What determines whether complex life will arise on a planet, or even any life at all? Questions such as these are investigated in this groundbreaking book. In doing so, the authors synthesize information from astronomy, biology, and paleontology, and apply it to what we know about the rise of life on Earth and to what could possibly happen elsewhere in the universe. Everyone who has been thrilled by the recent discoveries of extrasolar planets and the indications of life on Mars and the Jovian moon Europa will be fascinated by Rare Earth, and its implications for those who look to the heavens for companionship.
Following recent high profile cases of surgical error in the UK and USA, patient safety has become a key issue in healthcare, now placed at heart of junior doctor's training. Errors made by doctors are very similar to those made in other high risk organisations, such as aviation, nuclear and petrochemical industries. Practical Patient Safety aims to demonstrate how core principles of safety from these industries can be applied in surgical and medical practice, in particular through training for health care professionals and healthcare managers. Whilst theoretical aspects of risk management form the backdrop, the book focuses on key techniques and principles of patient safety in a practical way, giving the reader practical advice on how to avoid personal errors, and more importantly how to start patient safety training within his or her department or hospital.
This title is a practical guide to the detection and remedy of faults in claddings and fixings on buildings. It sets out the problems involved in common cladding systems for buildings, and relates these problems to all the materials used: stone, masonry, concrete and glass-reinforced composites.
Drawing on an innovative project exploring current mobility transition policies and practices in 14 countries around the world, including key institutions such as the European Union and the United Nations, this book provides a critique of current transitions, mobility and transport policies. The authors consider how our mobility futures have been imagined, what they will potentially look and feel like, what lives we might live in them and what choices we might have to make to get there.
This book throws new light on the impact of informal ‘old boy’ networks on British decolonisation. Duncan Sandys was one of the leading Conservative politicians of the middle decades of twentieth-century Britain. He was also a key figure in the Harold Macmillan’s ‘Winds of Change’ policy of decolonisation, serving as Secretary for the Colonies and Commonwealth Relations from 1960 to 1964. When he lost office he fought strenuously to undermine the new Labour Government’s attempts to accelerate colonial withdrawal and improve race relations in Britain. Sandys developed important private business interests in Africa and intervened personally through both public and official channels on the question of Rhodesia, Commonwealth immigration and the ‘East of Suez’ withdrawal in the late 1960s. This book will appeal to students of decolonisation and twentieth-century British politics alike.
The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.
The Seeker’s Guide to Faith confronts and answers the thirteen principal arguments against God that are now advanced by modern secularist movement (sometimes called New Atheism) using the powerful insights and teachings of The Church of Jesus Christ of Latter-day Saints. There are many books written to encourage faith for people who are experiencing doubts about God generally. However, this book is the only one of its kind by a Latter-day Saint author that directly and specifically challenges all the main arguments against faith in God that are now aggressively asserted by the belligerent modern secular movement. Its uniqueness is enhanced by the fact that the doctrines and teachings of The Church of Jesus Christ of Latter-day Saints are used whenever applicable to effectively answer the challenges raised by this movement. This author believes that the unique teachings and insights of the Church are better suited than those of any other faith for answering those challenges. Furthermore, the author’s professional and volunteer activities have afforded him the opportunity to know and work with people of nearly all religious backgrounds, in nearly all walks of life. Recent experiences have led him to examine the reasons many apparently intelligent people reject faith. His legal background and training have aided him in spotting and understanding the weaknesses and flaws of the logical underpinnings of atheism. His Gospel upbringing as a member of The Church of Jesus Christ of Latter-day Saints has helped him see through the fog of the dogma and arguments of atheism to the “More Excellent Way” afforded by the Gospel’s plan of happiness. He hopes The Seeker’s Guide to Faith will help others who stand at the crossroads of their doubts to find their faith in Heavenly Father and His Son, Jesus Christ.
This acclaimed book provides a topical and contextual outline of the principles, doctrines and institutions that underpin the United Kingdom constitution. The second edition of The Constitution of the United Kingdom has been extensively rewritten to take account of recent constitutional developments, particularly changes made following the 2010 general election. The chapters are written in sufficient detail for anyone coming to the subject for the first time to develop a clear and informed view of how the constitution is arranged and how it operates. The main themes include: discussion of the history, sources and conventions of the constitution; later chapters deal with: constitutional principles, the role of the Crown, Parliament and the electoral system, government and the executive, the constitutional role of courts including the protection of human rights, the territorial distribution of power between central, devolved and local government, and the European Union dimension. In addition, the book offers an analytical discussion of the development of the constitution, its strengths and perceived weaknesses, and of reforms aimed at its modernisation.
This volume presents an original view of the culture of early modern Italy. The book addresses particular themes - specifically those of perception and communication - as well as serving to exemplify modes of analysis in the currently developing field of historical anthropology.
This volume provides up-to-date and nuanced analysis across a wide spectrum of capital punishment issues. The essays move beyond the conventional legal approach and propose fresh perspectives, including a unique critique of the abolition sector. Written by a range of leading experts with diverse geographical, methodological and conceptual approaches, the essays in this volume challenge received wisdom and embrace a holistic understanding of capital punishment based on practical experience and empirical data. This collection is indispensable reading for anyone seeking a comprehensive and detailed understanding of the complexity of the death penalty discourse.
This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. Abstracts from the keynote addresses and invited talks are also included. The papers not only cover theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Whole-Genome Analysis of Dorsal Gradient Thresholds in the Drosophila Embryo (102 KB). Contents: Learning Predictive Models of Gene Regulation (C Leslie); Algorithms for Selecting Breakpoint Locations to Optimize Diversity in Protein Engineering by Site-Directed Protein Recombination (W Zheng et al.); Cancer Molecular Pattern Discovery by Subspace Consensus Kernel Classification (X Han); Transcriptional Profiling of Definitive Endoderm Derived from Human Embryonic Stem Cells (H Liu et al.); A Markov Model Based Analysis of Stochastic Biochemical Systems (P Ghosh et al.); Clustering of Main Orthologs for Multiple Genomes (Z Fu & T Jiang); Extraction, Quantification and Visualization of Protein Pockets (X Zhang & C Bajaj); Consensus Contact Prediction by Linear Programming (X Gao et al.); An Active Visual Search Interface for Medline (W Xuan et al.); Exact and Heuristic Algorithms for Weighted Cluster Editing (S Rahmann et al.); Reconcilation with Non-binary Species Trees (B Vernot et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. Graduate researchers in bioinformatics and computational biology.
A WWII Royal Navy commander recounts the struggle to control the narrow seas between Britain and the rest of Europe throughout the war. A Motor Torpedo Boat Commander in the Second World War, Sir Peter Scott—the son of explorer Robert Scott—was awarded the Distinguished Service Cross for his bravery in battle. Combining his own experience with extensive military research, he tells the story of the wide-ranging naval conflict against the Germans, fought in the congested waters of the Channel and the southern North Sea. Actions against convoys and E-boats, often under the shadows of French cliffs; an impossible sortie against Scharnhorst and Gneisenau as they ran the gauntlet through the Straits in February 1942; the attack on St Nazaire; and the defensive and offensive roles taken on by MTBs during the D-Day landings are just some of the events covered in the book. The bravery of the crews of these small ships became legendary. As the War dragged on, their exploits helped to raise the morale of the nation.
This book gives plenty of examples of ad hominem attacks, intimidation, slander, threats of litigation, deception, dishonesty, lies and other violations of good scientific practice. For some years I kept a folder labeled Dishonesty in breast cancer screening on top of my filing cabinet, storing articles and letters to the editor that contained statements I knew were dishonest. Eventually I gave up on the idea of writing a paper about this collection, as the number of examples quickly exceeded what could be contained in a single article.' From the Introduction The most effective way to decrease women's risk of becoming a breast cancer patient is to avoid attending screening. Mammography screening is one of the greatest controversies in healthcare, and the extent to which some scientists have sacrificed sound scientific principles in order to arrive at politically acceptable results in their research is extraordinary. In contrast, neutral observers increasingly find that the benefit has been much oversold and that the harms are much greater than previously believed. This groundbreaking book takes an evidence-based, critical look at the scientific disputes and the information provided to women by governments and cancer charities. It also explains why mammography screening is unlikely to be effective today. All health professionals and members of the public will find these revelations disturbingly illuminating. It will radically transform the way healthcare policy makers view mammography screening in the future. 'If Peter Gotzsche did not exist, there would be a need to invent him ...It may still take time for the limitations and harms of screening to be properly acknowledged and for women to be enabled to make adequately informed decisions. When this happens, it will be almost entirely due to the intellectual rigour and determination of Peter Gotzsche.' From the Foreword by Iona Heath, President, RCGP 'If you care about breast cancer, and we all should, you must read this book. Breast cancer is complex and we cannot afford to rely on the popular media, or on information from marketing campaigns from those who are invested in screening. We need to question and to understand. The story that Peter tells matters very much.' From the Foreword by Fran Visco, President, National Breast Cancer Coalition.
Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms
R. G. Collingwood is an important 20th-century historian, archaeologist and philosopher whose works are the subject of continued interest, analysis and study. There is an unquestionable need to support this research activity with the provision of a reference guide which is fully up-to-date, informed and authoritative. The Companion therefore lists all primary and secondary material relevant to the study of Collingwood in all his fields of expertise - historical theory, philosophy and archaeology. It also provides a guide to archive material relevant to his life, together with sources and locations. The resulting volume is an essential companion to the understanding of the life and thought of R. G. Collingwood.
This book examines conferences and commissions held for British colonial territories in East and Central Africa in the early 1960s. Until 1960, the British and colonial governments regularly employed hard methods of colonial management in East and Central Africa, such as instituting states of emergency and imprisoning political leaders. A series of events at the end of the 1950s made hard measures no longer feasible, including criticism from the United Nations. As a result, softer measures became more prevalent, and the use of constitutional conferences and commissions became an increasingly important tool for the British government in seeking to manage colonial affairs. During the period 1960-64, a staggering sixteen conferences and ten constitutional commissions were held for British colonies in East and Central Africa. This book is the first of its kind to provide a detailed overview of how the British sought to make use of these events to control and manage the pace of change. The author also demonstrates how commissions and conferences helped shape politics and African popular opinion in the early 1960s. Whilst giving the British government temporary respite, conferences and commissions ultimately accelerated the decolonisation process by transferring more power to African political parties and engendering softer perceptions on both sides. Presenting both British and African perspectives, this book offers an innovative exploration into the way that these episodes played an important part in the decolonisation of Africa. It shows that far from being dry and technical events, conferences and commissions were occasions of drama that tell us much about how the British government and those in Africa engaged with the last days of empire.
Ideal for neurosurgeons, neurologists, neuroanesthesiologists, and intensivists, Monitoring in Neurocritical Care helps you use the latest technology to more successfully detect deteriorations in neurological status in the ICU. This neurosurgery reference offers in-depth coverage of state-of-the-art management strategies and techniques so you can effectively monitor your patients and ensure the best outcomes. Understand the scientific basis and rationale of particular monitoring techniques and how they can be used to assess neuro-ICU patients. Make optimal use of the most advanced technology, including transcranial Doppler sonography, transcranial color-coded sonography, measurements of jugular venous oxygen saturation, near-infrared spectroscopy, brain electrical monitoring techniques, and intracerebral microdialysis and techniques based on imaging. Apply multimodal monitoring for a more accurate view of brain function, and utilize the latest computer systems to integrate data at the bedside. Access practical information on basic principles, such as quality assurance, ethics, and ICU design.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
This monumental text-reference places in clear persepctive the importance of nutritional assessments to the ecology and biology of ruminants and other nonruminant herbivorous mammals. Now extensively revised and significantly expanded, it reflects the changes and growth in ruminant nutrition and related ecology since 1982. Among the subjects Peter J. Van Soest covers are nutritional constraints, mineral nutrition, rumen fermentation, microbial ecology, utilization of fibrous carbohydrates, application of ruminant precepts to fermentive digestion in nonruminants, as well as taxonomy, evolution, nonruminant competitors, gastrointestinal anatomies, feeding behavior, and problems fo animal size. He also discusses methods of evaluation, nutritive value, physical struture and chemical composition of feeds, forages, and broses, the effects of lignification, and ecology of plant self-protection, in addition to metabolism of energy, protein, lipids, control of feed intake, mathematical models of animal function, digestive flow, and net energy. Van Soest has introduced a number of changes in this edition, including new illustrations and tables. He places nutritional studies in historical context to show not only the effectiveness of nutritional approaches but also why nutrition is of fundamental importance to issues of world conservation. He has extended precepts of ruminant nutritional ecology to such distant adaptations as the giant panda and streamlined conceptual issues in a clearer logical progression, with emphasis on mechanistic causal interrelationships. Peter J. Van Soest is Professor of Animal Nutrition in the Department of Animal Science and the Division of Nutritional Sciences at the New York State College of Agriculture and Life Sciences, Cornell University.
General Colin Gubbins was in charge of SOE during World War Two. This is the first biography of a man who was destined to live his life in the shadows. A biography of General Colin Gubbins, who was in charge of SOE during World War II. Gubbins was destined, by the nature of his profession, to live a secretive life, and the book, which incorporates much previously unpublished material, offers revelations about the man and his mysterious mission.
Audio Production Tips: Getting the Sound Right at the Source provides practical and accessible information detailing the production processes for recording today’s bands. By demonstrating how to "get the sound right at the source," author Peter Dowsett lays the appropriate framework to discuss the technical requirements of optimizing the sound of a source. Through its coverage of critical listening, pre-production, arrangement, drum tuning, gain staging and many other areas of music production, Audio Production Tips allows you to build the wide array of skills that apply to the creative process of music production. Broken into two parts, the book first presents foundational concepts followed by more specific production advice on a range of instruments. Key features: Important in-depth coverage of music theory, arrangement and its applications. Real life examples with key references to the author’s music production background. Presents concepts alongside the production of a track captured specifically for the book. A detailed companion website, including audio, video, Pro Tools session files of the track recording process, and videos including accompanying audio that can be examined in the reader’s DAW. Please visit the accompanying companion website, available at www.audioproductiontips.com, for resources that further support the book’s practical approach.
Now fully updated and totally revised, this highly regarded classic remains the most comprehensive study available of America’s military history. Called “the preeminent survey of American military history” by Russell F. Weigley, America’s foremost military historian, For the Common Defense is an essential contribution to the field of military history. This carefully researched third edition provides the most complete and current history of United States defense policy and military institutions and the conduct of America’s wars. Without diminishing the value of its earlier editions, authors Allan R. Millett, Peter Maslowski, and William B. Feis provide a fresh perspective on the continuing issues that characterize national security policy. They have updated the work with new material covering nearly twenty years of scholarship, including the history of the American military experience in the Balkans and Somalia, analyzing the wars in Iraq and Afghanistan from 2001 to 2012, and providing two new chapters on the Vietnam War. For the Common Defense examines the nation’s pluralistic military institutions in both peace and war, the tangled civil-military relations that created the country’s commitment to civilian control of the military, the armed forces’ increasing nationalization and professionalization, and America’s growing reliance on sophisticated technologies spawned by the Industrial Revolution and the Computer and Information Ages. This edition is also a timely reminder that vigilance is indeed the price of liberty but that vigilance has always been—and continues to be—a costly, complex, and contentious undertaking in a world that continually tests America’s willingness and ability to provide for the common defense.
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