An indispensable reference for any practicing synthetic organic or medicinal chemist, this book continues the tradition of Greene’s as comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology. • Presents valuable material, on the application of protective groups in organic chemistry, that is not easily found by casual searching • Helps chemists to plan, investigate, and carry out organic syntheses in an efficient manner • Adds over 2800 new references to update since the publication of the last edition • Reviews of the prior edition: "An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007) "...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007) "...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)
Pathology of the Human Placenta has become the gold standard in the field for pathologists and obstetrician-gynecologists. Completely up-to-date, this fifth edition continues to be the essential reference for professionals in the field and includes many revised features such as a more detailed index; 700 total illustrations (350 color illustrations); and updated tables.
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
“Our most provocative scholar of American power” reveals the forces behind the assassination of JFK—and their continuing influence over our world (David Talbot, Salon). On November 22, 1963, President John F. Kennedy was gunned down in Dallas by Lee Harvey Oswald. Shortly after, Oswald himself was killed. These events led many to believe there was a far greater plan at work, with a secret cabal of powerful men manipulating the public and shaping US policies both at home and abroad for their own interests. But no one could imagine how right they were. Beneath the orderly façade of the American government, there lies a complex network, only partly structural, linking Wall Street influence, corrupt bureaucracy, and the military-industrial complex. Here lies the true power of the American empire. This behind-the-scenes web is unelected, unaccountable, and immune to popular resistance. Peter Dale Scott calls this entity the deep state, and he has made it his life’s work to write the history of those who manipulate our government from the shadows. Since the aftermath of World War II, the deep state’s power has grown unchecked, and nowhere has it been more apparent than that day at Dealey Plaza. In this landmark volume, Scott traces how culpable elements in the CIA and FBI helped prepare for the assassination, and how the deep state continues to influence our politics today. As timely and important as ever in the current chaotic political climate, Dallas ’63 is a reality-shattering, frightening exposé not of those who govern us—but of those who govern those who govern us.
Here is the first major work that examines the benefits of applying social understanding to addiction. The author demonstrates how a social perspective shifts the paradigm from viewing a person in terms of "particles" to viewing a person in terms of relationships. This reorientation creates promising new opportunities for intervention. The book discusses recent advances in theories on community capacity building, resilience, and social ecology alongside their practical applications. Written in an engaging style, the book features numerous vignettes, key points, and illustrations that help you apply the material in your own practice.
As a consequence of the rapid proliferation of commercial gambling in Western-style democracies, governments and communities are encountering a complex array of economic, social and cultural harms associated with this expansion. This book focuses specifically on harms to democratic systems. It examines how people with key roles in democratic structures are vulnerable to subtle influence from the burgeoning profits of gambling. It focuses particularly on the Western-style democracies of North America, Europe and Australasia. It argues that governments have a duty of care to protect their own democratic processes from subtle degradations and that independence from the gambling industries needs to be proactively built into public sector structures and processes. It outlines how a public health approach, harm minimisation strategies and international conventions can provide the base for protecting the integrity of democratic systems.
Death studies have, over the last twenty years, witnessed a flourishing of research and scholarship particularly in areas such as dying and bereavement, cultural practices and fear of dying. But, despite its importance, a specific focus on the nature of personal mortality has attracted surprisingly little attention. Reflecting on the Inevitable combines evidence from several disciplinary fields to explore the varying ways each of us engages with the prospect of personal mortality. Chapters are organized around the question of how an ongoing relationship might be possible when the threat of consciousness coming to an end points to an unspeakable nothingness. The book then argues that, despite this threat, an ongoing relationship with one's own death is still possible by means of conceptual devices, or 'enabling frames', that help shape personal mortality into a relatable object. In each chapter the subtleties and applicability of key ideas are enhanced through a series of illustrative narratives built up around the lives of four people at different ages living in two adjacent houses. Reflecting on the Inevitable is relevant not only to academics of death studies, but also those training and practicing in people-helping professions, as well as anyone experiencing or attempting to make sense of major life events.
Are you thinking about studying nursing? Do you have an upcoming interview? Or have you just been accepted on a course? Do you need a guide? Then this book is for you. The number of students applying for nursing is increasing every year, making each place more competitive and more precious. This book will give you the edge in your application, knowledge for your interview, and support throughout your course. This trusty companion will answer your queries and settle your concerns, giving you an insight into the world of nursing. The experienced team of authors: - Introduce the different branches of nursing - Define the key concepts you will study on your course - Give you an insight into specialist study skills - Help you to understand research - Offer advice on professional development and life after university. Using case studies, activities and incorporating four end-of-part glossaries, this one-stop resource will prepare you for the experience of being a student nurse and equip you for the challenges of the profession.
Knowledge of thc chemical behavior of trace compounds in the atmosphere has grown steadily, and sometimes even spectacularly, in recent decades. These developments have led to the emergence of atmospheric chemistry as a new branch of science. This book covers all aspects of atmospheric chemistry on a global scale, integrating information from chemistry and geochemistry, physics, and biology to provide a unified account. For each atmospheric constituent of interest, the text summarizes the principal observations on global distribution, chemical reactions, natural and anthropogenic sources, and physical removal processes. Coverage includes processes in the gas phase, in aerosols and c1ouds, and in precipitation, as well as biogeochemical cycles and the evolution of the atmosphere. Chemistry of the Natural Atmosphere, Second Edition, will serve as a textbook for senior undergraduate and graduate courses, and as an essential reference for atmospheric chemists, meteorologists, and anyone studying the biogeochemical cycles of trace gases.* Updated extensively from the highly respected first edition * Treats the global-scale chemistry and distribution of atmospheric trace constituents * Emphasizes observations and their interpretation* Provides background on transport and reaction kinetics for interpretation of observational data* Includes chemistry in the gas phase and in aerosols and clouds* Details chemical reaction pathways for the most important trace constituents* Describes pertinent biogeochemical cycles* Written by an author with more than 40 years of research experience in atmospheric chemistry
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
This book presents the first single comprehensive analysis of the scope of geographical realities and relevance in health care work. Conceptually, the book conveys how space, place and geographical ideas matter to clinical practice, from the historical beginnings of professional roles and responsibilities in medicine to the present day. In 8 chapters, the book covers healthcare work across a range of job types (including physician, nurse, and multiple technical and therapeutic roles in multiple specialties), and across a range of scales (focusing on global issues and trends, national and regional particularities, urban and rural issues, institutional environments and various community settings). This book is intended for students, teachers, and researchers in geography, social science and various health sciences. Chapter 1 examines how geographical ideas have been central to practitioners' thinking and practice over time. Chapter 2 reviews the scope of contemporary geographical study of health care work. Chapter 3 presents an empirical case study of the geographies in hospital-based ward work. Chapter 4 presents an empirical case study of the geographies in ambulance/rapid response work. Chapter 5 presents a case study of the geographies associated with a high profile case of criminality and neglect in practice. Chapter 6 considers concepts and the geographies in person-centred care. Chapter 7 considers concepts and the geographies in skills attainment.
This book explores ways in which common metaphors can play a detrimental role in everyday life; how they can grow in outsized importance to dominate their respective terrains and push out alternative perspectives; and how forms of resistance might act to contain their dominance. The volume begins by unpacking the dynamics of metaphors, their power and influence and the ways in which they are bolstered by other rhetorical devices. Adams draws on four case studies to illustrate their destructive impact when they eclipse other points of view—the metaphor of mental illness; the metaphor of free-flowing markets; the metaphor of the mind as a mirror and the metaphor of men as naturally superior. Taken together, these examples prompt further reflection on the beneficiaries of these "monster metaphors" and how they promote such metaphors to serve their own interests but also on ways forward for challenging their dominance, strategies for preventing their rise and ways of creating space for alternatives. This book will be of interest to scholars interested in the study of metaphor, across such fields as linguistics, rhetoric and media studies.
2008 NOMINEE The Council on Botanical and Horticultural Libraries Annual Award for a Significant Work in Botanical or Horticultural Literature From medicinal, industrial, and culinary uses to cutting-edge laboratory techniques in modern research and plant conservation strategies, Natural Products from Plants
The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings. - This edition is in full color and features nearly 200 high-quality images - Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading - Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions
As an emerging technology, 3D printing holds much promise for foot and ankle reconstruction and difficult-to-treat pathologies. The first text of its kind, Clinical Application of 3D Printing in Foot and Ankle Surgery provides comprehensive, in-depth operative coverage as well as opinions and case examples from surgeons who are currently using 3D printing in their practices. This ground-breaking volume sets the standard for this rapidly advancing field and provides practical, real-world guidance on incorporating 3D printing into your surgical practice. - Presents clinically focused content in a templated, easy-to-read format of bulleted summaries and practical advice based on the editor's and authors' experience. - Features a practical focus on procedures, techniques, and cases, with tips, tricks, and pearls throughout. - Includes decision-making criteria on when to consider 3D printing. - Provides preoperative, intraoperative, and postoperative protocols developed by the authors. - Contains high-quality photographs and 3D imaging.
From the difficult to diagnose to the difficult to treat, Manson's Tropical Diseases prepares you to effectively handle whatever your patients may have contracted. Featuring an internationally recognized editorial team, global contributors, and expert authors, this revised and updated medical reference book provides you with the latest coverage on parasitic and infectious diseases from around the world. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Incorporate the latest therapies into your practice, such as recently approved drugs and new treatment options. - Find what you need easily and apply it quickly with highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams. - Make the most accurate Tropical Disease diagnoses through a completely redesigned and modernized format, which includes full-color images throughout plus a wealth of additional illustrations online at Expert Consult. - Apply the latest treatment strategies for HIV/AIDS, tropical neurology, malaria, and much more. - Put the latest international expertise to work for you and your patients with new chapters covering Global Health; Global Health Governance and Tropical Diseases; Non-communicable Diseases; Obesity in the Tropics; and Emergency and Intensive Care Medicine in Resource-poor Settings. - See which diseases are most prevalent in specific areas of the tropics through a new index of diseases by country, as well as online-only maps that provide additional detail. - Better understand the variations in treatment approaches across the globe.
This book develops a new and innovative way of understanding how language is used when people describe their spiritual and mystical encounters. Early chapters provide overviews of the nature of spiritual encounters, how commonly they occur, and the role of language. The book then develops a unique way of understanding the dynamics of talking about spirituality, using original research to support this perspective. In particular, Peter J. Adams explores how this characteristically vague way of speaking can be viewed as an intentional and not an incidental aspect of such communications because certain types of vagueness have the capacity to engage the imaginative participation of receptive listeners. This expressive vagueness is achieved by embedding missing bits, or “gaps,” in the flow of what is described and these in turn provide sites for listeners to insert their own content. Later chapters focus on practical ways people (including helping professionals) can improve their skills in talking about their spiritual encounters. All content is situated in café conversations between four people each of whom is, in their own way, concerned with the challenges they face in converting the content of their encounters into words.
With an editorial team of leading experts from the American College of Emergency Physicians and the American Heart Association, this book is the first complete, clinically oriented reference textbook in emergency cardiovascular care and CPR. The book translates bench research to the clinician's bedside needs and addresses end-of-life issues. The content is appropriate for a large audience including early caregivers, emergency department and CCU nurses, students, residents, fellows, and hospitalists responsible for cardiovascular emergency situations. A companion Website will include the fully searchable text, instructional videos produced by the AHA, and links to ACC, AHA, ASE, ACEP, and ILCOR guidelines and policy statements.
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. - Provides a comprehensive review of the growing literature in C-furanosides - Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases - Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models
This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
Navigating Everyday Life explores the special moments, big and small, that rupture the surface of everyday life and that can help readers adjust to the disrupting effects of major life crises. Peter Adams delves into the two forces, finitude (the aspects that constrain a person to a situation) and transcendence (those aspects that enable movement beyond such constraints). Building on this framework, Adams looks at the processes and circumstances that both facilitate and block the tensions between finitude and transcendence. He then illustrates how these tensions function in the personal and existential challenges faced by five members of a modern suburban family. Their stories traverse life transitions such as separation, depression, chronic illness, injury, violence, addiction, aging, death, and forgiveness. This book is recommended for scholars and others interested in the intersections between psychology and philosophy.
This publication is based on the plant processes and reaction sites for which reliable knowledge on both their physiology and biochem-istry and the mode of herbicidal action is available. Targets of the agrochemical research, such as enzymes of biosynthetic pathways or herbicide-binding peptides in the photosynthetic membrane, are highlighted. Detailed knowledge about the target sites will allow bio-chemical model systems to evaluate the biological activity of newly synthesized compounds before their conventional screening in the greenhouse. Quantitative structure/activity relationships should be performed more reliably with simple biological species or enzymol-ogy assays, to aid in the rational design of pesticides. This text is highly valuable for plant physiologists, pathologists, and chemists in the agrochemical industry and universities.
The Coronary Care Manual has been designed as a practical manual for the management of the acute coronary patient, and aims to achieve a balance between the large and rapidly changing evidence base and practical application in the CCU, ICU, ED and ambulance. The book has been written by a group of Australian and international experts for medical, nursing and paramedic staff working in these areas. This edition covers a broad range of coronary care medicine in enough detail to eliminate the need to refer to a larger reference book, providing a portable companion for a night "on call". Completely redesigned with new artwork, the manual is organized to suit academics and practitioners alike. • covers a broad range of coronary care medicine• provides specific advice on the management of common clinical problems• eliminates the need to refer to a larger reference book• features a consistent style and focus, with standardised artwork for figures• is now also available as an eBook! A code inside the Coronary Care Manual enables a full text download, allowing you to browse and search electronically, make notes and bookmarks in the electronic files and highlight material
Revised and updated, this edition covers general principles of overdose management; the automonic nervous system, neurotransmitters and drugs; drugs used in psychiatry; cardiac drugs; agents that burn; gases and abnormal haemoglobin formation; the
Prevention and Management of Cardiovascular and Metabolic Disease Provides accurate and well-documented information on the impact of diet and physical activity in the prevention and management of cardiovascular and metabolic diseases and healthy aging. This authoritative textbook examines the independent and combined impact of diet and physical activity in the prevention and management of cardiovascular and metabolic diseases, with special emphasis on the elderly populations. In this book the authors: Provide the latest data on the association between a suboptimal diet and physical inactivity and chronic disease. Examine the role of epigenetics on longevity. Discuss the fundamentals of healthy aging. Highlight the role of well-known dietary patterns such as the Mediterranean diet and the Nordic diet in favorable health outcomes, including cardiovascular, metabolic health, and healthy aging. Discuss the health outcomes of physical activity and healthy aging. Present the most recent evidence-based data on the independent and synergistic impact of diet and exercise on disease prevention and management including, heart disease, diabetes mellitus, hypertension, dyslipidemia, kidney failure, cancer and other conditions. Prevention and Management of Cardiovascular and Metabolic Disease: Diet, Physical Activity and Healthy Aging is an excellent textbook for upper-level undergraduate and graduate students in medical and health-related disciplines and for health professionals, including dietitians and nutritionists, exercise physiologists, athletic trainers, nurses, physicians, geriatricians, and other health professionals with a special focus in older adults. This book is also a highly useful reference for health professionals interested in introducing diet and physical activity as an intervention for healthy aging as well as the prevention and management of cardiovascular and other metabolic diseases that are prevalent in aging populations.
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