Nutrient-balance assessments are valuable tools for delineating the consequences of farming on soil fertility. Various approaches and methods for different situations have been used in the past. This bulletin presents a state-of-the-art review of nutrient balance studies. It brings out the evolution of the approaches and methods, provides for comparisons among them, features the improvements made, and highlights remaining issues. This analysis will be useful in further development of the assessment methodologies as reliable tools for devising time-scale soil fertility management interventions.
Bioassays are among the ecotoxicologist's most effective weapons in the evaluation of water quality and the assessment of ecological impacts of effluents, chemicals, discharges, and emissions on the aquatic environment. Information on these assessment aids is needed throughout the international scientific and environmental management community. This comprehensive reference provides an excellent overview of the small-scale aquatic bioassay techniques and applications currently in use around the world. This special volume is the result of several years of collaboration between Environment Canada and Fisheries and Oceans Canada. Internationally recognized research scientists at many institutions have contributed to this state-of-the-art examination of the exciting, environmentally important field of microscale testing in aquatic toxicology. Microscale Testing in Aquatic Toxicology contains over forty chapters covering relevant principles, new techniques and recent advancements, and applications in scientific research, environmental management, academia, and the private sector.
The complete last essays of acclaimed writer Peter Schjeldahl, the great New Yorker art critic and Pulitzer Prize finalist. Foreword by Steve Martin Introduction by Jarrett Earnest When the New Yorker art critic Peter Schjeldahl published his widely read autobiographical essay “The Art of Dying” in December 2019, he reported that he had lung cancer and his oncologist had given him six months to live, but his experimental treatment was showing some improvement. “These extra months,” he wrote, “are a luxury that I hope to have put to good use.” And he did. The Art of Dying: Writings, 2019-2022 begins with that essay and collects all 46 pieces that he wrote for the magazine before his death in October 2022. These last works express Schjeldahl’s hard-won reflections on art and life, against the backdrop of an intensely anxious period in America, spanning the pandemic, the George Floyd protests, the 2020 presidential election, and the war in Ukraine. Schjeldahl, who was the leading art writer of his generation, wrote with generosity and openness about the art world during these tempestuous three years.
Enables researchers to assess the effects of endocrine disrupters as well as comply with new environmental regulations Endocrine disrupters are chemicals both man-made and natural that interfere with the body's endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up-to-date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine-disrupting chemicals. Endocrine Disrupters is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including: Crustaceans and mollusks Insects Fish Amphibians and reptiles Birds and mammals Moreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost. Each chapter is written by one or more international experts in ecotoxicology, offering readers step-by-step guidance for implementing each method based on the latest research and the authors' firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers' comments. References at the end of each chapter guide readers to the literature in the field. Endocrine Disrupters is recommended for scientists who need to test chemicals for possible endocrine-disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemicals can be safely marketed.
Conflict between labor and capital reflects the competitive and conflict-laden relations within the working class itself, Peter Swenson maintains. Fair Shares examines the internal conflicts of organized labor regarding distribution of wages in order to explain both union leaders' market-structuring objectives in the "political economy", and their imperative to shape and fulfill workers' notions of pay fairness in the "moral economy". Swenson develops an innovative theoretical approach to labor politics through a detailed comparative analysis of union centralization and collective bargaining in Sweden and Germany since the turn of the century. To create solidarity and overcome workers' opposition to centralized control of the labor movement, Swenson argues, union leaders depend heavily on moral appeals concerning fair pair distribution and on success in fulfilling workers' expectation of fairness. Swenson interprets union politics as the attempt to overcome what he calls the "wage policy trilemma
Vikkan Lantry, a pianist with more talent than ambition, is content with his job at an upscale cocktail lounge until a request from reclusive soprano, Ulrike Vogel, draws him grudgingly back into the world of classical music. Ulrike’s mysterious past, and her friendship with elderly Viennese piano teacher, Dieter Mann, usher Vikkan into an intrigue that begins in the nineteenth century with an unknown song cycle composed by Robert Schumann, and ends in the present-day with a grisly double murder. As Vikkan probes the layers of deceit obscuring a killer’s identity, The Schumann Proof reveals itself to be a study in ambition gone awry. The theme is hardly new, but The Schumann Proof gives it a fresh slant, examining not only the devastating results of too much seeking after personal glory, but the painful consequences of too little.
The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.
Infections caused by parasites are still a major global health problem. Although parasitic infections are responsible for a significant morbidity and mortality in the developing countries, they are also prevalent in the developed countries. Early diagnosis and treatment of a parasitic infection is not only critical for preventing morbidity and mort
From one of the most prominent biographers of the Nazi period, a new and provocative portrait of the figure behind the century's worst crimes Acclaimed historian Peter Longerich, author of Goebbels and Heinrich Himmler now turns his attention to Adolf Hitler in this new biography. While many previous portraits have speculated about Hitler's formative years, Longerich focuses on his central role as the driving force of Nazism itself. You cannot separate the man from the monstrous movement he came to embody. From his ascendance through the party's ranks to his final hours as Führer in April 1945, Longerich shows just how ruthless Hitler was in his path to power. He emphasizes Hitler's political skills as Germany gained prominence on the world's stage. Hitler's rise to, and ultimate hold on, power was more than merely a matter of charisma; rather, it was due to his ability to control the structure he created. His was an image constructed by his regime - an essential piece self-created of propaganda. This comprehensive biography is the culmination of Longerich's life-long pursuit to understand the man behind the century's worst crimes.
This study explores the prevalence in German culture of myths about ancient matriarchal societies, discussing their presence in left and right wing politics, feminist and antifeminist writing, sociology, psychoanalysis and literary production. By tracing the influence of the works of the Swiss jurist and theorist of matriarchy, Johann Jakob Bachofen (1815–1887), and the controversies about the reception and interpretation of his work, this study shows how debate about the matriarchal origins of culture was inextricably linked with anxieties about modernity and gender identities at the turn of the twentieth century. By moving beyond the discussion of canonical authors and taking seriously the scope of the discussion, it becomes clear that it is not possible to reduce matriarchal theories to any particular political ideology; instead, they function as a mythic counterdiscourse to a modernity conceived as oppressive, rational and masculine. Writers considered include Ludwig Klages, Hofmannsthal, Kafka, Hauptmann, Lou Andreas-Salomé, Sir Galahad, Clara Viebig, Mathilde Vaerting, Thomas Mann, Elisabeth Langgässer, Ilse Langner, Otto Gross, Franz Werfel, and many others.
This book describes and analyses the rules and provisions of the United Nation Convention on the International Sale of Goods of 1980 - CISG-. The authors explain the details of the CISG’s text, report the essence of the scholarly discussions of its issues, and, in particular, present numerous cases decided by courts and arbitration tribunals both as illustrations of problems arising under the CISG and as case law interpreting the Convention. The book is mainly intended to be used in teaching, but it can also help practitioners to understand the structure and basic solutions of sales law issues encoded in the CISG.
“Mutual Aid: A Factor of Evolution” is a 1902 collection of essays by Russian naturalist and anarchist philosopher Peter Kropotkin. Originally published in “The Nineteenth Century” from 1890 to 1896, the essays examine mutually-beneficial cooperation and reciprocity in both animal and human societies. Contents include: “Mutual Aid Among Animals”, “Mutual Aid Among Animals (continued)”, “Mutual Aid Among Savages”, “Mutual Aid Among The Barbarians”, “Mutual Aid In The Mediaeval City”, “Mutual Aid In The Mediaeval City (continued)”, etc. Pyotr Alexeyevich Kropotkin (1842–1921) was a Russian writer, activist, revolutionary, economist, scientist, sociologist, essayist, historian, researcher, political scientist, geographer, geographer, biologist, philosopher and advocate of anarcho-communism. He was a prolific writer, producing a large number of pamphlets and articles, the most notable being “The Conquest of Bread and Fields, Factories and Workshops” and “Mutual Aid: A Factor of Evolution”. This classic work is being republished now in a new edition complete with an excerpt from “Comrade Kropotkin” by Victor Robinson.
The history of mountaineering has long served as a metaphor for civilization triumphant. Once upon a time, the Alps were an inaccessible habitat of specters and dragons, until heroic men—pioneers of enlightenment—scaled their summits, classified their strata and flora, and banished the phantoms forever. A fascinating interdisciplinary study of the first ascents of the major Alpine peaks and Mount Everest, The Summits of Modern Man surveys the far-ranging significance of our encounters with the world’s most alluring and forbidding heights. Our obsession with “who got to the top first” may have begun in 1786, the year Jacques Balmat and Michel-Gabriel Paccard climbed Mont Blanc and inaugurated an era in which Romantic notions of the sublime spurred climbers’ aspirations. In the following decades, climbing lost its revolutionary cachet as it became associated instead with bourgeois outdoor leisure. Still, the mythic stories of mountaineers, threaded through with themes of imperialism, masculinity, and ascendant Western science and culture, seized the imagination of artists and historians well into the twentieth century, providing grist for stage shows, poetry, films, and landscape paintings. Today, we live on the threshold of a hot planet, where melting glaciers and rising sea levels create ambivalence about the conquest of nature. Long after Hillary and Tenzing’s ascent of Everest, though, the image of modern man supreme on the mountaintop retains its currency. Peter Hansen’s exploration of these persistent images indicates how difficult it is to imagine our relationship with nature in terms other than domination.
This absorbing reference covers everyday life in ancient Egypt, spanning a period of more than 5,000 years—from the Stone Age to the advent of Christianity. The mysteries surrounding ancient Egypt continue to pique interest and prompt study thousands of years later. Intriguing questions—such as "Why were certain Egyptians mummified after death, while others were not?", "How were the pyramids constructed?", and "Were sexuality and courtship accurately portrayed in movies about the period?"—incite curiosity and inspire the imagination in the modern world. This comprehensive encyclopedia addresses these questions and more, revealing fascinating facts about all aspects of daily life in ancient Egypt. Starting with the beginning of the First Dynasty to the death of Cleopatra, this compendium explores the family life, politics, religion, and culture of the Nile Valley from Aswan to the Delta, as well as the peripheral areas of Nubia, the Oases, the Sinai, and the southern Levant. Each topical section opens with an introductory essay, followed by A–Z entries on such topics as food, fashion, housing, politics, and community. The book features a timeline of events, an extensive bibliography of print and digital resources, and numerous photographs and illustrations throughout.
The story behind the technology that revolutionized both aeronautics, and the course of history On a moonless night in January 1991, a dozen airplanes appeared in the skies over Baghdad. Or, rather, didn't appear. They arrived in the dark, their black outlines cloaking them from sight. More importantly, their odd, angular shapes, which made them look like flying origami, rendered them undetectable to Iraq's formidable air defenses. Stealth technology, developed during the decades before Desert Storm, had arrived. To American planners and strategists at the outset of the Cold War, this seemingly ultimate way to gain ascendance over the USSR was only a question. What if the United States could defend its airspace while at the same time send a plane through Soviet skies undetected? A craft with such capacity would have to be essentially invisible to radar - an apparently miraculous feat of physics and engineering. In Stealth, Peter Westwick unveils the process by which the impossible was achieved. At heart, Stealth is a tale of two aerospace companies, Lockheed and Northrop, and their fierce competition - with each other and with themselves - to obtain what was estimated one of the largest procurement contracts in history. Westwick's book fully explores the individual and collective ingenuity and determination required to make these planes and in the process provides a fresh view of the period leading up to the end of the Soviet Union. Taking into account the role of technology, as well as the art and science of physics and engineering, Westwick offers an engaging narrative, one that immerses readers in the race to produce a weapon that some thought might save the world, and which certainly changed it.
PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the pharmaceutical industries and their charade of fraudulent behaviour, both in research and marketing where the morally repugnant disregard for human lives is the norm. He convincingly draws close co
Scholarly and comprehensive yet accessible, this state-of-the-science work is widely regarded as the definitive graduate-level psychology of religion text. The authors synthesize classic and contemporary empirical research on numerous different religious groups. Coverage includes religious thought, belief, and behavior across the lifespan; links between religion and biology; the forms and meaning of religious experience; the social psychology of religious organizations; and connections to morality, coping, mental health, and psychopathology. Every chapter features thought-provoking quotations and examples that bring key concepts to life. New to This Edition *Revised and updated with the latest theories, methods, and empirical findings.*Many new research examples.*Restructured with fewer chapters for better “fit” with a typical semester.*More attention to the differences between religion and spirituality*Covers emerging topics: genetics and neurobiology, positive psychology, atheism, and more.
Warrior, mighty builder, and statesman, over the course of his 67-year-long reign (1279-1212 BCE), Ramesses II achieved more than any other pharaoh in the three millennia of ancient Egyptian civilization. Drawing on the latest research, Peter Brand reveals Ramesses the Great as a gifted politician, canny elder statesman, and tenacious warrior. With restless energy, he fully restored the office of Pharaoh to unquestioned levels of prestige and authority, thereby bringing stability to Egypt. He ended almost seven decades of warfare between Egypt and the Hittite Empire by signing the earliest international peace treaty in recorded history. In his later years, even as he outlived many of his own children and grandchildren, Ramesses II became a living god and finally, an immortal legend. With authoritative knowledge and colorful details Brand paints a compelling portrait of this legendary Pharaoh who ruled over Imperial Egypt during its Golden Age.
In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.
There is considerable current academic interest in the interface between geographical information systems (GIS) and the environment. This new monograph explores the process from start to finish. It begins with information acquisition in the environment and moves on to tool and techniques for manipulating the information, visualisation and navigation methods for exploring it, and computation and modelling techniques for its analysis. It then concludes with a survey of decision support, for its application. Spatial Information and the Environment is the eighth book in the Innovations in GIS series initiated in 1994. The series is in essence derived from a selection of the presentations made at the annual GIS Research UK conference 2000 held in York, and has now changed its focus by concentrating on a single topic, making each text distinctive.
The recent discovery of diverse fossil flowers and floral organs in Cretaceous strata has revealed astonishing details about the structural and systematic diversity of early angiosperms. Exploring the rich fossil record that has accumulated over the last three decades, this is a unique study of the evolutionary history of flowering plants from their earliest phases in obscurity to their dominance in modern vegetation. The discussion provides comprehensive biological and geological background information, before moving on to summarise the fossil record in detail. Including previously unpublished results based on research into Early and Late Cretaceous fossil floras from Europe and North America, the authors draw on direct palaeontological evidence of the pattern of angiosperm evolution through time. Synthesising palaeobotanical data with information from living plants, this unique book explores the latest research in the field, highlighting connections with phylogenetic systematics, structure and the biology of extant angiosperms.
This comprehensive and practical reference is the perfect resource for the medical specialist treating persons with spinal cord injuries. The book provides detail about all aspects of spinal cord injury and disease. The initial seven chapters present the history, anatomy, imaging, epidemiology, and general acute management of spinal cord injury. The next eleven chapters deal with medical aspects of spinal cord damage, such as pulmonary management and the neurogenic bladder. Chapters on rehabilitation are followed by nine chapters dealing with diseases that cause non-traumatic spinal cord injury. A comprehensive imaging chapter is included with 30 figures which provide the reader with an excellent resource to understand the complex issues of imaging the spine and spinal cord.
TRENDS IN LINGUISTICS is a series of books that open new perspectives in our understanding of language. The series publishes state-of-the-art work on core areas of linguistics across theoretical frameworks as well as studies that provide new insights by building bridges to neighbouring fields such as neuroscience and cognitive science. TRENDS IN LINGUISTICS considers itself a forum for cutting-edge research based on solid empirical data on language in its various manifestations, including sign languages. It regards linguistic variation in its synchronic and diachronic dimensions as well as in its social contexts as important sources of insight for a better understanding of the design of linguistic systems and the ecology and evolution of language. TRENDS IN LINGUISTICS publishes monographs and outstanding dissertations as well as edited volumes, which provide the opportunity to address controversial topics from different empirical and theoretical viewpoints. High quality standards are ensured through anonymous reviewing.
The iconic Periodic Table of the Elements is now in its most satisfyingly elegant form. This is because all the 'gaps' corresponding to missing elements in the seventh row, or period, have recently been filled and the elements named. But where do these names come from? For some, usually the most recent, the origins are quite obvious, but in others - even well-known elements such as oxygen or nitrogen - the roots are less clear. Here, Peter Wothers explores the fascinating and often surprising stories behind how the chemical elements received their names. Delving back in time to explore the history and gradual development of chemistry, he sifts through medieval manuscripts for clues to the stories surrounding the discovery of the elements, showing how they were first encountered or created, and how they were used in everyday lives. As he reveals, the oldest-known elements were often associated with astronomical bodies, and connections with the heavens influenced the naming of a number of elements. Following this, a number of elements, including hydrogen and oxygen, were named during the great reform of chemistry, set amidst the French Revolution. While some of the origins of the names were controversial (and indeed incorrect - some saying, for instance, that oxygen might be literally taken to mean 'the son of a vinegar merchant'), they have nonetheless influenced language used around the world to this very day. Throughout, Wothers delights in dusting off the original sources, and bringing to light the astonishing, the unusual, and the downright weird origins behind the names of the elements so familiar to us today.
Keeping doctors happy and productive requires a thorough understanding of the systemic causes and consequences of physician stress, as well as the role of resilience in maintaining a healthy mental state. The pressure of making life-or-death decisions along with those associated with the day-to-day challenges of doctoring can lead to poor patient care and communication, patient dissatisfaction, absenteeism, reductions in productivity, job dissatisfaction, and lowered retention. This edited volume will provide a comprehensive tool for understanding and promoting physician stress resilience. Specifically, the book has six interrelated objectives that, collectively, would advance the evidence-based understanding of (1) the extent to which physicians experience and suffer from work-related stress; (2) the various manifestations, syndromes, and reaction patterns directly caused by work-related stress; (3) the degree to which physicians are resilient in that they are successful or not successful in coping with these stressors; (4) the theories and direct evidence that account for the resilience; (5) the programs during and following medical school which help to promote resilience; and (6) the agenda for future theory, research, and intervention efforts for the next generation of physicians.
Multidimensional Pharmacochemistry: Design of Safer Drugs deals with techniques based on the theory of simultaneous statistical inference and the qualitative rules that can be applied in solving problems of high toxicity. This book points out that the multidimensional view of data analysis can be applied to solve problems in medicinal chemistry. Investigators use different approaches; a certain procedure can prove to be the most beneficial for a specific drug design. This text presents the theoretical assumptions that mathematicians make to derive the basis for their multivariate techniques. This book also describes, in nonmathematical terms, a set of methods that are valuable, as well as explain the different designs by using numerical examples. According to E.J. Ariens, drug action involves the pharmaceutical, pharmacokinetic-toxokinetic, and pharmacodynamics-toxodynamic phases. The multivariate structure-activity analysis (MASCA) Model of Pharmacochemistry is a highly unified multivariate approach to drug design. To develop a multidimensionally oriented pharmacology, the book notes that the investigator can use the "dynamic structure-activity analysis." This entails the experimentalist and chemist using quantitative approaches and intuitive elements from a small number of compounds toward larger groups, with successive changes being inputted in the desired biological activity. This book is strongly recommended for toxicologists, pharmacologists, applied mathematicians, medicinal and agricultural chemists.
The book covers the fundamentals of the field of biocatalysis that are not treated in such detail (or even not at all) in existing biocatalysis books or biochemistry textbooks. It of course does not substitute existing biochemistry textbooks but will serve a suitable supplement as it discusses biochemical fundamentals in connection with the respective topics.With focus on the interdisciplinary nature of biocatalysis, the book contains many aspects of fundamental organic chemistry and some of inorganic chemistry as well, which should make it interesting not only for biochemistry but also for chemistry students. An important theme being emphasized in the book is that applied biocatalysis is one of the main prerequisites for a sustainable development.The topics covered ranges from basic enzyme chemistry (biosynthesis, structure, properties, interaction forces, kinetics) to a detailed description of catalytic mechanisms. It covers the fundamentals of the different enzyme classes together with their applications in native and in immobilized state or in the form of whole cells in aqueous as well as non-conventional media. Topics such as catalytic antibodies, nucleic acid catalysts, non-ribosomal peptide synthesis, evolutionary methods, and the design of cells are also included.
In this comprehensive volume, Peter Longerich documents Goebbels' descent into antisemitism and ideology and ascent through the ranks of the Nazi party, where he became an integral member of Hitler's inner circle and where he shaped a brutal campaign of Nazi propaganda"--
Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
This study of sixth-century Hebrew thought, a part of the Old Testament Library series, grew out of Peter Ackroyd's influential Hulsean Lectures on the same topic. The Old Testament Library provides fresh and authoritative treatments of important aspects of Old Testament study through commentaries and general surveys. The contributors are scholars of international standing.
Exhibiting the Archive examines the role that exhibition plays in archives and analyses the impact they are understood to have on how users and visitors experience the archive. Drawing on research conducted in Europe, North America and Australia, the book analyses the key theoretical and social influences on exhibition-making in archives today and discusses the role of exhibitions in the archives of tomorrow. This is the first in-depth study to consider exhibition as more than outreach or advocacy: it frames exhibition as an encounter with archives and with people, and interprets it as a mechanism for change within the archive. Against a backdrop of increasing digital activity, Lester asks what experience within the physical space of the archive could be. Drawing on ideas of spatiality and embodiment, as well as social justice and activism, Lester considers the role of exhibitions within the physical archive and the part they can play in reshaping how experience is understood to happen within it. Exhibiting the Archive offers a new perspective on the archive that will be of interest to academics and students engaged in the study of archives and records. The discussions of cutting-edge practice offer new insights into how exhibitions are conceived and made, and will therefore be of interest to practitioners around the world.
It has been called the Tour de France’s ‘Hollywood climb’, and there is no doubt that Alpe d’Huez has played a starring role in cycling’s history since its first encounter with the sport back in 1952 when the legendary Fausto Coppi triumphed on the summit. Re-introduced to the Tour in 1976, Alpe d’Huez has risen to mythical status, thanks initially to a string of victories by riders from Holland, whose exploits attracted tens of thousands of their compatriots to the climb, which has become known as ‘Dutch mountain’. A snaking 13.8-kilometre ascent rising up through 21 numbered hairpins at an average gradient of 7.8%, Alpe d’Huez is the climb on which every great rider wants to win. Many of the sport’s most famous and now even infamous names have won on the Alpe, including Bernard Hinault, Joop Zoetemelk, Lucho Herrera, Marco Pantani and Lance Armstrong. As well as days of brilliance, there have controversies such as the high-speed and drug-fuelled duels of the EPO years in the 1990s and into the new millennium. In Alpe d’Huez, veteran cycling journalist Peter Cossins reveals the triumphs, passion and despair behind the great exploits on the Alpe and discloses the untold details that have led to the mountain becoming as important to the Tour as the race is to resort at its summit. It is a tale of man and machine battling against breath-taking terrain for the ultimate prize.
Progress in Standardization of Aquatic Toxicity Tests provides a critical evaluation of the level of standardization achieved by freshwater and marine ecotoxicity tests used to evaluate potential risk of new chemicals and wastewater effluents. Tests at the sub-cellular, individual, laboratory microcosm, and ecosystem levels are presented and critically evaluated. The influence of environmental and genetic heterogeneity on test standardization is also discussed. The book will be an excellent reference for industry professionals, consultants, regulatory officials, and students working in the ecotoxicology field.
This issue of Clinics in Chest Medicine, edited by Drs. Peter Marshall and Wassim Fares, focuses on Pulmonary Embolism, with topics including: Clinical Probability Tools for DVT, PE, & Bleeding; Prevention of DVTs and Pulmonary Emboli: General Measures and High-Risk Populations; Diagnosis of DVTs and PEs: New Imaging Tools and Modalities; Perfusion Defects Misdiagnosed as Pulmonary Emboli; The Vicious Cycle of Hypercoagulability and Pulmonary Hypertension; VTE in Special Populations; Preganncy and Thrombo-embolic Disease; Challenges and Changes to the Management of PE in the Emergency Department; The Value of Bedside Echocardiogram in the Setting of Acute & Chronic Pulmonary Embolism; Management of Low-Risk PE; Update on the 'Novel' and Direct Oral Anticoagulants; Risk Stratification: Definitive/Aggressive Treatment of Hemodynamically Stable but Intermediate Risk Patients; Pulmonary Embolism Response Team (PERT); Surgical and Other Interventions for DVTs; IVC Filters; Catheter-Based Therapies of Pulmonary Emboli; Surgical-Based Therapies for PEs; and Chronic Thrombo-embolic Pulmonary Hypertension (CTEPH).
More than a history of science; it is a tour de force in the genre." —New York Times Book Review A dramatic new account of the parallel quests to harness time that culminated in the revolutionary science of relativity, Einstein's Clocks, Poincaré's Maps is "part history, part science, part adventure, part biography, part meditation on the meaning of modernity....In Galison's telling of science, the meters and wires and epoxy and solder come alive as characters, along with physicists, engineers, technicians and others.…Galison has unearthed fascinating material" (New York Times). Clocks and trains, telegraphs and colonial conquest: the challenges of the late nineteenth century were an indispensable real-world background to the enormous theoretical breakthrough of relativity. And two giants at the foundations of modern science were converging, step-by-step, on the answer: Albert Einstein, an young, obscure German physicist experimenting with measuring time using telegraph networks and with the coordination of clocks at train stations; and the renowned mathematician Henri Poincaré, president of the French Bureau of Longitude, mapping time coordinates across continents. Each found that to understand the newly global world, he had to determine whether there existed a pure time in which simultaneity was absolute or whether time was relative. Esteemed historian of science Peter Galison has culled new information from rarely seen photographs, forgotten patents, and unexplored archives to tell the fascinating story of two scientists whose concrete, professional preoccupations engaged them in a silent race toward a theory that would conquer the empire of time.
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