The new Companion to Peripheral Neuropathy: Illustrated Case Studies by Dr. Peter J. Dyck, et al, which supplements Dyck and Thomas’ authoritative and comprehensive Peripheral Neuropathy, features illustrated case studies that explore the evaluation and management of the most common peripheral nerve disorders. Leading authorities in the field contribute clues to the diagnosis, clinical features, imaging studies, histopathology and more for each case. You’ll gain new insights into the causes of peripheral nerve disorders to help you diagnose and treat every condition. Offers new insights in clinical and electrophysiologic characterization, imaging, histopathology, and molecular genetics Shows you how abstract diagnosis and management principles apply in real situations Presents more illustrations than any competing reference so you can see disorders as they present in practice Offers expert clues to help you diagnose and manage patients quickly and effectively Provides references to the most significant literature in the field so you can stay at the forefront of this science
The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.
The mainstream view of the immune system is concerned with molecular and cellular details resulting in a picture of immense complexity. Many immunologists live with this complexity, hoping that a series of breakthroughs will eventually add up to a greater insight. However, the forest is ignored for the trees and a ‘Systems Approach’ is vital for a better understanding. Peter Bretscher develops here a unique perspective on how the immune system functions as an integrated organ, by taking account of observations and concepts at the ‘level of system’ that are often half forgotten or ignored. A colleague, on reading this book, wrote: “Those who have followed Peter’s work these past 50 years will recognize this book for what it really is — a rare achievement, a scientific masterpiece. It is a must read for all those Immunologists and Clinicians who want to find effective immunological cures for the many debilitating health issues that confront us. Peter Bretscher has produced a lucid and logical exposition of the rules governing how the adaptive immune system responds to all foreign antigens whether bacterial, viral or modifications of the self, which emerge in cancer or autoimmune conditions. This book is a testament to Louis Pasteur’s dictum that there is no applied science, just the application of basic science.” Rediscovering the Immune System is written in a jargon-free and accessible style. This personal perspective is an ideal guide to the immune system for students, researchers and the engaged, general reader alike.
This volume contains about 40 papers covering many of the latest developments in the fast-growing field of bioinformatics. The contributions span a wide range of topics, including computational genomics and genetics, protein function and computational proteomics, the transcriptome, structural bioinformatics, microarray data analysis, motif identification, biological pathways and systems, and biomedical applications. There are also abstracts from the keynote addresses and invited talks. The papers cover not only theoretical aspects of bioinformatics but also delve into the application of new methods, with input from computation, engineering and biology disciplines. This multidisciplinary approach to bioinformatics gives these proceedings a unique viewpoint of the field. Sample Chapter(s). Chapter 1: Exploring the Ocean''s Microbes: Sequencing the Seven Seas (122 KB). Contents: Exploring the Ocean''s Microbes: Sequencing the Seven Seas (M E Frazier et al.); Protein Network Comparative Genomics (T Ideker); Bioinformatics at Microsoft Research (S Mercer); Protein Fold Recognition Using Gradient Boost Algorithm (F Jiao et al.); Efficient Annotation of Non-Coding RNA Structures Including Pseudoknots via Automated Filters (C Liu et al.); Efficient Generalized Matrix Approximations for Biomarker Discovery and Visualization in Gene Expression Data (W Li et al.); Sorting Genomes by Translocations and Deletions (X Qi et al.); Detection of Cleavage Sites for HIV-1 Protease in Native Proteins (L You); Identifying Biological Pathways via Phase Decomposition and Profile Extraction (Y Zhang & Z Deng); Complexity and Scoring Function of MS/MS Peptide De Novo Sequencing (C Xu & B Ma); Simulating In Vitro Epithelial Morphogenesis in Multiple Environments (M R Grant et al.); and other papers. Readership: Research and application community in bioinformatics, systems biology, medicine, pharmacology and biotechnology. A useful reference for graduate researchers in bioinformatics and computational biology.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Hypermobility of Joints 4th Edition follows the same format as its successful predecessors. The aim of which was to provide an overview of hyperlaxity of joints and this edition follows that aim by describing the most recent research and new developments in biochemistry, as well as providing practical advice on clinical features and management. Hypermobility of Joints 4th Edition provides illustrative case histories, a review of hypermobility in the performing arts and sports and an outline of heritable hypermobility syndromes. This book is a valuable reference tool for a wide number of specialties, although it will particularly be of interest to rheumatologists, orthopedic surgeons and medical geneticists.
Auf fortgeschrittenem Niveau und mit didaktischem Anspruch bietet Ihnen dieser Band zahlreiche Fragen mit Antworten und eine breite Palette von Fallstudien aus der Industrie, ergänzt durch weiterführende Literaturhinweise und Referenzen der Originalliteratur. Insbesondere geht es um die modernsten katalytischen Prozesse mit ihren Anwendungen in der Pharmazie und der Feinchemikalien-Industrie, wobei auch kommerzielle Aspekte besprochen werden. Der Autor, ein erfahrener Dozent mit Industriepraxis, legt Chemikern und Chemieingenieuren damit ein praxistaugliches Hilfsmittel vor.
Freshwater field tests are an integral part of the process of hazard assessment of pesticides and other chemicals in the environment. This book brings together international experts on microcosms and mesocosms for a critical appraisal of theory and practice on the subject of freshwater field tests for hazard assessment. It is an authoritative and comprehensive summary of knowledge about freshwater field tests, with particular emphasis on their optimization for scientific and regulatory purposes. This valuable reference covers both lotic and lentic outdoor systems and addresses the choice of endpoints and test methodology. Instructive case histories show how to extrapolate test results to the real world.
This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medicinal chemistry. Entire chapters on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and protein selectivity studies, among others, offer a concise overview of this emerging field. As an added bonus, this handbook includes a CD-ROM with the latest commercial versions of the GRID program and related software.
Spanning both the history and future of knee replacement, this unique book recounts how artificial knees have reached the stage they are today, and whether their performance can be further improved. The author, who has been designing artificial knees for 50 years, starts the story in the late 1960’s with the early pioneers; during the 1970’s, the principles for successful artificial knees were established. While many different types were designed, a small number have become by far the most widely utilized. Yet other types of designs, so far little used, along with new materials and the application of computer-assisted surgery, could result in significant advancements in the treatment of knee arthritis. Each chapter provides a detailed description of the origins of the ideas and principles and their rationale, followed by the latest information and evidence. The book begins with an overview of the history and background of the artificial knee, in terms of design and implementation and the thought leaders involved. Fixation, biomechanics, and the types of designs are discussed in detail, both what has worked and what has not, and why. Instrumentation, testing and tribology, and functional evaluation methods are also covered. The book concludes with a look toward the future possibilities for the field of artificial knees. An illustrated glossary of terms, is included for quick reference. The Artificial Knee: An Ongoing Evolution will appeal to orthopedic surgeons and researchers, medical academics and orthopedic companies, and to those with a general interest in artificial knees.
A new addition to the popular "Getting Started" series, this easy-to-use introduction to security analysis provides the tools to understanding how and why a portfolio investment strategy works.
This book is a complete guide to total joint arthroplasty for orthopaedic surgeons presented as a collection of key protocols for surgery. Divided into four sections, the text begins with preoperative considerations, covering patient evaluation, clinical examination, indications, and implant selection. The following section provides step by step guidance on the complete range of arthroplasty techniques and associated procedures. Section three covers postoperative management such as wound care, transfusions, physical therapy, medication, and much more. The final chapters in the book discuss the management of numerous potential complications. Edited by an internationally recognised team of experts, led by Javad Parvizi from the renowned Rothman Institute in Philadelphia, this comprehensive guide is enhanced by surgical images and diagrams to assist learning. Key points Comprehensive guide to total joint arthroplasty for orthopaedic surgeons Presented as collection of key protocols for surgical procedures Provides step by step guidance from preoperative considerations, to surgical techniques, postoperative management, and complications Edited by internationally recognised experts from the Rothman Institute
From senior electrophysiologist and world-class educator George Klein, a fully illustrated guide with over 100 intracardiac tracings and figures that allow the physician to approach electrophysiologic problems effectively and systematically. The book is especially focused on electrophysiological maneuvers and provides a clear and understandable guide to their proper selection and interpretation using abundant clinical examples. Defines the integral role for "traditional" electrogram (EGM) analysis in order to understand the mechanism of a tachycardia. It goes without saying that a correct arrhythmia diagnosis is a prerequisite to catheter ablation regardless of the presence of sophisticated mapping and imaging technologies. Electrophysiological maneuvers are fundamental to this process, and proper selection and interpretation of maneuvers constitute a core skill of the electrophysiologist. In this volume, we make the case that most maneuvers are fundamentally similar in principle and can be understood by appreciating a few basic physiological and anatomical principles. The art lies not in a comprehensive knowledge by rote of every maneuver or its application, but rather a systematic approach using common principles. We illustrate this by showing abundant examples and emphasizing the "game plan," including checklists that can be applied to virtually any maneuver. —George J. Klein In my opinion, this book should be on the shelf of every electrophysiologist trainee as well as every clinical cardiac electrophysiologist. It is a classic, like its editor. Dr. Klein deserves high praise for organizing his and his colleagues’ clinical experiences and thought processes into a concise, practical text that should be part of all training programs in electrophysiology. —From the foreword by Mark E. Josephson, MD
This third edition of Hypermobility of Joints follows the same format as its successful predecessors. The aim of those editions was to provide an overview of hyperlaxity of joints and this edition follows that aim by describing the most recent research and new developments in biochemistry as well as providing practical advice on clinical features and management. Further chapters provide illustrative case histories, a review of hypermobility in the performing arts and sports and an outline of heritable hypermobility syndromes. Hypermobility of Joints has implications for a wide number of specialties although it will particularly be of interest to rheumatologists, orthopedic surgeons and medical geneticists.
The studies included in this selection - the opening two being published for the first time - are concerned with various aspects of the history of Christian Spain between the 6th century and the 14th. A recurrent theme is that of the invention of the past: of the manner in which, for reasons which have seemed good to them, at different times and places, from Toledo in the 1240s to Cambridge in the 1920s, men have sought to appropriate and recolonise that past. Three more technical articles on the subject of 13th-century papal diplomatic in a Spanish setting illustrate the related activity of the invention of the future as reflected in the activity of the agents or proctors and others whose services were retained in order to ensure that it was their employer's particular view of the present that prevailed. Les études comprises dans cette sélection, dont deux paraissent ici pour la première fois, traitent des différents aspects de l’histoire de l’Espagne chrétienne entre le 6e et le 14e siècle. Un thème fréquent est celui de l’invention du passé: la façon dont à différentes époques et à différents endroits, de Tolède en 1240 à Cambridge en 1920, et pour des raisons qui lui semblent être les bonnes, l’être humain s’est efforcé de s’approprier et de reconquérir le passé. Trois articles d’ordre plus techniques sur la diplomatique papale au 13e siècle dans un cadre espagnol, illustrent l’activité attenante qu’était l’invention de l’avenir, telle qu’elle se traduisait au travers de l’action d’agents, de fondés de pouvoir et autres, dont les services étaient requis afin que la vision du présent de leurs employeurs prévale.
A new edition of Peter and Rosemary Grant’s classic account of their groundbreaking forty-year study of Darwin’s finches 40 Years of Evolution is a landmark study of the finches first made famous by Charles Darwin, one that documents as never before the evolution of species through natural selection. In this now-legendary study, renowned evolutionary biologists Peter and Rosemary Grant draw on a vast and unparalleled range of ecological, behavioral, and genetic data to continuously measure changes in finch populations over a period of four decades on the small island of Daphne Major in the Galápagos archipelago. In the years since the book’s publication, the field of genomics has developed greatly. In this newly revised edition of 40 Years of Evolution, the Grants combine the results of their historic field study with genomic analyses of their primary findings, resolve unanswered questions from the field, and provide invaluable insights into the genetic basis of beak and body size variation and the history of this iconic adaptive radiation.
This first major empirical work on the semiotics of social action goes a long way toward answering substantive, theoretical and pragmatic questions on how codes actually operate in a specific social setting. It underscores the important yet often ignored role of the police as "sign" or "information workers."Calls to the police represent a rich variety of human troubles, concerns, and needs by focusing on how police handle calls from the public, how they ascertain what a call means and what should be done with it, and how this is transformed through subsystems within the organization, Peter Manning provides a novel way of looking at organizational communication."Symbolic Communication "provides examples of how members of an organization interpret their environment - in this instance, how the meaning of a call to the police is transformed as it moves across the boundaries of the organization (a transformation that involves a series of codings and recodings ensuring a continuous loose linkage of organization and environment). Manning shows why the police act in ways that differ from the way citizens and politicians would have them act, revealing the uncertainties that surround a policy agency's responsiveness. And he points out how today's computer technologies constrain the coding process, limiting in particular the effectiveness of the 911 systems used in most of our major cities.Peter K. Manning is a Professor of Psychiatry and of Sociology at Michigan State University and a member of the Centre for Socio-Legal Studies at Oxford. "Symbolic Communication "brings to fruition themes and ideas introduced in his previous books, "Police Work "and "The Narc's Game. Symbolic Communication" is included in the Organization Studies series, edited by John van Maanen.
Comprehensive and fully up to date, the six-volume Plastic Surgery remains the gold standard text in this complex area of surgery. Completely revised to meet the demands of both the trainee and experienced surgeon, Trunk and Lower Extremity, Volume 4 of Plastic Surgery, 5th Edition, features new, full-color clinical photos, procedural videos, lectures, and authoritative coverage of hot topics in the field. Editor-narrated video presentations offer a step-by-step audio-visual walkthrough of techniques and procedures. - New chapters cover diabetes and foot reconstruction; expands and updates coverage of lymphedema and gender affirmation surgery; and coverage throughout includes new, pioneering translational work shaping the future of trunk and lower extremity surgery. - New digital video preface by Dr. Peter C. Neligan addresses the changes across all six volumes. - New treatment and decision-making algorithms added to chapters where applicable. - New video lectures and editor-narrated slide presentations offer a step-by-step audiovisual walkthrough of techniques and procedures. - Evidence-based advice from an expanded roster of international experts allows you to apply the very latest advances in trunk and lower extremity surgery and ensure optimal outcomes. - Purchase this volume individually or own the entire set, with the ability to search across all six volumes online!
Widely recognized as the gold standard reference in the field, Rosen’s Breast Pathology provides comprehensive, up-to-date information on diseases of the breast from renowned experts at four leading medical centers, masterfully edited by Dr. Paul P. Rosen. The revised fifth edition covers the latest advances in immunohistochemical, pathobiological, and molecular aspects of benign and malignant breast diseases, helping you reach an accurate diagnosis with confidence. It’s an ideal reference for all physicians and medical personnel who require a thorough knowledge of breast pathology, including pathologists, surgeons, oncologists, radiologists, and radiation oncologists.
Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
Dynamic Interpersonal Therapy (DIT) is a brief psychodynamic psychotherapy developed for the treatment of mood disorders. It is now offered in the UK in NHS for the treatment of depression and has been applied worldwide in public health care settings as well as private settings. This book is a user-friendly, practical guide for the implementation of a brief psychodynamic intervention in routine clinical practice as well as in research protocols. It has been substantially updated since the first edition in 2011 with the addition of 5 new chapters to reflect new applications of the model in complex care, for patients with functional and somatic disorders and for internet delivered DIT and it outlines the changes in the training of DIT practitioners . It sets out clearly the theoretical framework, as well as the rationale and strategies for applying DIT with patients presenting with mood disorders (depression and anxiety). Throughout, it is illustrated with detailed examples that help the reader to implement the approach in their practice. The book will be required reading to support training initiatives in DIT, as well as providing a resource for mental health professionals specialising in psychodynamic psychotherapy and wishing to work within a limited time frame.
Improving the outcomes for patients in our changing healthcare system is not straightforward. This grounding publication on case management helps physicians better meet the unique needs of patients who present with poor health and high healthcare-related costs, i.e., health complexity. It details the many challenges and optimal practices needed to work effectively with various types of case managers to improve patient outcomes. Special attention is given to integrated case management (ICM), specifically designed for those with health complexity. The book provides a systematic method for identifying and addressing the needs of patients with biological, psychological, social, and health-system related clinical and non-clinical barriers to improvement. Through ICM, case managers are trained to conduct relationship-building multidisciplinary comprehensive assessments that allow development of prioritized care plans, to systematically assist patients to achieve and document health outcomes in real time, and then graduate stabilized patients so that others can enter the case management process. Patient-centered practitioner-case manager collaboration is the goal. This reference provides a lexicon and a roadmap for physicians in working with case managers as our health system explores innovative ways to improve outcomes and reduce health costs for patients with health complexity. An invaluable, gold-standard title, it adds to the literature by capturing the authors' personal experiences as clinicians, researchers, teachers, and consultants. The Physician's Guide: Understanding and Working With Integrated Case Managers summarizes how physicians and other healthcare leadership can successfully collaborate with case managers in delivering a full package of outcome changing and cost reducing assistance to patients with chronic, treatment resistant, and multimorbid conditions.
Another title in the award winning ‘Practical Manual’ series from Wiley-Blackwell, following on from Edmonds, Foster and Sanders‘ A Practical Manual of Diabetic Foot Care – winner of the British Medical Association’s Medical Book of the Year Award 2004. This practical clinical manual covers the diagnosis, treatment and long-term management of eye problems in people with diabetes, with a strong emphasis on the importance of early diagnosis. Edited and authored by world-renowned experts from leading centres, A Practical Manual of Diabetic Retinopathy Management presents evidence-based guidance relevant for a global audience. High quality photographs uniquely illustrate the lesions that occur in diabetic retinopathy and diagrams show the surgical techniques involved in vitreoretinal surgery for advanced stages of the disease Numerous real life case histories demonstrate the scenarios that one is likely to come across in a clinic treating patients with diabetic retinopathy The best colour guide to the spectrum of changes that occur in diabetic retinopathy This bookis a richly illustrated manual on the management of all stages of diabetic retinopathy, ideal for diabetologists, general endocrinologists who see patients with diabetes, retinal screeners, ophthalmologists and any other healthcare professionals involved in the care and management of diabetes.
In enforcing EU competition law, the Commission employs a unique doctrine of parental antitrust liability: it imposes fines on the parent company of an infringing subsidiary in cases where the parent exercises decisive influence over the subsidiary's commercial policy. Critics of this contentious aspect of EU competition law believe that the doctrine is unfair, ineffective, obscure, disproportionate, contrary to due process, and based upon a dubious, if not extremely flimsy, justificatory foundation. Such criticism raises serious and unanswered questions about the legitimacy of the Commission's efforts to enforce competition law. Parental Liability in EU Competition Law: A Legitimacy-Focused Approach is the first monograph to be dedicated to this controversial topic. Written by Professor Peter Whelan, the book contends that, although the general concept of parental liability can be justified in principle, the current EU-level doctrine of parental antitrust liability in fact suffers from a distinct and problematic lack of legitimacy. More specifically, the said doctrine displays significant deficiencies with respect to effectiveness, fairness, and legality. Given this undesirable state of affairs, Parental Liability in EU Competition Law offers a fully-rationalised, reformulated approach to parental antitrust liability for EU competition law violations that is built around the notion of parental fault. That approach provides a solid normative account of how to impose parental antitrust liability in a manner that is theoretically robust, effective in practice, fair in substance, and legally sound.
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. - Provides a comprehensive review of the growing literature in C-furanosides - Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases - Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
Traces the advent of robotic warfare, revealing its use in the war in Iraq, the latest technological achievements, and the secret Pentagon consultations with top science fiction authors.
All the major metallic stents available are discussed with recommendations for treatment, complications and how best to avoid them, and new developments
This volume starts the updating of the information on organonickel chemistry, one of the most active areas of modern organometallic chemistry. It covers all mononuclear compounds containing one nickel-to-carbon bond. The main part is devoted to the family of planar NiII compounds, RNi(D)2X, which within 20 years has increased from about 250 to more than 1000 members. This research interest has been stimulated by the fact that many compounds insert various unsaturated species into the Ni-C bond to create new organonickel species. Moreover, these compounds are important as intermediates in many catalytic processes involving organic halides. Compounds containing h*2-bonded heteroalkene molecules including the C1 fragments CO2 and CS2, and related metallocyclic compounds are also emphasized in this volume. These types of compounds play an important role in a number of nickel-catalyzed co-oligomerization reactions involving unsaturated organic compounds. Most of the compounds are well-characterized by modern spectroscopic techniques. The various types of compounds are in most cases confirmed by X-ray diffraction. The author of these volumes, a member of the M lheim group, has made many contributions of his own and is eminently qualified to critically review this area of research.
This handbook is intended for the advanced specialist and for the practitioner interested in the application of lasers in medicine. It provides state-of-the art summaries of all available medical laser systems and the indications for their clinical use. The first part introduces basic laser physics, including laser-tissue interactions as well as technical equipment and particular techniques developed for medical use in connection with laser. The second part of the text covers all areas of laser application in medicine presented by senior specialists from different countries, each having extensive practical experience.
2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. - Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. - Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. - Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy. - Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology. - Access the entire text and illustrations online, fully searchable, at Expert Consult.
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