A mysterious cult takes over a ranch in this western thriller starring a crime solver who “resonates with originality and energy” (Chicago Tribune). The Eides have owned cattle in Montana since 1882, but a few days after they pull up stakes and sell their property, their homestead goes up in flames. When Métis Indian investigator Gabriel Du Pré arrives on the scene, nothing is left but the ashes. A serene young man appears, insisting the fires were set purposely and firmly asking Du Pré to leave. He is a representative from the Host of Yahweh, the millennial cult that has purchased the sprawling ranch on the edge of the Badlands, and arson is just the beginning of their suspicious behavior. At first, the people of Toussaint try to ignore the secretive cult. But when Du Pré gets a tip from an FBI contact that seven Host of Yahweh defectors were recently shot to death, he takes another look at the glassy-eyed conclave. Behind their peaceful smiles, great evil lurks. Badlands is the 10th book in The Montana Mysteries Featuring Gabriel Du Pré series, but you may enjoy reading the series in any order.
It's not every day that a good man sets a killing in motion.' So begins the tale. Poor Chester has a serious problem. Tender-hearted and utterly devoted to his wife, he's convinced she will leave him in search of another and take their young daughter. Desperation overcomes him. But how far will he go? Well, a whole lot farther than you would ever think. Really. A tidy plan. An unusual killing. But is he in too deep? Sometimes humorous, sometimes mysterious, sometimes dark and chilling, sometimes high action. But always intriguing and unpredictable. Twists you won't see coming. Kirkus Reviews says, 'An entertaining, well-written, and smart crime tale: an excellent read.
“Truly mysterious—informed by Western legend, steeped in Indian superstition . . . Riding with Du Pré is some kind of enchantment” (The New York Times Book Review). A rumor circulates around academic circles that the long-lost journals of Meriwether Lewis are in the possession of a hard-bitten Montana fiddler named Gabriel Du Pré. A few years ago, the Métis Indian led a documentary film crew down the Missouri River to commemorate the bicentennial of the famous Lewis and Clark expedition, but he won’t say whether or not he has the journals. Only Benetsee, Du Pré’s mysterious spiritual guide, has any idea where the journals are, and only a fool would try to make Benetsee talk when he doesn’t feel like it. It’s quite possible, though, that billionaire Markham Millbank is a fool. His money cannot persuade Du Pré, and so he begins to consider other forms of pressure. When two of Du Pré’s friends are kidnapped, the fiddler faces a tough decision: Hand over the journal or risk innocent lives to keep it out of the wrong hands . . . The Tumbler is the 11th book in The Montana Mysteries Featuring Gabriel Du Pré series, but you may enjoy reading the series in any order.
The half Indian cattle inspector and “character of legendary proportions” is back—in this beloved contemporary western mystery series (Ridley Pearson). Officially, Gabriel Du Pré is the cattle inspector for Toussaint, Montana, responsible for making sure no one tries to sell cattle branded by another ranch. Unofficially, he is responsible for much more than cows’ backsides. The barren country around Toussaint is too vast for the town’s small police force, and so, when needed, this hard-nosed Métis Indian lends a hand. In Gabriel Du Pré “Bowen has taken the antihero of Hemingway and Hammett and brought him up to date . . . a fresh, memorable character” (The New York Times Book Review). Badlands: When a mysterious cult takes over a cattle ranch, the people of Toussaint try to ignore their suspicious behavior. But when Du Pré gets a tip from an FBI contact that seven Host of Yahweh defectors were recently shot to death, he takes another look at the glassy-eyed conclave. Behind their peaceful smiles, evil lurks. “Gripping and humorous . . . truly riveting.” —Publishers Weekly The Tumbler: A few years back, Du Pré led a documentary film crew down the Missouri River to commemorate the bicentennial of the Lewis and Clark expedition. Rumor now has it that the Montana fiddler is in possession of the long-lost writings of Meriwether Lewis, and an unscrupulous billionaire has kidnapped two of Du Pré’s friends to get his hands on the journals. “[Du Pré’s] moral center is unshakable. Another wonderful adventure in a great series.” —Booklist Stewball: When his aunt Pauline’s latest husband turns up shot, execution-style, Du Pré goes undercover to infiltrate a cabal of wealthy gamblers who pass their time racing horses in the barren Montana brush, among other nefarious activities. “[The] fast-paced narrative offers ample doses of local color, evenly spaced bursts of violence and an unforced laid-back style.” —Publishers Weekly
The contemporary western mystery series continues in these novels featuring a half Indian cattle inspector and “character of legendary proportions” (Ridley Pearson). Officially, Gabriel Du Pré is the cattle inspector for Toussaint, Montana, responsible for making sure no one tries to sell cattle branded by another ranch. Unofficially, he is responsible for much more than cows’ backsides. The barren country around Toussaint is too vast for the town’s small police force, and so, when needed, this hard-nosed Métis Indian lends a hand. In Gabriel Du Pré, “Bowen has taken the antihero of Hemingway and Hammett and brought him up to date . . . a fresh, memorable character” (The New York Times Book Review). Notches: Working alongside a Blackfoot FBI agent and his feisty female partner, Du Pré tracks a serial killer hunting young women in the Montana wilderness. “A haunting tale, punched out in arresting rhythms of speech powerful as a tribal drumbeat.” —Entertainment Weekly Thunder Horse: After an earthquake exposes an ancient burial site, Native American tribes fight over the remains and a fossilized Tyrannosaurus rex tooth is found in the hands of a murdered anthropologist. Time for Du Pré to start digging. “Strange, seductive . . . The wonder of these voices is that they are . . . blunt, crude, soaked in whiskey and raspy from laughter, but still capable of leaving echoes.” —Marilyn Stasio, The New York Times Book Review Long Son: After greedy, vicious Larry Messmer inherits his parents’ ranch, the FBI asks Du Pré to keep an eye on the pathological prodigal son. When violence inevitably erupts, Du Pré finds himself caught in the crosshairs. “Bowen’s writing is lean and full of mordant observations. His hardy characters . . . come to life, and his wry humor . . . provides relief from the haunting, wind-bitten cattle-ranch landscape.” —Publishers Weekly
“With his distinctive, minimalist prose . . . Bowen’s writing is lean. . . . An unsentimental, galvanizing portrait of life in small-town Montana” (Publishers Weekly). For generations, the Messmers have raised cattle in the rough country of eastern Montana. When the current owners die in a tragic accident, they leave the ranch to their son—an ominous development for everyone in the area. Larry Messmer left Toussaint years ago when he got in trouble for bludgeoning a horse to death. Gabriel Du Pré hoped he would never set eyes on him again. Larry announces his return by having his ranch hands kill every weak cow on the property. Unfortunately, the livestock will not be the last to die. The FBI asks Du Pré, a cattle inspector and occasional lawman, to keep an eye on Larry. What he uncovers is a ranch stricken by criminal greed, lorded over by a pathological son who should never have come home. And when violence erupts again, Du Pré finds himself in the cross hairs. Long Son is the 6th book in The Montana Mysteries Featuring Gabriel Du Pré series, but you may enjoy reading the series in any order.
The contemporary western mystery series follows the further adventures of a half Indian cattle inspector and “character of legendary proportions” (Ridley Pearson). Officially, Gabriel Du Pré is the cattle inspector for Toussaint, Montana, responsible for making sure no one tries to sell cattle branded by another ranch. Unofficially, he is responsible for much more than cows’ backsides. The barren country around Toussaint is too vast for the town’s small police force, and so, when needed, this hard-nosed Métis Indian lends a hand. In Gabriel Du Pré, “Bowen has taken the antihero of Hemingway and Hammett and brought him up to date . . . a fresh, memorable character” (The New York Times Book Review). The Stick Game: After a Native American boy turns up dead, Du Pré takes on a mining company that’s poisoning reservation children. Is there something more sinister than greed and indifference at work? “Wonderful . . . wise.” —The Washington Post Book World Cruzatte and Maria: While reluctantly serving as a consultant for a documentary about Lewis and Clark’s expedition up the Missouri River, Du Pré stumbles upon a national treasure: Meriwether Lewis’s lost journals. Then members of the film crew start dying . . . “A solid entry in a great series.” —Booklist Ash Child: In the midst of a drought in Toussaint, Montana, brushfires, meth dealers, and murder challenge the Métis Indian tracker and cattle investigator. “Compelling . . . plenty of action . . . a pleasure to read.” —Publishers Weekly
In modern-day Montana, brushfires, meth dealers, and murder challenge a deputy in a mystery that’s “a pleasure to read” (Publishers Weekly). In the midst of a drought in Toussaint, Montana, Métis Indian tracker and cattle investigator Gabriel Du Pré learns that Maddy Collins has been killed—and goes looking for answers. Du Pré suspects a pair of boys who, despite their good upbringing, have fallen in with a gang of crystal meth dealers. Not long after the murder, they vanish. As the town is threatened by a forest fire, Du Pré puts his own life at risk to hunt for the two young men, not knowing whether they’re alive or dead. But if the inferno reaches Toussaint, no one will be safe. Ash Child is the 9th book in The Montana Mysteries Featuring Gabriel Du Pré series, but you may enjoy reading the series in any order.
On 28 November 2004, banker and father-of-two Alistair Wilson was shot three times on his doorstep in a killing more commonly associated with inner city gang wars than a sleepy seaside town in the Scottish Highlands. All these years later, the question remains: why? Who would wish to kill this respectable husband and family man in such a brutal fashion? Was it simply a tragic case of mistaken identity, or did someone have reason to end Alistair's life? And what was the significance of the envelope handed to him before he was fatally wounded? Over the years, lines of enquiry have been investigated and dismissed, gossip has spread, theories offered and rumours debated at length. And yet, so long after Alistair's death, no arrest has ever been made and precious few motives have been made public. In this gripping true crime investigation, Peter Bleksley, top ex-undercover cop and The Chief on Channel 4's Hunted, strives to uncover the truth and hunt down Alistair's killer. He travels to Scotland, speaks to experts, and draws on his decades of investigative experience in order to provide new insight into Scotland's most mysterious murder case.
Gabriel Du Pré is back in action, coming to the aid of a whistleblower on the run, in this all-new novel in a “wonderfully eclectic and enjoyable series” (Booklist). When a hunted military whistleblower and his family need someplace to hide and someone to trust, Toussaint, Montana, is the place, and Gabriel Du Pré the man. The Métis Indian former cattle inspector and sometimes deputy is happy to offer protection, even though he’s already got his hands full with an ailing granddaughter, a meddling medicine man, and a Kazakh eagle hunter prowling the hills above town. As a guard at a Kabul prison, Hoyt Poe witnessed his fellow soldiers abusing the Afghan inmates. Poe’s testimony threatens to expose the military contractor that led the prison’s brutal interrogation program. Now, Temple Security’s billionaire founder, Lloyd Cutler, wants him dead. But how long can the fugitive and his family lay low before Cutler’s mercenaries come to Du Pré’s hometown looking for trouble? Packed with pulse-pounding suspense, wry humor, and the romance of small-town Montana, Solus continues the irresistible adventures of the one of a kind Gabriel Du Pré, “a character of legendary proportions” (New York Times–bestselling author Ridley Pearson). Solus is the 15th book in the Montana Mysteries Featuring Gabriel Du Pré, but you may enjoy reading the series in any order.
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev
Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally, the impact of contemporary memory research for psychiatry is illustrated.
The food technologist who wishes to produce a gelled product is faced with two basic options for achieving the desired effect; whether to use a protein or a polysaccharide. Although a gel can be formed by either a protein or a polysaccharide, the resultant gels have different characteristics: • Polysaccharide gels are characterised by their fine texture and transparency which is achieved at a low polymer concentration. They can be formed by heating and cooling, pH adjustment or specific ion addition . • Protein gels are characterised by a higher polymer concentration (5-10%) and are formed almost exclusively by heat denaturation. Before reaching a final decision, the technologist must take a number of factors into consideration. The purpose of this book is to help the technologist in his choice by providing fundamental practical information, in one book, on the properties of gels (and factors which influence them) for both types of biopolymer. To help the reader, each chapter is (wherever possible) organised in the same way so that, for example, information on structure will always be available in section 2. The examples in the Applications section of each chapter are not meant to be exhaustive, but to illustrate the various ways in which the particular polymer can be used to form a gelled product.
The field's bestselling reference, updated with the latest tools, data, techniques, and the latest recommendations from the Second Panel on Cost-Effectiveness in Health and Medicine Cost-Effectiveness Analysis in Health is a practical introduction to the tools, methods, and procedures used worldwide to perform cost-effective research. Covering every aspect of a complete cost-effectiveness analysis, this book shows you how to find which data you need, where to find it, how to analyze it, and how to prepare a high-quality report for publication. Designed for the classroom or the individual learner, the material is presented in simple and accessible language for those who lack a biostatistics or epidemiology background, and each chapter includes real-world examples and "tips and tricks" that highlight key information. Exercises throughout allow you to test your understanding with practical application, and the companion website features downloadable data sets for students, as well as lecture slides and a test bank for instructors. This new third edition contains new discussion on meta-analysis and advanced modeling techniques, a long worked example using visual modeling software TreeAge Pro, and updated recommendations from the U.S. Public Health Service's Panel on Cost-Effectiveness in Health and Medicine. This is the second printing of the 3rd Edition, which has been corrected and revised for 2018 to reflect the latest standards and methods. Cost-effectiveness analysis is used to evaluate medical interventions worldwide, in both developed and developing countries. This book provides process-specific instruction in a concise, structured format to give you a robust working knowledge of common methods and techniques. Develop a thoroughly fleshed-out research project Work accurately with costs, probabilities, and models Calculate life expectancy and quality-adjusted life years Prepare your study and your data for publication Comprehensive analysis skills are essential for students seeking careers in public health, medicine, biomedical research, health economics, health policy, and more. Cost-Effectiveness Analysis in Health walks you through the process from a real-world perspective to help you build a skillset that's immediately applicable in the field.
Peter Cornwell tells the story of the greatest air battle of the Second World War when six nations were locked in combat over north-western Europe for a traumatic six weeks in 1940. He describes the day-to-day events as the battle unfolds, and details the losses suffered by all six nations involved: Britain, France, Holland, Belgium, Germany and, rather belatedly, Italy. As far as RAF fighter squadrons in France were concerned, it was an all-Hurricane show, yet it was the Blenheim and Battle crews who suffered the brunt of the casualties. Every aircraft lost or damaged through enemy action while operating in France is listed together with the fate of the crews. The RAF lost more than a thousand aircraft of all types over the Western Front during the six-week battle, the French Air Force 1,400, but Luftwaffe losses were even higher at over 1,800 aircraft.
Examining the physical basis of the structure of macromolecules—proteins, nucleic acids, and their complexes—using calorimetric techniques Many scientists working in biology are unfamiliar with the basics of thermodynamics and its role in determining molecular structures. Yet measuring the heat of structural change a molecule undergoes under various conditions yields information on the energies involved and, thus, on the physical bases of the considered structures. Microcalorimetry of Macromolecules offers protein scientists unique access to this important information. Divided into thirteen chapters, the book introduces readers to the basics of thermodynamics as it applies to calorimetry, the evolution of the calorimetric technique, as well as how calorimetric techniques are used in the thermodynamic studies of macromolecules, detailing instruments for measuring the heat effects of various processes. Also provided is general information on the structure of biological macromolecules, proteins, and nucleic acids, focusing on the key thermodynamic problems relating to their structure. The book covers: The use of supersensitive calorimetric instruments, including micro and nano-calorimeters for measuring the heat of isothermal reactions (Isothermal Titration Nano-Calorimeter), the heat capacities over a broad temperature range (Scanning Nano-Calorimeter), and pressure effects (Pressure Perturbation Nano-Calorimeter) Two of the simplest but key structural elements: the α and polyproline helices and their complexes, the α-helical coiled-coil, and the pyroline coiled-coils Complicated macromolecular formations, including small globular proteins, multidomain proteins and their complexes, and nucleic acids Numerous examples of measuring the ground state of protein energetics, as well as changes seen when proteins interact The book also reveals how intertwined structure and thermodynamics are in terms of a macromolecule's organization, mechanism of formation, the stabilization of its three-dimensional structure, and ultimately, its function. The first book to describe microcalorimetric technique in detail, enough for graduate students and research scientists to successfully plumb the structural mysteries of proteins and the double helix, Microcalorimetry of Macromolecules is an essential introduction to using a microcalorimeter in biological studies.
A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. A useful reference for researchers and graduate students of macromolecular disciplines, these methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in the volume Sedimentation Velocity Analytical Ultracentrifugation: Interacting Systems. Software referenced in the book is available for download at: https://sedfitsedphat.nibib.nih.gov/default.aspx
Analytical ultracentrifugation (AUC) can supply rich information on the mass, shape, size distribution, solvation, and composition of macromolecules and nanoscopic particles. It also provides a detailed view of their reversible single- or multi-component interactions over a wide range of affinities. Yet this powerful technique has been hard to mast
This sparkling Handbook offers an unrivalled resource for those engaged in the cutting edge field of social network analysis. Systematically, it introduces readers to the key concepts, substantive topics, central methods and prime debates. Among the specific areas covered are: Network theory Interdisciplinary applications Online networks Corporate networks Lobbying networks Deviant networks Measuring devices Key Methodologies Software applications. The result is a peerless resource for teachers and students which offers a critical survey of the origins, basic issues and major debates. The Handbook provides a one-stop guide that will be used by readers for decades to come.
Metals in the earth's crust are very unevenly distributed and, traditionally, a small number of ore deposits, districts or countries have dominated the world supply and have influenced commodity prices. The importance of exceptionally large, or rich, deposits has greatly increased in the age of globalization when a small number of international corporations dominate the metals market, based on few very large ore deposits, practically anywhere in the world. Search for giant orebodies thus drives the exploration industry: not only the in-house teams of large internationals, but also hundreds of junior companies hoping to sell their significant discoveries to the "big boys". Geological characteristics of giant metallic deposits and their setting and the politico-economic constraints of access to and exploitation in prospective areas have been a "hot topic" in the past fifteen years, but the knowledge generated and published has been one-sided, scattered and fragmented. This is the first comprehensive book on the subject that provides body of solid facts rather than rapidly changing theories, written by author of the Empirical Metallogeny book series and founder of the Data Metallogenica visual knowledge system on mineral deposits of the world, who has had an almost 40 years long international academic and industrial experience. The book will provide abundant material for comparative research in metallogeny, practical information for the explorationists as to where to look for the "elephants", and some inspiration for commodity investors.
Like Ypres, Arras was a front line town throughout the Great War. From March 1916 it became home to the British Army and it remained so until the Advance to Victory was well under way. In 1917 the Battle of Arras came and went. It occupied barely half a season, but was then largely forgotten; the periods before and after it have been virtually ignored, and yet the Arras sector was always important and holding it was never easy or without incident; death, of course, was never far away. The area around Arras is as rich in Commonwealth War Graves Commission cemeteries as anywhere else on the Western Front, including the Somme and Ypres, and yet these quiet redoubts with their headstones proudly on parade still remain largely unvisited. This book is the story of the men who fell and who are now buried in those cemeteries; and the telling of their story is the telling of what it was like to be a soldier on the Western Front. Arras-South is the companion volume to Arras-North and is written by the same author. It contains comprehensive coverage of over 60 Commonwealth War Graves Commission cemeteries to be found in Arras and to the south of the town. It has a wealth of gallantry awards, including their citations, and features hundreds of officers and other ranks who fell, not just at the Battle of Arras in 1917, but also many of those who died in 1916 and the final year of the war. Many small actions, raids and operations are described in a book that tells the story of warfare on the Western Front through the lives of those who fought and died on the battlefields of Arras. There are personalities, interesting characters and the well-connected, ordinary soldiers and many unsung heroes, families torn apart by war, fathers, sons and brothers, poets and padres. There is a link to Ulster and the Curragh Incident and a connection to King George V and Queen Mary, a hero of the Messina earthquake disaster in 1908, a father whose search for his son's grave reaches its sad conclusion, a mysterious death in woodland, the moving spectacle of men waiting outside makeshift confessionals in a barn lit by candlelight before going up the line into battle, and a man whose father was a close collaborator with Sir Fabian Ware during the early days of the War Graves Registration Commission; there is even a remarkable prehistoric discovery and an improbable tale regarding an African hawk eagle that would not be out of place in a Harry Potter film. This is an essential reference guide for anyone visiting Arras and its battlefields.
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