Completely revised to meet the demands of today's trainee and practicing plastic surgeon, Principles, Volume 1 of Plastic Surgery, 4th Edition, features new full-color clinical photos, dynamic videos, and authoritative coverage of hot topics in the field. Editor-narrated PowerPoint presentations offer a step-by-step audio-visual walkthrough of techniques and procedures in plastic surgery. - Offers evidence-based advice from a diverse collection of experts to help you apply the very latest advances in plastic surgery and ensure optimal outcomes. - Provides updated coverage of: Digital technology in plastic surgery; Repair and grafting of fat and adipose tissue; Stem cell therapy and tissue engineering; and Treatment of Lymphedema - Includes brand-new color clinical photos, videos, and lectures. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos, and references from the book on a variety of devices.
Including new developments and publications which have appeared since the publication of the first edition in 1995, this second edition: *gives a comprehensive introductory account of event history modeling techniques and their use in applied research in economics and the social sciences; *demonstrates that event history modeling is a major step forward in causal analysis. To do so the authors show that event history models employ the time-path of changes in states and relate changes in causal variables in the past to changes in discrete outcomes in the future; and *introduces the reader to the computer program Transition Data Analysis (TDA). This software estimates the sort of models most frequently used with longitudinal data, in particular, discrete-time and continuous-time event history data. Techniques of Event History Modeling can serve as a student textbook in the fields of statistics, economics, the social sciences, psychology, and the political sciences. It can also be used as a reference for scientists in all fields of research.
Dr. Braunwald's masterwork returns ... bringing you the definitive guidance you need to overcome any challenge in clinical cardiology today, using the best approaches available! Hundreds of world authorities, many of them new to this edition, synthesize all of the recent developments that are revolutionizing practice - from the newest findings in molecular biology and genetics to the latest imaging modalities, interventional procedures, and medications. This multimedia e-dition includes not only the printed reference, but also access to the complete contents online, fully searchable, with regular updates and much more. The expertise of the contributors, the scope of the coverage, and the versatile, multimedia format all make this the ultimate reference for the practicing cardiologist. Locate the answers you need fast, thanks to a user-friendly, full-color design, complete with more than 1,500 color illustrations. Glean clinically actionable information quickly with Clinical Practice Points in every chapter. Access the complete contents of the 2-volume set online, fully searchable, plus regular updates to reflect the latest clinical developments · Focused Reviews · Commentaries · Late-Breaking Trials · and more. Apply the latest knowledge in your field with 7 new chapters on Acute Heart Failure · Device Therapy of Heart Failure · Emerging Therapies for Heart Failure · Complementary and Alternative Approaches to Management · Prevention and Management of Stroke · Hypertrophic Cardiomyopathy · and Coronary Arteriography Guidelines. Get fresh perspectives on your practice with contributions from more than 20 brand-new authors.
This title is directed primarily towards health care professionals outside of the United States. A new edition of a well-known dental dictionary, suitable for dental students, dental nurses and dental practice secretaries. - A comprehensive dictionary of the complete range of dental terminology - Line diagrams illustrated selected definitions. - Useful appendices cover such things as dental instruments, development and eruption of teeth etc. - Totally revised - new definitions added and obsolete ones deleted.
When his novel Killing Mister Watson was published in 1990, the reviews were extraordinary. It was heralded as "a marvel of invention . . . a virtuoso performance" (The New York Times Book Review) and a "novel [that] stands with the best that our nation has produced as literature" (Los Angeles Times Book Review). Now Peter Matthiessen brings us the second novel in his Watson trilogy, a project that has been nearly twenty years in the writing. A story of epic scope and ambition, Lost Man's River confronts the primal relationship between a dangerous father and his desperate sons and the ways in which his death has shaped their lives. Lucius Watson is obsessed with learning the truth about his father. Who was E. J. Watson? Was he a devoted family man, an inspired farmer, a man of progress and vision? Or was he a cold-blooded murderer and amoral opportunist? Were his neighbors driven to kill him out of fear? Or was it envy? And if Watson was a killer, should the neighbors fear the obsessed Lucius when he returns to live among them and ask questions? The characters in this tale are men and women molded by the harsh elements of the Florida Everglades--an isolated breed, descendants of renegades and pioneers, who have only their grit, instinct, and tradition to wield against the obliterating forces of twentieth-century progress: Speck Daniels, moonshiner and alligator poacher turned gunrunner; Sally Brown, who struggles to escape the racism and shame of her local family; R. B. Collins, known as Chicken, crippled by drink and rage, who is the custodian of Watson secrets; Watson Dyer, the unacknowledged namesake with designs on the remote Watson homestead hidden in the wild rivers; and Henry Short, a black man and unwilling member of the group of armed island men who awaited E. J. Watson in the silent twilight. Only a storyteller of Peter Matthiessen's dazzling artistry could capture the beauty and strangeness of life on this lawless frontier while probing deeply into its underlying tragedy: the brutal destruction of the land in the name of progress, and the racism that infects the heart of New World history.
NATIONAL BOOK AWARD WINNER • “Altogether gripping, shocking, and brilliantly told, not just a tour de force in its stylistic range, but a great American novel, as powerful a reading experience as nearly any in our literature.”—Michael Dirda, The New York Review of Books Killing Mister Watson, Lost Man’s River, and Bone by Bone—Peter Matthiessen’s great American epic about Everglades sugar planter and notorious outlaw E. J. Watson on the wild Florida frontier at the turn of the twentieth century—were originally conceived as one vast, mysterious novel. Now, in this bold new rendering, Matthiessen has marvelously distilled a monumental work while deepening the insights and motivations of his characters with brilliant rewriting throughout. Praise for Shadow Country “Magnificent . . . breathtaking . . . Finally now we have [this three-part saga] welded like a bell, and with Watson’s song the last sound, all the elements fuse and resonate.”—Los Angeles Times “Peter Matthiessen has done great things with the Watson trilogy. It’s the story of our continent, both land and people, and his writing does every justice to the blood fury of his themes.”—Don DeLillo “The fiction of Peter Matthiessen is the reason a lot of people in my generation decided to be writers. No doubt about it. Shadow Country lives up to anyone’s highest expectations for great writing.” —Richard Ford “Shadow Country, Matthiessen’s distillation of the earlier Watson saga, represents his original vision. It is the quintessence of his lifelong concerns, and a great legacy.”—W. S. Merwin “[An] epic masterpiece . . . a great American novel.”—The Miami Herald
Practical Pharmacology in Rehabilitation discusses the effects of medications in the rehabilitation process and assists rehabilitation professionals in designing patient-specific therapy plans based on coexisting disease states and medications used.
Nowadays, event history analysis can draw on a well-established set of statistical tools for the description and causal analysis of event history data. The second edition of Event History Analysis with Stata provides an updated introduction to event history modeling, along with many instructive Stata examples. Using the latest Stata software, each of these practical examples develops a research question, refers to useful substantive background information, gives a short exposition of the underlying statistical concepts, describes the organization of the input data and the application of the statistical Stata procedures, and assists the reader in performing a substantive interpretation of the obtained results. Emphasising the strengths and limitations of event history model techniques in each field of application, this book demonstrates that event history models provide a useful approach with which to uncover causal relationships or to map out a system of causal relations. It demonstrates how long-term processes can be studied and how changing context information on the micro, meso, and macro levels can be integrated easily into a dynamic analysis of longitudinal data. Event History Analysis with Stata is an invaluable resource for both novice students and researchers who need an introductory textbook and experienced researchers (from sociology, economics, political science, pedagogy, psychology, or demography) who are looking for a practical handbook for their research.
R Programming for Actuarial Science Professional resource providing an introduction to R coding for actuarial and financial mathematics applications, with real-life examples R Programming for Actuarial Science provides a grounding in R programming applied to the mathematical and statistical methods that are of relevance for actuarial work. In R Programming for Actuarial Science, readers will find: Basic theory for each chapter to complement other actuarial textbooks which provide foundational theory in depth. Topics covered include compound interest, statistical inference, asset-liability matching, time series, loss distributions, contingencies, mortality models, and option pricing plus many more typically covered in university courses. More than 400 coding examples and exercises, most with solutions, to enable students to gain a better understanding of underlying mathematical and statistical principles. An overall basic to intermediate level of coverage in respect of numerous actuarial applications, and real-life examples included with every topic. Providing a highly useful combination of practical discussion and basic theory, R Programming for Actuarial Science is an essential reference for BSc/MSc students in actuarial science, trainee actuaries studying privately, and qualified actuaries with little programming experience, along with undergraduate students studying finance, business, and economics.
Mosby's Dictionary of Medicine, Nursing & Health Professions has been acclaimed by students and educators for its clarity, comprehensiveness and currency. Now in its second edition, a thorough revision of this definitive reference for the ANZ region enhances the classic Mosby dictionary features and sees in its over 2000 pages: - precise and clear entries, plus encyclopaedic entries of significant terms; generous illustrations and apt use of tables - a detailed colour atlas of anatomy enhances the comprehension of anatomical terms - local spelling conventions and phonetic pronunciation guides - fully revised etymologies Online resources include a regional spellchecker, a printable colour atlas, all images from the text, and 18 valuable appendices, 9 of which appear in the main text. - encyclopaedic definitions - comprehensive entries for numerous fully updated drugs - over 2400 high quality full-colour illustrations and photographs to enhance and clarify definitions of terms - regionalised spellchecker - over 300 new drug entries - over 500 new images, including uniquely Australian sourced images for illustrating terms of particular local relevance - a total of 73 new and updated tables to provide key reference information to supplement definitions - revised to update and refine existing material and incorporate many new terms, tables and illustrations to ensure currency and relevance - all appendices have been updated to include the latest information - new terms include Swine influenza, Hendra disease, Nipah virus, Avian influenza, Multi-drug resistant TB and Vancomycin resistant enterococcus plus many, many more
This volume is the first book-length treatment of model-based geostatistics. The text is expository, emphasizing statistical methods and applications rather than the underlying mathematical theory. Analyses of datasets from a range of scientific contexts feature prominently, and simulations are used to illustrate theoretical results. Readers can reproduce most of the computational results in the book by using the authors' software package, geoR, whose usage is illustrated in a computation section at the end of each chapter. The book assumes a working knowledge of classical and Bayesian methods of inference, linear models, and generalized linear models.
Dickie Gordon, lucky to escape the Japanese Invading Burma in April,1941, is re-instated as a district officer in Bengal, India. He struggles to maintain the integrity of the Civil Service beseiged by ambitious politicians, corruption, and ruthless terrorists, a mix that hastens the disintegration of the Raj.
Trusted resource for students and educators in Australia and New Zealand Mosby’s Dictionary of Medicine, Nursing and Health Professions Australian and New Zealand edition is an established and acclaimed reference guide suitable for all students and clinicians wanting current, accurate definitions of medical terms. The fourth edition has been updated to reflect the latest changes in healthcare terminology, and retains the comprehensiveness, clarity and currency that readers expect from the Mosby Dictionary. It provides full coverage of nearly 40,000 terms as well as images, tables, graphs and an anatomy and physiology atlas for deeper insight into complex concepts. This resource is an ideal support for students throughout their studies in medicine, nursing and the broader health professions, and will remain a definitive reference for all clinicians who understand the importance of accurate terminology for better patient care. • Nearly 40,000 clear, precise entries –updated to take in recent healthcare developments to support study and research use • Over 2,000 high quality images and a detailed colour anatomy atlas to enhance comprehension • More than 30 medical and health specialties represented – suitable for all healthcare students, educators and clinicians • Local spelling conventions and phonetic pronunciation guides throughout – suitable for readers in Australia and New Zealand • Etymologies revised to ensure currency • Comprehensive entries for numerous drugs and medications • Useful appendices, including normal laboratory values for adults and children, units of measurement, nutrition guidelines, assessment guides, immunisation schedules, infection control and herb-drug interactions • An eBook included with print purchase
Scandals and high political office regularly coincide. Over the last five decades, with the world watching the American president as its preeminent international figure, scandals affecting the president have had both international origins and international consequences. Every president from Richard Nixon to Donald Trump has faced scandal but only a handful have faced a scandal so large that it threatened impeachment or even the political system itself. Hence, this is a study of five scandals or in the case of Clinton and Trump, scandalous presidencies that produced impeachments · Nixon and Watergate · Reagan and Iran-Contra · Clinton and Impeachment · Bush and the 2000 election/Trump and the 2016 election · Trump and Impeachments Along the way, several trends have shaped the course of presidential scandals. One set has been political. Scandal operates in tandem with partisanship. The intensity of party divisions was obviously a factor in creating the context for all the scandals discussed. Scandal also springs from personality. Few would disagree that the character of Nixon, Clinton and Trump was the seedbed for the scandals they faced. But more broadly, it seems the traits required of a successful presidential candidate have changed. What would once have damned a candidate is no longer an insurmountable obstacle. What blocked Gary Hart in 1988 could not stop Donald Trump in 2016. The second group of trends stem from the changing media landscape. Richard Nixon operated in a world dominated by major TV networks. Clinton in a time that saw the emergence of cable channels such as Fox News that tailored their coverage to the biases of their viewers; and Trump in a world of internet websites and social media, where securing attention takes precedence over accuracy. These trends have added fuel to gossip and therefore scandal. As the 2016 election demonstrated, they have also enabled a new form of cyber warfare that probes US weaknesses by fostering internal disunity. The question now is: Does scandal still carry a cost? In 2024, the jury is still deliberating.
Discover the heritage of Maitland, New South Wales, Australia! Fascinating facts, bewitching stories and awe-inspiring vintage photographs reveal its people and places, alluring readers to inhabit this treasured landscape. THE FOOTPRINTS OF MAITLAND’S OLD HANDS trilogy is a grand tapestry and a go-to guide to transport you back in time. Its an ambitious and comprehensive study of Maitland and its neighbouring historical estates. The author devoted thirty years to weave the tale of this town, weighing untold data left idle in ignored documents and undisturbed memories. With the keen eye of a seasoned historian, three centuries of Maitland’s history, gateway to the Hunter Valley, are recorded for future generations. Footprints left by ancestors are no longer hidden by nature’s fury of floods, fires or human forgetfulness. This three-book work is a treasure-trove for tens-of-thousands, young and old, whose families made Maitland the heritage gateway to the Hunter!
Dr Peter Pedersen’s scholarly study of Sir John Monash remains the finest analysis of Australia’s best known military leader. In 1918 the Australian Corps under Monash’s command played a leading role in the Allied advance to victory on the Western Front. Its successes in the battles of Hamel and Amiens, the taking of Mont St Quentin and Péronne and the breaching of the Hindenburg Line are among the most prominent landmarks in Australia’s military history. Monash was central to these pivotal achievements. This book traces Monash’s development as a commander from his pre-war militia service to his wartime experience at Gallipoli and on the Western Front. It examines in detail how each stage of his military career influenced his approach to command and the tactical problems he faced as the wartime commander of an infantry brigade and division and, ultimately, the Australian Corps. The influence of his education and civilian training are also examined in this meticulous study. What emerges from this nuanced and sophisticated assessment of Monash as a soldier is a superb portrayal of how a commander works and what he could achieve under conditions so inimical to the exercise of command as those that prevailed on the Western Front. Along the way, Dr Pedersen establishes Monash’s place among his contemporaries, British and Australian, and provides the definitive answer to the question ‘Just how good was Monash?’ Published for the centenary of the great victories of 1918, this new and updated edition of Dr Pedersen’s classic work is a timely study of Australia’s finest general.
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. - Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information - Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress - Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Dieses etwas andere Lehrbuch bietet keine vorgefertigten Rezepte und Problemlösungen, sondern eine kritische Diskussion ökonometrischer Modelle und Methoden: voller überraschender Fragen, skeptisch, humorvoll und anwendungsorientiert. Sein Erfolg gibt ihm Recht.
Freddie Fitzsimmons was among baseball's top pitchers during his 19-year career with the New York Giants and Brooklyn Dodgers. Famed for his knuckleball, Fitz also had the reputation as the game's best fielding pitcher. Fitzsimmons was both a fierce competitor and one of the most admired players of baseball's Golden Age. When discovered by Giants' manager John McGraw in 1925, Fitzsimmons became a household name to baseball fans around the country. A mainstay of the New York rotations of the 1920s and 1930s, Fitzsimmons pitched in the 1933 and 1936 World Series, where he suffered painful losses. Being traded to the Brooklyn Dodgers in 1937 rejuvenated Fitzsimmons and brought him back to the World Series one last fateful time in 1941. When his playing days ended, Fitzsimmons managed the Philadelphia Phillies and later coached for the Giants and several other teams. In Freddie Fitzsimmons: A Baseball Life, Peter J. De Kever brings to life Fitzsimmons's colorful character and most memorable games. Fitz's life in baseball spanned nearly half a century and brought him into contact with many of the game's luminaries, such as Babe Ruth, Bill Terry, Leo Durocher, and Willie Mays. A central player in the great 1941 pennant race, Fitzsimmons also witnessed Bobby Thomson's "shot heard 'round the world" a decade later. These and other stories figure prominently in this first biography of Freddie Fitzsimmons.
Patients are not alike! This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the “average” patient. As a result, potential variability between patients is ignored when presenting, e.g., the results of a multiple linear regression model. In medicine there are more and more attempts to individualize therapy; thus, from the author’s point of view biostatis- cians should support these efforts. Therefore, one of the tasks of the statistician is to identify heterogeneity of patients and, if possible, to explain part of it with known explanatory covariates. Finite mixture models may be used to aid this purpose. This book tries to show that there are a large range of applications. They include the analysis of gene - pression data, pharmacokinetics, toxicology, and the determinants of beta-carotene plasma levels. Other examples include disease clustering, data from psychophysi- ogy, and meta-analysis of published studies. The book is intended as a resource for those interested in applying these methods.
Within an international framework, this work provides a fully comprehensive approach to the geographical coverage of elections. Numerous applications of ideas and concepts from human geography are incorporated into a new political context, illustrating the manner in which electoral patterns reflect and help produce the overall geography of a region or state. Discussions of various topics are well supported by numerous maps and diagrams which help clarify arguments and serve to define elections within their basic geographical context.
Emergency physicians assess and manage a wide variety of problems from patients presenting with a diversity of severities, ranging from mild to severe and life-threatening. They are expected to maintain their competency and expertise in areas where there is rapid knowledge change. Evidence-based Emergency Medicine is the first book of its kind in emergency medicine to tackle the problems practicing physicians encounter in the emergency setting using an evidence-based approach. It summarizes the published evidence available for the diagnosis and treatment of common emergency health care problems in adults. Each chapter contextualizes a topic area using a clinical vignette and generates a series of key clinically important diagnostic and treatment questions. By completing detailed reviews of diagnostic and treatment research, using evidence from systematic reviews, RCTs, and prospective observational studies, the authors provide conclusions and practical recommendations. Focusing primarily on diagnosis in areas where evidence for treatment is well accepted (e.g. DVTs), and treatment in other diseases where diagnosis is not complex (e.g. asthma), this text is written by leading emergency physicians at the forefront of evidence-based medicine. Evidence-based Emergency Medicine is ideal for emergency physicians and trainees, emergency department staff, and family physicians specialising in the acute care of medical and injured patients.
The story of an American hero who stood against all the forces of Gilded Age America to help enshrine our civil rights and economic freedoms. Dissent. No one wielded this power more aggressively than John Marshall Harlan, a young union veteran from Kentucky who served on the US Supreme Court from the end of the Civil War through the Gilded Age. In the long test of time, this lone dissenter was proven right in case after case. They say history is written by the victors, but that is not Harlan's legacy: his views--not those of his fellow justices--ulitmately ended segregation and helped give us our civil rights and our economic freedoms. Derided by many as a loner and loser, he ended up being acclaimed as the nation's most courageous jurist, a man who saw the truth and justice that eluded his contemporaries. "Our Constitution is color blind and neither knows nor tolerates classes among citizens," he wrote in his famous dissent in Plessy v. Ferguson, one of many cases in which he lambasted his colleagues for denying the rights of African Americans. When the court struck down antitrust laws, Harlan called out the majority for favoring its own economic class. He did the same when the justices robbed states of their power to regulate the hours of workers and shielded the rich from the income tax. When other justices said the court was powerless to prevent racial violence, he took matters into his own hands: he made sure the Chattanooga officials who enabled a shocking lynching on a bridge over the Tennessee River were brought to justice. In this monumental biography, prize-winning journalist and bestselling author Peter S. Canellos chronicles the often tortuous and inspiring process through which Supreme Courts can make and remake the law across generations. But he also shows how the courage and outlook of one man can make all the difference. Why did Harlan see things differently? Because his life was different, He grew up alongside Robert Harlan, whom many believed to be his half brother. Born enslaved, Robert Harlan bought his freedom and became a horseracing pioneer and a force in the Republican Party. It was Robert who helped put John on the Supreme Court. At a time when many justices journey from the classroom to the bench with few stops in real life, the career of John Marshall Harlan is an illustration of the importance of personal experience in the law. And Harlan's story is also a testament to the vital necessity of dissent--and of how a flame lit in one era can light the world in another. --
The second edition of Chronic Pain now covers a vast scientific and clinical arena, with the scientific background and therapeutic options much expanded. In common with the other titles comprising Clinical Pain Management, the volume gathers together the available evidence-based information in a reader-friendly format without unnecessary detail, an
GI/Liver Secrets Plus, 4th Edition, by Peter R. McNally, DO, FACP, FACG - a volume in the popular Secrets Series® - uses a convenient Q&A approach to provide rapid reference and review of today's most common GI and liver disorders and their management. An expanded size and layout, user-friendly two-color page layout, question-and-answer approach, and list of the "Top 100 GI/Liver Secrets" make it a perfect concise board review tool and a handy clinical reference. Updated coverage throughout equips you with all of the most current and essential knowledge in the field. Uses bulleted lists, tables, boxes, short answers, and a highly detailed index to expedite reference. Includes Key Points and memory aids in each chapter that make it perfect for board review or clinical reference. Covers all of today's most common GI and liver disorders and their management. Features the new "Secrets PLUS" format - with an expanded size and layout, more information, and more visual elements - for easier review and an overall enhanced reference experience. Contains new images and illustrations to provide more detail and offer a clearer picture of what is seen in practice. Incorporates revisions throughout to provide you with an up-to-date overview of gastroenterology and hepatology, including new chapters on Esophageal and Stomach Pathology, Pathology of the Lower GI Tract, Gastroesophageal Reflux and Esophageal Hernias, and Surgery of Achalasia and Esophageal Cancer. Offers reorganized and expanded sections covering the bowels and colon for more specific and easier reference: Small and Large Bowel Disorders; Colon Disorders; and General Symptoms and Conditions.
A 2019 Axiom Business Award winner. In The Customer Centricity Playbook , Wharton School professor Peter Fader and Wharton Interactive's executive director Sarah Toms help you see your customers as individuals rather than a monolith, so you can stop wasting resources by chasing down product sales to each and every consumer.
Available for the First Time—Three Books in One! The Customer Centricity Ebook Collection is a must-have for any business leader looking to understand and implement customer-centric strategies. This collection includes three essential books by renowned experts Peter Fader, Bruce Hardie, Michael Ross, and Sarah Toms, all of whom are leaders in the field of customer centricity. The collection includes three books in a single volume:Customer Centricity, by Peter FaderThe Customer Centricity Playbook, by Peter Fader and Sarah TomsThe Customer-Base Audit, by Peter Fader, Bruce Hardie, and Michael Ross The Customer Centricity Ebook Collection offers a comprehensive guide to understanding, implementing, and measuring the impact of customer-centric strategies.
The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings. - This edition is in full color and features nearly 200 high-quality images - Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading - Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions
Lieutenant General Sir Frank Berryman is one of the most important, yet relatively unknown officers in the history of the Australian Army. Despite his reputedly caustic personality and noted conflicts with some senior officers, Berryman was crucial to Australia's success during the Second World War. But did the man known as 'Berry the Bastard' deserve his reputation? Bold, calculating and talented, Berryman was at the forefront of operations that led to the defeat of the Japanese, and his operational planning secured Australia's victories at Bardia, Tobruk and in New Guinea during the Pacific War. With access to rare private papers, Peter Dean charts Berryman's special relationships with senior US and Australian officers such as MacArthur, Chamberlin, Blamey, Lavarack and Morshead, and explains why the man poised to become the next Chief of General Staff would never fulfil his ambition.
Incidence rates are counts divided by person-time; mortality rates are a well-known example. Analysis of Incidence Rates offers a detailed discussion of the practical aspects of analyzing incidence rates. Important pitfalls and areas of controversy are discussed. The text is aimed at graduate students, researchers, and analysts in the disciplines of epidemiology, biostatistics, social sciences, economics, and psychology. Features: Compares and contrasts incidence rates with risks, odds, and hazards. Shows stratified methods, including standardization, inverse-variance weighting, and Mantel-Haenszel methods Describes Poisson regression methods for adjusted rate ratios and rate differences. Examines linear regression for rate differences with an emphasis on common problems. Gives methods for correcting confidence intervals. Illustrates problems related to collapsibility. Explores extensions of count models for rates, including negative binomial regression, methods for clustered data, and the analysis of longitudinal data. Also, reviews controversies and limitations. Presents matched cohort methods in detail. Gives marginal methods for converting adjusted rate ratios to rate differences, and vice versa. Demonstrates instrumental variable methods. Compares Poisson regression with the Cox proportional hazards model. Also, introduces Royston-Parmar models. All data and analyses are in online Stata files which readers can download. Peter Cummings is Professor Emeritus, Department of Epidemiology, School of Public Health, University of Washington, Seattle WA. His research was primarily in the field of injuries. He used matched cohort methods to estimate how the use of seat belts and presence of airbags were related to death in a traffic crash. He is author or co-author of over 100 peer-reviewed articles.
Complex chemically reacting flow simulations are commonly employed to develop quantitative understanding and to optimize reaction conditions in systems such as combustion, catalysis, chemical vapor deposition, and other chemical processes. Although reaction conditions, geometries, and fluid flow can vary widely among the applications of chemically reacting flows, all applications share a need for accurate, detailed descriptions of the chemical kinetics occurring in the gas-phase or on reactive surfaces. Chemically Reacting Flow: Theory and Practice combines fundamental concepts in fluid mechanics and physical chemistry, assisting the student and practicing researcher in developing analytical and simulation skills that are useful and extendable for solving real-world engineering problems. The first several chapters introduce transport processes, primarily from a fluid-mechanics point of view, incorporating computational simulation from the outset. The middle section targets physical chemistry topics that are required to develop chemically reacting flow simulations, such as chemical thermodynamics, molecular transport, chemical rate theories, and reaction mechanisms. The final chapters deal with complex chemically reacting flow simulations, emphasizing combustion and materials processing. Among other features, Chemically Reacting Flow: Theory and Practice: -Advances a comprehensive approach to interweaving the fundamentals of chemical kinetics and fluid mechanics -Embraces computational simulation, equipping the reader with effective, practical tools for solving real-world problems -Emphasizes physical fundamentals, enabling the analyst to understand how reacting flow simulations achieve their results -Provides a valuable resource for scientists and engineers who use Chemkin or similar software Computer simulation of reactive systems is highly effective in the development, enhancement, and optimization of chemical processes. Chemically Reacting Flow helps prepare both students and professionals to take practical advantage of this powerful capability.
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