In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.
This book covers water waves, surf zone hydrodynamics, tides in oceans and estuaries, storm surges, estuarine mixing, basic sediment transport, coastal morphodynamics and coastal groundwater dynamics. It is an introductory treatment, suitable for a first course in coastal and estuarine processes for earth scientists or engineers. Yet, there are substantial amounts of new material that are included, such as the explicit, analytical treatment of transient, forced long waves. Inclusion of this material will in turn strongly enhance the introductory treatment of tsunami, storm surges and surf beat. The treatment of sine wave theory emphasizes expressions which are explicit in the water depth h (using koh instead of kh) so that they can easily be differentiated or integrated with respect to h. This is a major pedagogical advantage because of the enhanced transparency. The treatment of turbulent mixing includes finite mixing length effects which provide an explanation for differential diffusion of different sediment sizes in suspension. The effects of acceleration skewness and boundary layer streaming are also included in the basic sediment transport models. The inclusion of beach groundwater dynamics — including the mechanisms by which waves as well as tides drive groundwater motion — provides a link between the previously unconnected fields of coastal hydraulics and regional groundwater modeling. Serving as a good reference book, it is fully indexed and comprehensively cross referenced. Abundant references to more detailed texts are also provided.
At a time when biological psychiatry claims that drugs and electroshock are the best methods for helping deeply disturbed persons, mental health professionals need to be reminded that psychological and social approaches to mental illnesses remain more effective, less harmful, and much more able to address the real needs of recovery, growth, and development for affected persons. Psychosocial Approaches to Deeply Disturbed Persons empowers counselors, psychiatrists, psychologists, and social workers to trust their intuitive and clinical understanding of how to help seriously disturbed people through humane, caring approaches.Psychosocial Approaches to Deeply Disturbed Persons introduces mental health professionals to an array of psychological and social alternatives that are available for helping patients considered “psychotic” or very emotionally disturbed. Focusing on psychological and social approaches to helping people who become labeled “psychotic” or who carry serious psychiatric diagnoses, contributors show mental health professionals psychological, social, and spiritual alternatives for approaching or treating these individuals. Readers learn about: a successful model for nonmedical, non-drug residential treatment centers utilizing the artwork of psychotic patients case histories of psychoanalytic therapy group therapy to help families with a “schizophrenic” member improve communication Re-evaluation Counseling (RC) with disturbed individuals psychoanalytically-oriented therapy World Health Organization research which demonstrates the positive effect of extended family and social relationships and the negative effect of modern biopsychiatric treatment research demonstrating the efficacy of psychotherapy with persons labeled “schizophrenic”These chapters combined with a review of empirical studies demonstrate to readers the efficacy of psychotherapy with psychotic patients. Students or experienced professionals in any of the mental health fields, including psychotherapy, counseling, clinical psychology, clinical social work, and Re-evaluation Counseling will find Psychosocial Approaches to Deeply Disturbed Persons a necessity for most effectively and humanely treating clients with serious psychiatric diagnoses.
Barley: Chemistry and Technology, Second Edition is an important resource for any cereal chemist, food scientist, or crop scientist who needs to understand the development, structure, composition, and end-use properties of the barley grain for cultivation, trade, and utilization. Editors Peter R. Shewry and Steven E. Ullrich bring together a wide range of international authorities on barley to create this truly unique, encyclopedic reference work that covers the massive increase in barley knowledge over the past 20 years, since the first edition of this book was published. Barley: Chemistry and Technology, Second Edition offers the latest coverage of barley’s applications in milling, breeding, and production for food, feed, malting, brewing, distilling, and biofuels. It delivers a complete update of the latest knowledge of barley’s many components, from the genetic and molecular level to its many constituents, such as proteins, carbohydrates, arabinoxylans, minerals, lipids, terpenoids, phenolics, and vitamins. This important book also includes chapters on barley’s plant and grain development from both the physiological and genetic perspectives, making it an important resource not only for cereal and food scientists but also for crop scientists involved in breeding, agronomy, and related plant sciences New coverage includes: Updated, comprehensive knowledge on barley’s components, including proteins, carbohydrates, arabinoxylans, and bioactive effects New end-use ideas for barley as an ingredient in food products Nonfood industrial applications for barley, including biofuels A new chapter on barley’s health benefits Molecular breeding for malting quality
RNA is a chemical found in the nucleus and cytoplasm of cells. RNA plays an important role in protein synthesis and other chemical activities of the cell. The structure of RNA is similar to that of DNA, although RNA is single stranded whereas DNA has a characteristic "double helix". Genetic information is stored by DNA in the nucleus of cells, and RNA carries that information to other parts of the cell where it is converted into protein. Three types of RNA are; mRNA (messenger RNA, which contains the specific sequence of nucleotides necessary to dictate amino acid sequence in proteins), tRNA (transfer RNA, which serves as the "adapter" to position the appropriate amino acid next to a growing polypeptide chain during protein synthesis), and rRNA (ribosomal RNA, which is the RNA component of ribosomes). This book presents state-of-the-research from throughout the world.
This century has seen the development of technologies for manipulating and controlling matter and light at the level of individual photons and atoms, a realm in which physics is fully quantum-mechanical. The dominant experimental technology is the laser, and the theoretical paradigm is quantum optics. The Quantum World of Ultra-Cold Atoms and Light is a trilogy, which presents the quantum optics way of thinking and its applications to quantum devices. This book — The Physics of Quantum-Optical Devices — provides a comprehensive treatment of theoretical quantum optics. It covers applications to the optical manipulation of the quantum states of atoms, laser cooling, continuous measurement, quantum computers and quantum processors, superconducting systems and quantum networks. The subject is consistently formulated in terms of quantum stochastic techniques, and a systematic and thorough development of these techniques is a central part of the book. There is also a compact overview of the ideas of quantum information theory. The main aim of the book is to present the theoretical techniques necessary for the understanding of quantum optical devices, with special attention to those devices used in quantum information processing and quantum simulation. Although these techniques were developed originally for the optical regime, they are also applicable to electromagnetic radiation from the microwave realm to the ultra-violet, and for atomic systems, Josephson junction systems, quantum dots and nano-mechanical systems. For more information, please visit: http://europe.worldscientific.com/quantum-world-of-ultra-cold-atoms-and-light.html
Quaggas were beautiful pony-sized zebras in southern Africa that had fewer stripes on their bodies and legs, and a browner body coloration than other zebras. Indigenous people hunted quaggas, portrayed them in rock art, and told stories about them. Settlers used quaggas to pull wagons and to protect livestock against predators. Taken to Europe, they were admired, exhibited, harnessed to carriages, illustrated by famous artists and written about by scientists. Excessive hunting led to quaggas' extinction in the 1880s but DNA from museum specimens showed rebreeding was feasible and now zebras resembling quaggas live in their former habitats. This rebreeding is compared with other de-extinction and rewilding ventures and its appropriateness discussed against the backdrop of conservation challenges—including those facing other zebras. In an Anthropocene of species extinction, climate change and habitat loss which organisms and habitats should be saved, and should attempts be made to restore extinct species?
This third edition provides a concise yet approachable introduction to seismic theory, designed as a first course for graduate students or advanced undergraduate students. It clearly explains the fundamental concepts, emphasizing intuitive understanding over lengthy derivations, and outlines the different types of seismic waves and how they can be used to resolve Earth structure and understand earthquakes. New material and updates have been added throughout, including ambient noise methods, shear-wave splitting, back-projection, migration and velocity analysis in reflection seismology, earthquake rupture directivity, and fault weakening mechanisms. A wealth of both reworked and new examples, review questions and computer-based exercises in MATLAB®/Python give students the opportunity to apply the techniques they have learned to compute results of interest and to illustrate Earth's seismic properties. More advanced sections, which are not needed to understand the other material, are flagged so that instructors or students pressed for time can skip them.
This book documents the history of pi from the dawn of mathematical time to the present. One of the beauties of the literature on pi is that it allows for the inclusion of very modern, yet accessible, mathematics. The articles on pi collected herein fall into various classes. First and foremost there is a selection from the mathematical and computational literature of four millennia. There is also a variety of historical studies on the cultural significance of the number. Additionally, there is a selection of pieces that are anecdotal, fanciful, or simply amusing. For this new edition, the authors have updated the original material while adding new material of historical and cultural interest. There is a substantial exposition of the recent history of the computation of digits of pi, a discussion of the normality of the distribution of the digits, and new translations of works by Viete and Huygen.
Following the acclaim for Learning Outside the Classroom in 2012, this latest book more deeply explains how well constructed outdoor learning experiences can benefit children and young people’s academic development and health and wellbeing. Outdoor Learning Across the Curriculum outlines the theory and practice to enable preservice and experienced primary and secondary school teachers to systematically incorporate meaningful outdoor learning opportunities into their daily teaching activities, in a range of environments and with diverse groups of students. Six of the chapters are substantially re-worked versions of the 2012 book, two are completely re-imagined, and four are entirely new. Topics for developing learning and teaching outdoors include: Inclusive educational design Learning for sustainability Community-based learning The role of student curiosity and wonder Evidencing learning Developing a whole school approach Place-responsive education Integrating digital technology With practical and engaging chapters containing aims, case studies, and guidelines for practice, this timely book provides teachers the tools with which they can integrate outdoor learning into their daily timetable. It will also be a valuable resource to other professions which use the outdoors for educational purposes.
This book is based on the findings, issues and questions related to an ongoing decade-old research project named the Innovation Lab (www.innovation-lab.org). The research project focuses on discontinuous innovation in more than thirteen countries, most of which are European, and provides useful insights into its different challenges. It also raises several questions related to the subject, some of which are: how do firms pick up weak signals on emerging — and possibly radically different — innovation? What should firms do when these weak signals hit their “mainstream” process? What are the criteria for allocating resources to a strategic innovation project? What actions should firms take to avoid being left out by the “corporate immune system”? How should firms organize projects that often break existing rules and require new rules to be created?This book attempts to provide answers to the above mentioned questions by gathering information from the research project and also from firms that have tried exploring various ideas, models and insights to tackle discontinuous innovation. Written in a simple and accessible manner, this book will be of interest to both practitioners and academics alike.
Now in a fully updated 9th Edition, Kendig's Disorders of the Respiratory Tract in Children, by Drs. Robert Wilmott, Andrew Bush, Robin Deterding, and Felix Ratjen, continues to provide authoritative, evidence-based information to residents, fellows, and practitioners in this wide-ranging specialty. Bringing key knowledge from global experts together in one easy-to-understand volume, it covers everything from the latest basic science and its relevance to today's clinical issues, to improving patient outcomes for the common and rare respiratory problems found in newborns and children worldwide. - Uses succinct, straightforward text, numerous tables and figures, summaries at the end of each chapter, and more than 500 full-color images to convey key information in an easy-to-digest manner. - Contains new chapters reflecting expanding knowledge on the respiratory complications of Down syndrome and other genetic disorders, modern molecular therapies for cystic fibrosis and asthma, and pulmonary embolism and thromboembolic disease. - Includes access to a new video library with demonstrations of key procedures. - Features a new templated format with more descriptive headings and bulleted text for quick reference and navigation. - Covers today's key issues, including the genetic basis of respiratory disease, new and emerging respiratory infections, interstitial lung diseases in infants and young children, technology and diagnostic techniques for pulmonary function tests, emerging lung infections, and new therapies for cystic fibrosis and asthma. - Provides up-to-date instruction on important procedures, such as bronchoscopy and pulmonary function testing. - Highlights the knowledge and expertise of three new editors, as well as more than 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Role-based access control (RBAC) is a widely used technology to control information flows as well as control flows within and between applications in compliance with restrictions implied by security policies, in particular, to prevent disclosure of information or access to resources beyond restrictions defined by those security policies. Since RBAC only provides the alternatives of either granting or denying access, more fine-grained control of information flows such as “granting access to information provided that it will not be disclosed to targets outside our organisation during further processing” is not possible. In business processes, in particular those spanning several organisations, which are commonly defined using business process execution language (BPEL), useful information flows not violating security policy-implied limitations would be prevented if only the access control capabilities offered by RBAC are in use. The book shows a way of providing more refined methods of information flow control that allow for granting access to information or resources by taking in consideration the former or further information flow in a business process requesting this access. The methods proposed are comparatively easy to apply and have been proven to be largely machine-executable by a prototypical realisation. As an addition, the methods are extended to be also applicable to BPEL-defined workflows that make use of Grid services or Cloud services. IT Security Specialists Chief Information Officers (CIOs) Chief Security Officers (CSOs) Security Policy and Quality Assurance Officers and Managers Business Process and Web/Grid/Cloud Service Designers, Developers, Operational Managers Interested Learners / Students in the Field of Security Management.
Business Models for Sustainability breaks new ground by combining three important insights. First, achieving sustainability requires socio-technical transitions that entail new technologies, production processes, lifestyles, and consumption patterns. Second, firms play crucial roles in mediating between sustainable production and consumption. Third, radical innovations require organizational innovations and new business models. Peter Wells successfully combines these big picture ideas with rich in-depth case studies drawing on years of accumulated expertise. Highly recommended. Frank W. Geels, University of Manchester, UK and Chairman of the Sustainability Transitions Research Network With increasing awareness that innovative technology alone is insufficient to make sustainable lifestyles a reality, this book brings into sharp focus the need to create radical new business models. This insightful book provides a theoretically grounded but also realistic account of how the design of business models can be a critical component in the overall transition to sustainability, and one that transcends the usual focus on innovative technology. Weaving together key principles and components for business sustainability, the book highlights five very different pathways to the future for sectors ranging from microbreweries and printing through to clothing, mobility and plastics. Business has only just started the first few tentative steps towards a very different approach to creating and sustaining value, but this book concludes that enormous opportunities will emerge alongside new ways of creating and capturing value. Academics and postgraduate students in the fields of sustainable business, business organisations and industrial ecology will find this book brings a greater understanding of business strategy and structure to the discipline. While traditionally referenced and structured, this academic book is accessibly written with key principles that may also appeal to the consultant community.
This comprehensive and self-contained text for researchers and professionals presents a detailed account of optical imaging from the viewpoint of both ray and wave optics.
This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
The four-volume set LNCS 2657, LNCS 2658, LNCS 2659, and LNCS 2660 constitutes the refereed proceedings of the Third International Conference on Computational Science, ICCS 2003, held concurrently in Melbourne, Australia and in St. Petersburg, Russia in June 2003. The four volumes present more than 460 reviewed contributed and invited papers and span the whole range of computational science, from foundational issues in computer science and algorithmic mathematics to advanced applications in virtually all application fields making use of computational techniques. These proceedings give a unique account of recent results in the field.
The seabed in southern Scandinavia contains numerous traces of a submerged landscape that is thought to be the remnant of a once important habitat for Mesolithic hunter-gatherers. Large parts of this landscape were gradually flooded by rising seas between 9500 and 4000 BC and perceptions of the Maglemose culture (9500-6400 BC) have, consequently, been based almost exclusively on former inland settlements. As a result, Early and Late Mesolithic societies have been understood as almost diametrically opposed with regards to their reliance upon marine resources and their degree of sedentism. The main objective of the book is to investigate two questions that are directly related to our current understanding of the populations of the now submerged areas: 1) Do we have a representative picture of the spread of Early Mesolithic sites in southern Scandinavia, or does the weighting towards inland sites reflect the fact that coastal sites have not been identified below present-day sea-level? 2) How did sea-level changes impact Mesolithic populations at different temporal and spatial scales, and how were these experienced from 8000-4000 BC? The book presents an extensive and up-to-date review of various types of evidence from the Boreal period such as faunal remains, fishing instruments, d13C values in bones, settlement positions and available marine resources. These are used to discuss the extent to which marine resources were utilised in the Maglemose culture. Another central component of this book is a series of new coastline models made to determine the Mesolithic sea-level changes / coastline positions. The eight new coastline models are created to facilitate new evaluations of possible relationships between sea-level changes and cultural changes. On the basis of the new coastline models the book also presents the preliminary results of 47 diver investigations conducted with the aim of identifying potential coastal settlements from the Maglemose culture.
This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. There are also abstracts from the keynote addresses and invited talks. The papers cover not only theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Exploring the Ocean''s Microbes: Sequencing the Seven Seas (122 KB). Contents: Exploring the Ocean''s Microbes: Sequencing the Seven Seas (M E Frazier et al.); Protein Network Comparative Genomics (T Ideker); Bioinformatics at Microsoft Research (S Mercer); Protein Fold Recognition Using Gradient Boost Algorithm (F Jiao et al.); Efficient Annotation of Non-Coding RNA Structures Including Pseudoknots via Automated Filters (C Liu et al.); Efficient Generalized Matrix Approximations for Biomarker Discovery and Visualization in Gene Expression Data (W Li et al.); Sorting Genomes by Translocations and Deletions (X Qi et al.); Detection of Cleavage Sites for HIV-1 Protease in Native Proteins (L You); Identifying Biological Pathways via Phase Decomposition and Profile Extraction (Y Zhang & Z Deng); Complexity and Scoring Function of MS/MS Peptide De Novo Sequencing (C Xu & B Ma); Simulating In Vitro Epithelial Morphogenesis in Multiple Environments (M R Grant et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. A useful reference for graduate researchers in bioinformatics and computational biology.
Behind rolling hills, overlooking the fjord and the islands of Southern Funen in Denmark, lies the Faaborg Museum. With its boldly coloured walls and decorative tile floors made from local clay, the building has quite literally sprung from Funen's soil in a symbiosis of local nature and culture. Inside, visitors will find art by the 'Funen Painters', created during the period 1880 to 1928, when Faaborg was home to one of Denmark's pre-eminent artists' colonies. With their paintings of rural Funen, farmworkers and domestic scenes, the artists Peter Hansen, Fritz and Anna Syberg, Jens Birkholm and Johannes Larsen introduced new subject matter and new methods of painting to Danish art. Faaborg Museum and the Artists' Colony presents the history of Faaborg Museum, its architecture, collection and artists to international audiences for the first time. Lavishly illustrated, the book features architectural photographs and plans as well as pictures of the museum's art.
After doctors diagnosed him with Crohn¿s Disease, Peter Nielsen dedicated his life to fitness and health. He shows how the principles of nutrition, exercise, and mental toughness can translate to a healthy lifestyle for anyone.
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