Cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC), represent an important group of liver diseases of the intra- and extrahepatic bile ducts frequently causing end-stage liver disease with significant morbidity and mortality due to limited treatment options. The limitations of the currently available medical therapy largely reflect our deficits in understanding the pathophysiology of cholestatic liver diseases. Therefore, there is an urgent need for reliable, well-defined and easily reproducible animal models to gain insights into the PSC and PBC pathophysiology and to test novel treatment modalities. We aimed to provide a systematic overview of currently available animal models for sclerosing cholangitis and biliary fibrosis and critically discuss the characteristics of rodent models for PSC and PBC, models of experimental biliary obstruction, models of inflammation-induced cholestasis, as well as models of inherited cholestatic syndromes.
Cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC), represent an important group of liver diseases of the intra- and extrahepatic bile ducts frequently causing end-stage liver disease with significant morbidity and mortality due to limited treatment options. The limitations of the currently available medical therapy largely reflect our deficits in understanding the pathophysiology of cholestatic liver diseases. Therefore, there is an urgent need for reliable, well-defined and easily reproducible animal models to gain insights into the PSC and PBC pathophysiology and to test novel treatment modalities. We aimed to provide a systematic overview of currently available animal models for sclerosing cholangitis and biliary fibrosis and critically discuss the characteristics of rodent models for PSC and PBC, models of experimental biliary obstruction, models of inflammation-induced cholestasis, as well as models of inherited cholestatic syndromes.
In Anarchy! An Anthology of Emma Goldman's Mother Earth, Peter Glassgold brings to the page political activist and anarchist Emma Goldman's most radical contribution, Mother Earth, a monthly journal about social science and literature. Glassgold has compiled Mother Earth's most provocative articles, with thematic categories ranging from "The Woman Question" to "The Social War" and features a diverse selection of writers, such as Leo Tolstoy, Margaret Sanger, Peter Kropotkin, and Alexander Berkman. Mother Earth was published from 1906 to 1918, when birth control, the labor movement, sexual freedom, and the arts where common subjects. The supporters of the journal helped form what was the "radical left" in the United States at the turn of the century. Goldman was imprisoned and ultimately deported to her native Russia. This new edition includes the transcripts from the trial and the summations of both Alexander Berkman and Goldman. With a new preface by the editor, this book offers historical grounding to many of our contemporary political movements, from libertarianism to the Occupy! actions. Anarchy! provides unprecedented access to Goldman's beliefs, offering insight to the political activism that existed at the time.
The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings. This edition is in full color and features nearly 200 high-quality images Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions
Zakim and Boyer's Hepatology-the defining work in hepatology-presents comprehensive coverage of both basic science and clinically relevant developments so you can provide the best possible patient care. Drs. Thomas Boyer, Michael Manns, and Arun Sanyal have reorganized and updated the contents of this trusted global reference to reflect today's more clinical approach to hepatology. They bring you up to date on hot topics including HIV Co-Infection Drug Toxicity, Hepatocellular Carcinoma (HCC), and much more. This new streamlined edition is now a single volume with access to the fully searchable contents and an image bank online at www.expertconsult.com making it easier to find the treatment information you need. Effectively treat all liver diseases currently seen in clinical practice with authoritative guidance from leading international authorities. Reinforce your foundation in basic science with the concise Pathophysiology of Therapeutic Targets section. See clear presentations of liver disease through hundreds of detailed, color illustrations. Explore topics further with up-to-date references that direct you to the significant literature. Access the complete, fully searchable contents of the book online at www.expertconsult.com, along with a downloadable image bank and complete list of references. Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout. Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology. Reference key information more easily thanks to streamlined content that now fits into one volume.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry’s Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. Includes new chapters on Zika virus and Guillain-Barré syndrome. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
The great American Westerns can be profoundly meaningful when read metaphorically. More than mere shoot 'em up entertainment, they are an essential part of a vibrant, evolving national mythology. Like other versions of the archetypal Hero's Journey, these films are filled with insights about life, love, nature, society, ethics, beauty and what it means to be human, and are key to understanding American culture. Part film guide, part historical survey, this book explores the mythic and artistic elements in 52 great Westerns--some orthodox, some subversive--from the genre's first half-century. Each film is given detailed critical analysis, from the earliest silent movies to Golden Age classics like Red River (1948), High Noon (1952) and Shane (1953).
This issue of Critical Care Clinics focuses on Obstetric and Gynecologic Emergencies in the ICU. Articles include: Respiratory Failure and Mechanical Ventilation in the Pregnant Patient, Anesthetic Complications in Pregnancy, Neurologic Complications in Pregnancy, Renal Failure in Pregnancy, Management Complex Cardiac Issues in the Pregnant Patient, Liver Failure in Pregnancy, Hypertensive Emergencies in Pregnancy, Ethical Issues in Pregnancy, and more!
Feigin and Cherry's Textbook of Pediatric Infectious Diseases helps you put the very latest knowledge to work for your young patients with unparalleled coverage of everything from epidemiology, public health, and preventive medicine through clinical manifestations, diagnosis, treatment, and much more. Ideal for all physicians, whether in an office or hospital setting, Feigin and Cherry’s equips you with trusted answers to your most challenging clinical infectious disease questions. Meet your most difficult clinical challenges in pediatric infectious disease, including today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases, with unmatched, comprehensive coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. Find the answers you need quickly thanks to an organization both by organ system and by etiologic microorganism, allowing you to easily approach any topic from either direction.
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