This is a story of a man who found his true self through great suffering. Much of what is revealed is seen through the eyes of a man close to death. This is a fast moving thriller with a narrative rich in drama, mystery, and suspense.
Peter Cornwell tells the story of the greatest air battle of the Second World War when six nations were locked in combat over north-western Europe for a traumatic six weeks in 1940. He describes the day-to-day events as the battle unfolds, and details the losses suffered by all six nations involved: Britain, France, Holland, Belgium, Germany and, rather belatedly, Italy. As far as RAF fighter squadrons in France were concerned, it was an all-Hurricane show, yet it was the Blenheim and Battle crews who suffered the brunt of the casualties. Every aircraft lost or damaged through enemy action while operating in France is listed together with the fate of the crews. The RAF lost more than a thousand aircraft of all types over the Western Front during the six-week battle, the French Air Force 1,400, but Luftwaffe losses were even higher at over 1,800 aircraft.
This sobering description of many computer-related failures throughout our world deflates the hype and hubris of the industry. Peter Neumann analyzes the failure modes, recommends sequences for prevention and ends his unique book with some broadening reflections on the future." —Ralph Nader, Consumer Advocate This book is much more than a collection of computer mishaps; it is a serious, technically oriented book written by one of the world's leading experts on computer risks. The book summarizes many real events involving computer technologies and the people who depend on those technologies, with widely ranging causes and effects. It considers problems attributable to hardware, software, people, and natural causes. Examples include disasters (such as the Black Hawk helicopter and Iranian Airbus shootdowns, the Exxon Valdez, and various transportation accidents); malicious hacker attacks; outages of telephone systems and computer networks; financial losses; and many other strange happenstances (squirrels downing power grids, and April Fool's Day pranks). Computer-Related Risks addresses problems involving reliability, safety, security, privacy, and human well-being. It includes analyses of why these cases happened and discussions of what might be done to avoid recurrences of similar events. It is readable by technologists as well as by people merely interested in the uses and limits of technology. It is must reading for anyone with even a remote involvement with computers and communications—which today means almost everyone. Computer-Related Risks: Presents comprehensive coverage of many different types of risks Provides an essential system-oriented perspective Shows how technology can affect your life—whether you like it or not!
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.
For more than 30 years, the highly regarded Secrets Series® has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Gastrointestinal and Liver Secrets, 6th Edition (formerly known as GI/Liver Secrets), offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style – making inquiry, reference, and review quick, easy, and enjoyable. - The proven Secrets Series® format gives you the most return for your time – succinct, easy to read, engaging, and highly effective. - Fully revised and updated throughout, making it an excellent resource for understanding the physiology and therapy of hepatic and digestive disease. - New chapters on Microbiome and Surgery for Inflammatory Bowel Disease. - Top 100 Secrets provide a fast overview of the secrets you must know for success in practice and on exams. - More than 250 full-color illustrations, endoscopic images, micrographs, and algorithms, plus videos and clinical vignettes online. - Bulleted lists, mnemonics, practical tips from global leaders in the field – all providing a concise overview of important board-relevant content. - Portable size makes it easy to carry with you for quick reference or review anywhere, anytime.
Now in full color, Maxillofacial Surgery, 3rd Edition covers the entire specialty of maxillofacial surgery, including craniofacial deformity, oral surgery, trauma, and oncology. Unlike other OMFS texts where the contributors are singly boarded in oral surgery, this richly illustrated text boasts OMFS contributors who are all dual boarded in both oral surgery and medicine. Thoroughly updated with evidence-based content, it addresses the advances in technology and procedures providing oral and maxillofacial surgeons with new and exciting treatment options. And with print and digital formats, it is easy to use in any setting. - Authoritative guidance on oral and maxillofacial surgery by internationally recognized experts in the field. - 2,800 illustrations, including radiographs and full color artwork and clinical photos, provide clinicians and OMS residents with a clear visual guide to diagnoses, key concepts, and surgical techniques, as well as examples of preoperative and postoperative results. - A multidisciplinary approach reflects the best practices in the disciplines of oral and maxillofacial surgery, head and neck surgery, plastic surgery, and otolaryngology. - Covers contemporary techniques and technological advances at the forefront of maxillofacial surgery. - Evidence-based content supports the newest, most up-to-date diagnostic and therapeutic options available for a wide variety of clinical problems. - Key Points and Pitfalls boxes clearly identify the most important information, as well as potential problem areas that can arise when treating patients. - Available in print and digital formats that can be easily accessed via mobile tablets and smart phones in any setting, making it perfect for the modern student of surgery. - NEW! Full-color images clearly depict pathologies, concepts, and procedures. - EXPANDED and UPDATED! Expanded from 82 to 111 chapters with thoroughly revised content that reflects current information and advances in OMS, so clinicians and students can depend on this text as their go-to resource on oral maxillofacial surgery. - NEW! 29 new state-of-the-art chapters covering new topics, including the salivary glands, thyroid and parathyroid glands, tissue engineering, navigational surgery, 3D modeling, and lasers in OMFS. - NEW! Two new editors, Professors Brennan and Schliephake, and new section editors and contributors have helped bring advances in the field of oral and maxillofacial surgery and offer a fresh perspective. - UPDATED! Expanded chapter on cancer keeps you in the know.
This is a story of a man who found his true self through great suffering. Much of what is revealed is seen through the eyes of a man close to death. This is a fast moving thriller with a narrative rich in drama, mystery, and suspense.
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