It had been difficult to find appropriate teaching material for students and newcomers to this field of brain electromagnetic topography. In part, this is due to the many disciplines involved, requiring some knowledge of the physical sciences, mathematics, neurophysiology and anatomy. It is my hope that this book will be found suitable for introducing interested workers to this exciting field. Advanced topics will not be covered, as there are many excellent texts available. Peter K.H. Wong vii ACKNOWLEDGEMENT My co-authors, Hal Weinberg and Roberto Bencivenga, for their support; Richard Hamer, for all his early advice; Ernst Rodin and Gene Ramsay, for their encouragement; Wendy Cummings for her assistance; Technologists from the Department of Diagnostic Neurophysiology for collecting such excellent data; Bio-Logic Systems Corp. for permission to use some data as illustration; and all my friends and colleagues. My wife Elke, for putting up with me throughout this presumptuous endeavour. The manuscript was delivered in camera-ready form to the Publisher. Illustrations were created using Harvard Graphics and CorelDraw software. ix CONTENTS Part 1: Fundamentals. 1 1.1 Introduction . . . 1 1.2 Data Aquisition. . 3 Map Construction. 8 Interpolation . . . 12 1.3 Spatial Sampling . . 16 1.4 Reference and Reference-Dependence 20 1.5 Map Display Methods ..... . 27 Scaling and Floating Voltage Scales. 37 Summary Maps .......... . 37 1.6 Identification of Topographic Features 41 1.7 Spike Mapping .. . 51 1.8 Post-Processing 61 Analog Front-end. 62 Digital Filtering . 63 Reference Manipulation .. 65 Statistical Mapping .
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.
Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology, helping you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more! Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines. Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations. Learn from leading international experts, including 53 new authors. Explore brand-new chapters, such as Principles of Cardiovascular Genetics and Biomarkers, Proteomics, Metabolomics, and Personalized Medicine. Access new and updated guidelines covering Diseases of the Aorta, Peripheral Artery Diseases, Diabetes and the Cardiovascular System, Heart Failure, and Valvular Heart Disease. Stay abreast of the latest diagnostic and imaging techniques and modalities, such as three-dimensional echocardiography, speckle tracking, tissue Doppler, computed tomography, and cardiac magnetic resonance imaging. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
For three editions, Rosen’s Breast Pathology has been widely recognized as the “gold standard” reference. Now in its Fourth Edition, this classic text continues its legacy of being the leading reference work on the pathology of the breast. Precise pathological diagnosis of breast disease is the most critical factor in determining treatment and establishing prognosis. The Fourth Edition of Rosen’s Breast Pathology provides the most comprehensive, updated information on diseases of the breast. Intended primarily for pathologists, the book will be an indispensible reference for all surgeons, oncologists, radiologists, radiation oncologists, as well as other physicians and medical personnel who require a thorough knowledge of breast pathology to provide optimal care for their patients. Discussions of most disease entities include clinical and radiological presentation, epidemiology, gross pathology, microscopic pathology, treatment, and prognosis. Surgical and oncological aspects of the various diseases are addressed wherever appropriate. Numerous images, a large proportion of which are new, complement the encyclopedic descriptions of the surgical pathology and cytology of diseases of the breast.
The book describes in detail the technical aspects of Living Donor Liver Transplantation (LDLT), the routine practice of the world renowned Liver Transplant Team at Hong Kong's Queen Mary Hospital, and our views on various issues of the operation. The thorough review on the history and technical procedures of LDLT and discussion on various aspects of the operation and its future perspectives will serve as a unique reference for surgeons, researchers, nurses, medical students, patients and laypersons seeking information on LDLT.This latest edition offers updated operative results from our center and the latest modifications of the technique. With contributions from a leading microvascular surgeon, a critical care clinician, a psychiatrist, and two anesthetists from the same liver transplant team, the LDLT experience at Queen Mary Hospital is depicted in an even greater extent.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Plant cell walls are complex, dynamic cellular structures essential for plant growth, development, physiology and adaptation. Plant Cell Walls provides an in depth and diverse view of the microanatomy, biosynthesis and molecular physiology of these cellular structures, both in the life of the plant and in their use for bioproducts and biofuels. Plant Cell Walls is a textbook for upper-level undergraduates and graduate students, as well as a professional-level reference book. Over 400 drawings, micrographs, and photographs provide visual insight into the latest research, as well as the uses of plant cell walls in everyday life, and their applications in biotechnology. Illustrated panels concisely review research methods and tools; a list of key terms is given at the end of each chapter; and extensive references organized by concept headings provide readers with guidance for entry into plant cell wall literature. Cell wall material is of considerable importance to the biofuel, food, timber, and pulp and paper industries as well as being a major focus of research in plant growth and sustainability that are of central interest in present day agriculture and biotechnology. The production and use of plants for biofuel and bioproducts in a time of need for responsible global carbon use requires a deep understanding of the fundamental biology of plants and their cell walls. Such an understanding will lead to improved plant processes and materials, and help provide a sustainable resource for meeting the future bioenergy and bioproduct needs of humankind.
Comprehensive and fully up to date, Dr. Peter Neligan's six-volume masterwork, Plastic Surgery, 5th Edition, remains the gold standard text in this complex area of surgery. Completely revised to meet the demands of both the trainee and experienced surgeon, it features new, full-color clinical photos, procedural videos, and lectures across all six volumes. Bonus material online includes additional text, images, and over 200 procedural videos that help you improve your mastery of the latest techniques. - Easily find the answers you need with an organization that features separate volumes covering Principles • Aesthetic • Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery • Lower Extremity, Trunk and Burns • Breast • and Hand and Upper Extremity. Each easily readable, individual volume is a standalone comprehensive text full of salient and applicable anatomy and techniques. - Key procedures include gender affirmation management and surgery, microsurgery and surgery for lymphedema, aesthetic facial surgery, aesthetic body surgery, and the education, training and practice of plastic surgery. - New digital video preface by Dr. Neligan addresses the changes across all six volumes. - New treatment and decision-making algorithms added to chapters where applicable. - New video lectures and editor-narrated slide presentations offer a step-by-step audiovisual walkthrough of techniques and procedures. - Four new international experts join the editorial team, and lead editor Peter C. Neligan creates a cohesive tone throughout the chapters and content across all six volumes. - Evidence-based advice from a diverse collection of experts allows you to apply the very latest advances in every area of plastic surgery and ensure optimal outcomes. - Purchase only the volumes you need or own the entire set, with the ability to search across all six volumes online!
Comprehensive and fully up to date, the six-volume Plastic Surgery remains the gold standard text in this complex area of surgery. Completely revised to meet the demands of both the trainee and experienced surgeon, Craniofacial, Head and Neck Surgery and Pediatric Plastic Surgery, Volume 3 of Plastic Surgery, 5th Edition, features new, full-color clinical photos, procedural videos, lectures, and authoritative coverage of hot topics in the field. Editor-narrated video presentations offer a step-by-step audio-visual walkthrough of techniques and procedures. - New chapters cover surgical management of facial pain, facial feminization, idiopathic progressive hemifacial atrophy, and cleft palate; coverage throughout includes new, pioneering translational work shaping the future of craniofacial, head and neck, and pediatric plastic surgery. - New digital video preface by Dr. Peter C. Neligan addresses the changes across all six volumes. - New treatment and decision-making algorithms added to chapters where applicable. - New video lectures and editor-narrated slide presentations offer a step-by-step audiovisual walkthrough of techniques and procedures. - Evidence-based advice from an expanded roster of international experts allows you to apply the very latest advances in hand and upper extremity plastic surgery and ensure optimal outcomes. - Purchase this volume individually or own the entire set, with the ability to search across all six volumes online! - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems. This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.
The book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.
The book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.
This definitive guide to modern organic electro-optic and photonic technologies provides critical insight into recent advances in organic electro-optic materials, from the underlying quantum and statistical concepts through to the practical application of materials in modern devices and systems. • Introduces theoretical and experimental methods for improving organic electro-optic and photonic technologies • Reviews the central concepts of nonlinear optics, focusing on multi-scale theoretical methods • Provides clear insight into the structure and function relationships critical to optimizing the performance of devices based on organic electro-optic materials. Serving as a primer for the systematic nano-engineering of soft matter materials, this is an invaluable resource for those involved in the development of modern telecommunication, computing, and sensing technologies depending on electro-optic technology. It is also an indispensable work of reference for academic researchers and graduate students in the fields of chemistry, physics, electrical engineering, materials science and engineering, and chemical engineering.
In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.
This book provides a clear and understandable text for users and developers of advanced engineered materials, particularly in the area of thin films, and addresses fundamentals of modifying the optical, electrical, photo-electric, triboligical, and corrosion resistance of solid surfaces and adding functionality to solids by engineering their surface, structure, and electronic, magnetic and optical structure. Thin film applications are emphasized. Through the inclusion of multiple clear examples of the technologies, how to use them,and the synthesis processes involved, the reader will gain a deep understanding of the purpose, goals, and methodology of surface engineering and engineered materials. Virtually every advance in thin film, energy, medical, tribological materials technologies has resulted from surface engineering and engineered materials. Surface engineering involves structures and compositions not found naturally in solids and is used to modify the surface properties of solids and involves application of thin film coatings, surface functionalization and activation, and plasma treatment. Engineered materials are the future of thin film technology. Engineered structures such as superlattices, nanolaminates, nanotubes, nanocomposites, smart materials, photonic bandgap materials, metamaterials, molecularly doped polymers and structured materials all have the capacity to expand and increase the functionality of thin films and coatings used in a variety of applications and provide new applications. New advanced deposition processes and hybrid processes are being used and developed to deposit advanced thin film materials and structures not possible with conventional techniques a decade ago. Properties can now be engineered into thin films that achieve performance not possible a decade ago.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
Macular Surgery, Second Edition serves as a comprehensive and contemporary review of macular diseases and their management. An exhaustive review of the latest proven surgical techniques and therapies for treatment of macular disorders is provided, with emphasis on proven techniques from extensive reviews of controlled clinical trials. Specific chapters of the book are devoted to age-related macular degeneration, diabetic retinopathy, macular holes, epiretinal membranes, subretinal hemorrhage, and choroidal neovascularization. An entire section is devoted to prevention of complications from macular surgery. All chapters are written by leading experts within the field.
Diffusion in Natural Porous Media: Contaminant Transport, Sorption/Desorption and Dissolution Kinetics introduces the general principles of diffusion in the subsurface environment and discusses the implications for the fate and transport of contaminants in soils and groundwater. Emphasis is placed on sorption/desorption and the dissolution kinetics of organic contaminants, both of which are limited by the slow speed of molecular diffusion. Diffusion in Natural Porous Media: Contaminant Transport, Sorption/Desorption and Dissolution Kinetics compiles methods for calculating the diffusion coefficients of organic compounds (in aqueous solution or vapor phase) in natural porous media. The author uses analytical solutions of Fick's 2nd law and some simple numerical models to model diffusive transport under various initial and boundary conditions. A number of these models may be solved using spreadsheets. The book examines sorption/desorption rates of organic compounds in various soils and aquifer materials, and also examines the dissolution kinetics of nonaqueous phase liquids in aquifers, in both the trapped residual phase and in pools. Diffusion in Natural Porous Media: Contaminant Transport, Sorption/Desorption and Dissolution Kinetics concludes with a discussion of the impact of slow diffusion processes on soil and groundwater decontamination and the implications of these processes for groundwater risk assessment.
Thoroughly updated for its Second Edition, Non-Hodgkin Lymphomas is the definitive textbook on the biology, diagnosis, staging, and treatment of all forms of non-Hodgkin lymphomas. With backgrounds in medical and radiation oncology, molecular biology, and pathology, the editors and contributors provide an international, multidisciplinary approach to the topic. This edition is the first text using the new World Health Organization classification of non-Hodgkin lymphomas. The book offers complete coverage of the most current techniques for diagnosis, staging, and treatment, the approach to specific types of lymphoma, and special problems common to the management of patients with these disorders.
Pathology of the Human Placenta has become the gold standard in the field for pathologists and obstetrician-gynecologists. Completely up-to-date, this fifth edition continues to be the essential reference for professionals in the field and includes many revised features such as a more detailed index; 700 total illustrations (350 color illustrations); and updated tables.
This volume contains contributions from cooperative research activities in physics and chemistry and addresses heterogeneous systems like atoms and molecules in complex environments, dye molecules like the retinal chromophore in the protein box of the human eye, interacting atoms/molecules in the interlayer of adsorbed structures, nucleation and domain formation processes in magnetic and martensitic systems. The particular aim of the contributions is to deduce the connection between different grades of heterogeneity and to bridge the gap between chemicals and heterogeneity on the atomic scale, and the physics of macroscopically heterogeneous systems. Besides the diverse experimental tools employed in the investigations, accompanying theoretical investigations range from ab initio molecular dynamics studies of the microscopic systems to Monte-Carlo simulations of the larger-scale problems.
Randomised Clinical Trials: Design, Practice and Reporting provides a detailed overview of the methodology for conducting clinical trials, including developing protocols, data capture, randomisation, analysis and reporting. Assuming no prior background, this user-friendly resource describes the statistical, regulatory, and practical components required for conducting randomised clinical trials. Numerous examples and case studies from industry, academia, and the research literature help readers understand each stage of the clinical trial process. This second edition contains extensively revised material throughout, including new chapters covering designs for repeated measures, non-inferiority, cluster and stepped wedge trials. Other new chapters describe data and safety monitoring, biomarker studies, and feasibility studies. Updated and expanded sections discuss situations where multiple organs, different body locations or competing risks are involved, subgroup analysis, and multiple outcomes. Written by an author team with extensive experience in conducting clinical trials, this book: Provides comprehensive coverage of randomised clinical trials, ranging from basic to advanced Features several new chapters, updated case studies and examples, and references to changes in regulations Explains basic randomised trials, including the parallel two-group controlled trial with a single outcome measure Covers paired trial designs and trials with more than two interventions Includes a chapter on miscellaneous topics such as adaptive designs, large simple trials, Bayesian methods for very small trials, alpha-spending functions and the predictive probability test Randomised Clinical Trials is essential reading for clinicians, nurses, data managers, and medical statisticians involved in clinical trials, and for health practitioners responsible for direct patient care in a clinical trial setting.
The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described. Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye. - Adopts a translational approach, summarizing the biological knowledge regarding the structure and function of the fovea, the roles of Müller cells in mediating the structural integrity, and function of the fovea - Provides overviews of both basic types of the vertebrate fovea, countering the popular belief that there is only one type of the vertebrate fovea, the human fovea - Thoroughly shows the mechanisms involved in the development of the fovea that explain the rapid improvement of visual acuity in newborns - Explains pathological changes in the foveal structure and function with evaluation pointing toward possible prevention and/or cure
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
This book constitutes the refereed proceedings of the 13th International Conference on Field-Programmable Logic and Applications, FPL 2003, held in Lisbon, Portugal in September 2003. The 90 revised full papers and 56 revised poster papers presented were carefully reviewed and selected from 216 submissions. The papers are organized in topical sections on technologies and trends, communications applications, high level design tools, reconfigurable architecture, cryptographic applications, multi-context FPGAs, low-power issues, run-time reconfiguration, compilation tools, asynchronous techniques, bio-related applications, codesign, reconfigurable fabrics, image processing applications, SAT techniques, application-specific architectures, DSP applications, dynamic reconfiguration, SoC architectures, emulation, cache design, arithmetic, bio-inspired design, SoC design, cellular applications, fault analysis, and network applications.
The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.
Neoplastic mimics or "pseudotumors" can simulate neoplasms on all levels of analysis- clinical, radiologic, and pathologic--and thus represent particular diagnostic pitfalls for the pathologist that can ultimately lead to therapeutic misdirection. This book provides the pathologist with detailed morphologic descriptions and diagnostic guidance in recognizing these neoplastic mimics as they occur in the genitourinary system. In addition, descriptions and diagnostic guidance are provided for the range of genitourinary lesions tumors that may mimic benign masses but are in fact neoplastic. Throughout the book comparisons of neoplastic mimics with true neoplasms are provided, at clinical, gross, and histologic levels. In the presentation of every entity, the points that contribute to differential diagnosis are emphasized. More than 500 color images and this analysis of diagnostic mimics guide the pathologist through recognizing and distinguishing the unusual variants, morphologic anomalies and misleading features that may easily lead to an inaccurate interpretation and missed diagnosis. Since many of entities described are uncommon Neoplastic Mimics in Genitourinary emphasizes imaging and clinical correlations throughout to support the pathologist as consultant to the entire diagnostic and clinical management team. Every pathologist who sees genitourinary cases will find this book an invaluable working tool to ensure accurate diagnosis. Neoplastic Mimics in Genitourinary Pathology features: Over 500 high-quality images showing the full range of neoplastic mimics in the genitourinary tract Concise, specific text descriptions make the book easy to use as a visual reference Expert authors guide the reader to recognizing and distinguishing misleading specimens
This bestselling textbook will introduce undergraduate bioengineering students to the fundamental concepts and techniques, with the basic theme of integrative bioengineering. It covers bioengineering of several body systems, organs, tissues, and cells, integrating physiology at these levels with engineering concepts and approaches; novel developments in tissue engineering, regenerative medicine, nanoscience and nanotechnology; state-of-the-art knowledge in systems biology and bioinformatics; and socio-economic aspects of bioengineering.One of the distinctive features of the book is that it is integrative in nature (integration of biology, medicine and engineering, across different levels of the biological hierarchy, and basic knowledge with applications). It is unique in that it covers fundamental aspects of bioengineering, cutting-edge frontiers, and practical applications, as well as perspectives of bioengineering development. Furthermore, it covers important socio-economical aspects of bioengineering such as ethics and entrepreneurism.
One of the key tools in effectively managing critical illness is the use of mechanical ventilator support. This essential text helps you navigate this rapidly evolving technology and understand the latest research and treatment modalities. A deeper understanding of the effects of mechanical ventilation will enable you to optimize patient outcomes while reducing the risk of trauma to the lungs and other organ systems. A physiologically-based approach helps you better understand the impact of mechanical ventilation on cytokine levels, lung physiology, and other organ systems. The latest guidelines and protocols help you minimize trauma to the lungs and reduce patient length of stay. Expert contributors provide the latest knowledge on all aspects of mechanical ventilation, from basic principles and invasive and non-invasive techniques to patient monitoring and controlling costs in the ICU. Comprehensive coverage of advanced biological therapies helps you master cutting-edge techniques involving surfactant therapy, nitric oxide therapy, and cytokine modulators. Detailed discussions of both neonatal and pediatric ventilator support helps you better meet the unique needs of younger patients.
This monumental text-reference places in clear persepctive the importance of nutritional assessments to the ecology and biology of ruminants and other nonruminant herbivorous mammals. Now extensively revised and significantly expanded, it reflects the changes and growth in ruminant nutrition and related ecology since 1982. Among the subjects Peter J. Van Soest covers are nutritional constraints, mineral nutrition, rumen fermentation, microbial ecology, utilization of fibrous carbohydrates, application of ruminant precepts to fermentive digestion in nonruminants, as well as taxonomy, evolution, nonruminant competitors, gastrointestinal anatomies, feeding behavior, and problems fo animal size. He also discusses methods of evaluation, nutritive value, physical struture and chemical composition of feeds, forages, and broses, the effects of lignification, and ecology of plant self-protection, in addition to metabolism of energy, protein, lipids, control of feed intake, mathematical models of animal function, digestive flow, and net energy. Van Soest has introduced a number of changes in this edition, including new illustrations and tables. He places nutritional studies in historical context to show not only the effectiveness of nutritional approaches but also why nutrition is of fundamental importance to issues of world conservation. He has extended precepts of ruminant nutritional ecology to such distant adaptations as the giant panda and streamlined conceptual issues in a clearer logical progression, with emphasis on mechanistic causal interrelationships. Peter J. Van Soest is Professor of Animal Nutrition in the Department of Animal Science and the Division of Nutritional Sciences at the New York State College of Agriculture and Life Sciences, Cornell University.
Cardiac Magnetic Resonance (CMR) is a rapidly evolving imaging technology and is now increasingly utilized in patient care. Its advantages are noninvasiveness, superb image resolutions, and body tissue characterization. CMR is now an essential part of both cardiology and radiology training and has become part of the examination for Board certification. This book provides a condensed but comprehensive and reader friendly educational tool for cardiology fellows and radiology residents. It contains multiple choice questions similar to board examinations with concise comment and explanation about the correct answer.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
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