Malaria causes more death and disease than any other parasitic pathogen known today. This multiauthored text covers the important areas of malaria research, particularly focusing on those sectors which are of clinical importance for the understanding of the disease, the parasite, and its vector. The chapter authors are all leading experts within their own particular fields. The biology and molecular biology of the parasite, the clinical spectrum of the disease, the pathogenesis of malaria, and the immunology and emergence of malaria vaccines are some examples of the scientific spheres that are discussed. The book is suitable as a text for graduate students and clinicians as well as researchers at universities and companies involved in treating or studying infectious diseases.
The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.
The standard reference in the field, this acclaimed work synthesizes findings from hundreds of carefully selected studies of mental health treatments for children and adolescents. Chapters on frequently encountered clinical problems systematically review the available data, identify gaps in what is known, and spell out recommendations for evidence-based practice. The authors draw on extensive clinical experience as well as research expertise. Showcasing the most effective psychosocial and pharmacological interventions for young patients, they also address challenges in translating research into real-world clinical practice. New to This Edition *Incorporates over a decade of research advances and evolving models of evidence-based care. *New chapter topic: child maltreatment. *Separate chapters on self-injurious behavior, eating disorders, and substance use disorders (previously covered in a single chapter on self-harming disorders). *Expanded chapters on depression, anxiety, and conduct disorder. *Includes reviews of the burgeoning range of manualized psychosocial "treatment packages" for children.
Fully updated to meet the demands of the 21st-century surgeon, this title provides you with all the most current knowledge and techniques across your entire field, allowing you to offer every patient the best possible outcome. Edited by Drs. Mathes and Hentz in its last edition, this six-volume plastic surgery reference now features new expert leadership, a new organization, new online features, and a vast collection of new information - delivering all the state-of-the-art know-how you need to overcome any challenge you may face. Renowned authorities provide evidence-based guidance to help you make the best clinical decisions, get the best results from each procedure, avoid complications, and exceed your patients' expectations.
Fully updated to meet the demands of the 21st-century surgeon, Plastic Surgery provides you with all the most current knowledge and techniques across your entire field, allowing you to offer every patient the best possible outcome. Edited by Drs. Mathes and Hentz in its last edition, this six-volume plastic surgery reference now features new expert leadership, a new organization, new online features, and a vast collection of new information - delivering all the state-of-the-art know-how you need to overcome any challenge you may face. Renowned authorities provide evidence-based guidance to help you make the best clinical decisions, get the best results from each procedure, avoid complications, and exceed your patients’ expectations. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Apply the very latest advances in every area of plastic surgery and ensure optimal outcomes with evidence-based advice from a diverse collection of world-leading authorities. Master the latest on stem cell therapy, tissue engineering, and inductive therapies • aesthetic surgical techniques and nonsurgical treatments • conjoined twin separation and other craniofacial surgery advances • microsurgical lymphatic reconstruction, super microsurgery, and sternal fixation • autologous lipofilling of the breast • nerve transfers in hand surgery, hand allotransplantation, and functional prosthetics • and much, much more. Easily find the answers you need with a new organization that features separate volumes covering Principles • Aesthetic • Craniofacial, Head and Neck Surgery • Lower Extremity, Trunk and Burns • Breast • and Hand and Upper Extremity, plus a more templated, user-friendly, high-yield presentation. Visualize procedures more clearly through an abundance of completely redrawn full-color illustrations and new color clinical photographs. Access the complete, fully searchable contents of each volume online, download all the tables and figures, view 160 procedural videos, and take advantage of additional content and images at www.expertconsult.com!
Fully updated to meet the demands of the 21st-century surgeon, Principles, Volume 1 of Plastic Surgery, 3rd Edition, provides you with the most current knowledge and techniques in the principles of plastic surgery, allowing you to offer every patient the best possible outcome. Access all the state-of-the-art know-how you need to overcome any challenge you may face and exceed your patients’ expectations. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Apply the very latest advances in plastic surgery and ensure optimal outcomes with evidence-based advice from a diverse collection of world-leading authorities. Stay abreast of the latest information on business practices, stem cell therapy, and tissue engineering, and walk through the history, psychology, and core principles of reconstructive and aesthetic plastic surgery. Know what to look for and what results you can expect with over 1,000 color photographs and illustrations. Easily find the answers you need with a more templated, user-friendly, high-yield presentation.
Life and Times of a Big River" weaves together the fascinating cultural and natural history of interior Alaska through the story of a field expedition conducted by 5 biologists in a 4000-square-mile, roadless area of interior Alaska. The expedition was ordered by the United States government following the signing into law of the Alaska Native Claims Settlement Act, and was to help decide the fate of a vast area that would ultimately become the Yukon-Charley Rivers National Preserve. And yet this is a human story, related through the personal experiencesthe uncertainties, discoveries, accidents, and encounters with othersrecorded by this disparate (and at one point desperate) group of biologists. Weaving in and out of this narrative is an account of the natural and cultural history of the area, told as it related to the expedition and to people living in the bush. The five scientists explore every aspect of the land itself: from fossil tree ferns to rare insects and little-known mammals, deciphering a record of change in a land often thought of as static and monotonous. Against this background the history of both aboriginal and Anglo exploitation and adaptation to a very demanding environment is also told. In the context of the expedition, the natural and cultural history takes on an uncommon relevance and insight. This expedition may well represent the last of its kind, conducted before the explosion of satellite communications and geographic positioning technology forever changed scientific field work in remote regions.
Transport Properties of Concrete covers how to measure the ability of ions and fluids to move through concrete material, and how to use the results to model performance. These transport properties largely determine the durability of concrete and of steel embedded within it, as well as the effectiveness of structures such as landfill containment barriers. The book begins by explaining in detail what transport properties are and how to write computer models for transport processes. Early chapters present and explain computer models written in basic code. Coverage then proceeds to a wide range of tests for the transport properties of concrete, and methods for calculating the values for these properties from the test results using analytical and numerical models. The final chapters then show how the values obtained can be used to predict the durability of reinforced concrete, to model the effect of gas pressure, and to model waste containment structures. A number of practical examples are given, in which the calculations and computer models have been applied to real experimental data. Transport Properties of Concrete provides a comprehensive examination of the subject, and will be of use to all concerned with the durability and effectiveness of concrete structures. - Provides a detailed understanding of the various transport mechanisms that take place during testing in concrete - Shows how to obtain fundamental transport properties
Rarely visited by outsiders, the ranchers of the Sierra de la Giganta in Baja California Sur live much as their ancestors have for the past two centuries. They raise goats and cattle and grow a magnificent variety of fruits, vegetables, and flowers. In this book a gifted photojournalist introduces us to individual ranchers and their families and describes their traditional practices and the ways they have adapted to twenty-first-century challenges and technological advances. Marchand’s photographs and text are both informative and intimate. His introduction to this little-known corner of Mexico will delight travelers and scholars alike.
The standard reference in the field, this acclaimed work synthesizes findings from hundreds of carefully selected studies of mental health treatments for children and adolescents. Chapters on frequently encountered clinical problems systematically review the available data, identify gaps in what is known, and spell out recommendations for evidence-based practice. The authors draw on extensive clinical experience as well as research expertise. Showcasing the most effective psychosocial and pharmacological interventions for young patients, they also address challenges in translating research into real-world clinical practice. New to This Edition *Incorporates over a decade of research advances and evolving models of evidence-based care. *New chapter topic: child maltreatment. *Separate chapters on self-injurious behavior, eating disorders, and substance use disorders (previously covered in a single chapter on self-harming disorders). *Expanded chapters on depression, anxiety, and conduct disorder. *Includes reviews of the burgeoning range of manualized psychosocial "treatment packages" for children.
Peter J. MarchandÕs Life in the Cold remains the one book that offers a comprehensive picture of the interactions of plants and animalsÑincluding humansÑwith their cold-weather environment. Focusing on the problems of Òwinter-activeÓ organisms, Marchand illuminates the many challenges of sustaining life in places that demand extraordinary adaptations. The fourth edition of this classic text includes a new chapter on climate change and its effects on plants and animals wintering in the North.
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. - Provides a comprehensive review of the growing literature in C-furanosides - Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases - Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
Peter Godman presents the first intellectual history of Florentine humanism from the lifetime of Angelo Poliziano in the later fifteenth century to the death of Niccolo Machiavelli in 1527. Making use of unpublished and rare sources, Godman traces the development of philological and official humanism after the expulsion of the Medici in 1494 up to and beyond their restoration in 1512. He draws long overdue attention to the work of Marcello Virgilio Adriani--Poliziano's successor in his Chair at the Studio and Machiavelli's colleague at the Chancery of Florence. And he examines in depth the intellectual impact of Savonarola and the relationship between secular and religious and oral and print cultures. Godman shows a complex reaction of rivalry and antagonism in Machiavelli's approach to Marcello Virgilio, who was the leading Florentine humanist of the day. But he also demonstrates that Florentine humanists shared a common culture, marked by a preference for secular over religious themes and by constant anxiety about surviving and prospering in the city's dangerous political climate. The book concludes with an appendix, drawn from previously incaccessible archives, about the censorship of Machiavelli by the Inquisition and the Index. From Poliziano to Machiavelli adds new depth to the intellectual history of Forence during his most dynamic period in its history. Originally published in 1998. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
When Richard Nixon signed the Alaska Native Claims Settlement Act in 1971, eighty million acres were flagged as possible national park land. Field expeditions were tasked with recording what was contained in these vast acres. Under this decree, five men were sent into the sprawling, roadless interior of Alaska, unsure of what they’d encounter and ultimately responsible for the fate of four thousand pristine acres. Life and Times of a Big River follows Peter J. Marchand and his team of biologists as they set out to explore the land that would ultimately become the Yukon-Charley Rivers National Preserve. Their encounters with strange plants, rare insects, and little-known mammals bring to life a land once thought to be static and monotonous. And their struggles to navigate and adapt to an unforgiving environment capture the rigorous demands of remote field work. Weaving in and out of Marchand's narrative is an account of the natural and cultural history of the area as it relates to the expedition and the region’s Native peoples. Life and Times of a Big River chorincles this riveting, one-of-a-kind journey of uncertainty and discovery from a disparate (and at one point desperate) group of biologists.
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