Our Conrad is about the American reception of Joseph Conrad and its crucial role in the formation of American modernism. Although Conrad did not visit the country until a year before his death, his fiction served as both foil and mirror to America's conception of itself and its place in the world. Peter Mallios reveals the historical and political factors that made Conrad's work valuable to a range of prominent figures—including Fitzgerald, Faulkner, Richard Wright, Woodrow Wilson, and Theodore and Edith Roosevelt—and explores regional differences in Conrad's reception. He proves that foreign-authored writing can be as integral a part of United States culture as that of any native. Arguing that an individual writer's apparent (national, gendered, racial, political) identity is not always a good predictor of the diversity of voices and dialogues to which he gives rise, this exercise in transnational comparativism participates in post-Americanist efforts to render American Studies less insular and parochial.
This book considers the shifts in aesthetic representation over the period 1885-1930 that coincide both with the rise of literary Modernism and imperialism's high point. Peter Childs argues that modernist literary writing should be read in terms of its response and relationship to events overseas and that it should be seen as moving towards an emergent post-colonialism instead of struggling with a residual colonial past. Each of the core chapters focuses on one key writer and discuss a range of others, including: Conrad, Lawrence, Kipling, Eliot, Woolf, Joyce, Conan Doyle and Haggard.
This is the second volume in the series of proceedings from the International Workshop on Life Science Grid. It represents the few, if not the only, dedicated proceedings volumes that gathers together the presentations of leaders in the emerging sub-discipline of grid computing for the life sciences.The volume covers the latest developments, trends and trajectories in life science grid computing from top names in bioinformatics and computational biology: A Konagaya; J C Wooley of the National Science Foundation (NSF) and DoE thought leader in supercomputing and life science computing, and one of the key people in the NSF CIBIO initiative; P Arzberger of PRAGMA fame; and R Sinnott of UK e-Science.
This book treats the Atiyah-Singer index theorem using the heat equation, which gives a local formula for the index of any elliptic complex. Heat equation methods are also used to discuss Lefschetz fixed point formulas, the Gauss-Bonnet theorem for a manifold with smooth boundary, and the geometrical theorem for a manifold with smooth boundary. The author uses invariance theory to identify the integrand of the index theorem for classical elliptic complexes with the invariants of the heat equation.
As the site of the first permanent English settlement in North America, the birthplace of a presidential dynasty, and the gateway to western growth in the nation’s early years, Virginia can rightfully be called the “cradle of America.” Peter Wallenstein traces major themes across four centuries in a brisk narrative that recalls the people and events that have shaped the Old Dominion. The second edition is updated with new material throughout, including a new chapter on Virginia and world affairs from the Korean War through 9/11 and beyond, and, an expanded bibliography. Historical accounts of Virginia have often emphasized harmony and tradition, but Wallenstein focuses on the impact of conflict and change. From the beginning, Virginians have debated and challenged each other’s visions of Virginia, and Wallenstein shows how these differences have influenced its sometimes turbulent development. Casting an eye on blacks as well as whites, and on people from both east and west of the Blue Ridge Mountains, he traces such key themes as political power, racial identity, and education. Bringing to bear his long experience teaching Virginia history, Wallenstein takes readers back, even before Jamestown, to the Elizabethan settlers at Roanoke Island and the inhabitants they encountered, as well as to Virginia’s leaders of the American Revolution. He chronicles the state’s dramatic journey through the Civil War era, a time that revealed how the nation’s evolution sometimes took shape in opposition to the vision of many leading Virginians. He also examines the impact of the civil rights movement and considers controversies that accompany Virginia into its fifth century. The text is copiously illustrated to depict not only such iconic figures as Pocahontas, George Washington, and Robert E. Lee, but also such other prominent native Virginians as Carter G. Woodson, Patsy Cline, and L. Douglas Wilder. Sidebars throughout the book offer further insight, while maps and appendixes of reference data make the volume a complete resource on Virginia’s history.
Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.
Our Conrad is about the American reception of Joseph Conrad and its crucial role in the formation of American modernism. Although Conrad did not visit the country until a year before his death, his fiction served as both foil and mirror to America's conception of itself and its place in the world. Peter Mallios reveals the historical and political factors that made Conrad's work valuable to a range of prominent figures—including Fitzgerald, Faulkner, Richard Wright, Woodrow Wilson, and Theodore and Edith Roosevelt—and explores regional differences in Conrad's reception. He proves that foreign-authored writing can be as integral a part of United States culture as that of any native. Arguing that an individual writer's apparent (national, gendered, racial, political) identity is not always a good predictor of the diversity of voices and dialogues to which he gives rise, this exercise in transnational comparativism participates in post-Americanist efforts to render American Studies less insular and parochial.
Almayer’s Folly, Joseph Conrad’s first novel, is a tale of personal tragedy as well as a broader meditation on the evils of colonialism. Set in the lush jungle of Borneo in the late 1800s, it tells of the Dutch merchant Kaspar Almayer, whose dreams of riches for his beloved daughter, Nina, collapse under the weight of his own greed and prejudice. Nadine Gordimer writes in her Introduction, “Conrad’s writing is lifelong questioning . . . What was ‘Almayer’s Folly’? The pretentious house never lived in? His obsession with gold? His obsessive love for his daughter, whose progenitors, the Malay race, he despised? All three?” Conrad established in Almayer’s Folly the themes of betrayal, isolation, and colonialism that he would explore throughout the rest of his life and work.
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