This completely updated and enlarged third edition of the classic text adopts a practical approach to describe the fundamentals of freeze-drying, backed by many explanatory examples. Following an introduction to the fundamentals, the book goes on to discuss process and plant automation as well as methods to transfer pilot plant qualifications and process data to production. An entire section is devoted to a large range of different pharmaceutical, biological, and medical products. New to this edition are chapters on antibodies, freeze-dry microscopy, TEMPRIS, microwave freeze-drying, spray freeze-drying, and PAT. Their many years of experience in freeze-drying enable the authors to supply valuable criteria for the selection of laboratory, pilot and production plants, discussing the advantages, drawbacks and limitations of different plant designs. Alongside guidelines for the evaluation and qualification of plants and processes, the author also includes a troubleshooting section.
Many modern pharmaceutical and biological products, e.g. blood derivatives, vaccines, cytostatic drugs, antibiotics, bacteria cultures but also consumer goods such as soluble coffee are freeze-dried to transform perishable substances into a form that can be stored and reconstituted to their almost original state without loss of quality. The book describes the up-to-date fundamentals of freeze-drying, not just presenting the process in all its seven steps theoretically, but explaining it with many practical examples. Many years of experience in freeze-drying allow the authors to supply valuable criteria for the selection of laboratory, pilot and production plants, discussing the advantages, drawbacks and limitations of different plant designs. In this second, completely revised edition, process and plant automation are introduced in a separate section and methods to transfer pilot plant qualifications and process data to production are presented. The guidelines for process and plant evaluation and qualifications have been updated and enlarged. Trouble shooting is concentrated in a section of its own and literature has been updated with 100 new quotations to include references as recent as 2002, and 100 new tables and figures have been added.
As the King's young cousin, an admired scholar living in Italy, it falls to Reginald Pole to make the case for Henry's divorce from Katherine of Aragon. And it falls to the hapless Michael Throckmorton - the younger son of an impecunious titled family - to become Thomas Cromwell's messenger to Pole in Rome. This dubious privilege makes of Throckmorton's life a tragicomedy of endless journeys back and forth between England and Italy, but it also makes him a canny observer of the great dramas of his time. And like his King, he too nurses a thwarted desire.
I Reactivity: E. Uggerud: Physical Organic Chemistry of the Gas Phase. Reactivity Trends for Organic Cations.- S. Petrie, D.K. Bohme: Mass Spectrometric Approaches to Interstellar Chemistry.- F. Turecek: Transient Intermediates of Chemical Reactions by Neutralization-Reionization Mass Spectrometry.- II Metalorganic Chemistry: D. Schröder, H. Schwarz: Diastereoselective Effects in Gas-Phase Ion Chemistry.- D.A. Plattner: Metalorganic Chemistry in the Gas Phase: Insight into Catalysis.- III Mass Spectrometric Methodology: T. Wyttenbach, M.T. Bowers: Gas-Phase Conformations: The Ion Mobility/Ion Chromatography Method.- P.B. Armentrout: Threshold Collision-Induced Dissociations for the Determination of Accurate Gas-Phase Binding Energies and Reaction Barriers.- IV Medicinal Chemistry: S.A. Trauger, T. Junker, G. Siuzdak: Investigating Viral Proteins and Intact Viruses with Mass Spectrometry M. Brönstrup: High-Throughput Mass Spectrometry for Compound Characterization in Drug Discovery.
The history of the voluntary sector in British towns and cities has received increasing scholarly attention in recent years. Nevertheless, whilst there have been a number of valuable contributions looking at issues such as charity as a key welfare provider, charity and medicine, and charity and power in the community, there has been no book length exploration of the role and position of the recipient. By focusing on the recipients of charity, rather than the donors or institutions, this volume tackles searching questions of social control and cohesion, and the relationship between providers and recipients in a new and revealing manner. It is shown how these issues changed over the course of the nineteenth century, as the frontier between the state and the voluntary sector shifted away from charity towards greater reliance on public finance, workers' contributions, and mutual aid. In turn, these new sources of assistance enriched civil society, encouraging democratization, empowerment and social inclusion for previously marginalized members of the community. The book opens with an introduction that locates medicine, charity and mutual aid within their broad historiographical and urban contexts. Twelve archive-based, inter-related chapters follow. Their main chronological focus is the nineteenth and early twentieth centuries, which witnessed such momentous changes in the attitudes to, and allocation of, charity and poor relief. However, individual chapters on the early modern period, the eighteenth century and the aftermath of the Second World War provide illuminating context and help ensure that the volume provides a systematic overview of the subject that will be of interest to social, urban, and medical historians.
* Chronicles all three of Mallory's Everest expeditions * Illuminates how Mallory reconciled his ambitions on Everest with his unquestioned love for his wife and family Since the discovery in 1999 of George Mallory's body on Everest, controversy has raged over whether Mallory and Andrew Irvine could have summitted the mountain. Every detail of the climb has been dissected and Mallory's skill as a mountaineer has been hotly debated. Observing the debate, Peter and Leni Gillman felt that the essence of who Mallory was as an individual had been lost. In The Wildest Dream they offer the most comprehensive biography ever written about one of the 20th century's most intriguing personalities. Exploring Mallory's early years, the Gillmans take the reader to Cambridge and Bloomsbury where Mallory consorted with some of the most colorful literary and artistic figures of Edwardian England: Rupert Brooke, James and Lytton Strachey, Maynard and Geoffrey Keynes, and Duncan Grant, among others. The Wildest Dream moves on to examine exactly what Mallory accomplished as a climber, evaluating the quality of his routes and skills within the context of climbing in the early 1900s. At the heart of this biography, and of Mallory's life, is his wife, Ruth. The letters they exchanged during the many separations caused by World War I and three Everest expeditions reveal the depth of their commitment to each other and the unwavering support and strength Ruth offered George. The Everest expeditions are also insightfully rendered, offering perspective on criticisms levied at Mallory after the 1921 and 1922 attempts. The authors examine how Mallory, a dedicated husband and father, arrived at his fateful decision to participate in the doomed 1924 expedition and why he continued to press for a summit attempt when the odds seemed stacked against him. As Mallory once declared, a climber was what he was, and this is what climbers did; this was how they fulfilled their wildest dreams.
Dictionary of Carbohydrates print entries are listed in alphabetical order by entry name, name index, and molecular formula index. The data included in each entry includes:
This completely updated and enlarged third edition of the classic text adopts a practical approach to describe the fundamentals of freeze-drying, backed by many explanatory examples. Following an introduction to the fundamentals, the book goes on to discuss process and plant automation as well as methods to transfer pilot plant qualifications and process data to production. An entire section is devoted to a large range of different pharmaceutical, biological, and medical products. New to this edition are chapters on antibodies, freeze-dry microscopy, TEMPRIS, microwave freeze-drying, spray freeze-drying, and PAT. Their many years of experience in freeze-drying enable the authors to supply valuable criteria for the selection of laboratory, pilot and production plants, discussing the advantages, drawbacks and limitations of different plant designs. Alongside guidelines for the evaluation and qualification of plants and processes, the author also includes a troubleshooting section.
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