This book offers the first comprehensive analysis after the Lisbon Treaty came into force of the EU Presidency's impact on national administrations in the Member States of Poland, Denmark and Cyprus before, during and after the Presidency. Placing the practical issues facing officials and policy-makers into a "governmentality" framework, it analyses the impact on the daily activities of bureaucrats and ministers. The book utilises comprehensive and novel empirical material including around 100 interviews with key officials, documentary sources and academic literature. It uncovers the kind of negotiations, management and coordination triggered by the immense challenge of presiding over the EU –including being a part of a Trio. This text will be of key interest to scholars, students of political science, European Union studies and public administration, as well as more broadly to Comparative Politics and International Relations. It will also be of interest to officials and policy members in EU Member states approaching the Presidency.
The book analyses the administrative system in the European Union with a focus on the efficiency and legitimacy of the administrative practices. In the analysis three distinct theoretical perspectives are used (a structural, a procedural and a cultural), thus ensuring that a broad variety of factors are included.
Hypnosis in the Management of Sleep Disorders combines history and medical science to show that the use of hypnosis and hypnotic techniques is effective in the treatment of sleep disorders -- and that this is increasingly validated through modern tools (computers, fMRI images). Dr. Kohler and Kurz show readers that hypnosis and hypnotic techniques are not to be feared or avoided, but that their use can contribute to effective, non-intrusive, and cost-effective approaches to the treatment of sleep problems. This volume is a much needed reference for therapists and their patients alike on how hypnosis can be helpful in the treatment of certain sleep disorders"--The publisher
In this book, Peter Juul Nielsen examines the foundations of morphological theory from a structural-functional perspective on language as a sign system. He offers a framework for the analysis of morpheme relations based on a thorough discussion of syntagmatic and paradigmatic structure, indexical relations, zero as meaningful absence and morphological relations across grammatical categories. It is argued that when paradigmatically related morphological structures have different syntactic functions, the semantics of the paradigmatic opposition consists in the specification of functional potential. The framework is applied in three detailed studies of Danish nonfinite verbs presenting new accounts of their morphological structure, semantic coding and paradigmatic organisation.
This book examines the European Union (EU) coordination of the G7, G8 and G20 (Gx). The author comprehensively maps out the different coordination processes for each Gx forum and assesses the procedures used, the actors involved as well as the evolution of the Gx forum over time.
This title features a collection of 14 papers in which contributors use diverging critical methods on a selection of extracts from Vergil's epic, with the examination of political references in the work being prominent, as well as the question of the Aeneid's central meaning. Contents include: Vergil announcing the Aeneid. On Geo. 3.1-48 (Egil Kraggerud); The Peopling of the Underworld (Anton Powell); Vergil as a Republican (Eckard Lefevre); The Sword-Belt of Pallas: Moral Symbolism and Political Ideology (Stephen Harrison); The Isolation of Turnus (Richard F. Thomas) and The End and the Meaning (David West)
First published in 1998, this volume is a study of Asger Jorn’s attempt to formulate the ‘first complete revision of the existing philosophical system’ from the standpoint of the artist in the period 1961-67. The Danish artist Asger Jorn (1914-73), painter, draughtsman, potter and sculptor, was one of the most prominent figures of his generation in Europe. His characteristic paintings were spontaneous, using energetic brushstrokes, splashing and spotting with a wide-ranging palette. Jorn’s eclectic intellect absorbed an astonishing range of influences and involved him in many causes, including an ambitious programme to re-publish, with commentary, material vital to Scandinavian cultural history. He was also a founder member of Cobra (1948-51) and subsequently several other international groupings, which coalesced in 1957 in the setting-up of the Situationist International with French and Italian writers and artists. Fascinated by the philosophical debate on the position of the artist in contemporary life and the artist’s relationship to the past, Jorn broke with the Situationist International in 1961 over the issue of whether an artist is an instigator of cultural change or only an instrument of political change. For the next four years, he committed himself to ‘a first complete revision of the existing philosophical system’ with the intention of placing the artist at the centre. Many of his ideas were first tried out in French in various Situationist publications and have since stirred considerable debate. His much more comprehensive texts in Danish of 1961-67 have never been made available in English. In Comparative Vandalism, Peter Shield offers the first detailed study of Jorn’s revision of modern philosophy, exploring the origins and formulation of his ideas. The book includes colour and black and white reproductions chosen from his mature work to illustrate the connection between his writing and painting.
An expert guide to contemporary research in the field of emergency services management, this short-form book will help academics, scholars, and practitioners to appreciate the important role and contribution of these services. Contemporary emergency services have been rapidly changing in response to increasing demand, reducing resources, the impact of COVID-19 and the increasingly complex threats to public safety. Academics, practitioners, the emergency services and their key stakeholders all need to have a clear understanding of the changing role and contribution of these services as well as finding ways to improve their management and performance so that policy solutions to new and emerging threats may be efficiently developed and effectively implemented. The book looks at the application of public management theories to emergency services and the development of professionalism within the police, fire and rescue, and ambulance services. It examines the increasing need for better collaboration and identifies the nature and extent of the academic and practitioner divide and the research gap between the academic and professional communities in each of the services. This book will be invaluable to researchers, scholars, practitioners, and students in the fields of governance, leadership, and management, especially those focusing on emergency services and management during crises.
In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).
Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally, the impact of contemporary memory research for psychiatry is illustrated.
In recent decades, international research on Virgil has been marked, if not dominated, by the ideas of the 'Harvard School' and similar trends, according to which the poet was engaged in an elaborate work of subtle subversion, directed against the new ruler of the Roman world, Octavian-Augustus. Much of Virgil's oeuvre consists prima facie of eulogy of the ruler, and of emphatic prediction of his enduring success: this is explained by numerous modern critics as generic convention, or as studied ambiguity, or as irony. This paradoxical position, which runs against ancient-as well as much modern-interpretation of the poet, continues to create widespread unease. Stahl's new monograph is the most thorough study so far to question modern Virgilian criticism on philological grounds. He based himself on the internal logic and rhetoric of the Aeneid, and considers also political, historical, archaeological and philosophical subjects addressed by the poem. He finds that the poet has so presented the morality of his central figure, Augustus' supposed ancestor Aeneas, and of those who (eventually) clash with him, Turnus and Dido, as to make it certain that Roman readers and hearers of the poem were meant to conclude in Aeneas' favour. Virgil's intention emerges from Stahl's thorough, ingenious and original argumentation as decisively pro-Augustan. Stahl's work, in short, will not only enliven debate on current critical hypotheses but for many will enduringly affect their credibility.
This book focuses on conflict, diplomacy and religion as factors in the relationship between Rome and Sasanian Persia in the third and fourth centuries AD. During this period, military conflict between Rome and Sasanian Persia was at a level and depth not seen mostly during the Parthian period. At the same time, contact between the two empires increased markedly and contributed in part to an increased level of conflict. Edwell examines both war and peace – diplomacy, trade and religious contact – as the means through which these two powers competed, and by which they sought to gain, maintain and develop control of territories and peoples who were the source of dispute between the two empires. The volume also analyses internal factors in both empires that influenced conflict and competition between them, while the roles of regional powers such as the Armenians, Palmyrenes and Arabs in conflict and contact between the two "super powers" receive special attention. Using a broad array of sources, this book gives special attention to the numismatic evidence as it has tended to be overshadowed in modern studies by the literary and epigraphic sources. This is the first monograph in English to undertake an in-depth and critical analysis of competition and contact between Rome and the early Sasanians in the Near East in the third and fourth centuries AD using literary, archaeological, numismatic and epigraphic evidence, and one which includes the complete range of mechanisms by which the two powers competed. It is an invaluable study for anyone working on Rome, Persia and the wider Near East in Late Antiquity.
How does science work? Does it tell us what the world is “really” like? What makes it different from other ways of understanding the universe? In Theory and Reality, Peter Godfrey-Smith addresses these questions by taking the reader on a grand tour of more than a hundred years of debate about science. The result is a completely accessible introduction to the main themes of the philosophy of science. Examples and asides engage the beginning student, a glossary of terms explains key concepts, and suggestions for further reading are included at the end of each chapter. Like no other text in this field, Theory and Reality combines a survey of recent history of the philosophy of science with current key debates that any beginning scholar or critical reader can follow. The second edition is thoroughly updated and expanded by the author with a new chapter on truth, simplicity, and models in science.
Freshwater turtles and goldfish can survive for several days without oxygen, some diving turtles for several months; hibernating animals can exist without food for long periods; others can survive extreme conditions such as desiccation, freezing, and thawing. These creatures are, in effect, self-sustaining life-support systems, with a mysterious ability to regulate their own metabolisms. These capabilities raise important questions, which Hochachka and Guppy explore in this seminal new book. What mechanisms turn down (or off) cell metabolism and other cell functions? How does an animal such as an opossum know when to activate mechanisms for slowing or stopping tissue and organ functions? How does it know when to turn them on again? How extensive is metabolic arrest as a defense against harsh environmental conditions? Can we decipher universal principles of metabolic arrest from available data? The lessons to be learned are of potentially great interest to clinicians, because the authors provide a theoretical framework in which to organize an attack on the all-too-practical problem of protecting tissues against hypoxia. Areas that may be influenced include research on cardiac arrest, strokes, acute renal failure, liver ischemia, lung injury, respiratory defense syndrome, claudication, shock, and organ transplant. Investigation of other metabolic arrest mechanisms may be similarly useful in both clinical and agricultural fields. This is a pioneering book of great use to biomedical/clinical researchers and to biologists, biochemists, and physiologists generally.
TRENDS IN LINGUISTICS is a series of books that open new perspectives in our understanding of language. The series publishes state-of-the-art work on core areas of linguistics across theoretical frameworks as well as studies that provide new insights by building bridges to neighbouring fields such as neuroscience and cognitive science. TRENDS IN LINGUISTICS considers itself a forum for cutting-edge research based on solid empirical data on language in its various manifestations, including sign languages. It regards linguistic variation in its synchronic and diachronic dimensions as well as in its social contexts as important sources of insight for a better understanding of the design of linguistic systems and the ecology and evolution of language. TRENDS IN LINGUISTICS publishes monographs and outstanding dissertations as well as edited volumes, which provide the opportunity to address controversial topics from different empirical and theoretical viewpoints. High quality standards are ensured through anonymous reviewing.
This volume showcases different forms of natural and non-professional translation and interpreting at work at multilingual sites in a single city, shedding new light on our understanding of the intersection of city, migration and translation. Flynn builds on work in translation studies, sociolinguistics, linguistic ethnography and anthropology to offer a translational perspective on scholarship on multilingualism and translation, focusing on examples from the superdiverse city of Ghent in Belgium. Each chapter comprises a different multilingual site, ranging from schools to eateries to public transport, and unpacks specific dimensions of translation practices within and against constantly shifting multilingual settings. The book also reflects on socio-political factors and methodological considerations of concern when undertaking such an approach. Taken together, the chapters seek to provide a composite picture of translation in a multilingual city, demonstrating how tracing physical, linguistic and social trajectories of movement in these contexts can deepen our understanding of the contemporary dynamics of multilingualism and natural translation and of translanguaging, more broadly. This book will be of interest to students and scholars in translation and interpreting studies, sociolinguistics, multilingualism, linguistic anthropology and migration studies.
This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear. Neurosurgical specimens from patients presenting with mesial temporal lobe epilepsy (MTLE) demonstrate marked reactive gliosis. Since recent studies have implicated astrocytes in important physiological roles in the CNS, such as synchronization of neuronal firing, it is plausible that they may also have a role in seizure generation and/or seizure spread. In support of this view, various membrane channels, receptors, and transporters in astrocytic membranes are altered in the epileptic brain. Excitingly, recent evidence suggests that in the course of the pathogenesis of MTLE, these glial changes alter homeostatic network functions and temporally precede the alterations in neurons. These findings might eventually classify MTLE as a glial rather than a neuronal disorder, and identify astrocytes as promising new targets for the development of more specific antiepileptogenic therapeutic strategies. Although research on astrocytes in epilepsy is still in its infancy, this book clearly demonstrates a critical role of astrocytes in the disturbance of K+ and transmitter homeostasis and its impact on seizure generation.
This comprehensive and comparative book makes clear what party families are and, in doing so, helps categorise and make sense of parties in different countries. It describes the ideology of the families in Western Europe as well as classifying political parties accordingly. Furthermore, the book examines who the party families’ supporters are in terms of their social background and political values. What role do class, education, and religion play in the 21st century? Finally, the book provides a discussion of the degree to which the concept of party families is still meaningful in the 21st century and how it needs to be studied comparatively and comprehensively. Is party family still valid as a conceptual device to classify and compare parties across countries in Western Europe? This text will be of key interest to scholars, students, and practitioners working in the field of political behaviour, political parties and party politics, policy studies, and more broadly comparative and European politics.
Meaning is embodied - but it is also social. If Cognitive Linguistics is to be a complete theory of language in use, it must cover the whole spectrum from grounded cognition to discourse struggles and bullshit. This book tries to show how. Cognitive Linguistics knocked down the wall between language and the experiential content of the human mind. Frame semantics, embodiment, conceptual construal, figure-ground organization, metaphorical mapping, and mental spaces are among the results of this breakthrough, which at the same time provided cognitive science as a whole with an essential human dimension. A new phase began when Cognitive Linguistics started to see itself as part of the wider movement of 'usage-based' linguistics. Bringing about an alliance between mind and discourse, it complemented the conceptual dimension that had been dominant until then with a 'use' dimension - thereby living up to the explicit 'experiential' commitment of Cognitive Linguistics. This outward expansion is continuing: The focus on 'meaning construction', which began with the theory of blending, highlights emergent, online effects rather than underlying mappings. Cognitive Linguistics is integrating the evolutionary perspective, which links up individual and population-based features of language. The empirical obligations incurred by this expansion have led to greatly increased attention to corpus and experimental methods, especially in relation to sociolinguistic and language acquisition research. The book describes this development and goes on to discuss the foundational challenge that it creates for Cognitive Linguistics as it begins to cover issues that are also central to types of discourse analysis focusing on social processes of determination. The book argues for a synthesis based on a renewed Cognitive Linguistics, which can accommodate everything from bodily grounding to deconstructible floating signifiers in an integrated complete picture, which also covers the roles of arbitrariness and structure.
A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems. This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.
The genetic correlates of neuropsychiatric disorders are now known, but none have come close to explaining the great variety of human psychiatric illnesses. This volume, written by a neuropsychiatrist and an evolutionary biologist, offers a new paradigm for understanding these disorders. Proposing that neuronal pathways which underlie neuropsychiatric conditions mirror unique human capabilities, the authors iterate a new paradigm by which to understand human psychiatric illnesses. Human capabilities such as theory of mind, language, and complex social behaviors are explored through their histological, neuroanatomical and functional brain imaging correlates. The capacity for representation, the authors suggest, is central to the understanding of the human brain. Brain structures such as the frontal pole, temporal pole, and fronto-insular cortex are highly developed in humans and are associated with representation. Other brain regions, including the dorsal anterior cingulate cortex, auditory cortex, and hippocampus, are linked with directed effort while the ventral anterior cingulate cortex, orbital frontal cortex, and amygdala are related to emotional encoding. Both networks interact with representional regions and the dorsolateral prefrontal cortex. Conditions like schizophrenia may result, in part, from a failure of the networks associated with directed effort while bipolar disorders may arise from a failure of networks associated with emotional encoding. Similarly, autism may result from a failure of representational brain regions; frontotemporal dementia may be associated with failure of several discrete networks in later life. From this perspective, neuropsychiatric disorders are selective failures of brain networks involved in the integration of cognition, affect and perception. A better understanding of these brain networks will assist psychiatric and mental health researchers in the search for environmental factors and genetic correlates of disorders as well as aid in the development of more effective treatments for these diseases. This volume will be of interest to psychiatrists, neurologists, psychologists, biologists, and imaging scientists--anyone who has ever wondered what makes the human brain human.
With concise, full-color coverage of this rapidly enlarging field, Critical Care Handbook of the Massachusetts General Hospital, Seventh Edition, is your go-to guide for practical, complete, and current information on medical and surgical critical care. Edited by Drs. Edward A. Bittner, Lorenzo Berra, Peter J. Fagenholz, Jean Kwo, Jarone Lee, and Abraham Sonny, this user-friendly handbook is designed for rapid reference, providing reliable, hospital-tested protocols that reflect today's most advanced critical care practices. An at-a-glance outline format and portable size make it an essential manual for medical students, residents with rotations in ICUs, and physicians and nurses who work in critical care.
How can our societies be stabilized in a crisis? Why can we enjoy and understand Shakespeare? Why are fruitflies uniform? How do omnivorous eating habits aid our survival? What makes the Mona Lisa’s smile beautiful? How do women keep our social structures intact? – Could there possibly be a single answer to all these questions? This book shows that the statement: "weak links stabilize complex systems" provides the key to understanding each of these intriguing puzzles, and many more besides. The author, a recipient of several distinguished science communication prizes, explains weak or low probability interactions, and uses them as connecting threads in a vast variety of networks from proteins to ecosystems. This unique book and the ideas it develops will have a significant impact on diverse, seemingly unrelated fields of study.
Surviving Hypoxia: Mechanisms of Control and Adaptation is a synthesis of findings and thoughts concerning hypoxia. The thermodynamics of hypoxia are discussed in detail, including acid-base balance and self-pollution resulting from the accumulation of anaerobic end-products. The book focuses on descriptions and discussions of common facets, contrasting solutions in a variety of physiological hypoxia defense strategies, including those shown by plants, invertebrates, and vertebrates. Special treatment is given to the distinctive problems that hypoxia presents to vulnerable organs such as the kidney, liver, and brain. It also addresses pathological events in addition to protective mechanisms. Clinical implications of basic research are examined in the book, which provides new insights into underlying pathological processes occuring in hypoxic-induced organ failure and indicates new paths for successful clinical intervention. Surviving Hypoxia: Mechanisms of Control and Adaptation is an excellent reference for all researchers interested in the physiological effects of hypoxia, underlying pathological events, and protective mechanisms.
Exploring British Politics is a concise, comprehensive, and accessible guide to the subject. Fully updated and revised, the new edition covers developments since 2016 in the role of the executive, parliament, the civil service, political parties, general elections, party ideology, and membership, as well as examining turmoil and leadership battles within the Labour and Conservative parties, the politics of growing inequality, public action and reaction, demographic trends and their political consequences, and the future of the UK itself. Stimulating critical analysis and lively debate, it provides new perspectives on two key themes – the health of British democracy and the transition from traditional models of government to more flexible forms of ‘governance’. Key features include: Comprehensive analysis of the 2019 general election, Brexit developments since the 2016 Referendum to today’s ongoing impacts, and the shadow cast by the COVID-19 global pandemic and its implications; Topical coverage of the fall of the Truss leadership, the new Johnson and Sunak era, the rise and fall of the ‘Change UK’ party, the economic crisis, the role of special advisers, new social movements such as Extinction Rebellion and Black Lives Matter, and much more; Extensive guides to further reading at the end of each chapter; Richly illustrated through examples and data, often visually represented; Online support in the form of a comprehensive website with additional content. Whilst the book provides an essential historical background, contemporary issues are to the fore throughout and readers are encouraged to assess critically received wisdoms and develop their own thoughts and ideas. Whether studying the subject for the first time or revisiting it, Exploring British Politics is the ideal undergraduate text.
Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.With contributions from Petronella L.M. Reijven. - Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectives - Highlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this response - Explains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory cause - Includes case studies and slides
Meningiomas, by M. Necmettin Pamir, MD, Peter M. Black, MD, PhD, and Rudolf Fahlbusch, MD, presents current and comprehensive guidance on this most common, yet clinically challenging type of brain tumor. Written and edited by the world’s most prominent brain tumor neurosurgeons, it helps you to not only determine the type and location of the tumor, but also the most ideal surgical approach to provide your patients with the best outcomes. An extensive collection of surgical photographs covers unique and original cases, while discussions of pre-surgical techniques and approaches emphasize decision making with the help of all imaging modalities and analysis of symptoms and patient history. Expert Consult functionality enhances your reference power with convenient online access to the complete text and illustrations from the book, along with videos that depict surgical techniques in real time. Provides access to the complete text online—fully searchable, along with all of the illustrations downloadable for your personal presentations, and real-time surgical videos covering microscopic extended endonasal approach to suprasellar meningioma, and more, at expertconsult.com. Covers today’s full range of management methods, including adjuvant therapies, providing you with the best strategies for obtaining optimal outcomes. Features the work of the world’s most prominent brain tumor neurosurgeons—a completely international authorship—bringing you the best procedures globally. Offers an in-depth section on surgical methods and approaches based upon tumor location, to help you in the decision-making process. Includes coverage of spinal meningiomas including pre-diagnosis symptoms and outcomes.
#1 NEW YORK TIMES BESTSELLER • OVER ONE MILLION COPIES SOLD • A groundbreaking manifesto on living better and longer that challenges the conventional medical thinking on aging and reveals a new approach to preventing chronic disease and extending long-term health, from a visionary physician and leading longevity expert “One of the most important books you’ll ever read.”—Steven D. Levitt, New York Times bestselling author of Freakonomics AN ECONOMIST AND BLOOMBERG BEST BOOK OF THE YEAR Wouldn’t you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health. For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimer’s disease, and type 2 diabetes. Too often, it intervenes with treatments too late to help, prolonging lifespan at the expense of healthspan, or quality of life. Dr. Attia believes we must replace this outdated framework with a personalized, proactive strategy for longevity, one where we take action now, rather than waiting. This is not “biohacking,” it’s science: a well-founded strategic and tactical approach to extending lifespan while also improving our physical, cognitive, and emotional health. Dr. Attia’s aim is less to tell you what to do and more to help you learn how to think about long-term health, in order to create the best plan for you as an individual. In Outlive, readers will discover: • Why the cholesterol test at your annual physical doesn’t tell you enough about your actual risk of dying from a heart attack. • That you may already suffer from an extremely common yet underdiagnosed liver condition that could be a precursor to the chronic diseases of aging. • Why exercise is the most potent pro-longevity “drug”—and how to begin training for the “Centenarian Decathlon.” • Why you should forget about diets, and focus instead on nutritional biochemistry, using technology and data to personalize your eating pattern. • Why striving for physical health and longevity, but ignoring emotional health, could be the ultimate curse of all. Aging and longevity are far more malleable than we think; our fate is not set in stone. With the right roadmap, you can plot a different path for your life, one that lets you outlive your genes to make each decade better than the one before.
This work focuses on some of the more unfamiliar aspects of the Roman experience, where the historian needs not just knowledge but also imagination. It expores how the Romans made sense of their past and how people today can understand that history, despite the inadequate evidence for early Rome and the Republic. All Latin and Greek source material is translated. The first essay in this collection was the Ronald Syme Lecture for 1993; "The Origins of Roman Historiography" argues that dramatic performances at the public games were the medium through which the Romans in the "pre-literary" period made sense of their own past.
Thoroughly updated for its Second Edition, Non-Hodgkin Lymphomas is the definitive textbook on the biology, diagnosis, staging, and treatment of all forms of non-Hodgkin lymphomas. With backgrounds in medical and radiation oncology, molecular biology, and pathology, the editors and contributors provide an international, multidisciplinary approach to the topic. This edition is the first text using the new World Health Organization classification of non-Hodgkin lymphomas. The book offers complete coverage of the most current techniques for diagnosis, staging, and treatment, the approach to specific types of lymphoma, and special problems common to the management of patients with these disorders.
This commentary pays close critical attention to Dio's historical sources, methods, and assumptions as it also strives to present him as a figure in his own right. During a long life (ca. 164-after 229), Dio served as a Roman senator under seven emperors from Commodus to Severus Alexander, governed three Roman provinces, and was twice consul."--BOOK JACKET.
This volume provides a comprehensive understanding of HIV/AIDS and neuro-AIDS, including a history of the disease, and an explanation of many of the conditions that can arise in afflicted patients, including opportunistic infections, central nervous system tumors, spinal cord disorders, myopathies and progressive encephalopathy, amongst others. Clinicians will gain a greater understanding of the complex mechanisms of the disease. Beginning with a basic introduction to HIV infections and Neuro-AIDS, practitioners will find useful data on advances in molecular biology, neuroepidemiology, neuroimaging, neuropathology, neuropharmacology, as well as information on the development of therapeutic strategies appropriate for the disorder, including groundbreaking retroviral therapies. In addition, the socioeconomic and political constraints that hinder treatment and disease management in developing parts of the world are presented. * A comprehensive understanding of HIV/AIDS and neuro-AIDS, and the progression of the scientific community's understanding of the disease * Detailed information on fields such as neuroepidemiology, neuropathology, neuropharmacology, and neuroimaging and their contributions to HIV/AIDS research * Subject specific chapters on conditions associated with HIV/AIDS, including opportunistic infections, central nervous system tumors, and myopathies, amongst others
Handbook for the Assessment of Children’s Behaviours with Wiley Desktop Edition This ground-breaking book takes a new approach to the assessment of behaviour in children and adolescents. Written by an expert author team, combining one (Jonathan Williams) with higher qualifications in general practice, child neuropsychiatry, and child and adolescent psychiatry, with one (Peter Hill) with higher qualifications in medicine, paediatrics and child and adolescent psychiatry, the book draws on many thousands of multidisciplinary case discussions, at Great Ormond Street Hospital, in the Children’s Multispecialty Assessment Clinic in North London, and in private practice. The book is ideal for the busy mental health professional working in a small team. Organised to allow rapid look-up of behaviours with comprehensive lists of their possible causes, it synthesizes research evidence and clinical experience. The authors interpret behaviour broadly, including not just voluntary actions, but also actions whose voluntary nature is questionable (such as drop attacks, personal preferences, and pseudobehaviours). They also include problems that lead to referral through their behavioural manifestations (e.g. aggression, anxiety, or a poor relationship with mother). Overall, the book spans the behavioural, cognitive, social and emotional problems of children and adolescents. With the child and family in the room, and with detailed school reports and psychometric results available, it is usually possible to identify causes of symptoms that are specific to the child and his environment, and which can guide behavioural, cognitive, social, and family interventions. Purchasers of the book will also be entitled to a Wiley Desktop Edition—an interactive digital version featuring downloadable text and images, highlighting and note taking facilities, in-text searching, and linking to references and glossary terms.
Long recognized as an essential reference for therapists and surgeons treating the hand and the upper extremity, Rehabilitation of the Hand and Upper Extremity helps you return your patients to optimal function of the hand, wrist, elbow, arm, and shoulder. Leading hand surgeons and hand therapists detail the pathophysiology, diagnosis, and management of virtually any disorder you're likely to see, with a focus on evidence-based and efficient patient care. Extensively referenced and abundantly illustrated, the 7th Edition of this reference is a "must read" for surgeons interested in the upper extremity, hand therapists from physical therapy or occupational therapy backgrounds, anyone preparing for the CHT examination, and all hand therapy clinics. - Offers comprehensive coverage of all aspects of hand and upper extremity disorders, forming a complete picture for all members of the hand team—surgeons and therapists alike. - Provides multidisciplinary, global guidance from a Who's Who list of hand surgery and hand therapy editors and contributors. - Includes many features new to this edition: considerations for pediatric therapy; a surgical management focus on the most commonly used techniques; new timing of therapeutic interventions relative to healing characteristics; and in-print references wherever possible. - Features more than a dozen new chapters covering Platelet-Rich Protein Injections, Restoration of Function After Adult Brachial Plexus Injury, Acute Management of Upper Extremity Amputation, Medical Management for Pain, Proprioception in Hand Rehabilitation, Graded Motor Imagery, and more. - Provides access to an extensive video library that covers common nerve injuries, hand and upper extremity transplantation, surgical and therapy management, and much more. - Helps you keep up with the latest advances in arthroscopy, imaging, vascular disorders, tendon transfers, fingertip injuries, mobilization techniques, traumatic brachial plexus injuries, and pain management—all clearly depicted with full-color illustrations and photographs.
Feigin and Cherry's Textbook of Pediatric Infectious Diseases helps you put the very latest knowledge to work for your young patients with unparalleled coverage of everything from epidemiology, public health, and preventive medicine through clinical manifestations, diagnosis, treatment, and much more. Ideal for all physicians, whether in an office or hospital setting, Feigin and Cherry’s equips you with trusted answers to your most challenging clinical infectious disease questions. Meet your most difficult clinical challenges in pediatric infectious disease, including today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases, with unmatched, comprehensive coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. Find the answers you need quickly thanks to an organization both by organ system and by etiologic microorganism, allowing you to easily approach any topic from either direction.
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