Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
A light-hearted, but engaging conversation about one of the key technologies of our age.I recommend this book to anyone interested in the broader issues around Artificial Intelligence.'Richard HartleyAustralian National University, Australia This book engages with the title question: what is artificial intelligence (AI)? Instead of reiterating received definitions or surveying the field from a disciplinary perspective, the question is engaged here by putting two standpoints into conversation. The standpoints are different in their disciplinary groundings — i.e. technology and the humanities — and also in their approaches — i.e. applied and conceptual. Peter is an AI engineer: his approach is in terms of how to make AI work. Suman is a humanities researcher: his approach is in terms of what people and academics mean when they say 'AI'.A coherent argument, if not a consensus, develops by putting the two standpoints into conversation. The conversation is presented in 32 short chapters, in turn by Suman and Peter. There are two parts: Part 1, Questioning AI, and Part 2, AI and Government Policy. The first part covers issues such as the meaning of intelligence, automation, evolution, artificial and language. It outlines some of the processes through which these concepts may be technologically grounded as AI. The second part addresses policy considerations that underpin the development of AI and responds to the consequences. Themes taken up here include: rights and responsibilities; data usage and state-level strategies in the USA, UK and China; unemployment and policy futures.
This book is a collective journal of the COVID-19 pandemic. With first-hand accounts of the pandemic as it unfolded, it explores the social and the political through the lens of the outbreak. Featuring contributors located in India, the United States, Brazil, the United Kingdom, Germany, and Bulgaria, the book presents us with simultaneous multiple histories of our time. The volume documents the beginning of social distancing and lockdown measures adopted by countries around the world and analyses how these bore upon prevailing social conditions in specific locations. It presents the authors’ personal observations in a lucid conversational style as they reflect on themes such as the reorganization of political debates and issues, the experience of the marginalized, theodicy, government policy responses, and shifts into digital space under lockdown, all of these under an overarching narrative of the healthcare and economic crisis facing the world. A unique and engaging contribution, this book will be useful to students and researchers of sociology, public health, political economy, public policy, and comparative politics. It will also appeal to general readers interested in pandemic literature.
The study of operator algebras, which grew out of von Neumann's work in the 1920s and the 1930s on modelling quantum mechanics, has in recent years experienced tremendous growth and vitality. This growth has resulted in significant applications in other areas - both within and outside mathematics. The field was a natural candidate for a 1994-1995 programme year in Operator Algebras and Applications held at The Fields Institute for Research in the Mathematical Sciences. This volume contains a selection of papers that arose from the seminars and workshops of the programme. Topics covered include the classification of amenable C ]*-algebras, the Baum-Connes conjecture, E [0 semigroups, subfactors, E-theory, quasicrystals, and the solution to a long-standing problem in operator theory: can almost commuting self-adjoint matrices be approximated by commuting self-adjoint matrices?
The letters of Abelard and Heloise contain a vivid account of one of the most celebrated love affairs in the western world that raised questions about love, marriage, and religious life in the Middle Ages. This much needed new edition of the Latin text contains English translation, a full introduction, extensive annotation, and detailed indexes.
This book presents a range of investment appraisal methods and models to help readers make good investment decisions. Each approach is thoroughly described, evaluated, and illustrated using examples, with its assumptions and limitations analyzed in terms of their implications for investment decision-making practice. Getting investment decisions right is crucial but due to a complex and dynamic business environment this remains a challenging management task.
The Practical Philosophy of AI-Assistants presents a formal conversation between an AI engineer, Peter, and a humanities researcher, Suman. The book ensures that specialist concepts in AI research are made comprehensible to a humanities researcher, while humanities theories can be easily grasped by an AI engineer.The authors establish ground rules to design an AI-Assistant, that is, an AI system that could act as a personal friend, consultant and confidante for every individual, to be integrated into our daily lives. These rules apply to four large areas of AI development: recognition and identification, communication, explanation, and civility.In discussing these areas, this book provides an accessible account of the current state of AI research, as well as adding nuance to the underpinning assumptions informing the relevant technologies, reflecting on their social implications.The broader ideological objective of The Practical Philosophy of AI-Assistants is captured by the phrase 'practical philosophy', which expresses a commitment to bringing AI development to work towards a good life for all.
Water-filtered infrared A irradiation (wIRA) is a special application of infrared A irradiation. Its preferential induction of thermal, but also nonthermal, effects which have a high tissue penetration and low heat load to the skin surface makes wIRA a promising therapeutic method. Since its introduction in 1989, wIRA has been applied experimentally and clinically to human and animal patients to treat and improve an impressive variety of disease entities. This book summarizes recent developments by presenting a wide range of up-to-date clinical applications and offers an excellent overview on the topic, which will be of relevance to readers from clinical disciplines and basic researchers alike. The book is organized into two main fields: "Principles" and "Clinical Practice". "Clinical Practice" is the most substantial field being divided into parts on application of wIRA in oncology, psychiatry, neonatology, dermatology, rheumatology, and infectiology. "Principles" summarizes the historic development of wIRA, focusing on the physical basics, body's reaction to hyperthermia, thermography, and thermometry, and recommends clear terminology when applying wIRA.
In this volume, the geometry of spherical space form groups is studied using the eta invariant. The author reviews the analytical properties of the eta invariant of Atiyah-Patodi-Singer and describes how the eta invariant gives rise to torsion invariants in both K-theory and equivariant bordism. The eta invariant is used to compute the K-theory of spherical space forms, and to study the equivariant unitary bordism of spherical space forms and the Pinc and Spinc equivariant bordism groups for spherical space form groups. This leads to a complete structure theorem for these bordism and K-theory groups.There is a deep relationship between topology and analysis with differential geometry serving as the bridge. This book is intended to serve as an introduction to this subject for people from different research backgrounds.This book is intended as a research monograph for people who are not experts in all the areas discussed. It is written for topologists wishing to understand some of the analytic details and for analysists wishing to understand some of the topological ideas. It is also intended as an introduction to the field for graduate students.
This is a book that should be required reading for all Secretaries of State for Education. It was easy to read and ought to find a place in as many staff libraries as possible." Education Review
Volatility underpins financial markets by encapsulating uncertainty about prices, individual behaviors, and decisions and has traditionally been modeled as a semimartingale, with consequent scaling properties. The mathematical description of the volatility process has been an active topic of research for decades; however, driven by empirical estimates of the scaling behavior of volatility, a new paradigm has emerged, whereby paths of volatility are rougher than those of semimartingales. According to this perspective, volatility behaves essentially as a fractional Brownian motion with a small Hurst parameter. The first book to offer a comprehensive exploration of the subject, Rough Volatility contributes to the understanding and application of rough volatility models by equipping readers with the tools and insights needed to delve into the topic, exploring the motivation for rough volatility modeling, providing a toolbox for computation and practical implementation, and organizing the material to reflect the subject’s development and progression. This book is designed for researchers and graduate students in quantitative finance as well as quantitative analysts and finance professionals.
The first paper in the volume, Stochastic Evolution Equations by N V Krylov and B L Rozovskii, was originally published in Russian in 1979. After more than a quarter-century, this paper remains a standard reference in the field of stochastic partial differential equations (SPDEs) and continues to attract attention of mathematicians of all generations, because, together with a short but thorough introduction to SPDEs, it presents a number of optimal and essentially non-improvable results about solvability for a large class of both linear and non-linear equations.
Concise and clinically focused, Gout, by Drs. Naomi Schlesinger and Peter E. Lipsky, provides a one-stop overview of recent developments regarding this common form of inflammatory arthritis. Impacting an estimated 8.3 million people in the U.S. alone, gout is seen frequently by both primary care physicians as well as rheumatologists. This resource provides detailed coverage of the epidemiology, causes, diagnosis, management, and treatment of patients with both acute and chronic gout. - Addresses key topics such as genetics, hyperuricemia, comorbidities of gout, treatment guidelines for acute and chronic gout, classification and diagnosis, and imaging. - Discusses future outlooks for improving pharmacological and nonpharmacological treatment options, including an overview of drugs in the pipeline. - Consolidates today's available information on this timely topic into one convenient resource.
Australia’s venomous snakes are widely viewed as the world’s most deadly and are regarded with cautious curiosity, fascination and, regrettably, fear. Australia’s Dangerous Snakes examines the biology, natural history, venom properties and bite treatment of medically important venomous marine and terrestrial snakes. It contains comprehensive identification profiles for each species, supported by keys and photographs. In addition to their medical importance, the environmental roles of these snakes and the threats that are causing the decline of many of these reptiles are discussed. Drawing on the authors’ experience in the fields of herpetology, toxinology and clinical medicine, this book stimulates respect and admiration and dispels fear of Australia’s fascinating snakes. Australia’s Dangerous Snakes will provide hours of rewarding reading and valuable information for anyone interested in Australia’s unique wildlife and natural history, and will be an essential reference for herpetologists, toxinologists, physicians, zoo personnel and private snake collectors.
A pioneering monograph on tensor methods applied to distributional problems arising in statistics, this work begins with the study of multivariate moments and cumulants. An invaluable reference for graduate students and professional statisticians. 1987 edition.
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