Macular Surgery, Second Edition serves as a comprehensive and contemporary review of macular diseases and their management. An exhaustive review of the latest proven surgical techniques and therapies for treatment of macular disorders is provided, with emphasis on proven techniques from extensive reviews of controlled clinical trials. Specific chapters of the book are devoted to age-related macular degeneration, diabetic retinopathy, macular holes, epiretinal membranes, subretinal hemorrhage, and choroidal neovascularization. An entire section is devoted to prevention of complications from macular surgery. All chapters are written by leading experts within the field.
Censorship may have to do with literature', Nadine Gordimer once said, 'but literature has nothing whatever to do with censorship.' As the history of many repressive regimes shows, this vital borderline has seldom been so clearly demarcated. Just how murky it can sometimes be is compellingly exemplified in the case of apartheid South Africa. For reasons that were neither obvious nor historically inevitable, the apartheid censors were not only the agents of the white minority government's repressive anxieties about the medium of print. They were also officially-certified guardians of the literary. This book is centrally about the often unpredictable cultural consequences of this paradoxical situation. Peter D. McDonald brings to light a wealth of new evidence - from the once secret archives of the censorship bureaucracy, from the records of resistance publishers and writers' groups both in the country and abroad - and uses extensive oral testimony. He tells the strangely tangled stories of censorship and literature in apartheid South Africa and, in the process, uncovers an extraordinarily complex web of cultural connections linking Europe and Africa, East and West. The Literature Police affords a unique perspective on one of the most anachronistic, exploitative, and racist modern states of the post-war era, and on some of the many forms of cultural resistance it inspired. It also raises urgent questions about how we understand the category of the literary in today's globalized, intercultural world.
Take advantage of this unique book - the first single-volume resource to explore all important aspects of neurogenic inflammation. An unrivaled compilation of up-to-date information, Neurogenic Inflammation contains chapters written by recognized authorities in their areas of expertise. It covers the basic mechanisms and the pathophysiological implications of neurogenic inflammatory processes and points to novel therapeutic strategies in the field of inflammatory and related diseases. The book highlights the many systems and mechanisms involved in neurogenic inflammation, including vasodilatation, plasma extravasation, leukocyte adhesion, smooth muscle contraction, exocrine gland secretion, and recruitment of inflammatory cells. The authors discuss the contribution of neurogenic inflammation to human diseases, such as migraine, asthma, arthritis, and inflammatory bowel disease, linked to the ubiquitous distribution of sensory nerves to organs and tissues at both the somatic and visceral level. Neurogenic Inflammation is the clear choice for a one-step, authoritative guide to the latest developments in this dynamic field.
Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life - Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework - Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature - Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type - Demonstrates the causal power of system-level understanding of genomic control process - Conceptually organizes a constellation of complex and diverse biological phenomena - Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models - Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
Clinical Trials and Tribulations evaluates the multiple layers of complexities around research management, also exploring current practices, challenges and future directions. The book provides answers to readers questions and problems through extensive use of real-world examples, case studies and lessons learned. Following an approach to provide pragmatic viewpoints as well as concepts and methodologies and its alignment with specific practices, the book explores paradigms between planning and conducting research in academia vs. healthcare vs. industry in the UK vs. Europe vs. America. It highlights practical solutions to real-world complex issues that have been documented by independent regulators. This will be an indispensable book for all staff working in clinical research within healthcare, academia and industry, as well as students intending to work in clinical trials. - Covers key topics across pre-clinical, clinical research and clinical practice - Highlights areas such as the socioeconomics of conducting research, capacity and capability, research quality and performance (including performance indicators, adaptive design and practical solutions) - Provides lessons learned from breach of protocols, ethical breaches, SAE/SUSARs, aseptic pharmacy preparation issues, and instability within research structures - Includes a focus on the UK clinical research system, offering key insights into working within the UK and collaborating with UK partners
Aimed at senior undergraduate and post-graduate students following courses in International Business and Industrial Relations this book examines the labour market effects of multinational business. In reflecting the complexity and dynamism of developments in this area, the book makes clear the need to underpin analysis of the labour market effects of multinational business with conceptual understanding of the theory of multinational enterprise.
Some forms of literature interfere with the workings of the literate brain, posing a challenge to readers of all kinds, including professional literary critics. In Artefacts of Writing, Peter D. McDonald argues they pose as much of a challenge to the way states conceptualise language, culture, and community. Drawing on a wealth of evidence, from Victorian scholarly disputes over the identity of the English language to the constitutional debates about its future in Ireland, India, and South Africa, and from the quarrels over the idea of culture within the League of Nations in the interwar years to UNESCO's ongoing struggle to articulate a viable concept of diversity, McDonald brings together a large ensemble of legacy writers, including T.S. Eliot, James Joyce, and Rabindranath Tagore, putting them in dialogue with each other and with the policy-makers who shaped the formation of modern states and the history of internationalist thought from the 1860s to the 1940s. In the second part of the book, he reflects on the continuing evolution of these dialogues, showing how a varied array of more contemporary writers from Amit Chaudhuri, J. M. Coetzee, and Salman Rushdie to Antjie Krog, Arvind Krishna Mehrotra, and Es'kia Mphahlele cast new light on a range of questions concerning education, literacy, human rights, translation, indigenous knowledge, and cultural diversity that have preoccupied UNESCO since 1945. At once a novel contribution to institutional and intellectual history and an innovative exercise in literary and philosophical analysis, Artefacts of Writing affords a unique perspective on literature's place at the centre of some of the most fraught, often lethal public controversies that defined the long-twentieth century and that continue to haunt us today
Sampling-based computational methods have become a fundamental part of the numerical toolset of practitioners and researchers across an enormous number of different applied domains and academic disciplines. This book provides a broad treatment of such sampling-based methods, as well as accompanying mathematical analysis of the convergence properties of the methods discussed. The reach of the ideas is illustrated by discussing a wide range of applications and the models that have found wide usage. The first half of the book focuses on general methods; the second half discusses model-specific algorithms. Exercises and illustrations are included.
The use of formulae has become widespread in recent years across most developed countries. In the UK, a conservative estimate is that annually £150 billion of public service expenditure is distributed using formulae, in services such as health care, local government, social security and higher education. This book offers a comprehensive introduction to the theory and practice underlying the use of such formulae as a basis for funding public services. The philosophy, design and economic consequences of funding formulae have become key policy issues worldwide. However, till now, there has been no text which brings together the economic, statistical and political issues underlying formula funding. This key book fills that gap. Written by a leading international expert on the design of funding formulae, this important book includes empirical evidence from a range of countries and will be a valuable resource for all those involved in this field.
How abstract design decisions in 2D platform games create rich worlds of meaning for players. Since the 1980s, 2D platform games have captivated their audiences. Whether the player scrambles up the ladders in Donkey Kong or leaps atop an impossibly tall pipe in Super Mario Bros., this deceptively simple visual language has persisted in our cultural imagination of video games. In Run and Jump, Peter McDonald surveys the legacy of 2D platform games and examines how abstract and formal design choices have kept players playing. McDonald argues that there is a rich layer of meaning underneath, say, the quality of an avatar’s movement, the pacing and rhythm of level design, the personalities expressed by different enemies, and the emotion elicited by collecting a coin. To understand these games, McDonald draws on technical discussions by game designers as well as theoretical work about the nature of signs from structuralist semiotics. Interspersed throughout are design exercises that show how critical interpretation can become a tool for game designers to communicate with their players. With examples drawn from over forty years of game history, and from games made by artists, hobbyists, iconic designers, and industry studios, Run and Jump presents a comprehensive—and engaging—vision of this slice of game history.
Goodwood Remembered is a unique collection of previously unpublished photographs, sketches and recollections of Peter Redman, an enthusiastic spectator. As well as over 150 of his photographs from the late 1940s and 1950s, Peter Redman has included more than 50 sketches of cars and drivers of the period and 13 of his cartoons that help bring motor racing at Goodwood between 1948 and 1960 to life. The book is full of interesting snippets. Bernie Ecclestone’s second place in a 500 cc race, and World Champion Juan Manuel Fangio nursing an “off-song” Cooper-Bristol into sixth place in a Formula Libre race, are just two examples. It is a fascinating insight into the range of racing cars and drivers at Goodwood in that period: from World Champions such as Fangio, Farina and Hawthorn to handicap races for lady drivers. Goodwood Remembered will be of great interest to anyone who remembers those times and for the huge number who follow historic motor racing or want to know more of the roots of modern motor sport.
Thoroughly revised and updated, the third edition of the best-selling textbook Prison and Jail Administration: Practice and Theory covers all aspects of prison administration, from organizational structure and management accountability to food service, personnel corruption, and the impact of technology on penal institutions. Authored by over sixty leading experts in the field, the text provides students with a unique balance of practice and theory, and includes suggested readings, learning objectives, and discussion questions to help students gain an in-depth understanding of the material. The third edition includes all-new pedagogical features, instructor resources, and new chapters on current topics, such as women offenders, the world of a corrections officer, hiring and retention of staff, institution pre-release programs, and restorative justice. The most comprehensive and accessible prison administration textbook available, Prison and Jail Administration: Practice and Theory, Third Edition is essential reading for students in correctional administration courses.
Prison and Jail Administration: Practice and Theory, Second Edition has been completely revised an updated to include the latest research and best practices in corrections management. This book is the compendium for correctional administration courses, covering everything from organizational structure and management accountability to food service, personnel corruption, and the impact of technology in penal institutions. With chapters contributed by over sixty leading academics and practitioners, this text provides students with a unique balance of practice and theory. Suggested readings, learning objectives, discussion questions, and a glossary help students gain an in-depth understanding of the material.
This volume starts the updating of the information on organonickel chemistry, one of the most active areas of modern organometallic chemistry. It covers all mononuclear compounds containing one nickel-to-carbon bond. The main part is devoted to the family of planar NiII compounds, RNi(D)2X, which within 20 years has increased from about 250 to more than 1000 members. This research interest has been stimulated by the fact that many compounds insert various unsaturated species into the Ni-C bond to create new organonickel species. Moreover, these compounds are important as intermediates in many catalytic processes involving organic halides. Compounds containing h*2-bonded heteroalkene molecules including the C1 fragments CO2 and CS2, and related metallocyclic compounds are also emphasized in this volume. These types of compounds play an important role in a number of nickel-catalyzed co-oligomerization reactions involving unsaturated organic compounds. Most of the compounds are well-characterized by modern spectroscopic techniques. The various types of compounds are in most cases confirmed by X-ray diffraction. The author of these volumes, a member of the M lheim group, has made many contributions of his own and is eminently qualified to critically review this area of research.
The field of asthma has expanded in the last decade with specific drugs targeting the disease mechanisms. This book is an updated treatise covering diagnoses, phenotypes and endotypes of asthma along with its management. It includes diagnostic work-up which is required prior to medical assistance and basic immunology assessment, illustrating the types, severity, number of exacerbations due to disease activity, allergy or infections. As the treatment selection has changed from one size fits all to precision-based medicine, it aims to refine asthma management with right medication usage, neither overuse nor underuse, and initiation of the new hospital administered biologic drugs. Key Features • Covers both respiratory physiology and airway inflammation • Highlights the use of biologic drugs • Discusses precision-based medicine • Explores the comorbidities through clinical cases
Selected by the editors of the prestigious Ellery Queen's Mystery Magazine and Alfred Hitchcock's Mystery Magazine, here are 14 tales of extraordinary cats and uncommon crimes. Features lead story by bestselling novelist Lilian Jackson Braun as well as selections from Dorothy L. Sayers, Ellis Peters, and others.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.