution to the national economy. Underperformance in these urban centres has been a major contributor to persistent geographical inequality in the UK. • Addressing the UK’s geographical economic inequalities and the plight of left behind places requires substantially more decentralization of power and resources to place-based agencies. This would enable the current UK government’s "levelling up" agenda to capitalize on the many advantages of more "place-based" policymaking to diagnose problems, build on local capabilities, strengthen resilience and adapt to local changes in circumstances. • Crucially, place-based efforts need to be coordinated and aligned with place-sensitive national policies. The key challenge of a levelling up mission is to integrate "place-based" policies with greater place sensitivity in national policies and in regulation and mainstream economic spending. • It is important to develop policies that spread the benefits from agglomeration and ensure that the income effects and innovations produced by high-skill concentrations diffuse to the wider cityregional economies and their firms (especially small and medium-sized enterprises) and workers. There is a clear need for more policy thinking on how this can be achieved. • Policy for levelling-up needs to align and coordinate with the other national missions for net zero carbon and post-pandemic recovery. This suggests that a strong "place-making" agenda focused on quality of life, infrastructure and housing in many left behind places is important for post-industrial and service growth. • Genuine place-making is a long-term process involving public, private and civic participation which allows local responses to those economic, environmental, and social constraints and problems that most strongly reduce the quality of life in local areas. A truly "total place" approach is required. The quality of infrastructure, housing stock and public services is crucial for the quality of place as well as the ability to secure and attract more dispersed forms of growth. There is little hope of delivering "place-making" if public sector austerity is once again allowed to cut back public services more severely in poorer and more deprived areas. The way forward: • The scale and nature of the UK’s contemporary "left behind places" problem are such that only a transformative shift in policy model and a resource commitment of historic proportions are likely to achieve the "levelling up" ambition that is central to the current government’s political ambitions. KEY RECOMMENDATIONS In summary, our recommendations are that the UK government should: • Grasp the transformative moment for local, regional and urban development policy as the UK adjusts to a post-Covid-19 world and seeks a net zero carbon future. • Establish a clear and binding national mission for "levelling up". • Realize the potential of place in policymaking. • Decentralize and devolve towards a multilevel federal polity. • Strengthen subnational funding and financing and adopt new financing models involving the public, private sector and civic sectors to generate the resources required. • Embed geography in the national state and in national policy machinery. • Improve subnational strategic research, intelligence, monitoring and evaluation capacity. A failure to learn from the lessons of the last 70 years of spatial policy risks the UK becoming an ever more divided nation, with all the associated economic, social and political costs, risks and challenges that this presents.
This book is the first comprehensive and authoritative analysis of the New Deal and examines how far the programme has succeeded in responding to the diversity of conditions in local labour markets across the UK. Argues that profound differences in local labour market conditions have exerted a telling influence on the New Deal’s achievements Includes extensive new research data on the current conditions of local labour markets in the UK and local impacts of the New Deal Illustrated by a large series of original maps and figures. Based on numerous interviews with local and regional policy actors.
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. - Provides a comprehensive review of the growing literature in C-furanosides - Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases - Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
Among all the numerical methods in seismology, the finite-difference (FD) technique provides the best balance of accuracy and computational efficiency. This book offers a comprehensive introduction to FD and its applications to earthquake motion. Using a systematic tutorial approach, the book requires only undergraduate degree-level mathematics and provides a user-friendly explanation of the relevant theory. It explains FD schemes for solving wave equations and elastodynamic equations of motion in heterogeneous media, and provides an introduction to the rheology of viscoelastic and elastoplastic media. It also presents an advanced FD time-domain method for efficient numerical simulations of earthquake ground motion in realistic complex models of local surface sedimentary structures. Accompanied by a suite of online resources to help put the theory into practice, this is a vital resource for professionals and academic researchers using numerical seismological techniques, and graduate students in earthquake seismology, computational and numerical modelling, and applied mathematics.
This key new book synthesises Peter Buckley's work on ‘the global factory’ – the modern networked multinational enterprise. The role of interfirm networks, entrepreneurship and cooperation in the creation and management of global factories leads to a discussion of their governance, internal knowledge transfer strategies and performance, including their role in potentially combating societal failures. Emerging country multinationals are examined as a special case of global factories with a focus on Indian and Chinese multinationals, their involvement in tax havens and offshore financial centres, the performance and processes of their acquisition strategies – all seen as key aspects of globalisation.
A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems. This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.
The 2004 World Health Day is dedicated to the theme of road safety by the World Health Organization (WHO) due mostly to the enormous socio economic costs attributed to trafik accidents. More than 140,000 people are injured, 3,000 killed, and 15,000 disabled for life everyday on the world's roads. The field of trauma biomechanics, or injury biomechanics, uses the principles of mechanics to study the response and tolerance level of biological tissues under extreme loading conditions. Through an understanding of mechanical factors that influence the function and structure of human tissues, countermeasures can be developed to alleviate or even eliminate such injuries. This book, Trauma-Biomechanics, surveys a wide variety of topics in injury biomechanics including anatomy, injury c1assification, injury mechanism, and injury criteria. It is the first collection I am aware of that lists regional injury reference values, or injury criterion, either currently in use or proposed by both U. S. and European communities. Although the book is meant to be an introduction for medical doctors and engineers who are beginners in the field of injury biomechanics, sufficient references are provided for those who wish to conduct further research, and even established researchers will find it useful as a reference for finding the biomechanical background of each proposed injury mechanism and injury criterion.
As the twenty-first century begins, significant changes are occurring in the way that services and goods are produced and consumed. One of the key drivers of this change is information and communications technology (ICT). It has transformed the role of space and time in patterns of economic development, in the rise of globalization and in the scale and structure of organizations. ICT has therefore accelerated the process of continual change and evolution that is the hallmark of both the capitalist economy and of organizations. Giving a student-friendly account of the diversity of theoretical perspectives, this outstanding book aids understanding the evolving economic geography of advanced capitalist economies. A series of detailed firm and employees' case studies from Europe, North America and the Asia Pacific, are used to inform useful theoretical case studies, which also investigate the significance of increased blurring of the lines between services and manufacturing functions in the production and consumption process.
The Action Plan for Australian Mammals 2012 is the first review to assess the conservation status of all Australian mammals. It complements The Action Plan for Australian Birds 2010 (Garnett et al. 2011, CSIRO Publishing), and although the number of Australian mammal taxa is marginally fewer than for birds, the proportion of endemic, extinct and threatened mammal taxa is far greater. These authoritative reviews represent an important foundation for understanding the current status, fate and future of the nature of Australia. This book considers all species and subspecies of Australian mammals, including those of external territories and territorial seas. For all the mammal taxa (about 300 species and subspecies) considered Extinct, Threatened, Near Threatened or Data Deficient, the size and trend of their population is presented along with information on geographic range and trend, and relevant biological and ecological data. The book also presents the current conservation status of each taxon under Australian legislation, what additional information is needed for managers, and the required management actions. Recovery plans, where they exist, are evaluated. The voluntary participation of more than 200 mammal experts has ensured that the conservation status and information are as accurate as possible, and allowed considerable unpublished data to be included. All accounts include maps based on the latest data from Australian state and territory agencies, from published scientific literature and other sources. The Action Plan concludes that 29 Australian mammal species have become extinct and 63 species are threatened and require urgent conservation action. However, it also shows that, where guided by sound knowledge, management capability and resourcing, and longer-term commitment, there have been some notable conservation success stories, and the conservation status of some species has greatly improved over the past few decades. The Action Plan for Australian Mammals 2012 makes a major contribution to the conservation of a wonderful legacy that is a significant part of Australia’s heritage. For such a legacy to endure, our society must be more aware of and empathetic with our distinctively Australian environment, and particularly its marvellous mammal fauna; relevant information must be readily accessible; environmental policy and law must be based on sound evidence; those with responsibility for environmental management must be aware of what priority actions they should take; the urgency for action (and consequences of inaction) must be clear; and the opportunity for hope and success must be recognised. It is in this spirit that this account is offered.
Reproduction is among the most basic of human biological functions, both for our distant ancestors and for ourselves, whether we live on the plains of Africa or in North American suburbs. Our reproductive biology unites us as a species, but it has also been an important engine of our evolution. In the way our bodies function today we can see both the imprint of our formative past and implications for our future. It is the infinitely subtle and endlessly dramatic story of human reproduction and its evolutionary context that Peter T. Ellison tells in On Fertile Ground. Ranging from the latest achievements of modern fertility clinics to the lives of subsistence farmers in the rain forests of Africa, this book offers both a remarkably broad and a minutely detailed exploration of human reproduction. Ellison, a leading pioneer in the field, combines the perspectives of anthropology, stressing the range and variation of human experience; ecology, sensitive to the two-way interactions between humans and their environments; and evolutionary biology, emphasizing a functional understanding of human reproductive biology and its role in our evolutionary history. Whether contrasting female athletes missing their periods and male athletes using anabolic steroids with Polish farm women and hunter-gatherers in Paraguay, or exploring the intricate choreography of an implanting embryo or of a nursing mother and her child, On Fertile Ground advances a rich and deeply satisfying explanation of the mechanisms by which we reproduce and the evolutionary forces behind their design.
This volume seeks to contribute to an interdisci-plinary, comparative, and historical study of Western welfare states. It attempts to link their historical dynamics and contemporary problems in an international perspective. Building on collaboration between European-and American-based research groups, the editors have coordinated contributions by economists, political scientists, sociologists, and historians. The developments they analyze cover a time span from the initiation of modern national social policies at the end of the nineteenth century to the present. The experiences of all the presently existing Western European systems except Spain and Por-tugal are systematically encompassed, with com-parisons developed selectively with the experi-ences of the United States and Canada. The devel-opment of the social security systems, of public expenditures!and taxation, of public education and educational opportunities, and of income inequal-ity are described, compared, and analyzed for varying groupings of the Western European and North American nations. This volume addresses itself mainly to two audi-ences. The first includes all students of policy problems of the welfare states who seek to gain a comparative perspective and historical under-standing. A second group may be more interested in the theory and empirical analysis of long-term societal developments. In this context, the growth of the welfare states ranges as a major departure, along with the development of national states and capitalist economies. The welfare state is interpreted as a general phenomenon of modernization, as a product of the increasing differentiation and the growing size of societies on the one hand, and of processes of social and political mobilization on the other. It is an important element of the structural convergence of modern societies by its mere weight in all countries and at the same time a source of divergence by the variations within its institutional structure.
Using formal descriptions, graphical illustrations, practical examples, and R software tools, Introduction to Multivariate Statistical Analysis in Chemometrics presents simple yet thorough explanations of the most important multivariate statistical methods for analyzing chemical data. It includes discussions of various statistical methods, such as
This detailed and comprehensive identification guide follows in the mould of Sylvia Warblers and Pipits and Wagtails. It primarily covers the genera Acrocephalus, Locustella, Cettia and Bradypterus, together with a few smaller related genera. To the uninitiated, these are the archetypal 'little brown jobs' and as if they weren't hard enough to identify anyway, many of them are hard to see as well! This authoritative handbook covers their identification in breathtaking detail, illustrated with line drawings, sonograms, wonderful colour plates and photographs. It is destined to become the ultimate reference for these challenging birds.
The definitive text on globalization, this book provides an accessible, jargon-free analysis of how the world economy works and its effects on people and places. Peter Dicken synthesizes the latest ideas and empirical data to blaze a clear path through the thicket of globalization processes and debates. The book highlights the dynamic interactions among transnational corporations, nations, and other key players, and their role in shaping the uneven contours of development. Mapping the changing centers of gravity of the global economy, Dicken presents in-depth case studies of six major industries. Now in full color throughout, the text features 228 figures. Companion websites for students and instructors offer extensive supplemental resources, including author videos, applied case studies with questions, lecture notes with PowerPoint slides, discipline-specific suggested further reading for each chapter, and interactive flashcards. New to This Edition: *Every chapter thoroughly revised and updated. *All 228 figures (now in color) are new or redesigned. *Addresses the ongoing fallout from the recent global financial crisis. *Discussions of timely topics: tax avoidance and corporate social responsibility; global problems of unemployment, poverty, and inequality; environmental degradation; the Eurozone crisis; and more. *Enhanced online resources for instructors and students.
Intended for cell biologists, biophysicists, biochemists, molecular biologists, physiologists, researchers in hemostatsis and thrombosis and pathologists, this book provides an insight into cell adhesion from three interdisciplinary perspectives: fundamental facts of adhesion; molecular biochemistry of adhesion and physiological aspects. It summarizes the basic aspects of surfaces in general and describes the theoretical and experimental tools necessary to investigate cell adhesion, including the basic biochemistry and molecular biology of adhesion. The book offers concise treatment of individual topics, features current material, and provides key references as a guide to further study.
Hypermobility of Joints 4th Edition follows the same format as its successful predecessors. The aim of which was to provide an overview of hyperlaxity of joints and this edition follows that aim by describing the most recent research and new developments in biochemistry, as well as providing practical advice on clinical features and management. Hypermobility of Joints 4th Edition provides illustrative case histories, a review of hypermobility in the performing arts and sports and an outline of heritable hypermobility syndromes. This book is a valuable reference tool for a wide number of specialties, although it will particularly be of interest to rheumatologists, orthopedic surgeons and medical geneticists.
This 3e, edited by Peter M. Martin, PNNL 2005 Inventor of the Year, is an extensive update of the many improvements in deposition technologies, mechanisms, and applications. This long-awaited revision includes updated and new chapters on atomic layer deposition, cathodic arc deposition, sculpted thin films, polymer thin films and emerging technologies. Extensive material was added throughout the book, especially in the areas concerned with plasma-assisted vapor deposition processes and metallurgical coating applications.
An introductory text that explores Psychology's major theories, and the evidence that supports and refutes them. This title incorporates research, helping students to probe for the purposes and biological origins of behavior - the 'whys' and 'hows' of Human Psychology.
Obtain the best outcomes from the latest techniques with help from a "who's who" of orthopaedic trauma experts! In print and online, you'll find the in-depth knowledge you need to manage any type of traumatic injury in adults. Major updates keep you up to speed on current trends such as the management of osteoporotic and fragility fractures, locked plating technology, post-traumatic reconstruction, biology of fracture repair, biomechanics of fractures and fixation, disaster management, occupational hazards of radiation and blood-borne infection, effective use of orthotics, and more. A DVD of operative video clips shows you how to perform 25 key procedures step by step. A new, full-color page layout makes it easier to locate the answers you need quickly. And now, for the first time, you can access the complete contents online, for enhanced ease and speed of reference! Complete, absolutely current coverage of relevant anatomy and biomechanics, mechanisms of injury, diagnostic approaches, treatment options, and associated complications equips you to confidently approach every form of traumatic injury. Enhanced and updated coverage keeps you current on the latest knowledge, procedures, and trends - including post-traumatic reconstruction, management of osteoporotic and fragility fractures, locked plating systems, mini incision techniques, biology of fracture repair, biomechanics of fractures and fixation, disaster management, occupational hazards of radiation and blood-borne infection, effective use of orthotics, and much more. More than six hours of operative videos on DVD demonstrate 25 of the very latest and most challenging techniques in real time, including minimally invasive vertebral disc resection, vertebroplasty, and lumbar decompression and stabilization. Online access allows you to rapidly search the complete contents from any computer. New editor Christian Kretek contributes additional international expertise to further enhance the already exceptional editorial lineup. An all-new, more user-friendly full-color text design enables you to find answers more quickly, and more efficiently review the key steps of each operative technique. More than 2,400 high-quality line drawings, diagnostic images, and full-color clinical photos show you exactly what to look for and how to proceed.
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