Wilms tumors are pediatric tumors of the kidney found in young children with a mean age of 40 months. Genes found mutated in Wilms tumors have essential functions in the early stages of nephron development. Different subsets of Wilms tumors can be recognized via genetic and transcriptomic analysis and ontological analysis of expression patterns suggests different developmental origins for different tumor classes. A better understanding of normal early kidney development will help the design of new therapeutic approaches for different classes of Wilms tumors.
Wilms tumors are pediatric tumors of the kidney found in young children with a mean age of 40 months. Genes found mutated in Wilms tumors have essential functions in the early stages of nephron development. Different subsets of Wilms tumors can be recognized via genetic and transcriptomic analysis and ontological analysis of expression patterns suggests different developmental origins for different tumor classes. A better understanding of normal early kidney development will help the design of new therapeutic approaches for different classes of Wilms tumors.
Many arborists learn tree work practices without fully understanding the biological and physiological principles behind them. However, outcomes for the health and longevity of trees are greatly improved when an arborist understands the science behind the care of tree root systems and crowns. In Applied Tree Biology, Drs. Hirons and Thomas draw upon their decades of experience in the laboratory, classroom, and the field – as well as the expertise of distinguished contributors to this volume – to provide those responsible for tree care with the scientific information that informs best practices for planting, pruning, soil decompaction, irrigation, and much more. Takes a multidisciplinary approach, integrating knowledge from plant biology, physiology, arboriculture, ecology, and more Provides a systematic presentation of fundamental tree biology and the scientific principles informing high quality tree care Presents accessible scientific information and best practices that help promote the health and longevity of trees Reflects the authors’ decades of experience as tree biology researchers and educators, as well as their years of professional experience across the globe Applied Tree Biology is an indispensable source of practical, succinct information on tree biology, physiology, and ecology for professionals and interested amateurs involved with the care of trees. Arborists, foresters, and horticulturists at all stages of their careers will find this text particularly useful.
The three volumes in the PRINCIPLES OF ELECTRON OPTICS Series constitute the first comprehensive treatment of electron optics in over forty years. While Volumes 1 and 2 are devoted to geometrical optics, Volume 3 is concerned with wave optics and effects due to wave length. Subjects covered include: Derivation of the laws of electron propagation from SchrUdinger's equation Image formation and the notion of resolution The interaction between specimens and electrons Image processing Electron holography and interference Coherence, brightness, and the spectral function Together, these works comprise a unique and informative treatment of the subject. Volume 3, like its predecessors, will provide readers with both a textbook and an invaluable reference source.
Advances in Imaging and Electron Physics merges two long-running serials--Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. The series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
The literature of the 16th and 17th centuries was informed by the symbolic thought embodied in the mixed art form of emblems. This study explores the relationship between the emblem and the literature of England and Germany during the period.
When Frederick II (later known as Frederick the Great) came to the throne in 1740, he had three advantages for which he owed thanks to his father: a modern, well-organised state; full coffers; and a properly trained and equipped army. Under a leader as renowned as Seydlitz, the Prussian cavalry achieved the nearest to a state of perfection that it was ever going to. So great was its reputation in the Seven Years' War that Napoleon made a special point of warning his men at the beginning of the 1806 campaign to beware of the Prussian cavalry.
Handbook of Evidence-Based Practice in Clinical Psychology, Volume 2 covers the evidence-based practices now identified for treating adults with a wide range of DSM disorders. Topics include fundamental issues, adult cognitive disorders, substance-related disorders, psychotic, mood, and anxiety disorders, and sexual disorders. Each chapter provides a comprehensive review of the evidence-based practice literature for each disorder and then covers several different treatment types for clinical implementation. Edited by the renowned Peter Sturmey and Michel Hersen and featuring contributions from experts in the field, this reference is ideal for academics, researchers, and libraries.
For the British 1st Airborne Division Operation Market Garden in September 1944 was a disaster. The Division was eliminated as a fighting force with around a half of its men were captured. The Germans were faced with dealing with 6,000 prisoners in a fortnight; many of them seriously wounded. Somehow the men were processed and despatched to camps around Germany and German occupied eastern Europe. Here the men experienced the reality of the collapsing regime – little food and shrinking frontiers. Once liberated in 1945 returning former prisoners were required to complete liberation questionnaires. Some refused. Others returned before ’Operation Endor’ to handle released men and their repatriation to Britain was in place. Around a third did. However the questionnaires that do exist give an picture of every day experience for the 2,357 of these elite troops’ time in captivity from capture to release. They show that German procedures still operating, but that men were often treated inhumanely, when moved to camps by closed box cars and when camps were evacuated. Although their interrogators were interested in Allied aircraft and airfields, their interrogators were also concerned the effect of the new miracle weapons and with politics, how Germany would be treated after an Allied victory? Nevertheless the airborne men’s morale remained high; carrying out sabotage at artificial oil plants, railway repairs, factories and mines. Some overcame their guards when being evacuated at the end of the War, in some cases joining the Resistance. They record help received from Dutch, French and German civilians.
Updated to reflect today’s practice guidelines, the new edition of this comprehensive text remains the definitive resource on all aspects of renal transplantation, including immunological, pathological, psychological and ethical considerations. It examines evaluation, management, and procurement of living and deceased donor kidneys, the selection of suitable recipients, interpretation of graft dysfunction, and expected survival based upon a large database of information. There are comprehensive chapters on pediatric renal transplantation and on renal transplantation in the developing world. Extensive tables and figures and comprehensive lists of references with each chapter enhance its value to the transplant team. A multidisciplinary approach from internationally renowned contributors from around the world-many new to this edition-offers practice-applicable guidance for all members of the transplant team, with coverage encompassing applied science, clinical information, and surgical procedures. This 6th edition remains the balanced reference you need to stay apprised of issues important to successful kidney transplantation. Provides a comprehensive description of surgical techniques, immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, both in adults and children, in one convenient reference. Presents more than 335 superb illustrations-50 in full color-that demonstrate key concepts and nuances of techniques. Features a multidisciplinary approach from contributors from around the world-many new to this edition-offers practice-applicable guidance for all members of the transplant team, with coverage encompassing applied science, clinical information, and surgical procedures. Offers evidence-based decision making advice in renal transplantation-supported by a wealth of data in chapters written by internationally recognized experts-to help you make the most informed clinical decisions. Offers new tables and figures as well as revised and updated chapters that report new data and present current practice guidelines. Features a new chapter on transplantation in the sensitized patient to assist you with transplant cases that present unique challenges. Describes the latest preclinical and clinical immunosuppressive strategies, to help you see the link between clinical issues and the basic sciences. Offers tissue typing methodology updates, equipping you with the newest methods of assessing immune responses to the kidney. Features a new chapter on chronic allograft nephropathy.
Former Munich police detective Willi Geismeier is drawn out of hiding to find a deranged serial killer. Former Munch detective Willi Geimeiser is a wanted man. He sacrificed his career and put his life on the line by exposing a high-ranking Nazi official as a murderer, and is now in hiding in a cabin deep in the Bavarian forest. But when his friend, Lola, is savagely attacked, Willi returns to Munich in disguise and under a new identity - Karl Juncker - determined to find the perpetrator. Meanwhile, the discovery of the body of a woman in the River Isar leads Willi's old colleague and friend, Detective Hans Bergemann, to uncover similar disturbing murders stretching back years. A serial killer who preys on young women is running loose on Munich's streets. Could they be responsible for the attack on Lola, and can Willi catch a deranged murderer before the Gestapo catches him?
The multi-national region of Europe situated between the German-speaking lands and those of the former Soviet Union has witnessed many varied manifestations of nationalism over the last two centuries. Professor Sugar has been in the forefront of those seeking to understand and explain these Eastern European nationalisms, and eleven of his essays on the subject are included in this second selection of his studies. The first two essays deal with problems of ethnicity and its specific manifestations in the region; the next three present the growth of national antagonisms during the 19th century. The third, and longest, section then sets out to examine the interaction of fully developed nationalism in Eastern Europe with the various political movements and religious organizations that impacted upon these lands.
This report is part of a series of 21 Synthesis and Assessments (SAP) aimed at providing current assessments of climate change science to inform public debate, policy, and operational decisions. These reports are also intended to help develop future program research priorities. The guiding vision is to provide the Nation and the global community with the science-based knowledge needed to manage the risks and capture the opportunities associated with climate and related environmental changes. This SAP assesses abrupt climate change events where key aspects of the climate system change faster than the responsible forces would suggest and/or faster than society can respond to those changes. Illustrations.
Principles of Electron Optics: Second Edition, Advanced Wave Optics provides a self-contained, modern account of electron optical phenomena with the Dirac or Schrödinger equation as a starting point. Knowledge of this branch of the subject is essential to understanding electron propagation in electron microscopes, electron holography and coherence. Sections in this new release include, Electron Interactions in Thin Specimens, Digital Image Processing, Acquisition, Sampling and Coding, Enhancement, Linear Restoration, Nonlinear Restoration – the Phase Problem, Three-dimensional Reconstruction, Image Analysis, Instrument Control, Vortex Beams, The Quantum Electron Microscope, and much more. Includes authoritative coverage of many recent developments in wave electron optics Describes the interaction of electrons with solids and the information that can be obtained from electron-beam techniques Includes new content on multislice optics, 3D reconstruction, Wigner optics, vortex beams and the quantum electron microscope
A Holocaust survivor tells his compelling family story of escape and survival in China and Australia during WW2. Living in Berlin in 1939, three-year-old Peter Nachemstein and his parents were forced to escape Nazi Germany by fleeing to Shanghai – one of the only havens left for them and 18,000 other European Jews. Although safe, they became displaced and isolated from the rest of their family, who were scattered across Europe. In Escape from Berlin, Peter Nash retraces what became of his family members following the devastating impact of WW2. Using remarkable photographs and documents to bring their captivating stories to life, Peter recounts his own experiences of dislocation as a young boy in alien Shanghai, and then later as a teenager and adult in Australia. Meticulously researched and impeccably detailed, Escape from Berlin brings light to a fascinating but not widely known chapter of Holocaust history in a family story that reflects the experiences of many in the Jewish community.
Attuned to the complexities of real-world clinical situations, this authoritative volume belongs on the desks of practitioners, researchers, and students in clinical and counseling psychology, psychiatry, and social work, as well as health care administrators and planners. In the classroom, it serves as a uniquely informative text in advanced undergraduate- and graduate-level courses in psychotherapy research and clinical practice."--BOOK JACKET.
Carl Schurz was a larger-than-life public figure whose exploits, real and concocted appeared in newspapers nationwide during the nineteenth century. His letters to Fanny Chapman, his secret love, leave a picture of an age of turmoil, corruption, social graces, and artistic explosion. It took a renaissance man like Carl Schurz to travel among the greats in the literary, artistic and political arenas with grace and judgement. The tragedy of his life, if there was one, is that he is nearly forgotten in the modern world in the face of revisionist history. He was a fighter for human rights including all races and creeds and a pioneer muckraker in a corrupt city of a “Gilded Age”. Lost are his educational contributions, his unpopular and prophetic political stance for Civil Service reform and his fight against a trend toward national imperialism.
The Routledge Encyclopedia of Second Language Acquisition offers a user-friendly, authoritative survey of terms and constructs that are important to understanding research in second language acquisition (SLA) and its applications. The Encyclopedia is designed for use as a reference tool by students, researchers, teachers and professionals with an interest in SLA. The Encyclopedia has the following features: * 252 alphabetized entries written in an accessible style, including cross references to other related entries in the Encyclopedia and suggestions for further reading * Among these, 9 survey entries that cover the foundational areas of SLA in detail: Development in SLA, Discourse and Pragmatics in SLA, Individual Differences in SLA, Instructed SLA, Language and the Lexicon in SLA, Measuring and Researching SLA, Psycholingustics of SLA, Social and Sociocultural Approaches to SLA, Theoretical Constructs in SLA. * The rest of the entries cover all the major subdisciplines, methodologies and concepts of SLA, from "Accommodation" to the "ZISA project." Written by an international team of specialists, the Routledge Encyclopedia of Second Language Acquisition is an invaluable resource for students and researchers with an academic interest in SLA.
A dramatic account of life in Czechoslovakia's great capital during the Nazi Protectorate With this successor book to Prague in Black and Gold, his account of more than a thousand years of Central European history, the great scholar Peter Demetz focuses on just six short years—a tormented, tragic, and unforgettable time. He was living in Prague then—a "first-degree half-Jew," according to the Nazis' terrible categories—and here he joins his objective chronicle of the city under German occupation with his personal memories of that period: from the bitter morning of March 15, 1939, when Hitler arrived from Berlin to set his seal on the Nazi takeover of the Czechoslovak government, until the liberation of Bohemia in April 1945, after long seasons of unimaginable suffering and pain. Demetz expertly interweaves a superb account of the German authorities' diplomatic, financial, and military machinations with a brilliant description of Prague's evolving resistance and underground opposition. Along with his private experiences, he offers the heretofore untold history of an effervescent, unstoppable Prague whose urbane heart went on beating despite the deportations, murders, cruelties, and violence: a Prague that kept its German- and Czech-language theaters open, its fabled film studios functioning, its young people in school and at work, and its newspapers on press. This complex, continually surprising book is filled with rare human detail and warmth, the gripping story of a great city meeting the dual challenge of occupation and of war.
In 1848, the penultimate year of his life, Chopin visited England and Scotland at the instigation of his aristocratic Scots pupil, Jane Stirling. In the autumn of that year, he returned to Paris. The following autumn he was dead. Despite the fascination the composer continues to hold for scholars, this brief but important period, and his previous visit to London in 1837, remain little known. In this richly illustrated study, Peter Willis draws on extensive original documentary evidence, as well as cultural artefacts, to tell the story of these two visits and to place them into aristocratic and artistic life in mid-nineteenth-century England and Scotland. In addition to filling a significant hole in our knowledge of the composer’s life, the book adds to our understanding of a number of important figures, including Jane Stirling and the painter Ary Scheffer. The social and artistic milieux of London, Manchester, Glasgow and Edinburgh are brought to vivid life.
Peter Cornwell tells the story of the greatest air battle of the Second World War when six nations were locked in combat over north-western Europe for a traumatic six weeks in 1940. He describes the day-to-day events as the battle unfolds, and details the losses suffered by all six nations involved: Britain, France, Holland, Belgium, Germany and, rather belatedly, Italy. As far as RAF fighter squadrons in France were concerned, it was an all-Hurricane show, yet it was the Blenheim and Battle crews who suffered the brunt of the casualties. Every aircraft lost or damaged through enemy action while operating in France is listed together with the fate of the crews. The RAF lost more than a thousand aircraft of all types over the Western Front during the six-week battle, the French Air Force 1,400, but Luftwaffe losses were even higher at over 1,800 aircraft.
Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms
Thought-provoking and entices the reader to take a discerning look at science.' Claire Garven, MA Senior Lecturer at the University of the West of England, Bristol, UK. ̃An approach to planning and teaching primary science that gives children permission to question their own preconceptions. This enables teachers to encourage children to actively think and discuss what they see, and give reasons for their developing scientific ideas. Strongly recommended for teachers who want their children to learn to think scientifically.' Jane Gibson, Senior Lecturer and Coordinator of primary science in ITE at the University of St Mark and St John (Marjon), UK This second edition brings science subject knowledge and pedagogy together to support, inform and inspire those training to teach primary science. Written in a clear and accessible way, the book provides comprehensive coverage of science themes. Ideas for teaching and examples from practice provide a basis for inspiring children to explore science and look at the world in new and intriguing ways. Hallmark features Ideas for practice exemplify how you can help children to use scientific knowledge and concepts to satisfy their curiosity about natural phenomena. Something to think about scenarios help to extend and develop your own understanding of key ideas. The companion website includes links to suggested reading and Teachers TV clips for your own development and for use in the classroom. New to this edition A new chapter called Views of Science Learning encourages the teacher to take a central role in helping children develop scientific attitudes, skills and conceptual understanding. Learning Outside the Classroom is a new chapter that provides ideas and guidance that helps to develop children’s scientific skills and knowledge, while also promoting positive attitudes to science. New Global Dimensions sections offer starting points for discussion and research into how scientific ideas can be positively applied and can be used to evaluate the impact of human activity on the natural world. Talk Skills and Science Discussion sections enable you to develop children's scientific knowledge and verbal reasoning skills.
An authoritative practitioner guide and student text, this book offers clear advice on how to structure and lead cognitive-behavioral therapy (CBT) groups and overcome common challenges that arise. Specific, evidence-based group assessment and treatment protocols are provided for a range of frequently encountered disorders. Emphasizing that a CBT group is more than the sum of its individual members, the authors show how to understand and use group process to optimize outcomes. Up to date, accessible, and highly practical, the book is filled with session outlines, sample dialogues, checklists, troubleshooting tips, and other user-friendly features.
The fascinating history of how coal-based energy became entangled with American security. Since the early twentieth century, Americans have associated oil with national security. From World War I to American involvement in the Middle East, this connection has seemed a self-evident truth. But, as Peter A. Shulman argues, Americans had to learn to think about the geopolitics of energy in terms of security, and they did so beginning in the nineteenth century: the age of coal. Coal and Empire insightfully weaves together pivotal moments in the history of science and technology by linking coal and steam to the realms of foreign relations, navy logistics, and American politics. Long before oil, coal allowed Americans to rethink the place of the United States in the world. Shulman explores how the development of coal-fired oceangoing steam power in the 1840s created new questions, opportunities, and problems for U.S. foreign relations and naval strategy. The search for coal, for example, helped take Commodore Matthew Perry to Japan in the 1850s. It facilitated Abraham Lincoln's pursuit of black colonization in 1860s Panama. After the Civil War, it led Americans to debate whether a need for coaling stations required the construction of a global empire. Until 1898, however, Americans preferred to answer the questions posed by coal with new technologies rather than new territories. Afterward, the establishment of America's string of island outposts created an entirely different demand for coal to secure the country's new colonial borders, a process that paved the way for how Americans incorporated oil into their strategic thought. By exploring how the security dimensions of energy were not intrinsically linked to a particular source of power but rather to political choices about America's role in the world, Shulman ultimately suggests that contemporary global struggles over energy will never disappear, even if oil is someday displaced by alternative sources of power.
The English version of the book has been extensively revised and expanded since its original publication in German. This edition includes a new preface and an updated bibliography.
This Fascinating biography chronicles Puccini's life and times, with dozens of photographs and illustrations of the period. His Musical heritage, his scandalous elopement with Elvira, his relationship with Caruso and the dramas of his own life and unfolded in loving detail.
This acclaimed work provides a systematic, comprehensive, and balanced evaluation of the current status of all major psychotherapeutic approaches. With a primary focus on adults, detailed evidence is presented for the efficacy of widely used interventions for frequently encountered mental disorders and specific populations. The book also explains the concepts that underpin psychotherapy research, examines methodological challenges in translating research into practice, and considers the impact on outcome of factors common to all therapies, such as therapist and patient characteristics.
Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians. Summarizes the key morphological and cellular events Emphasizes up-to-date research relating to molecular control mechanisms Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease Distils common themes and differences for comparative studies Highlights key remaining questions and sets the agenda for future research
Hoffmann examines the growing recognition by some Germans in the 1930s of the malign nature of the Nazi regime, the ways in which these people became involved in the resistance, and the views of those who staked their lives in the struggle against tyranny and murder.
Over many centuries, the world has been gripped by warfare, and from this chaos there have risen many heroes and villains. This book takes a look at various individuals and their deeds, including the year and place of birth (wherever possible). Their ranks range from the lowliest Private soldier to Field Marshals. They have been decorated in some cases for their actions, and the student of history will be stunned to discover just how they acted. Some of these have included ancient leaders such as Emperors, and their various campaigns covered most of Europe and also the Middle East.
The Wortatlas der arabischen Dialekte / Word Atlas of Arabic Dialects (WAD) intends to provide an unprecedented survey of the lexical richness and diversity of the Arabic dialects as spoken from Uzbekistan to Mauretania and Nigeria, from Malta to Sudan, and including the Ki-Nubi Creole as spoken in Uganda and Kenya. The multilingual word atlas consists of four volumes in total with some 500 onomasiological maps in full colour. Each map presents a topic or notion and its equivalents in Arabic as collected from the dialectological literature (dictionaries, grammars, text collections, ethnographic reports, etc.), from the editors’ own field work, from questionnaires filled out by native speakers or by experts for a certain dialect region, and also from the internet. Polyglot legends in German, English, French, Spanish, Italian accompany the maps to facilitate further access. Each map is followed by a commentary in German, providing more details about the sources and the individual forms, and discussing semantic and etymological issues. All quotations are in their original language. The maps mainly show lexical types, detailed and concrete forms are given in the commentaries. An introduction is provided in Volume 1 in both German and English. Indices of all lexemes in the atlas will be available for each volume. The first volume Band I: Mensch, Natur, Fauna und Flora / Volume 1: Mankind, Nature, Fauna and Flora contains subjects such as ‘family members’, ‘professions’, ‘human qualities’. The second volume, Band II: Materielle Kultur, deals with material culture (‘house’, ‘utensils’, ‘food’, ‘clothing’, ‘vehicles’, etc.). The third volume Band III: Verben, Adjektive, Zeit und Zahlen focuses on verbs, and adjectives. The forth volume Band IV: Funktionswörter und Phraseologisches contains functionwords and some phraseological items. The atlas is indispensable for everyone interested in the modern spoken Arabic language, as well as for dialectologists and for semanticists.
The Fovea: Structure, Function, Development, and Disease summarizes the current biological knowledge regarding the two types of the vertebrate fovea (and its main structural elements, the Müller cells). This information is then used to explain different aspects of human vision, foveal development, and macular disorders. Sections give an overview of the retinal structure and the different types of retinal glia, survey the structure and function of the primate and non-mammalian fovea types, discuss foveal development—with a focus on the human fovea, cover the roles of Müller cells and astrocytes in the pathogenesis and regeneration of various human macular disorders are described. Using a translational approach, this reference is a valuable text for scientists, clinicians and physicians interested in the fovea. Readers will gain a new understanding of the cellular basics of the fovea, which is the most important part of the eye. Adopts a translational approach, summarizing the biological knowledge regarding the structure and function of the fovea, the roles of Müller cells in mediating the structural integrity, and function of the fovea Provides overviews of both basic types of the vertebrate fovea, countering the popular belief that there is only one type of the vertebrate fovea, the human fovea Thoroughly shows the mechanisms involved in the development of the fovea that explain the rapid improvement of visual acuity in newborns Explains pathological changes in the foveal structure and function with evaluation pointing toward possible prevention and/or cure
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