The quiet moments of global terrorism are over. They were silently on the move and highly motivated against the USA, first and foremost. To the radical extremist fascists international terrorists network, the USA was the easiest to infiltrate amongst the worlds super powers. Their ultimate target was the entertainment capital of the world, the city of sin and pleasure for the western free world. Assisted by human traffickers and smugglers, this time, thei suicidal martyr is a Woman of Mass Destruction (WMD). Westernized and American educated, desired by almost every man, a woman well adorned as well as scorned, the self appointed terrorist, the self declared jihadist, the self-anointed martyr is now ready to make her move. It all began in an island archipelago in the Pacific, where three young men who started out as childhood friends were separated by fate. One became the most wanted notorious non Christian rebel leader in that region, another became a hardened military combat zone officer and the third became an American. Noor was a casualty turned weapon against the Infidels. Her mission before she perishes was to inflict as much damage and pain to portions of the society that caused her miseries. To make their statement that the war against terrorism is not over, and will not be over, and will not be won by the Infidels. Noor was the networks ultimate weapon against the USA as the start of reviving the plan to totally disabling the US Mainland was initiated. She has been very well prepared for a self declared war compounded by ideological pressures from her own kind covering under the protection of religion. Learning is not compulsory. Neither is survival. W. Edwards Deming (1900-1993)
The book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.
This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.
The book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.
Long recognized as an essential reference for therapists and surgeons treating the hand and the upper extremity, Rehabilitation of the Hand and Upper Extremity helps you return your patients to optimal function of the hand, wrist, elbow, arm, and shoulder. Leading hand surgeons and hand therapists detail the pathophysiology, diagnosis, and management of virtually any disorder you're likely to see, with a focus on evidence-based and efficient patient care. Extensively referenced and abundantly illustrated, the 7th Edition of this reference is a "must read" for surgeons interested in the upper extremity, hand therapists from physical therapy or occupational therapy backgrounds, anyone preparing for the CHT examination, and all hand therapy clinics. - Offers comprehensive coverage of all aspects of hand and upper extremity disorders, forming a complete picture for all members of the hand team—surgeons and therapists alike. - Provides multidisciplinary, global guidance from a Who's Who list of hand surgery and hand therapy editors and contributors. - Includes many features new to this edition: considerations for pediatric therapy; a surgical management focus on the most commonly used techniques; new timing of therapeutic interventions relative to healing characteristics; and in-print references wherever possible. - Features more than a dozen new chapters covering Platelet-Rich Protein Injections, Restoration of Function After Adult Brachial Plexus Injury, Acute Management of Upper Extremity Amputation, Medical Management for Pain, Proprioception in Hand Rehabilitation, Graded Motor Imagery, and more. - Provides access to an extensive video library that covers common nerve injuries, hand and upper extremity transplantation, surgical and therapy management, and much more. - Helps you keep up with the latest advances in arthroscopy, imaging, vascular disorders, tendon transfers, fingertip injuries, mobilization techniques, traumatic brachial plexus injuries, and pain management—all clearly depicted with full-color illustrations and photographs.
For the gold-standard resource on pediatric fractures, reach for Rockwood and Wilkins’ Fractures in Children. Written by leading orthopaedic surgeons from around the world, the revised and expanded 8th edition of this classic bestselling text presents complete, up-to-date coverage of all types of children’s fractures. A must-read for pediatric orthopedic surgeons and orthopedic residents.
Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book’s longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.
Apply cutting-edge expertise to manage your patients’ scarring issues! Scarring and fibrosis affect millions of people worldwide, and can be devastating both physically and psychologically, whether they result from major trauma such as burns or common conditions such as acne. Put today’s most advanced clinical approaches to work for your patients with The Scar Book: Formation, Mitigation, Rehabilitation, and Prevention! A multidisciplinary team of leading world experts presents the state of the art in scar pathophysiology and treatment, breaking down the barriers between medical disciplines to provide unprecedented holistic guidance.
The easy way to boost employee engagement Today more than ever, companies and leaders need a road map to help them boost employee engagement levels. Employee Engagement For Dummies helps employers implement the necessary plans to create and sustain an engaging culture, allowing them to attract and retain the best people while boosting their productivity and creativity. Employee Engagement For Dummies helps you foster employee engagement, a concept that furthers an organization′s interests through ensuring that employees remain involved in, committed to, and fulfilled by their work. It covers: practical steps to boost employee engagement with your company or team; how to engage different generations of employees; the keys to reduce voluntary employee turnover; practical tools to help retain and engage your employees; processes that will boost employee retention and productivity; hiring the best fits from the start; and much more. Helps you recognize and understand the impact of positive employee engagement Helps you attract and retain the best employees Employee Engagement For Dummies is for business leaders at all levels who are looking to better engage their employees and increase morale and productivity.
With contributions from experts in orthopaedic surgery, the latest edition of this comprehensive resource presents up-to-date technical procedures for treating a wide range of fractures in children and adolescents. Content and chapters are easier to read than ever before. How? All clinical sections follow a templatized format—as in previous editions—and now you’ll find even more treatment algorithms, checklists, charts, and tables, helping you quickly identify and apply critical information in a care situation.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
The atmosphere and climate of Mars is a crucial factor, both for understanding the planet's past and appreciating the possibilities of its future. Given the high level of current interest in Mars, and the major advances afforded by recent space exploration, this book seeks to examine and review our knowledge and understanding of the meteorology and climate of Mars in its present state. This is based not only upon direct observations, but also on the newer techniques of modelling: numerical simulation and data assimilation. This authoritative discussion of Mars' atmosphere and climate gives a balanced review of some of the hottest issues concerning Mars' environments, its present and past climate and potential to support life, and its possible future following manned exploration.
Many patients referred for an epilepsy evaluation actually suffer from one of many conditions that can imitate it. Imitators of epilepsy are a diverse group that involve consideration of many areas of internal medicine, neurology, and psychiatry. The most important imitators of epileptic seizures are dizziness, vertigo, syncope, complicated migraine; and somewhat less frequently sleep disorders, transient cerebral ischemia, paroxysmal movement disorders, endocrine or metabolic dysfunction, delirium, psychiatric conditions or transient global amnesia. Clearly under-recognized are hyperventilation episodes, panic attacks, and other psychogenic and psychiatric paroxysmal disorders that may simulate epileptic seizures. This volume provides a comprehensive review of the differential diagnosis of seizures: how do the imitators of epilepsy present clinically, what are their particular distinguishing historical features, and what tests are helpful with diagnosis? Expanding beyond the first edition, this second edition is divided into four sections. The first deals with an introduction and approach diagnosing spells, the electroencephalography of epilepsy and its imitators, and specialized tests of diagnosis such as measurement of serum prolactin. There are chapters on epileptic seizures that do not look like typical epileptic seizures, and conversely, apparent epileptic seizures that are not. A second section approaches imitators of epileptic seizures along age-based lines; i.e., what sorts of spells are likely to beset infants, children, or the elderly? A third section addresses individual imitators of epilepsy, ranging from the common to the rare, from dizziness and faintness to startle disease, arranged according to whether they might simulate partial, generalized, or both types of epileptic seizures. The volume finishes off with hyperventilation syndrome, psychogenic seizures (with or without epilepsy), and panic disorders. Most chapters review the basic definitions and physiology of the respective imitator, followed by the clinical characteristics. Emphasis is given to those features that may differentiate it from an epileptic event, but also mark it for what it is, and give possible criteria for an alternate diagnosis. Case vignettes are used to illustrate particular aspects, along with tables that compare and contrast phenotypically similar conditions. Based on their extensive clinical experience, the authors provide a personal perspective on diagnosis and treatment.
This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. Abstracts from the keynote addresses and invited talks are also included. The papers not only cover theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Whole-Genome Analysis of Dorsal Gradient Thresholds in the Drosophila Embryo (102 KB). Contents: Learning Predictive Models of Gene Regulation (C Leslie); Algorithms for Selecting Breakpoint Locations to Optimize Diversity in Protein Engineering by Site-Directed Protein Recombination (W Zheng et al.); Cancer Molecular Pattern Discovery by Subspace Consensus Kernel Classification (X Han); Transcriptional Profiling of Definitive Endoderm Derived from Human Embryonic Stem Cells (H Liu et al.); A Markov Model Based Analysis of Stochastic Biochemical Systems (P Ghosh et al.); Clustering of Main Orthologs for Multiple Genomes (Z Fu & T Jiang); Extraction, Quantification and Visualization of Protein Pockets (X Zhang & C Bajaj); Consensus Contact Prediction by Linear Programming (X Gao et al.); An Active Visual Search Interface for Medline (W Xuan et al.); Exact and Heuristic Algorithms for Weighted Cluster Editing (S Rahmann et al.); Reconcilation with Non-binary Species Trees (B Vernot et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. Graduate researchers in bioinformatics and computational biology.
With the combined expertise of leading hand surgeons and therapists, Rehabilitation of the Hand and Upper Extremity, 6th Edition, by Drs. Skirven, Osterman, Fedorczyk and Amadio, helps you apply the best practices in the rehabilitation of hand, wrist, elbow, arm and shoulder problems, so you can help your patients achieve the highest level of function possible. This popular, unparalleled text has been updated with 30 new chapters that include the latest information on arthroscopy, imaging, vascular disorders, tendon transfers, fingertip injuries, mobilization techniques, traumatic brachial plexus injuries, and pain management. An expanded editorial team and an even more geographically diverse set of contributors provide you with a fresh, authoritative, and truly global perspective while new full-color images and photos provide unmatched visual guidance. Access the complete contents online at www.expertconsult.com along with streaming video of surgical and rehabilitation techniques, links to Pub Med, and more. Provide the best patient care and optimal outcomes with trusted guidance from this multidisciplinary, comprehensive resource covering the entire upper extremity, now with increased coverage of wrist and elbow problems. Apply the latest treatments, rehabilitation protocols, and expertise of leading surgeons and therapists to help your patients regain maximum movement after traumatic injuries or to improve limited functionality caused by chronic or acquired conditions. Effectively implement the newest techniques detailed in new and updated chapters on a variety of sports-specific and other acquired injuries, and chronic disorders. Keep up with the latest advances in arthroscopy, imaging, vascular disorders, tendon transfers, fingertip injuries, mobilization techniques, traumatic brachial plexus injuries, and pain management See conditions and treatments as they appear in practice thanks to detailed, full-color design, illustrations, and photographs. Access the full contents online with streaming video of surgical and rehabilitation techniques, downloadable patient handouts, links to Pub Med, and regular updates at www.expertconsult.com. Get a fresh perspective from seven new section editors, as well as an even more geographically diverse set of contributors.
Offering practical guidance for all members of the transplant team, Kidney Transplantation, Principles and Practice, 8th Edition, provides the balanced, up-to-date information you need to achieve optimal outcomes for your patients. A global team of internationally renowned surgeons and nephrologists, many new to this edition, offers fresh perspectives on everything from applied science and surgical techniques to immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, in both adults and children. - Offers state-of-the-art coverage of all areas of kidney transplantation such as preservation of kidneys; mechanisms of rejection and the induction of tolerance; techniques of laparoscopic live donor nephrectomy; and immunosuppression. - Contains up-to-date outcomes data and analysis of the evidence supporting current practice in the field. - Includes new information on desensitization and considerable new data on the clinical use of costimulation blockade. - Keeps you current with new chapters on kidney allocation policy that reflects the ethical and societal values of different countries and populations; and biomarkers of kidney injury and rejection, including the need for better monitoring tools to guide therapy and patient management. - Covers hot topics such as management of chronic allograft failure, the sensitized patient and antibody-mediated rejection, and paired exchange principles. - Features hundreds of superb illustrations to help you visualize key concepts and nuances of renal transplantation. - Provides dynamic visual guidance with new real-time video coverage of ultrasound-guided pancreas allograft biopsy; a new animation of calcineurin inhibitor mechanism of action animation; and videos that demonstrate the formation of an immune synapse, 3-D rotational images of immune synapses, an NK cell killing its target, peritoneal dialysis-catheter insertion techniques, laparoendoscopic single site (LESS) donor nephrectomy, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices
Data model. Queries. Types. Sysems. A syntax for data. XML.. Query languages. Query languages for XML. Interpretation and advanced features. Typing semistructured data. Query processing. The lore system. Strudel. Database products supporting XML. Bibliography. Index. About the authors.
Introduced forty years ago, relational databases proved unusually succe- ful and durable. However, relational database systems were not designed for modern applications and computers. As a result, specialized database systems now proliferate trying to capture various pieces of the database market. Database research is pulled into di?erent directions, and speci- ized database conferences are created. Yet the current chaos in databases is likely only temporary because every technology, including databases, becomes standardized over time. The history of databases shows periods of chaos followed by periods of dominant technologies. For example, in the early days of computing, users stored their data in text ?les in any format and organization they wanted. These early days were followed by information retrieval systems, which required some structure for text documents, such as a title, authors, and a publisher. The information retrieval systems were followed by database systems, which added even more structure to the data and made querying easier. In the late 1990s, the emergence of the Internet brought a period of relative chaos and interest in unstructured and “semistructured data” as it wasenvisionedthateverywebpagewouldbelikeapageinabook.However, with the growing maturity of the Internet, the interest in structured data was regained because the most popular websites are, in fact, based on databases. The question is not whether future data stores need structure but what structure they need.
As democracy encounters difficulties, many citizens are turning to the domain of alternative politics and, in so doing, making considerable use of the new communication technologies. This volume analyses the various factors that shape such participation, and addresses such key topics as civic subjectivity, web intellectuals, and cosmopolitanism.
Differing from other books on the subject, this one uses the framework of constraint databases to provide a natural and powerful generalization of relational databases. An important theme running through the text is showing how relational databases can smoothly develop into constraint databases, without sacrificing any of the benefits of relational databases whilst gaining new advantages. Peter Revesz begins by discussing data models and how queries may be addressed to them. From here, he develops the theory of relational and constraint databases, including Datalog and the relational calculus, concluding with three sample constraint database systems -- DISCO, DINGO, and RATHER. Advanced undergraduates and graduates in computer science will find this a clear introduction to the subject, while professionals and researchers will appreciate this novel perspective on their subject.
The most respected, all-in-one global STD reference -- now in full-color A Doody's Core Title! 5 STAR DOODY'S REVIEW! "With a level of detail that is unmatched by any other textbook in the field of sexually transmitted diseases (STDs), this book is the ultimate reference in this area . . . No question about it -- this book is the ultimate resource for information about sexually transmitted diseases. -- Doody's Review Service" With a level of detail and scientific rigor that no other text can match, Sexually Transmitted Diseases takes you through all aspects of STDs, from epidemiology to diagnosis and public health measures. Featuring an exciting new full-color format, the fourth edition of Sexually Transmitted Diseases delivers the most encyclopedic overview of the clinical, microbiological, and public health aspects of STDs, including HIV. Turn to any page, and you'll find essential coverage of critical new developments in vaccines and prevention, global epidemiology, new treatments, and much more. Features of the Fourth Edition: The ultimate sourcebook on STDs, with top-to-bottom coverage of all STDs and all etiologies, from bacteria to viruses and more Cutting-edge insights and clinically relevant perspectives from a distinguished roster of international authorities in medicine, infectious disease, and public health NEW! Brand-new chapters that cover: Drug Use and STDs, Cervical Cancer and STDs, Prevention of Opportunistic Infections in AIDS, Pregnancy and Bacterial STDs, Pregnancy and Perinatal Transmission of STDs, The Role of Primary Care Clinicians in Managing STDs, and STD and HIV Vaccines NEW! Eye-catching full-color format with hundreds of precise illustrations that drive home chapter concepts and help you visualize various conditions
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