This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology.NEW TO THE THIRD EDITION:* Covers drug induced pathology in preclinical (animal) studies and their relevance for patients or volunteers in clinical studies* General comments to each chapter about the relevance of pathological findings to humans* Provides essential information that can help decide the relevance of particular lesions for patients
Take advantage of this unique book - the first single-volume resource to explore all important aspects of neurogenic inflammation. An unrivaled compilation of up-to-date information, Neurogenic Inflammation contains chapters written by recognized authorities in their areas of expertise. It covers the basic mechanisms and the pathophysiological implications of neurogenic inflammatory processes and points to novel therapeutic strategies in the field of inflammatory and related diseases. The book highlights the many systems and mechanisms involved in neurogenic inflammation, including vasodilatation, plasma extravasation, leukocyte adhesion, smooth muscle contraction, exocrine gland secretion, and recruitment of inflammatory cells. The authors discuss the contribution of neurogenic inflammation to human diseases, such as migraine, asthma, arthritis, and inflammatory bowel disease, linked to the ubiquitous distribution of sensory nerves to organs and tissues at both the somatic and visceral level. Neurogenic Inflammation is the clear choice for a one-step, authoritative guide to the latest developments in this dynamic field.
This book examines the fundamental question of how legislators and other rule-makers should handle remembering and forgetting information (especially personally identifiable information) in the digital age. It encompasses such topics as privacy, data protection, individual and collective memory, and the right to be forgotten when considering data storage, processing and deletion. The authors argue in support of maintaining the new digital default, that (personally identifiable) information should be remembered rather than forgotten. The book offers guidelines for legislators as well as private and public organizations on how to make decisions on remembering and forgetting personally identifiable information in the digital age. It draws on three main perspectives: law, based on a comprehensive analysis of Swiss law that serves as an example; technology, specifically search engines, internet archives, social media and the mobile internet; and an interdisciplinary perspective with contributions from various disciplines such as philosophy, anthropology, sociology, psychology, and economics, amongst others.. Thanks to this multifaceted approach, readers will benefit from a holistic view of the informational phenomenon of “remembering and forgetting”. This book will appeal to lawyers, philosophers, sociologists, historians, economists, anthropologists, and psychologists among many others. Such wide appeal is due to its rich and interdisciplinary approach to the challenges for individuals and society at large with regard to remembering and forgetting in the digital age.
Emma Kunz (1892-1963), Heilerin, Forscherin und Visionärin, wächst als eines von zehn Kindern einer armen Handweber-Familie im aargauischen Brittnau auf. Drei ihrer Geschwister sterben im Kindesalter, der Vater und ein Bruder nehmen sich das Leben, als Emma 17jährig ist. Im Alter von 19 Jahren folgt sie ihrer Liebe nach Amerika und kehrt enttäuscht zurück. Die junge Frau besitzt aussergewöhnliche Fähigkeiten. Sie liest die Gedanken anderer Menschen, heilt Krankheiten und sagt zukünftige Ereignisse voraus. Sie forscht leidenschaftlich nach den universellen Mustern des Lebens; die Anerkennung der wissenschaftlichen Welt bleibt ihr versagt. Emma wird als Hexe gebrandmarkt, Behörden hetzen sie durh die halbe Schweiz. Als die mit 70 Jahren einsam stirbt, hinterlässt sie Methoden, mit denen sie die Zukunft präzise voraussagen und die Ursachen und Heilungsmöglichkeiten von Krankheiten bestimmen konnte - Methoden, deren Geheimnis bis heute nicht entschlüsselt ist. Yvon Mutzner und Peter Donatsch sind in Archiven und in Gesprächen mit Zeitzeugen den Spuren von Emma Kunz gefolgt. Historische Bruchstücke haben sie mit fiktiven Teilen zu einem Ganzen ergänzt. Entstanden ist ein ebenso bewegender wie spannender biographischer Roman.
In 1828 a teenage boy was discovered on the streets of Nuremberg. Barely able to walk, he clutched a letter in his hand. This youth, Kaspar Hauser, who couldn't properly speak or write, was soon to become an international phenomenon known as "the Child of Europe." The story of Kaspar Hauser presents many mysteries. According to his account, the young boy spent most of his life confined in a darkened space. Unable to stand up, and with no knowledge of his captors, he was fed a diet of bread and water. Eventually released from this macabre prison, he survived an assassination attempt only to be stabbed to death in 1833. Why was a child kept in such squalid circumstances? Who were his parents? Who was responsible for such a cruel attack on childhood? Who murdered him? In this seminal work Peter Tradowsky addresses these questions through the insights of Anthroposophy. His analysis reveals some of the secrets of Kaspar Hauser's short life, and the occult significance of his incarnation, spiritual nature and individuality.
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